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Exploration of graft conditioning methods during machine perfusion to augment mitochondrial function and antioxidant ability in steatotic liver graft

Research Project

Project/Area Number 16H05398
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionHokkaido University

Principal Investigator

Shimamura Tsuyoshi  北海道大学, 大学病院, 准教授 (00333617)

Co-Investigator(Kenkyū-buntansha) 島田 慎吾  北海道大学, 大学病院, 医員 (40755576)
深井 原  北海道大学, 医学研究院, 特任講師 (60374344)
布田 博敏  北海道大学, 保健科学研究院, 特任教授 (60576172)
武冨 紹信  北海道大学, 医学研究院, 教授 (70363364)
惠 淑萍  北海道大学, 保健科学研究院, 教授 (90337030)
早坂 孝宏  北海道大学, 医学研究院, 特任助教 (90415927)
木村 太一  北海道大学, 医学研究院, 客員研究員 (90435959)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords肝移植 / 虚血再灌流 / 脂肪肝 / ミトコンドリア / 機械灌流 / 移植・再生医療 / 外科 / 発現制御 / 臓器保存 / 臓器灌流
Outline of Final Research Achievements

To establish the methods for pre-conditioning the steatotic graft by machine perfusion, and to find out the reliable marker to predict later severity of ischemia and reperfusion injury (IRI), we explored the following issues. Using steatotic rat livers and hepatocytes cell line treated by fatty acids-rich culture, they were subjected to cold storage and/or machine perfusion (or mimicking conditions) in various temperatures, preservation and perfusion solutions commercially available, with or without supplementation of antioxidant and other agents to augment some protective proteins. We found that pre-conditioning during machine perfusion with antioxidant and some agents, having property to induce expression of protective proteins and to activate protective transcription factors, effectively prevent progression of IRI. These results indicate that properly pre-conditioned steatotic graft could become a safe source of liver transplantation.

Academic Significance and Societal Importance of the Research Achievements

本研究は肝移植におけるドナー不足解消を目指すものである。そのために、脂肪肝の移植後の障害を軽減する肝臓の修復灌流法を確立し、移植前に予後を予測し得るマーカーを確立することを目指すものである。ラット脂肪肝、脂肪肝肝細胞(株)の冷保存、機械灌流実験を行い、既存保存液、灌流液に新規薬剤を添加し、または、自作液を用いて、その傷害、機能を検証した。また、それらの試料を網羅的に解析し、傷害、機能を評価し得る脂質、脂肪酸を見出した。これらの結果は、脂肪肝を安全に移植に利用できる可能性を提示するものであり、臨床的に意義深い。さらに、その保護機構の一部が明らかになり、学術的にも意義深いものである。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (46 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 14 results,  Open Access: 4 results) Presentation (29 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results) Remarks (1 results)

  • [Journal Article] A Multicenter Japanese Survey Assessing the Long-Term Outcomes of Liver Retransplantation using Living Donor Grafts2020

    • Author(s)
      Kuramitsu Kaori、Fukumoto Takumi、Egawa Hiroto、Ohdan Hideki、Umeshita Koji、Uemoto Shinji、Hibi Taizo、Kasahara Mureo、Yoshizumi Tomoharu、Mizuta Koichi、Shimamura Tsuyoshi、Furukawa Hiroyuki
    • Journal Title

      Transplantation

      Volume: 104 Issue: 4 Pages: 754-761

    • DOI

      10.1097/tp.0000000000002958

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcome of Living-Donor Liver Transplantation Using Grafts from Donors Treated for Fatty Liver2020

    • Author(s)
      Fujii Yuki、Kawamura Norio、Zaitsu Masaaki、Watanabe Masaaki、Goto Ryoichi、Kamiyama Toshiya、Taketomi Akinobu、Shimamura Tsuyoshi
    • Journal Title

