Stratification of gastric cancer and identification of molecular mechanism of gastric tumorigenesis based on aberrant DNA methylation profile

• Project/Area Number: 16H05412
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Chiba University
• Principal Investigator: Kaneda Atsushi 千葉大学, 大学院医学研究院, 教授 (10313024)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2018: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2016: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: がん / エピゲノム / 癌

Outline of Final Research Achievements

We conducted genome-wide DNA methylation analysis of clinical gastric cancer samples to classify gastric cancer into several molecular subtypes, and we also conducted exon-sequencing analysis to identify genetic mutations specifically observed in each subtype. As for high-methylation gastric cancer subtypes, we clarified molecular mechanisms of gastric cancer through synergy of genetic mutations and aberrant DNA methylation. Moreover, we analyzed the mechanisms to induce aberrant epigenomic aberrations in gastric epithelial cells. We infected Epstein-Barr virus to gastric epithelial cells in vitro, and showed that EBV infection induced extensive DNA hypermethylation within four weeks genomewidely, and repression of TET2 was one of the molecular mechanisms for DNA methylation induction.

Academic Significance and Societal Importance of the Research Achievements

癌は我が国において生涯のうちに1/2の者が罹患し1/3の者の死因となる疾患であり、網羅的解析により癌の原因を明らかにすることは学術的にも、また新たな治療方法を構築して社会的に貢献する意味でも大変重要である。その中でも胃癌は重要な癌死要因の１つであり、胃癌における分子異常を詳細に同定し、その中から胃発癌に重要な分子異常を同定したこと、またどのようにその分子異常が蓄積したのかその原因の一端を明らかにしたことは、発癌機構を理解する上で学術的にも、また今後新たな胃癌治療法を確立する上でも、意義のある成果をあげた。

Research Products

• [Journal Article] The frequency of promoter DNA hypermethylation is decreased in colorectal neoplasms of familial adenomatous polyposis. (2018)
  • Author(s): Takane K, Fukuyo M, Matsusaka K, Ota S, Rahmutulla B, Matsushita K, Miyauchi H, Nakatani Y, Matsubara H, Kaneda A.
  • Journal Title: Oncotarget. Volume: 9 Issue: 66 Pages: 32653-32666
  • DOI: 10.18632/oncotarget.25987
  • Peer Reviewed / Open Access
• [Journal Article] Gastritis-Infection-Cancer Sequence of Epstein-Barr Virus-Associated Gastric Cancer. (2018)
  • Author(s): Fukayama M, Kunita A, Kaneda A
  • Journal Title: Adv Exp Med Biol. Volume: 1045 Pages: 437-457
  • DOI: 10.1007/978-981-10-7230-7_20
  • ISBN: 9789811072291, 9789811072307
  • Peer Reviewed / Open Access
• [Journal Article] Synergistic Cytotoxic Effect on Gastric Cancer Cells of an Immunotoxin Cocktail in Which Antibodies Recognize Different Epitopes on CDH17 (2018)
  • Author(s): Kusano-Arai O, Iwanari H, Kudo S, Akiba H, Matsusaka K, Kaneda A, Fukayama M, Tsumoto K, Hamakubo T.
  • Journal Title: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy Volume: 37 Issue: 1 Pages: 1-11
  • DOI: 10.1089/mab.2017.0043
  • Peer Reviewed
• [Journal Article] Epigenetic aberration at enhancer regions in gastric cancer. (2018)
  • Author(s): Okabe A, Kaneda A.
