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Role of immune cells in anti-tumor effect of HF10

Research Project

Project/Area Number 16H05413
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionNagoya University

Principal Investigator

Kasuya Hideki  名古屋大学, 医学系研究科, 教授 (00402636)

Co-Investigator(Kenkyū-buntansha) 小寺 泰弘  名古屋大学, 医学系研究科, 教授 (10345879)
駱 晨虹  名古屋大学, 医学系研究科, 招へい教員 (40759627)
珠玖 洋  三重大学, 医学系研究科, 寄附講座大学教員 (80154194)
藤井 努  名古屋大学, 医学系研究科, 准教授 (60566967)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2017: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords腫瘍溶解性ウイルス / HF10 / 癌免疫 / 腫瘍溶解ウイルス / 免疫チェックポイント / PD-L1 / 癌 / ウイルス / 免疫チェックポイント阻害剤 / in situ Vaccination
Outline of Final Research Achievements

HF10 showed a strong antitumor effect on squamous cell carcinoma cell line SCC7. Furthermore, a synergistic antitumor effect was observed in combination with the PD-L1 antibody. Next, we examined what kind of immune cells infiltrated into the tumor. As a result, infiltration of T cells, macrophages, NK cells and dendritic cells was observed at a high rate in the tumors administered in the HF10 and HF10 / anti-PD-L1 antibody combination group. On the other hand, in non-treated tumors, T cell infiltration was found at a high rate. From this, infiltration of immune cells into the tumor was observed in the HF10 and HF10/anti-PD-L1 antibody combination group, which suggested that infiltration of these immune cells was involved in the enhancement of the combined effect.

Academic Significance and Societal Importance of the Research Achievements

本研究により、腫瘍溶解性ウイルス治療により、多くの免疫細胞、特にT細胞が腫瘍に浸潤し、腫瘍を攻撃すること、さらに、腫瘍溶解性ウイルスと免疫チェックポイント阻害剤である抗PD-L1抗体の併用により腫瘍の増殖を著しく抑制する有効性が明らかになった。このことから、臨床において従来の治療にないHF10と抗PD-L1抗体併用の新たな治療法の可能性を提案することが出来た。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (40 results)

All 2018 2017 2016 Other

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (31 results) (of which Int'l Joint Research: 7 results,  Invited: 2 results) Book (3 results) Remarks (2 results)

  • [Journal Article] A Phase I clinical trial of EUS-guided intratumoral injection of the oncolytic virus, HF10 for unresectable locally advanced pancreatic cancer2018

    • Author(s)
      Hirooka Yoshiki、Kasuya Hideki、Ishikawa Takuya、Kawashima Hiroki、Ohno Eizaburo、Villalobos Itzel B.、Naoe Yoshinori、Ichinose Toru、Koyama Nobuto、Tanaka Maki、Kodera Yasuhiro、Goto Hidemi
    • Journal Title

      BMC Cancer

      Volume: 18 Issue: 1 Pages: 596-596

    • DOI

      10.1186/s12885-018-4453-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Current Status and Future Prospects of Oncolytic Viruses in Clinical Trials against Melanoma, Glioma, Pancreatic, and Breast Cancers2018

    • Author(s)
      Eissa Ibrahim、Bustos-Villalobos Itzel、Ichinose Toru、Matsumura Shigeru、Naoe Yoshinori、Miyajima Noriyuki、Morimoto Daishi、Mukoyama Nobuaki、Zhiwen Wu、Tanaka Maki、Hasegawa Hitoki、Sumigama Seiji、Aleksic Branko、Kodera Yasuhiro、Kasuya Hideki
    • Journal Title

      Cancers

      Volume: 10 Issue: 10 Pages: 356-356

    • DOI

      10.3390/cancers10100356

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genomic Signature of the Natural Oncolytic Herpes Simplex Virus HF10 and Its Therapeutic Role in Preclinical and Clinical Trials.2017

    • Author(s)
      Eissa IR, Naoe Y, Bustos-Villalobos I, Ichinose T, Tanaka M, Zhiwen W, Mukoyama N, Morimoto T, Miyajima N, Hitoki H, Sumigama S, Aleksic B, Kodera Y, Kasuya H.
    • Journal Title

      Front Oncol

      Volume: 7 Pages: 147-147

    • DOI

      10.3389/fonc.2017.00149

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Curative effect of HF10 on liver and peritoneal metastasis mediated by host antitumor immunity2017