      Annals of Transplantation

      Volume: 25

    • DOI

      10.12659/aot.920677

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heavy Water (D2O) Containing Preservation Solution Reduces Hepatic Cold Preservation and Reperfusion Injury in an Isolated Perfused Rat Liver (IPRL) Model2019

    • Author(s)
      Shimada Shingo、Fukai Moto、Shibata Kengo、Sakamoto Sodai、Wakayama Kenji、Ishikawa Takahisa、Kawamura Norio、Fujiyoshi Masato、Shimamura Tsuyoshi、Taketomi Akinobu
    • Journal Title

      Journal of Clinical Medicine

      Volume: 8 Issue: 11 Pages: 1818-1829

    • DOI

      10.3390/jcm8111818

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term donor quality of life after living donor liver transplantation in Japan2019

    • Author(s)
      Morooka Y, Umeshita K, Taketomi A, Shirabe K, Yoshizumi T, Yamamoto M, Shimamura T, Oshita A, Ohdan H, Kawagishi N, Hagiwara K, Eguchi H, Nagano H.
    • Journal Title

      Clinical Transplantation

      Volume: 33(6) Issue: 6 Pages: 1-11

    • DOI

      10.1111/ctr.13584

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expanded living‐donor liver transplantation criteria for patients with hepatocellular carcinoma based on the Japanese nationwide survey: the 5‐5‐500 rule ‐ a retrospective study2019

    • Author(s)
      Shimamura Tsuyoshi、Akamatsu Nobuhisa、Fujiyoshi Masato、Kawaguchi Atushi、Morita Satoshi、Kawasaki Seiji、Uemoto Shinji、Kokudo Norihiro、Hasegawa Kiyoshi、Ohdan Hideki、Egawa Hiroto、Furukawa Hiroyuki、Todo Satoru、the Japanese Liver Transplantation Society
    • Journal Title

      Transplant International

      Volume: 32 Issue: 4 Pages: 356-368

    • DOI

      10.1111/tri.13391

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Necessity for a Significant Maintenance Dosage Reduction of Voriconazole in Patients with Severe Liver Cirrhosis (Child–Pugh Class C)2018

    • Author(s)
      Yamada Takehiro、Imai Shungo、Koshizuka Yasuyuki、Tazawa Yuki、Kagami Keisuke、Tomiyama Naoki、Sugawara Ryosuke、Yamagami Akira、Shimamura Tsuyoshi、Iseki Ken
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 41 Issue: 7 Pages: 1112-1118

    • DOI

      10.1248/bpb.b18-00164

    • NAID

      130007387129

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2018-07-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of herbal medicine daikenchuto on oral and enteral caloric intake after liver transplantation: A multicenter, randomized controlled trial2018

    • Author(s)
      Kaido Toshimi、Shinoda Masahiro、Inomata Yukihiro、Yagi Takahito、Akamatsu Nobuhisa、Takada Yasutsugu、Ohdan Hideki、Shimamura Tsuyoshi、Ogura Yasuhiro、Eguchi Susumu、Eguchi Hidetoshi、Ogata Satoshi、Yoshizumi Tomoharu、Ikegami Toshihiko、Yamamoto Michio、Morita Satoshi、Uemoto Shinji
    • Journal Title

      Nutrition

      Volume: 54 Pages: 68-75

    • DOI

      10.1016/j.nut.2018.02.022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Post-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from donors after cardiac death: a preliminary study.2018

    • Author(s)
      Ishikawa T, Shimada S, Fukai M, Kimura T, Umemoto K, Shibata K, Fujiyoshi M, Fujiyoshi S, Hayasaka T, Kawamura N, Kobayashi N, Shimamura T, Taketomi A.
    • Journal Title

      Surgery Today

      Volume: 48(12) Issue: 12 Pages: 1081-88

    • DOI

      10.1007/s00595-018-1693-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A crucial role of AMPK targeted to hepatic steatosis and ischemia reperfusion injury2018