  • Journal Title: J Cancer Treat Diagn Volume: 2 Pages: 31-35
  • Peer Reviewed / Open Access
• [Journal Article] 大腸腫瘍におけるエピゲノム異常 (2018)
  • Author(s): 金田篤志、八木浩一、酒井英嗣、松坂恵介、高根希世子、岡部篤史．
  • Journal Title: INTESTINE Volume: 22 Pages: 421-428
• [Journal Article] がんエピジェネティクスの重要性と研究の現状 (2018)
  • Author(s): 金田篤志
  • Journal Title: 日本唾液腺学会誌 Volume: 59 Pages: 10-11
• [Journal Article] 次世代シーケンサーを用いたクロマチン相互作用解析法とその応用 (2018)
  • Author(s): 岡部篤史、金田篤志
  • Journal Title: 生化学 Volume: 90 Pages: 839-841
  • NAID: 40021783244
• [Journal Article] エピジェネティクスとがん進化 (2018)
  • Author(s): 福世真樹、金田篤志
  • Journal Title: 実験医学 Volume: 36 Pages: 232-235
• [Journal Article] Regulation of tumour related genes by dynamic epigenetic alteration at enhancer regions in gastric epithelial cells infected by Epstein-Barr virus. (2017)
  • Author(s): Okabe A, Funata S, Matsusaka K, Namba H, Fukuyo M, Rahmutulla B, Oshima M, Iwama A, Fukayama M, Kaneda A.
  • Journal Title: Scientific reports Volume: 7 Issue: 1 Pages: 7924-7924
  • DOI: 10.1038/s41598-017-08370-7
  • Peer Reviewed / Open Access
• [Journal Article] A. Histone modification alteration coordinated with acquisition of promoter DNA methylation during Epstein-Barr virus infection. (2017)
  • Author(s): Funata S, Matsusaka K, Yamanaka R, Yamamoto S, Okabe A, Fukuyo M, Aburatani H, Fukayama M, Kaneda A.
  • Journal Title: Oncotarget Volume: 8 Issue: 33 Pages: 55265-55279
  • DOI: 10.18632/oncotarget.19423
  • Peer Reviewed / Open Access
• [Journal Article] Epstein-Barr virus infection induces genome-wide de novo DNA methylation in non-neoplastic gastric epithelial cells. (2017)
  • Author(s): Matsusaka K, Funata S, Fukuyo M, Seto Y, Aburatani H, Fukayama M, Kaneda A.
  • Journal Title: Journal of Pathology Volume: 242 Issue: 4 Pages: 391-399
  • DOI: 10.1002/path.4909
  • Peer Reviewed / Open Access
• [Journal Article] がんゲノムとは． (2017)
  • Author(s): 金田篤志．
  • Journal Title: ALPHA CLUB Volume: 419 Pages: 2-3
• [Journal Article] エピゲノム解析 (2017)
  • Author(s): 岡部篤史、金田篤志
  • Journal Title: 日本臨床 Volume: 75 Pages: 677-685
• [Journal Article] 胃がん発生におけるエピゲノム異常とその誘導機構 (2017)
  • Author(s): 南波宏枝、金田篤志
  • Journal Title: 細胞 Volume: 49 Pages: 13-16
• [Journal Article] 癌におけるエピゲノム研究の意義． (2017)
  • Author(s): 岡部篤史、金田篤志
  • Journal Title: BIO Clinica Volume: 32 Pages: 599-601
• [Journal Article] DNA methylation epigenotype and clinical features of NRAS-mutation(+) colorectal cancer. (2017)
  • Author(s): Takane K. Akagi K. Fukuyo M. Yagi K. Takayama T. Kaneda A.
  • Journal Title: Cancer Med Volume: 印刷中 Issue: 5 Pages: 1023-1035
  • DOI: 10.1002/cam4.1061
  • Peer Reviewed / Open Access
• [Journal Article] TET2 functions as a resistance factor against DNA methylation acquisition during Epstein-Barr virus infection. (2016)
  • Author(s): Namba-Fukuyo H, Funata S, Matsusaka K, Fukuyo M, Rahmutulla B, Mano Y, Fukayama M, Aburatani H, Kaneda A
  • Journal Title: Oncotarget Volume: 7 Issue: 49 Pages: 81512-81526
  • DOI: 10.18632/oncotarget.13130
  • Peer Reviewed / Open Access
• [Journal Article] Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome. (2016)
  • Author(s): Hasegawa N, Oshima M, Sashida G, Matsui H, Koide S, Saraya A, Wang C, Muto T, Takane K, Kaneda A, Shimoda K, Nakaseko C, Yokote K, Iwama A.
