Next-generation bioabsorbable spacer for miminum invasive radiotherapy
Project/Area Number |
16H05391
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Kobe University |
Principal Investigator |
SASAKI RYOHEI 神戸大学, 医学部附属病院, 教授 (30346267)
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Co-Investigator(Kenkyū-buntansha) |
赤坂 浩亮 神戸大学, 医学部附属病院, 特命助教 (20707161)
出水 祐介 神戸大学, 医学研究科, 客員准教授 (50452496)
犬伏 祥子 (カリヤ) 神戸大学, 医学研究科, 特命助教 (60585959)
福本 巧 神戸大学, 医学研究科, 教授 (70379402)
王 天縁 神戸大学, 医学部附属病院, 特命技術員 (90757288)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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Keywords | Particle therapy / Spacer / Cancer / スペーサー / 粒子線治療 / 吸収性素材 / 膵臓癌 / 生態適合性材料 / 放射線治療 |
Outline of Final Research Achievements |
We have developed a novel bioabsorbable polyglycolic acid (PGA) spacer. This is a promising method designed to allow for increased tumor dose while limiting exposure to adjacent organs without remaining a foreign body after the treatment. In the preclinical animal study, biological safety was evaluated, resulting that no weight loss or appetite loss was observed. There were minimum adhesion, and a Seprafilm helped to decrease those adhesions. With long term observation in animals, the PGA spacer was slowly decreased in size and seemed to be useful and safe for clinical application Then, a first-in-human phase I clinical study using the PGA spacer aimed to evaluate the safety and efficacy of SMPT in patients with unresectable malignant tumor located adjacent to normal organs.
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Academic Significance and Societal Importance of the Research Achievements |
我々が開発した吸収性のPGAスペーサーを用いた新規粒子線治療は、これまで根治的治療が困難であった腫瘍と正常臓器が近接する症例において新たな治療戦略と成り得ることを前臨床の動物試験と第1相臨床試験によって証明できた。またPGAスペーサーの唯一の問題点とも言える癒着に関してもその対象方法を解明できた。今後は本治療法が広く適用され、難治癌に対する有用な治療選択肢になることが期待される。本邦発の新たな医療機器の有用性と安全性が確認され証明できた結果からも、本研究課題とその成果が社会的意義が高い研究を裏付ける結果である。
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Comparison of dosimetric parameters in the treatment planning of magnetic resonance imaging-based intracavitary image-guided adaptive brachytherapy with and without optimization using the central shielding technique.2018
Author(s)
Nishikawa R, Yoshida K, Ebina Y, Omoteda M, Miyawaki D, Ishihara T, Ejima Y, Akasaka H, Satoh H, Kyotani K, Takahashi S, Sasaki R.
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Journal Title
Journal of Radiation Research
Volume: 印刷中
Issue: 3
Pages: 316-326
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Myo-inositol concentration in MR spectroscopy for differentiating high grade glioma from primary central nervous system lymphoma.2018
Author(s)
Nagashima H, Sasayama T, Tanaka K, Kyotani K, Sato N, Maeyama M, Kohta M, Sakata J, Yamamoto Y, Hosoda K, Itoh T, Sasaki R, Kohmura E.
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Journal Title
J Neurooncol.
