| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2016: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Outline of Final Research Achievements |
On the basis of our drug design of self-assembled nanoparticle probes which show high biocompatibility and high cellular uptake, we developed new theranostic nanoprobes useful for cancer-targeted molecular imaging and therapy. We synthesized self-assembled nanoparticles by coating core component (dendrimer, liposome, and gold nanorod) with various anionic polymers targeting cancers. Since these probes highly accumulated in the target cancer cells/tissues, and had a potential for cancer therapy, we demonstrated the effectiveness of these probes as cancer-targeted theranostics probes.
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