  • Journal Title: Leukemia Volume: in press Issue: 4 Pages: 861-871
  • DOI: 10.1038/leu.2016.268
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Coupling CDH17 and CLDN18 markers for comprehensive membrane-targeted detection of human gastric cancer. (2016)
  • Author(s): K. Matsusaka, T. Ushiku, M. Urabe, M. Fukuyo, H. Abe, S. Ishikawa, Y. Seto, H. Aburatani, T. Hamakubo, A. Kaneda, M. Fukayama
  • Journal Title: Oncotarget Volume: 7 Issue: 39 Pages: 64168-64181
  • DOI: 10.18632/oncotarget.11638
  • Peer Reviewed / Open Access
• [Journal Article] Coupling CDH17 and CLDN18 markers for comprehensive membrane-targeted detection of human gastric cancer. (2016)
  • Author(s): Matsusaka K, Ushiku T, Urabe M, Fukuyo M, Abe H, Ishikawa S, Seto Y, Aburatani H, Hamakubo T, Kaneda A, Fukayama M.
  • Journal Title: Oncotarget Volume: 7 Issue: 51 Pages: 64168-64181
  • DOI: 10.18632/oncotarget.11510
  • Peer Reviewed / Open Access
• [Journal Article] Tumor Content Chart-Assisted HER2/CEP17 Digital PCR Analysis of Gastric Cancer Biopsy Specimens. (2016)
  • Author(s): Matsusaka K, Ishikawa S, Nakayama A, Ushiku T, Nishimoto A, Urabe M, Kaneko N, Kunita A, Kaneda A, Aburatani H, Fujishiro M, Seto Y, Fukayama M.
  • Journal Title: PLoS One Volume: 11 Issue: 4 Pages: e0154430-e0154430
  • DOI: 10.1371/journal.pone.0154430
  • Peer Reviewed / Open Access
• [Journal Article] Extracellular Release of Annexin A2 is Enhanced upon Oxidative Stress Response via the p38 MAPK Pathway after Low-Dose X-Ray Radiation. (2016)
  • Author(s): Kita, K., Sugita, K., Sato, C., Sugaya, S. Sato T, Kaneda, A
  • Journal Title: Radiat. Res Volume: 186 Issue: 1 Pages: 79-91
  • DOI: 10.1667/rr14277.1
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] TP53 mutation at early stage of colorectal cancer progression from two types of laterally spreading tumors. (2016)
  • Author(s): Sakai E, Fukuyo M, Matsusaka K, Ohata K, Doi N, Takane K, Matsuhashi N, Fukushima J, Nakajima A, Kaneda A
  • Journal Title: Cancer Science Volume: 印刷中 Issue: 6 Pages: 820-7
  • DOI: 10.1111/cas.12930
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway. (2016)
  • Author(s): Sakai E, Fukuyo M, Ohata K, Matsusaka K, Doi N, Mano Y, Takane K, Abe H, Yagi K, Matsuhashi N, Fukushima J, Fukayama M, Akagi K, Aburatani H, Nakajima A, Kaneda A.
  • Journal Title: Int J Cancer Volume: 138 Issue: 7 Pages: 1634-44
  • DOI: 10.1002/ijc.29903
  • Peer Reviewed / Open Access
• [Journal Article] エピジェネティクスと癌 (2016)
  • Author(s): 金田篤志、眞野恭伸
  • Journal Title: アンチ・エイジング医学 Volume: 12 Pages: 752-7
• [Journal Article] エピゲノムで胃がん発生を俯瞰する (2016)
  • Author(s): 浦辺雅之、金田篤志
  • Journal Title: 実験医学 Volume: 34 Pages: 1589-92
• [Journal Article] ゲノム情報・ゲノム修飾情報とがん医療 (2016)
  • Author(s): 金田篤志
  • Journal Title: 千葉県医師会医学会誌 Volume: 13 Pages: 56-62
• [Presentation] Comprehensive epigenetic classification of HPV-associated oropharyngeal cancer (2019)
  • Author(s): Takuya Nakagawa, Keisuke Matsusaka, Kiyoshi Misawa, Masaki Fukuyo, Masato Mima, Tomoya Kurokawa, Daiju Sakurai, Toyoyuki Hanazawa, Yoshitaka Okamoto, Atsushi Kaneda.