Volume: 136
Issue: 2
Pages: 317-326
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Particle Therapy Using Protons or Carbon Ions for Unresectable or Incompletely Resected Bone and Soft Tissue Sarcomas of the Pelvis,2017
Author(s)
Yusuke Demizu, Dongcun Jin, Nor Shazrina Sulaiman, Fumiko Nagano, Kazuki Terashima, Sunao Tokumaru, Takashi Akagi, Osamu Fujii, Takashi Daimon, Ryohei Sasaki, Nobukazu Fuwa, Tomoaki Okimoto,
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Journal Title
Int J Radiat Oncol Biol Physc,
Volume: 98(2)
Issue: 2
Pages: 367-374
DOI
Related Report
Peer Reviewed
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[Journal Article] Sparing of tissue by using micro-slit-beam radiation therapy reduces neurotoxicity compared with broad-beam radiation therapy.2017
Author(s)
Naritoshi Mukumoto, Masao Nakayama, Hiroaki Akasaka, Yasuyuki Shimizu, Saki Osuga, Daisuke Miyawaki, Kenji Yoshida, Yasuo Ejima, Yasushi Miura, Keiji Umetani, Takeshi Kondoh, Ryohei Sasaki,
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Journal Title
J Radiat Res
Volume: 58(1)
Issue: 1
Pages: 17-23
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] [18F]Fluorodeoxyglucose uptake by positron emission tomography predicts outcomes for oropharyngeal and hypopharyngeal cancer treated with definitive radiotherapy2017
Author(s)
Takeaki Ishihara, Kazuhiro Kitajima, Yuko Suenaga, Yasuyuki Shimizu, Saki Osuga, Yasuo Ejima, Hirokazu Komatsu, Naoki Otsuki, Kenichi Nibu, Naomi kiyota, Satoru Takahashi, and Ryohei Sasaki,
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Journal Title
Nagoya Journal of Medical Science
Volume: 79
Issue: 1
Pages: 27-36
DOI
NAID
ISSN
2186-3326
URL
Related Report
Peer Reviewed
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[Journal Article] Characterization of titanium dioxide nanoparticles modified with polyacrylic acid and H2O2 for use as a novel Radiosensitizer,2016
Author(s)
Morita K, Miyazaki S, Numaki C, Ikeno S, Sasaki R, Nishimura Y, Ogino C, Kondo A,
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Journal Title
Free Radical Research,
Volume: 50(12)
Issue: 12
Pages: 1319-1328
DOI
Related Report
Peer Reviewed
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[Journal Article] Prospective Cohort Study of Performance Status and Activities of Daily Living after Surgery for Spinal Metastasis2016
Author(s)
Kakutani K, Sakai Y, Maeno Y, Takada T, Yurube T, Kurakawa T, Miyazaki S, Terashima Y, Ito M, Hara H, Kawamoto T, Ejima Y, Sakashita A, Kizawa Y, Sasaki R, Akisue T, Minami H, Kuroda R, Kurosaka R, Nishida K
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Journal Title
Clinical Spine Surgery
Volume: -
Issue: 8
Pages: E1026-E1032
DOI
Related Report
Peer Reviewed
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[Journal Article] Titanium peroxide nanoparticles enhanced cytotoxic effects of X-ray irradiation against pancreatic cancer model through reactive oxygen species generation in vitro and in vivo2016
Author(s)
Masao Nakayama, Ryohei Sasaki, Chiaki Ogino, Tsutomu Tanaka, Kenta Morita, Mitsuo Umetsu, Satoshi Ohara, Zhenquan Tan, Yuya Nishimura, Hiroaki Akasaka, Kazuyoshi Sato, Chiya Numako, Seiichi Takami, Akihiko Kondo
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Journal Title
Radiat Oncol.
Volume: 11(1)
Issue: 1
Pages: 91-91
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Diagnostic value of glutamate with 2-hydroxyglutarate in magnetic resonance spectroscopy for IDH1 mutant glioma2016
Author(s)
Nagashima H, Tanaka K, Sasayama T, Irino Y, Sato N, Takeuchi Y, Kyotani K, Mukasa A, Mizukawa K, Sakata J, Yamamoto Y, Hosoda K, Itoh T, Sasaki R, Kohmura E.
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Journal Title
Neuro Oncol
Volume: 18(11)
Pages: 1559-1568
DOI
Related Report
Peer Reviewed
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[Journal Article] Efficacy of Stereotactic Body Radiotherapy for Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis / Inferior Vena Cava Tumor Thrombosis: Evaluation by Comparison with Conventional Three-Dimensional Conformal Radiotherapy,2016
Author(s)
Yoshiro Matsuo, Kenji Yoshida, Hideki, Nishimura, Yasuo Ejima, Daisuke Miyawaki, Haruka Uezono, Takeaki Ishihara, Hiroshi Mayahara, Takumi Fukumoto, Yonson Ku, Masato Yamaguchi, Koji Sugimoto, and Ryohei Sasaki,
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Journal Title
J Radiat Res
Volume: 57(5)
Issue: 5
Pages: 512-523
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Radiotherapy for brainstem gliomas in children and adults: A single-institution experience and literature review.2016
Author(s)
Yoshida K, Sulaiman NS, Miyawaki D, Ejima Y, Nishimura H, Ishihara T, Matsuo Y, Nishikawa R, Sasayama T, Hayakawa A, Kohmura E, Sasaki R
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Journal Title
Asia Pac J Clin Oncol.