    • Author(s)
      Hotta Y, Kasuya H, Bustos I, Naoe Y, Ichinose T, Tanaka M, Kodera Y
    • Journal Title

      Oncolytic Virotherapy

      Volume: 6 Pages: 31-38

    • DOI

      10.2147/ov.s127179

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Combination therapy of oncolytic HSV HF10 and immunecheckpoint inhibitor2018

    • Author(s)
      H Kasuya, Y Naoe, S Matsumura, I Bustos, T Ichinose, I Eissa, W Zhiwe, N Miyajima, D Morimoto, M Tanaka
    • Organizer
      International Oncolytic Virus Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Overview of the Immunotherapy Combinations with HF10 from Clinical Trial and Basic Research2018

    • Author(s)
      H Kasuya
    • Organizer
      Armed Oncolytic Immunotherapies Summit
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Final total Data of Clinical trial using HF10 with Gemcitabine and Erlotinib against Unresectable Pancreatic Cancer2018

    • Author(s)
      Hideki Kasuya, Yoshiki Hirooka, Yoshinori Naoe, Shigeru Matsumura, Itzel Bustos, Toru Ichinose, Ibrahim Eissa, Wu Zhiwen, Nobuaki Mukoyama, Noriyuki Miyajima, Daishi Morimoto, Hidemi Goto, Maki Tanaka
    • Organizer
      第24回日本遺伝子細胞治療学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The synergistic effect of the combination therapy of PD-L1 immune checkpoint inhibitor and oncolytic herpes simplex virus HF102018

    • Author(s)
      Nobuaki Mukoyama, Ibrahim Eissa, Yoshinori Naoe, Toru Ichinose, Shigeru Matsumura, Itzel Bustos, Wu Zhiwen, Noriyuki Miyajima, Daishi Morimoto, Maki Tanaka, Yasushi Fujimoto, Michihiko Sone, Yasuhiro Kodera, Hideki Kasuya
    • Organizer
      第24回日本遺伝子細胞治療学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Involvement of cGAS and STING in sensitivity to oncolytic virus HF10 in breast cancer cell lines2018

    • Author(s)
      Noriyuki Miyajima, Yoshinori Naoe, Shigeru Matsumura, Itzel Bustos, Toru Ichinose, Ibrahim Eissa, Wu Zhiwen, Nobuaki Mukoyama, Daishi Morimoto, Maki Tanaka, Hideki Kasuya
    • Organizer
      第24回日本遺伝子細胞治療学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Does the expression level of STING correlate with susceptibility to oncolytic virus HF10 in human pancreatic cell lines?2018

    • Author(s)
      Daishi Morimoto, Yoshinori Naoe, Shigeru Matsumura, Toru Ichinose, Ibrahim Eissa, Itzel Bustos, Noriyuki Miyajima, Nobuaki Mukoyama, Wu Zhiwen, Maki Tanaka, Yasuhiro Kodera, Hideki Kasuya
    • Organizer
      第24回日本遺伝子細胞治療学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Clinical trial using HF10 with Gemcitabine and Erlotinib for 9 patients of Unresectable pancreatic cancer2018

    • Author(s)
      Hideki Kasuya, Yoshiki Hirooka, Yoshinori Naoe, Shigeru Matsumura, Itzel Bustos, Toru Ichinose, Ibrahim Eissa, Wu Zhiwen, Nobuaki Mukoyama, Noriyuki Miyajima, Daishi Morimoto, Hidemi Goto, Maki Tanaka
    • Organizer
      第56回日本癌治療学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The synergistic effect of the combination therapy of PD-L1 immune checkpoint inhibitor and oncolytic herpes simplex virus Canerpaturev(C-REV)2018

    • Author(s)
      Yoshinori Naoe, Nobuaki Mukoyama, Ibrahim Eissa, Toru Ichinose, Shigeru Matsumura, Itzel Bustos, Wu Zhiwen, Noriyuki Miyajima, Daishi Morimoto, Maki Tanaka, Yasushi Fujimoto, Michihiko Sone, Yasuhiro Kodera, Hideki Kasuya
    • Organizer
      第56回日本癌治療学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] STING is dispensable for low susceptibility to C-REV(HF10) in pancreatic cancer cell lines2018