  • Organizer: 11th AACR-JCA Joint Conference
  • Int'l Joint Research
• [Presentation] Induction of dynamic epigenomic activation and inactivation by Epstein-Barr virus infection in gastric cancer. (2019)
  • Author(s): Atsushi Okabe, Keisuke Matsusaka, Masaki Fukuyo, Sayaka Funata, Hiroe Namba, Masashi Fukayama, Atsushi Kaneda.
  • Organizer: 11th AACR-JCA Joint Conference
  • Int'l Joint Research
• [Presentation] Aberrant regulation of super-enhancers in castration resistant prostate cancer. (2019)
  • Author(s): Hiroaki Sato, Masahiro Sugiura, Atsushi Okabe, Masaki Fukuyo, Shinichi Sakamoto, Tomohiko Ichikawa, Atsushi Kaneda.
  • Organizer: Keystone Symposia
  • Int'l Joint Research
• [Presentation] Dynamic epigenetic and chromatin structural change in gastric epithelial cells infected by Epstein-Barr virus (2019)
  • Author(s): Atsushi Okabe, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Atsushi Kaneda.
  • Organizer: Keystone Symposia
  • Int'l Joint Research
• [Presentation] HPV関連中咽頭癌の網羅 (2019)
  • Author(s): 中川拓也, 松坂恵介, 福世真樹, 岡本美孝, 金田篤志
  • Organizer: 日本薬学会第139年会
  • Invited
• [Presentation] 去勢抵抗性前立腺癌におけるAR-V7標的遺伝子の同定および新期治療戦略の検討 (2019)
  • Author(s): 杉浦正洋, 佐藤広明, 岡部篤史, 福世真樹, 坂本信一, 金田篤志, 市川智彦
  • Organizer: 日本薬学会第139年回
  • Invited
• [Presentation] エピジェネティック阻害剤による治療モデル(前立腺癌) (2019)
  • Author(s): 佐藤広明, 杉浦正洋, 金坂学斗, 岡部篤史, 福世真樹, 坂本信一, 市川智彦, 金田篤志.
  • Organizer: 日本薬学会第139年回
  • Invited
• [Presentation] Frequent promoter hypermethylation correlates with better prognosis in pharyngeal cancer. (2018)
  • Author(s): Nakagawa T, Matsusaka K, Misawa K, Takane K, Fukuyo M, Rahmutulla B, Shinohara K, Ota S, Kunii N, Sakurai D, Hanazawa T, Nakatani Y, Okamoto Y, Kaneda A.
  • Organizer: AACR Annual meeting
  • Int'l Joint Research
• [Presentation] 消化管発がんにおけるエピゲノム異常の誘導 (2018)
  • Author(s): 金田篤志
  • Organizer: 名古屋大学大学院医学研究科Cancer Science Course
  • Invited
• [Presentation] 中咽頭癌における網羅的エピゲノム解析 (2018)
  • Author(s): 中川拓也, 松坂恵介, 三澤清, 福世真樹, 太田聡, 國井直樹, 櫻井大樹, 花澤豊行,岡本美孝, 金田篤志
  • Organizer: 第119回日本耳鼻咽喉科学会総会・学術講演会
• [Presentation] 中咽頭癌における網羅的エピゲノム解析 (2018)
  • Author(s): 中川拓也, 松坂恵介, 三澤清, 福世真樹, 太田聡, 國井直樹, 櫻井大樹, 花澤豊行, 岡本美孝, 金田篤志.
  • Organizer: 第42回頭頸部癌学会
• [Presentation] 胃癌におけるTP53変異とは独立したゲノム・エピゲノム相互作用の同定 (2018)
  • Author(s): 松坂恵介, 眞野恭伸, 福世真樹, 浦辺雅之, 喜多和子, 根本哲宏, バハテヤリ・ラヒムトラ, 瀬戸泰之, 深山正久, 金田篤志
  • Organizer: 第107回日本病理学会総会
• [Presentation] ウイルス感染が発癌へと誘導するエンハンサー領域の異常制御の探索. (2018)
  • Author(s): 日浦伸宏, 岡部篤史, 松坂恵介, 福世真樹, 深山正久, 金田篤志.
