| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Outline of Final Research Achievements |
Using a mouse stroke model, we elucidated the molecular and cellular mechanisms underlying tissue repair after ischemic stroke and its association with functional recovery. We found that tissue repair absolutely requires the recovery of blood flow within infarct areas thorough recanalization of occluded artery or promotion of collateral blood flow via leptomeningeal anastomosis, where microvascular pericytes play a crucial role. The pericyte-mediated intra-infarct tissue repair induces activation of astrocytes, differentiation of oligodendrocyte precursor cells and reorganization of neural network in peri-infarct areas, thereby contributing to functional recovery.
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