    • Author(s)
      Shigeru Matsumura, Daishi Morimoto, Yoshinori Naoe, Toru Ichinose, Maki Tanaka, Yasuhiro Kodera, Hideki Kasuya
    • Organizer
      4th ONCOLYTIC VIROTHERAPY Summit
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 膵空腸吻合におけるBlumgart 変法縫合(Nagoya method)の短期および長期成績2017

    • Author(s)
      藤井 努, 山田 豪, 杉本 博行, 高見 秀樹, 林 真路, 神田 光郎, 二宮 豪, 高野 奈緒, 森本 大士, 多代 充, 田中 伸孟, 岩田 直樹, 丹羽 由紀子, 小林 大介, 田中 千恵, 中山 吾郎, 粕谷 英樹, 小池 聖彦, 藤原 道隆, 小寺 泰弘
    • Organizer
      第117 回日本外科学会定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト膵癌異種移植モデルにおけるnab-Paclitaxel(nab-PTX)と腫瘍溶解性単純ヘルペスウイルスHF10 との併用療法2017

    • Author(s)
      森本 大士, 直江 吉則, 一ノ瀬 亨, Bustos Itzel, 神田 光郎, 丹羽 由紀子, 岩田 直樹, 林 真路, 小林 大介, 田中 千恵, 山田 豪, 中山 吾郎, 杉本 博行, 小池 聖彦, 藤原 道隆, 藤井 努, 田中 舞紀, 粕谷 英樹, 小寺 泰弘
    • Organizer
      第117 回日本外科学会定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト大腸がんモデルにおけるセツキシマブとの併用による腫瘍溶解性ウイルスHF10 の抗腫瘍効果2017

    • Author(s)
      呉 智聞, 一ノ瀬 亨, 駱 晨虹, 直江 吉則, イッツェル・ブストス・ビジャロボス, 山田 豪, 藤井 努, 杉本 博行, 森本 大士, 向山 宣昭, 小寺 泰弘, 田中 舞紀, 粕谷 英樹
    • Organizer
      第117 回日本外科学会定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] HF10 ウイルス療法におけるin situ vaccination効果についての検討2017

    • Author(s)
      粕谷 英樹, 直江 吉則, Bustos Itzel, 一ノ瀬 亨, 森本 大士, 向山 宣昭, 呉 智聞, 藤井 努, 小寺 泰弘, 田中 舞紀
    • Organizer
      第117 回日本外科学会定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Combination therapy of oncolytic herpes virus and anti-angiogenesis agent (bevacizumab) against human gastric cancer xenograft2017

    • Author(s)
      H. Kasuya, G. Tan, C. Luo, T. Ichinose, I. Bustos, Y. Naoe
    • Organizer
      EACR-AACR-SIC Special Conference 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Combination therapy of PD-L1 immune checkpoint inhibitor and oncolytic herpes simplex virus HF102017

    • Author(s)
      Mukoyama N, Naoe Y, Ichinose T, Nassr E. I. R, Luo C, Villalobos I. B, Zhiwen W, Miyajima N, Morimoto D, Tanaka M, Fujimoto Y, Sone M, Kodera Y, Kasuya H.
    • Organizer
      第23回日本遺伝子細胞治療学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Combination therapy against human pancreatic cancer with oncolytic herpes virus HF10 and abraxane2017

    • Author(s)
      Wu Z, Ichinose T, Luo C, Naoe Y, Villalobos I. B, Yamada S, Fujii T, Sugimoto H, Miyajima N, Morimoto D, Mukoyama N, Nishikawa Y, Koide U, Kuwahara T, Kodera Y, Tanaka M, Kasuya H.
    • Organizer
      第23回日本遺伝子細胞治療学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Systemic therapeutic potential of oncolytic herpes simplex virus HF10 adsorbed on antigen-specific lymphocytes2017

    • Author(s)
      Ichinose T, Naoe Y, Nassr E. I. R, Luo C, Villalobos I. B, Zhiwen W, Mukoyama N, Miyajima N, Morimoto D, Yamada S, Fujii T, Sugimoto H, Tanaka M, Kodera Y, Kasuya H.,
    • Organizer
      第23回日本遺伝子細胞治療学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Clinical trial data using HF10, oncolytic herpes simplex virus2017