  • Organizer: 平成30年度関東研究医養成コンソーシア
• [Presentation] 新規化学合成化合物によるTP53依存的抗がん作用の検証. (2018)
  • Author(s): 井上貴登、松田和暁、宮﨑柊子、竹野有加里、新宅敬彦、 依田夏美、池田英里
  • Organizer: 平成30年度関東研究医養成コンソーシアム
• [Presentation] 胃癌のエピゲノム異常と発癌分子機構への関与. (2018)
  • Author(s): 金田篤志
  • Organizer: 第79回病理診断学講座 Seminar in Diagnostic Pathology
  • Invited
• [Presentation] 網羅的エピゲノム解析による中咽頭癌の層別化 (2018)
  • Author(s): 中川拓也, 松坂恵介, 三澤清, 福世真樹, 太田聡, 國井直樹, 櫻井大樹, 花澤豊行,岡本美孝, 金田篤志.
  • Organizer: 第31回日本口腔咽頭科学会総会
• [Presentation] The frequency of promoter DNA hypermethylation is decreased in colorectal neoplasms of familial adenomatous polyposis. (2018)
  • Author(s): Kiyoko Takane, Masaki Fukuyo, Keisuke Matsusaka, Satoshi Ota, Bahityar Rahmutulla, Kazuyuki Matsushita, Hideaki Miyauchi, Yukio Nakatani, Hisahiro Matsubara, Atsushi Kaneda.
  • Organizer: 第6回FAP研究会学術集会
• [Presentation] Genetic and Epigenetic features of highly methylated subgroups of gastric cancer (2018)
  • Author(s): Atsushi Kaneda
  • Organizer: The 77th Annual Meeting of the Japanese Cancer Association.
  • Int'l Joint Research / Invited
• [Presentation] lassification of HPV-associated oropharyngeal cancer by definition of DNA methylation epigenotypes. (2018)
  • Author(s): Takuya Nakagawa, Keisuke Matsusaka, Kiyoshi Misawa, Masaki Fukuyo, Bahityar Rahmutulla, Satoshi Ota, Naoki Kunii, Daiju Sakurai, Toyoyuki Hanawzawa, Yoshitaka Okamoto, Atsushi Kaneda.
  • Organizer: The 77th Annual Meeting of the Japanese Cancer Association
  • Int'l Joint Research
• [Presentation] Identification of genetic/epigenetic alterations based on wild-type TP53 in high methylation gastric cancer. (2018)
  • Author(s): Keisuke Matsusaka, Yasunobu Mano, Masaki Fukuyo, Masayuki Urabe, Rahmutulla Bahityar, Eriko Ikeda, Kazuko Kita, Hiroyuki Abe, Tetsuhiro Nemoto, Yasuyuki Seto, Masashi Fukayama, Atsushi Kaneda.
  • Organizer: The 77th Annual Meeting of the Japanese Cancer Association
  • Int'l Joint Research
• [Presentation] The frequency of promoter DNA hypermethylation is decreased in colorectal neoplasms of familial adenomatous polyposis. (2018)
  • Author(s): Kiyoko Takane, Masaki Fukuyo, Keisuke Matsusaka, Satoshi Ota, Bahityar Rahmutulla, Kazuyuki Matsushita, Hideaki Miyauchi, Yukio Nakatani, Hisahiro Matsubara, Atsushi Kaneda
  • Organizer: The 77th Annual Meeting of the Japanese Cancer Association
  • Int'l Joint Research
• [Presentation] 悪性黒色腫におけるゲノム・エピゲノム変異. (2018)
  • Author(s): 山本 洋輔, 松坂 恵介, 高根 希世子, 福世 真樹, 太田 聡, 松江 弘之, 金田 篤志
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] DNA低メチル化肺扁平上皮癌と特発性肺線維症合併の関連性 (2018)
  • Author(s): 畑 敦, 中島崇裕, 福世真樹, 松坂恵介, 吉野一郎, 金田篤志
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] 去勢抵抗性前立腺癌におけるAR-V7標的遺伝子の同定 (2018)
  • Author(s): 杉浦正洋, 佐藤広明, 岡部篤史, 福世真樹, 坂本信一, 市川智彦, 金田篤志.