    • Author(s)
      島田慎吾, 柴田賢吾、小林希、三好早香、早坂孝宏、深井原、嶋村剛、武冨紹信
    • Journal Title

      Organ Biology

      Volume: 25 Issue: 2 Pages: 134-139

    • DOI

      10.11378/organbio.25.134

    • NAID

      130007418369

    • ISSN
      1340-5152, 2188-0204
    • Related Report
      2018 Annual Research Report
    • Open Access
  • [Journal Article] Longitudinal CT study of sarcopenia due to hepatic failure after living donor liver transplantation2018

    • Author(s)
      Onuma Takahiro、Kamishima Tamotsu、Shimamura Tsuyoshi、Kawamura Norio、Yamashita Kenichiro、Sutherland Kenneth、Takeda Hiroshi
    • Journal Title

      Quant Imaging Med Surg

      Volume: 8 Issue: 1 Pages: 25-31

    • DOI

      10.21037/qims.2018.01.07

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amyloid Polyneuropathy and Myocardial Amyloidosis 10 Years after Domino Liver Transplantation from a Patient with a <i>Transthyretin</i> Ser50Arg Mutation2017

    • Author(s)
      Matsushima Masaaki、Yabe Ichiro、Tsuda Masaya、Sakakibara Mamoru、Shimamura Tsuyoshi、Sasaki Hidenao
    • Journal Title

      Internal Medicine

      Volume: 56 Issue: 23 Pages: 3231-3235

    • DOI

      10.2169/internalmedicine.8434-16

    • NAID

      130006235553

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen Gas Ameliorates Hepatic Reperfusion Injury After Prolonged Cold Preservation in Isolated Perfused Rat Liver2016

    • Author(s)
      Shimada S, Wakayama K, Fukai M, Shimamura T, Ishikawa T, Fukumori D, Shibata M, Yamashita K, Kimura T, Todo S, Ohsawa I, Taketomi A
    • Journal Title

      Artif Organs

      Volume: 40 Issue: 12 Pages: 1128-1136

    • DOI

      10.1111/aor.12710

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 14-3-3ζ-mediated stimulation of oxidative phosphorylation exacerbates oxidative damage under hypothermic oxygenated conditions in human renal tubular cells (HK-2)2016

    • Author(s)
      Fukai M, Kobayashi N, Ishikawa T, Wakayama K, Shimada S, Umemoto K, Ohtani S, MFujiyoshi M, Yamashita K, Shimamura T, Taketomi A
    • Journal Title

      Transplant Proc.

      Volume: 48 Issue: 4 Pages: 1288-1291

    • DOI

      10.1016/j.transproceed.2015.09.066

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A pilot study of operational tolerance with a regulatory T cell-based cell therapy in living donor liver transplantation.2016

    • Author(s)
      ①Todo S, Yamashita K, Goto R, Zaitsu M, Nagatsu A, Oura T, Watanabe M, Aoyagi T, Suzuki T, Shimamura T, Kamiyama T, Sato N, Sugita J, Hatanaka K, Bashuda H, Habu S, Demetris AJ, Okumura K
    • Journal Title

      Hepatology

      Volume: 00 Issue: 2 Pages: 00-00

    • DOI

      10.1002/hep.28459

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Outcomes of Living Donor Liver Transplantation Alone for Patients on Maintenance Renal Replacement Therapy in Japan: Results of a Nationwide Survey.2016

    • Author(s)
      Eguchi S, Furukawa H, Uemoto S, Umeshita K, Imamura H, Soyama A, Shimamura T, Isaji S, Ogura Y, Egawa H, Kawachi S, Kasahara M, Nagano H, Ku Y, Ohdan H, Maehara Y, Sato S, Inomata Y
    • Journal Title

      Transplant Direct.