    • Author(s)
      Kasuya H, Ichinose T, Naoe Y, Villalobos I. B, Nassr E. I. R, Luo C, Zhiwen W, Mukoyama N, Miyajima N, Morimoto D, Hirooka Y, Goto H, Tanaka M.
    • Organizer
      第23回日本遺伝子細胞治療学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] COMBINATION THERAPY AGAINST HUMAN COLORECTAL CANCER WITH THE EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR CETUXIMAB AND ONCOLYTIC HERPES SIMPLEX VIRUS HF102017

    • Author(s)
      呉 智聞, 一ノ瀬 亨, 駱 晨虹, 直江 吉則, ヴィラロボス イッツェル・バストス, 山田 豪, 杉本 博行, 宮嶋 則行, 森本 大士, 向山 宣昭, 西川 洋子, 小出 悠介, 小寺 泰弘, 田中 舞紀, 粕谷 英樹
    • Organizer
      第55回日本癌治療学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Combination therapy of PD-L1 immune checkpoint inhibitor and oncolytic herpes simplex virus HF102017

    • Author(s)
      森本 大士, 直江 吉則, 向山 宜明, 一ノ瀬 亨, Itzel Bustos Villalobos, 神田 光郎, 丹羽 由紀子, 岩田 直樹, 林 真路, 小林 大介, 田中 千恵, 中山 吾郎, 山田 豪, 杉本 博行, 小池 聖彦, 藤原 道隆, 田中 舞紀, 藤本 保志, 粕谷 英樹, 小寺 泰
    • Organizer
      第28回日本消化器癌発生学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 腫瘍溶解性単純ヘルペスウイルスHF10と免疫チェックポイント阻害剤の併用2017

    • Author(s)
      森本 大士, 直江 吉則, 向山 宜明, 宮嶋 則行, Ibrahim Ragab Eissa, 一ノ瀬 亨, Itzel Bustos-Villalobos, 山田 豪, 田中 舞紀, 藤本 保志, 小寺 泰弘, 粕谷 英樹
    • Organizer
      第51回制癌剤適応研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト癌異種移植モデルにおける腫瘍溶解性単純ヘルペスウイルスHF10と既存化学療法薬との併用療法の検討2017

    • Author(s)
      森本大士, 直江吉則, 一ノ瀬亨, 駱晨虹, Itzel Bustos Villalobos, 呉 智聞, 山田豪, 杉本博行, 田中舞紀, 藤井努, 粕谷英樹, 小寺泰弘
    • Organizer
      第50回制癌剤適応研究会
    • Place of Presentation
      ホテルクレメント徳島(徳島県徳島市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Effectiveness Comparison of Different Routes of Administration of Oncolytic Virus in Abdominal Tumors2016

    • Author(s)
      Hideki Kasuya
    • Organizer
      The 2nd Annual Oncolytic Virotherapy Summit
    • Place of Presentation
      サンディエゴ(アメリカ合衆国)
    • Year and Date
      2016-12-07
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effectiveness of HF10 in Clinical Trial against Pancreatic Cancer2016

    • Author(s)
      Hideki Kasuya
    • Organizer
      第54回日本癌治療学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Most recent clinical trial data using HF10 for 9 patients with non resectable pancreatic cancer2016

    • Author(s)
      Yoshinori Naoe, Toru Ichinose, Chenhong Luo, Wu Zhiwen, Nobuaki Mukoyama, Noriyuki Miyajima, Daishi Morimoto, Maki Tanaka, Hideki Kasuya
    • Organizer
      The 10th International Meeting on Replicating Oncolytic Virus Therapeutics
    • Place of Presentation
      バンクーバー(カナダ)
    • Year and Date
      2016-10-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ENHANCED ANTI-TUMORAL ACTIVITY OF ONCOLYTIC HERPES SIMPLEX VIRUS HF10 WITH CETUXIMAB AGAINST HUMAN COLORECTAL CANCER2016

    • Author(s)
      Zhiwen Wu, Toru Ichinose, Chenhong Luo, Suguru Yamada, Tsutomu Fujii, Hiroyuki Sugimoto, Noriyuki Miyajima, Daishi Morimoto, Nobuaki Mukoyama, Yoko Nishikawa, Usuke Koide, Toshie Kuwahara, Yasuhiro Kodera, Maki Tanaka, Hideki Kasuya
    • Organizer
      第22回日本遺伝子細胞治療学会学術集会
    • Place of Presentation
      虎ノ門ヒルズフォーラム(東京都港区)
    • Year and Date
      2016-07-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Combination treatment of human cancer xenograft models with the conventional chemotherapeutic drug and oncolytic herpes simplex virus HF102016