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] BRD4とDOT1Lの同時阻害は前立腺癌に対するエピジェネティックな新規治療標的となり得る. (2018)
  • Author(s): 佐藤広明, 杉浦正洋, 岡部篤史, 福世真樹, 今村有佑, 坂本信一, 小宮顕, 市川智彦, 金田篤志.
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] HPV関連中咽頭癌の網羅的エピゲノム解析に基づいた層別化 (2018)
  • Author(s): 中川拓也, 松坂恵介, 三澤清, 福世真樹, 太田聡, 國井直樹, 櫻井大樹, 花澤豊行, 岡本美孝, 金田篤志
  • Organizer: 第3回日本HPV研究会学術集会
• [Presentation] ウイルス感染がダイナミックに誘導するプロモーターおよびエンハンサー領域の発癌性エピゲノム変化 (2018)
  • Author(s): 金田篤志
  • Organizer: 第29回日本消化器癌発生学会総会
• [Presentation] 高メチル化胃癌におけるTP53変異非依存性ゲノム・エピゲノム異常の相乗効果 (2018)
  • Author(s): 松坂恵介、眞野恭伸、福世真樹、松田和暁、井上貴登、浦辺雅之、バハテヤリ・ラヒムトラ、池田英里子、阿部浩幸、喜多和子、瀬戸泰之、根本哲宏、深山正久、金田篤志
  • Organizer: 第29回日本消化器癌発生学会総会
• [Presentation] Epstein-Barrウイルスエピソーム形成がもたらすエンハンサー活性化 (2018)
  • Author(s): 岡部篤史、松坂恵介、福世真樹、南波宏枝、船田さやか、金田篤志
  • Organizer: 第29回日本消化器癌発生学会総会
• [Presentation] 家族性大腸腺腫症の大腸腫瘍におけるプロモーターメチル化頻度の減少 (2018)
  • Author(s): 高根希世子、福世真樹、松坂恵介、太田聡、バハテヤリ・ラヒムトラ、松下一之、宮内英聡、中谷行雄、松原久裕、金田篤志
  • Organizer: 第29回日本消化器癌発生学会総会
• [Presentation] HPV関連中咽頭癌のDNAメチル化による層別化 (2018)
  • Author(s): 中川拓也、松坂恵介、三澤清、福世真樹、黒川友哉、國井直樹、櫻井大樹、花澤豊行、岡本美孝、金田篤志
  • Organizer: 第29回日本消化器癌発生学会総会
• [Presentation] エンハンサーを標的としたエピゲノム阻害剤の癌治療への応用 (2018)
  • Author(s): 佐藤広明、杉浦正洋、金坂学斗、岡部篤史、福世真樹、市川智彦、金田篤志
  • Organizer: 第29回日本消化器癌発生学会総会
• [Presentation] 胃がんの遺伝子分類～層別化治療への入り口～ (2018)
  • Author(s): 金田篤志
  • Organizer: 除菌時代について考える会
  • Invited
• [Presentation] 抗がん活性を有する新規化学合成化合物の詳細解析 (2018)
  • Author(s): 池田英里子, 喜多和子, 井上貴登, 松田和暁, 宮崎柊子, 竹野有加里, 新宅 敬彦, 依田夏美, 福世真樹, 篠原憲一, 松坂恵介, 根本哲宏, 金田篤志
  • Organizer: 第41回分子生物学会年会
• [Presentation] Epstein-Barrウイルスエピソーム形成がもたらすエンハンサー活性化 (2018)
  • Author(s): 岡部篤史, 松坂恵介, 福世真樹, 南波宏枝, 船田さやか, 金田篤志
  • Organizer: 第41回分子生物学会年会
• [Presentation] JAG1活性化細胞と正常細胞の共培養による老化誘導機構の解析 (2018)
  • Author(s): 眞野恭伸, 福世真樹, 岡部篤史, 松坂恵介, 山中遼太, 油谷浩幸, 金田篤志.