Volume: Mar 3
Issue: 2
Pages: 1-8
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Randomized Trial of Standard Pain Control with or without Gabapentin for Pain Related to Radiation-induced Mucositis in Head and Neck Cancer.2016
Author(s)
Tomoko Kataoka, Naomi Kiyota, Takanobu Shimada, Yohei Funakoshi, Naoko Chayahara, Masanori Toyoda, Yutaka Fujiwara, Kenichi Nibu, Takahide Komori, Ryohei Sasaki, Toru Mukohara, and Hironobu Minami,
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Journal Title
Auris Nasus Larynx,
Volume: 43(6)
Issue: 6
Pages: 677-84
DOI
Related Report
Peer Reviewed
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[Journal Article] A Dosimetric Comparison of Volumetric Modulated Arc Therapy (VMAT) with Unflattened Beams to VMAT with Flattened Beams and TomoTherapy for Head and Neck Cancer2016
Author(s)
Toshiyuki Ogata, Hideki Nishimura, Hiroshi Mayahara, Aya Harada, Yoshiro Matsuo, Masao Nakayama, Kazuyuki Uehara, Shinji Tsudou, Yasuo Ejima, Ryohei Sasaki, Takanobu Okayama
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Journal Title
Journal of Nuclear Medicine and Radiation Therapy
Volume: 7
Issue: 01
Pages: 274-274
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Concomitant chemoradiotherapy for advanced squamous cell carcinoma of temporal bone2016
Author(s)
Shinomiya H, Hasegawa S, Yamashita D, Ejima Y, Kenji Y, Otsuki N, Kiyota N, Sakakibara S, Nomura T, Hashikawa K, Kohmura E, Sasaki R, Nibu KI.
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Journal Title
Head Neck.
Volume: 38 Suppl 1
Issue: S1
DOI
Related Report
Peer Reviewed
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[Presentation] Investigating a spacer system to avoid the late effect of particle therapy in pediatric patients with cancer2018
Author(s)
KAMEI Michi, IWATA Hiromitsu, MASUMOTO Kouji, NAKAO Tomohei, SHINKAI Toko, FUKUSHIMA Takashi, SAKURAI Hideyuki, TAKAGI Daisuke, FUMINO Shigehisa, DEMIZU Yusuke, ISHIDA Yuji, TAJIRI Tatsuro, OGO Etsuyo, SOEJIMA Toshinori, SASAKI Ryohei
Organizer
12th St. Jude VIVA Forum, Paediatric Oncology
Related Report
Int'l Joint Research
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[Presentation] 73.Assessment of the threshold dose for radiation fibrosis in thoracic esophageal cancer patients.2016
Author(s)
Yasuo Ejima, Kenji Yoshida, Daisuke Miyawaki, Takeaki Ishihara, Ryo Nishikawa, Hiroki Kawaguchi, Yoshiro Matsuo, Atsuki Ikeda, Masanori Toyoda, Tetsu Nakamura, Ryohei Sasaki,
Organizer
The 1st Meeting of the Federation of Asisan Organizations for Radiation Oncology (FARO),
Place of Presentation
Kyoto, Japan
Year and Date
2016-11-25
Related Report
Int'l Joint Research / Invited
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[Book] Radiotherapy2017
Author(s)
Yasuo Ejima, Takeaki Ishihara, Daisuke Miyawaki, Kenichiro Kakutani, Kotaro Nishida, Junichiro Inoue, Yoshitada Sakai, Tianyuan Wang, Sasaki R,
Publisher
Intech
Related Report
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[Book] Non-woven Fabrics2016
Author(s)
Ryohei Sasaki, Hiroaki Akasaka, Yusuke Demizu, Sachiko Inubushi, Tianyuan Wang, Takumi Fukumoto.
Total Pages
324
Publisher
Intech
Related Report
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[Book] Radiotherapy2016
Author(s)
Yasuo Ejima, Takeaki Ishihara, Daisuke Miyawaki, Kenichiro Kakutani, Kotaro Nishida, Junichiro Inoue, Yoshitada Sakai, Tianyuan Wang, Ryohei Sasaki,
Publisher
Intech
Related Report
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