    • Author(s)
      Daishi Morimoto, Chenhong Luo, Yusuke Koide, Noriyuki Miyajima, Nobuaki Mukoyama, Wu Zhiwen, Toru Ichinose, Maki Tanaka, Yasushi Fujimoto, Yasuhiro Kodera, Hideki Kasuya
    • Organizer
      第22回日本遺伝子細胞治療学会学術集会
    • Place of Presentation
      虎ノ門ヒルズフォーラム(東京都港区)
    • Year and Date
      2016-07-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Combination therapy of squamous cell carcinoma mouse models with PD-L1 immune checkpoint inhibitor and oncolytic herpes simplex virus HF102016

    • Author(s)
      Nobuaki Mukoyama, Toru Ichinose, Chenhong Luo, Yusuke Koide, Wu Zhiwen, Noriyuki Miyajima, Daishi Morimoto, Maki Tanaka, Yasushi Fujimoto, Michihiko Sone, Yasuhiro Kodera, Hideki Kasuya
    • Organizer
      第22回日本遺伝子細胞治療学会学術集会
    • Place of Presentation
      虎ノ門ヒルズフォーラム(東京都港区)
    • Year and Date
      2016-07-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 腫瘍溶解性ヘルペスウイルスHF10を使用した新規膵癌治療法の研究2016

    • Author(s)
      粕谷英樹、廣岡芳樹、後藤秀実、小寺泰弘、田中舞紀
    • Organizer
      第71回日本消化器外科学会総会
    • Place of Presentation
      あわぎんホール・アスティとくしま(徳島県徳島市)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] EUS-Guided Injection of HF10 for Unresectable Locally Advanced Pancreatic Cancer (Phase 1 Dose-Escalation Clinical Trial)2016

    • Author(s)
      Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Hideki Kasuya, Maki Tanaka, Hidemi Goto
    • Organizer
      the 12th AFSUMB 2016
    • Place of Presentation
      Kyoto International Conference Center, Grand Prince Hotel Kyoto (京都府京都市)
    • Year and Date
      2016-05-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腫瘍溶解性ヘルペスウイルスHF10を使用した新規がん治療法の研究2016

    • Author(s)
      粕谷英樹、山村和生、藤井努、堀田佳宏、西山幸廣、小出悠介、田中舞紀 、駱晨虹、一ノ瀬亨、宮嶋則行、向山宣昭、中尾昭公、小寺泰弘
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル大阪(大阪府大阪市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Book] 遺伝子医学MOOK 31号 がん免疫療法 - What's now and what's next? 第2章の4の3) 腫瘍溶解性ウイルスHF10による再発乳がん多発結節症例, 切除不能進行膵がん症例に対する臨床研究2017

    • Author(s)
      粕谷 英樹, 直江 吉則, 一ノ瀬 亨, 廣岡 芳樹, 後藤 秀実, 田中 舞紀
    • Total Pages
      294
    • Publisher
      (株)メディカル ドゥ
    • ISBN
      9784944157617
    • Related Report
      2017 Annual Research Report
  • [Book] 次世代がん治療 ~発症・転移メカニズムからがん免疫療法・ウイルス療法、診断法まで~ 第3章 第2節 単純ヘルペスウイルスI型自然変異株「HF10」の実用化に向けた臨床開発2017

    • Author(s)
      粕谷 英樹
    • Total Pages
      386
    • Publisher
      (株)エヌ・ティー・エス
    • ISBN
      9784860435035
    • Related Report
      2017 Annual Research Report
  • [Book] Innovation of Diagnosis and Treatment for Pancreatic Cancer Part 4, Chap. 18 The Potential of Oncolytic Virus Therapy for Pancreatic Cancer2017

    • Author(s)
      Hideki Kasuya, et al Editor: Hiroki Yamaue
    • Total Pages
      260
    • Publisher
      Springer
    • ISBN
      9789811024863
    • Related Report
      2017 Annual Research Report
  • [Remarks] 名古屋大学大学院医学系研究科 癌免疫治療研究室

    • URL

      https://www.med.nagoya-u.ac.jp/intlexch/cancerimmuno/www/index.html

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 名古屋大学大学院医学系研究科 癌免疫治療研究室 研究業績

    • URL

      https://www.med.nagoya-u.ac.jp/intlexch/cancerimmuno/www/achievements/index.html

    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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