  • Organizer: 第41回分子生物学会年会
• [Presentation] がんエピジェネティクスの重要性と研究の現状 (2018)
  • Author(s): 金田篤志
  • Organizer: 日本唾液腺学会第63回学術集会
  • Invited
• [Presentation] ゲノム網羅的解析と融合拠点を活かした癌トランスレーショナル研究 (2017)
  • Author(s): 金田篤志
  • Organizer: 第10回「システム疾患生命科学による先端医療技術開発」シンポジウム
  • Place of Presentation: 武田ホール(東京都・東京）
  • Year and Date: 2017-03-11
  • Invited
• [Presentation] 環境因子により後天的に獲得するゲノム修飾と発癌 (2017)
  • Author(s): 金田篤志
  • Organizer: 第10回ちばBasic & Clinical Research Conference
  • Place of Presentation: ガーネットホール（千葉県・千葉市）
  • Year and Date: 2017-02-04
  • Invited
• [Presentation] 消化管発がんにおけるエピゲノム異常のインパクト. (2017)
  • Author(s): 金田篤志．
  • Organizer: 第17回日本抗加齢医学総会
  • Invited
• [Presentation] 胃発がんにおける可塑的なエピゲノム変化． (2017)
  • Author(s): 金田篤志．
  • Organizer: 第５回がんと代謝研究会
  • Invited
• [Presentation] Epigenomic landscape of Epstein-Barr virus associated gastric cancer. (2017)
  • Author(s): Atsushi Kaneda.
  • Organizer: 76th Annual Meeting of the Japanese Cancer Association
  • Int'l Joint Research / Invited
• [Presentation] Induction of epigenetic alterations in gastric epithelium and their contribution to gastric tumorigenesis (2017)
  • Author(s): Kaneda A.
  • Organizer: International Conference on Cancer Epigenetics and Biomarkers.
  • Int'l Joint Research / Invited
• [Presentation] Development of novel therapeutic strategy based on stratification of gastric cancer cases through comprehensive analysis. (2017)
  • Author(s): Kaneda A.
  • Organizer: France Japan Epigenetics Workshop 2017
  • Int'l Joint Research / Invited
• [Presentation] Epigenomic aberrations to induce gastrointestinal cancer. (2017)
  • Author(s): Atsushi Kaneda
  • Organizer: 第5回千葉県遺伝医療研究会
  • Invited
• [Presentation] Identification of unique genetic/epigenetic alteration in gastric cancer with high DNA methylation. (2017)
  • Author(s): 松坂恵介, 眞野恭伸、福世真樹、浦辺雅之、バハテヤリ・ラムヒトラ、油谷浩幸、瀬戸泰之、深山正久、金田篤志.
  • Organizer: 第106回日本病理学会学術総会
• [Presentation] Epstein-Barrウイルス感染胃癌におけるTET2発現低下とDNA異常高メチル化獲得機 (2017)
  • Author(s): 南波宏枝、舩田さやか、松坂恵介、深山正久、金田篤志
  • Organizer: 第11回日本エピジェネティクス研究会．
• [Presentation] 高メチル化胃癌における特異的なゲノム・エピゲノム変異の同定 (2017)
  • Author(s): 松坂恵介、眞野恭伸、福世真樹、浦辺雅之、油谷浩幸、深山正久、瀬戸泰之、金田篤志.
  • Organizer: 第76回日本癌学会総会
• [Presentation] Epstein-Barrウイルス感染による異常エピゲノム変化に伴うクロマチン構造変化. (2017)
  • Author(s): 岡部篤史、松坂恵介、南波宏枝、船田さやか、福世真樹、金田篤志.
  • Organizer: 第76回日本癌学会総会．
• [Presentation] Involvement of ATF3 in Epstein-Barr virus associated gastric cancer. (2017)
  • Author(s): 浅川悠太、岡部篤史、船田さやか、松坂恵介、南波宏枝、福世真樹、金田篤志.