      Volume: 2

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 低音酸素化状態におけるタンパク機能制御2016

    • Author(s)
      深井原、島田慎吾、小林 希、石川隆壽、梅本浩平、大谷晋太郎、山下健一郎、嶋村剛、武冨紹信
    • Journal Title

      Organ Biology

      Volume: 23 Pages: 173-179

    • Related Report
      2016 Annual Research Report
  • [Presentation] Elucidation of the role of lyso-phospholipids on hepatic warm ischemia and reperfusion injury; Comprehenive analysis by imaging mass spectrometry2019

    • Author(s)
      Shibata Kengo, Hayasaka Takahiro , Fukai Moto, Kato Koichi, Ishikawa Takahisa, Kohei Umemoto, Shimada Shingo, Kobayashi Nozomi, Shimamura Tsuyoshi, Kimura Taichi, Taketomi Akinobu
    • Organizer
      19th Congress of the European Society for Organ Transplantation (ESOT 2019). Copenhagen, Denmark
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elucidation of the mechanisms of hepatic warm ischemia and reperfusion injury in rats; Exploration of predictive markers of IRI by imaging mass spectrometry.2019

    • Author(s)
      Shibata Kengo, Hayasaka Takahiro, Fukai Moto, Kato Koichi, Ishikawa Takahisa, Umemoto Kohei, Shimada Shingo, Kobayashi Nozomi, Shimamura Tsuyoshi, Kimura Taichi, Taketomi Akinobu
    • Organizer
      16th Congress of the Asian Society of Transplantation (CAST 2019). Greator Noida, India.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生存シグナル増強を目指した機械灌流による肝グラフトの薬剤性コンディショニング法の探索2019

    • Author(s)
      深井原、柴田賢吾, 島田慎吾, 石川隆壽, 若山顕治, 藤好直, 小林希, 加藤紘一, 早坂孝宏, 三野和宏, 川村典生, 嶋村剛,武冨紹信
    • Organizer
      第119回日本外科学会定期学術集会, 大阪国際会議場
    • Related Report
      2019 Annual Research Report
  • [Presentation] 温虚血再灌流障害におけるリゾリン脂質の役割に関する基礎的研究―質量分析イメージング法による解析2019

    • Author(s)
      柴田賢吾、橋本咲月、早坂孝宏、深井原、加藤紘一、中薮拓哉、島田慎吾、小林希、梅本浩平、大谷晋太郎、三野和宏, 嶋村剛,木村太一、武冨紹信
    • Organizer
      第119回 日本外科学会定期学術集会, 大阪,大阪国際会議場
    • Related Report
      2019 Annual Research Report
  • [Presentation] 肝移植の位置づけ, 特別発言2019

    • Author(s)
      嶋村剛
    • Organizer
      第55回日本肝癌研究会、パネルディスカッション、東京
    • Related Report
      2019 Annual Research Report
  • [Presentation] 肝細胞癌に対する肝移植適応基準(5-5-500基準):全国集計から2019

    • Author(s)
      嶋村剛
    • Organizer
      第81回日本臨床外科学会、パネルディスカッション、高知
    • Related Report
      2019 Annual Research Report
  • [Presentation] 当院における原発性胆汁性胆管炎に対する生体・脳死肝移植症例の特徴2019

    • Author(s)
      後藤了一、巖築慶一、川村典生、渡辺正明、神山俊哉、嶋村剛、武冨紹信
    • Organizer
      第55回日本移植学会総会、広島
    • Related Report
      2019 Annual Research Report
  • [Presentation] De novo ドナー特異的HLA抗体陽性の生体肝グラフト線維化進行症例の特徴2018

    • Author(s)
      後藤了一、川村典生、渡辺正明、財津雅昭、嶋村 剛、武冨紹信
    • Organizer
      第54回日本移植医学会総会、東京
    • Related Report
      2018 Annual Research Report
  • [Presentation] 当院における原発性胆汁性胆管炎に対する生体・脳死肝移植症例の特徴2018

    • Author(s)
      後藤了一、巖築慶一、川村典生、渡辺正明、神山俊哉、嶋村剛、武冨紹信
    • Organizer
      第54回日本移植医学会総会、東京
    • Related Report
      2018 Annual Research Report
  • [Presentation] 心停止ドナー肝のNrf2と生存シグナルを増強させる薬剤性コンディショニング法の探索2018

    • Author(s)
      深井原, 島田慎吾, 小林希, 中藪拓哉, 石川隆壽, 柴田賢吾, 梅本浩平, 鈴木崇史,三野和宏,嶋村剛, 武冨紹信
    • Organizer
      第118回 日本外科学会学術集会、東京
    • Related Report
      2018 Annual Research Report
  • [Presentation] 温虚血再灌流障害におけるリゾリン脂質の役割に関する基礎的研究―質量分析イメージング法による解析2018

    • Author(s)
      柴田賢吾、橋本咲月、早坂孝宏、深井原、加藤紘一、中薮拓哉、島田慎吾、小林希、梅本浩平、鈴木崇史, 大谷晋太郎、三野和宏, 嶋村剛,木村太一、武冨紹信
    • Organizer
      第45回 日本臓器保存生物医学会学術集会、名古屋
    • Related Report
      2018 Annual Research Report
  • [Presentation] 臓器灌流時のコンディショニング法の探索2017

    • Author(s)
      深井原, 島田慎吾, 梅本浩平, 中藪拓哉, 柴田賢吾, 早坂孝宏, 鈴木崇史,大谷晋太郎, 橋本咲月, 三野和宏, 嶋村剛, 武冨紹信
    • Organizer
      第44回 日本臓器保存生物医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 小腸上皮細胞の低温保存における溶存酸素と酸化ストレスの影響2017

    • Author(s)
      深井原, 島田慎吾,小林希,梅本浩平,柴田賢吾, 早坂孝宏、鈴木崇史、大谷晋太郎、橋本咲月、三野和宏, 嶋村剛,武冨紹信
    • Organizer
      第44回 日本臓器保存生物医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生体肝移植ドナー肝グラフト再手術におけるPringle法-行うvs行わない-2017

    • Author(s)
      嶋村剛
    • Organizer
      第117回日本外科学会定期学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 安全・安心な臓器移植のためにできること:臓器提供推進と免疫寛容の誘導2017

    • Author(s)
      嶋村剛
    • Organizer
      第72回日本消化器外科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 臓器移植法から20年:いま社会システムとしての臓器提供の推進を考える2017

    • Author(s)
      嶋村剛
    • Organizer
      第53回日本移植学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肝移植における移植前抗ドナー抗体陽性の臨床的意義2017

    • Author(s)
      嶋村剛、川村典生、腰塚靖之、渡辺正明、太田 稔、山下健一郎、武冨紹信
    • Organizer
      第53回日本移植学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肝移植へのブリッジとしての門脈圧亢進症治療2017

    • Author(s)
      嶋村剛
    • Organizer
      第24回日本門脈圧亢進症学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Novel Personalized Immune-Monitoring Assay for Predicting Operational Tolerance by Using Humanized Mouse Model2017

    • Author(s)
      Fukasaku Y, Goto R, Ganchiku Y, Zaitsu M, Watanabe M, Kawamura N, Koshizuka Y, Yamashita K, Shimamura T, Taketomi A
    • Organizer
      American Transplant Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The outcome of living donor liver transplantation using treated fatty liver grafts.2017

    • Author(s)
      Fujii Y, Kawamura N, Koshizuka Y, Watanabe M, Goto R, Yamashita K, Taketomi A, Shimamura T
    • Organizer
      Annual congress of the International Liver Transplantation Society (ILTS)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Time course of autophagy and oxidative phosphorylation during hypothermic oxygenated conditions and subsequent re-warming in human renal tubular cell line (HK2)2016