  • Organizer: 第76回日本癌学会総会
• [Presentation] TET2 repression contributes to DNA methylation acquisition during Epstein-Barr virus infection in gastric cancer. (2017)
  • Author(s): Namba H, Funata S, Matsusaka K, Fukuyo M, Fukayama M, Aburatani H, Kaneda A.
  • Organizer: France Japan Epigenetics Workshop 2017
  • Int'l Joint Research
• [Presentation] 胃癌分子異常の網羅的解析に基づいた層別化とそれに基づいた新規治療戦略の開発． (2017)
  • Author(s): 金田篤志
  • Organizer: ．第28回日本消化器癌発生学会総会・第9回国際消化器癌発生会議
  • Int'l Joint Research
• [Presentation] 癌におけるDNA異常メチル化に伴うクロマチン構造変化. (2017)
  • Author(s): 岡部篤史、松坂恵介、南波宏枝、船田さやか、福世真樹、金田篤志
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] JAG1-Notchシグナルの活性化を介したRas/Raf 誘導性早期細胞老化誘導機構. (2017)
  • Author(s): 眞野恭伸、福世真樹、山中遼太、岡部篤史、油谷浩幸、金田篤志.
  • Organizer: 第40回分子生物学会年会.
• [Presentation] Dynamic epigenetic and chromatin structural change in gastric epithelial cells infected by Epstein-Barr virus． (2017)
  • Author(s): Atsushi Okabe, Keisuke Matsusaka, Hiroe Namba, Sayaka Funata, Masaki Fukuyo, Atsushi Kaneda．
  • Organizer: KEYSTONE SYMPOSIA, Cancer Epigenetics: New Mechanisms, New Therapies．
  • Int'l Joint Research
• [Presentation] ゲノム情報・ゲノム修飾情報とがん医療 (2016)
  • Author(s): 金田篤志
  • Organizer: 千葉県医師会医学会 第17回学術大会
  • Place of Presentation: ホテルポートプラザちば（千葉県・千葉市）
  • Year and Date: 2016-11-03
  • Invited
• [Presentation] Critical DNA hypermethylation in gastrointestinal cancer and its region-specific inhibition by small-molecule compounds (2016)
  • Author(s): 金田篤志
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-10-08
• [Presentation] エピゲノム異常の大腸発癌過程におけるインパクト (2016)
  • Author(s): 金田篤志
  • Organizer: 第53回日本臨床分子医学会
  • Place of Presentation: 有楽町フォーラム（東京都・東京）
  • Year and Date: 2016-04-16
  • Invited
• [Book] DNA and Histone Methylation as Cancer Targets (2017)
  • Author(s): Atsushi Kaneda & Yu-ichi Tsukada
  • Total Pages: 622
  • Publisher: Humana Press,
• [Book] DNA and Histone Methylation in Gastric Cancer (2017)
  • Author(s): Matsusaka K, Kaneda A.
  • Publisher: Springer
• [Book] 胃がん発生におけるエピゲノム異常とその誘導機構 (2017)
  • Author(s): 南波宏枝、金田篤志
  • Publisher: ニューサイエンス社
• [Book] MassARRAYを用いた定量的DNAメチル化解析技法 (2017)
  • Author(s): 高根希世子、八木浩一、金田篤志
  • Publisher: 羊土社
• [Book] De novo methylation in cancer. (2016)
  • Author(s): Funata S, Fukayama M, Kaneda A.
  • Total Pages: 7
  • Publisher: John Wiley & Sons, Ltd
• [Remarks] 千葉大学大学院医学研究院分子腫瘍学HP
  • URL: http://www.m.chiba-u.ac.jp/class/moloncol/
• [Remarks] 分子腫瘍学HP - 千葉大学大学院医学研究院・医学部
  • URL: http://www.m.chiba-u.ac.jp/class/moloncol/
• [Remarks] 千葉大学大学院医学研究院分子腫瘍学
  • URL: http://www.m.chiba-u.ac.jp/class/moloncol/index.html