    • Author(s)
      Fukai M, Ishikawa T, Wakayama K, Shimada S, Fujiyoshi M, Kimura T, Yamashita K, Shimamura T, Taketomi A.
    • Organizer
      Transplantation Science Symposium (TSS) Asian Regional Meeting 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The current strategies for preexisting donor specific antibodies in liver transplantation.2016

    • Author(s)
      Goto R, Koshizuka Y, Kawamura N, Zaitsu M, Ota M, Yamashita K, Taketomi A, Shimamura T.
    • Organizer
      Transplantation Science Symposium (TSS) Asian Regional Meeting 2016
    • Related Report
      2016 Annual Research Report
  • [Presentation] A proteasome inhibitor, bortezomib prevents pancreatic islet graft loss after transplantation.2016

    • Author(s)
      Ono H, Asahi Y, Yoshida T, Koshizuka Y, Watanabe M, Tomaru U, Kobayashi N, Emoto S, Fukai M, Shimamura T, Taketomi A, Todo S, Yamashita K.
    • Organizer
      Transplantation Science Symposium (TSS) Asian Regional Meeting 2016
    • Related Report
      2016 Annual Research Report
  • [Presentation] Optimizing small for sized graft: Our experience in Living Donor Liver Transplantation using GV/SV less than 35% grafts.2016

    • Author(s)
      Norio Kawamura, Masaaki Zaitsu, Yasuyuki Koshizuka, Ryoichi Goto, Tomomi Suzuki, Toshiya Kamiyama, Kenichiro Yamashita, Akinobu Taketomi, Tsuyoshi Shimamura.
    • Organizer
      22th International Liver Transplant Society annual international congress
    • Related Report
      2016 Annual Research Report
  • [Presentation] イメージング質量分析によるラット脂肪肝虚血再灌流障害の評価2016

    • Author(s)
      橋本咲月、深井原、早坂孝宏、梅本浩平、大谷晋太郎、白澤憲典、中薮拓哉、島田慎吾、惠淑萍、千葉仁志、山下健一郎、嶋村剛、武冨紹信
    • Organizer
      第34回 日本肝移植研究会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 心臓死ドナーグラフトにおける水素ガスの肝保護効果の検討2016

    • Author(s)
      石川隆壽、深井原、若山顕治、島田慎吾、梅本浩平、藤好真人、山下健一郎、嶋村剛、武冨紹信
    • Organizer
      第116回 日本外科学会定期学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 低温酸素化状態における14-3-3zetaによるエネルギー産生と細胞内シグナルの制御-ヒト尿細管上皮細胞株 (HK2) を用いた検討2016

    • Author(s)
      深井原、小林希、梅本浩平、島田慎吾、若山顕治、大谷晋太郎、橋本咲月、藤好真人、山下健一郎、嶋村剛、武冨紹信
    • Organizer
      第116回 日本外科学会定期学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] ラット肝冷保存再灌流における重水含有臓器液 (Dsol) の保護効果~Autophagyと細胞生存・死シグナルへの影響2016

    • Author(s)
      梅本浩平、深井原、島田慎吾、石川隆壽、大谷晋太郎、橋本咲月、藤好真人、若山顕治、山下健一郎、嶋村剛、武冨紹信
    • Organizer
      第116回 日本外科学会定期学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 臓器灌流法の先にあるべき技術の開発2016

    • Author(s)
      深井原, 島田慎吾, 小林希, 梅本浩平, 大谷晋太郎, 中藪拓哉, 三野和宏, 山下健一郎, 嶋村剛, 武冨紹信
    • Organizer
      第43回 日本臓器保存生物医学会学術集会
    • Related Report
      2016 Annual Research Report
  • [Remarks] 北海道大学病院・臓器移植医療部

    • URL

      http://www.huhp.hokudai.ac.jp/hotnews/detail/00000204.html

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report

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Published: 2016-04-21   Modified: 2021-12-27  

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