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Identification of abnormal cellular signals and clinical targets rerated to the various pathology of neurofibromatosis

Research Project

Project/Area Number 16H05440
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurosurgery
Research InstitutionKumamoto University

Principal Investigator

araki norie  熊本大学, 大学院生命科学研究部(医), 准教授 (80253722)

Co-Investigator(Kenkyū-buntansha) 尹 浩信  熊本大学, 大学院生命科学研究部(医), 教授 (20282634)
中村 英夫  久留米大学, 医学部, 准教授 (30359963)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Keywords神経線維腫症 / NF1 / NF2 / 融合オミクス / シグナルトランスダクション / プロテオミクス / シグナルネットワーク / 融合プロテオミクス / ネットワーク解析
Outline of Final Research Achievements

Neurofibromatosis (NF) is an autosomal dominant disease that predisposes individuals to developing various phenotypes including neural tumors with unknown mechanism being difficult to cure. In this study, to elucidate the mechanism of development of various tumor pathologies related to this disease and to develop therapeutic targets, we established NF model cells from NF gene-deficient patient tumors and NF-KD tumor (stem) cells, and subjected to a unique integrated-omics system using our original software iPEACH/ MANGO plus. As the results of extracting specific networks using these cells, novel NF specific signal networks related to the anti-apoptosis, complex molecules of the protein translation extension, and growth regulation signalings were identified. After several validations, we demonstrate that these signal molecules could be novel therapeutic targets and useful for the development of curatives against NF related tumors.

Academic Significance and Societal Importance of the Research Achievements

神経線維腫症(NF)は、1991-1994年に原因遺伝子NF1/2が同定された。NF1は頻度の高さ(1/3000)から、NF2は脳神経系病態の深刻さから、これらの多彩な発病機構の解明とその治療法・治療薬の開発が大きく望まれているが、現在まで成功していない。ユニークに構築されたNF遺伝子変異/欠失病態モデル細胞を用いて、これらの細胞内で特異的に活性化するシグナル分子群の同定を目的として、独自開発による融合オミクスによって大規模分子解析を行い、特異的な治療標的となる候補分子群を世界で初めて同定した。この成果は根治療不可能である本疾患の治療法・薬剤開発に重要な基礎情報として貢献できる可能性が高い。

Report

(4 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (72 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (6 results) Journal Article (13 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 13 results,  Open Access: 13 results,  Acknowledgement Compliant: 1 results) Presentation (51 results) (of which Int'l Joint Research: 22 results,  Invited: 31 results) Remarks (2 results)

  • [Int'l Joint Research] マルタ国立大学(マルタ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] タイ王立コンケン大学(タイ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Khon Kaen University(タイ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Malta University(マルタ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] EMBL-EBI(英国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Taiwan Academia Sinica(台湾)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] O-GalNAcylating enzyme GALNT5 mediates carcinogenesis and progression of cholangiocarcinoma via activation of AKT/ERK signaling2020

    • Author(s)
      Datarya M, Sawanyawisuth K, Aphivatanasiri C, Chuangchaiya S, Saranaruk P, Sukprasert L, Silsirivanit A, Araki N, Wongkham S, Wongkham C
    • Journal Title

      Glycobiology

      Volume: 30(5) Issue: 5 Pages: 312-324

    • DOI

      10.1093/glycob/cwz098

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of a Specific Translational Machinery via TCTP-EF1A2 Interaction Regulating NF1-associated Tumor Growth by Affinity Purification and Data-independent Mass Spectrometry Acquisition (AP-DIA)2019

    • Author(s)
      Kobayashi Daiki, Tokuda Takaho, Sato Kyosuke, Okanishi Hiroki, Nagayama Megumi, Hirayama-Kurogi Mio, Ohtsuki Sumio, Araki Norie
    • Journal Title

      Molecular & Cellular Proteomics

      Volume: 18 Issue: 2 Pages: 245-262

    • DOI

      10.1074/mcp.ra118.001014

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The jPOST environment: an integrated proteomics data repository and database2018

    • Author(s)
      Moriya Yuki、Kawano Shin、Okuda Shujiro、Watanabe Yu、Matsumoto Masaki、Takami Tomoyo、Kobayashi Daiki、Yamanouchi Yoshinori、Araki Norie、Yoshizawa Akiyasu C、Tabata Tsuyoshi、Iwasaki Mio、Sugiyama Naoyuki、Tanaka Satoshi、Goto Susumu、Ishihama Yasushi
    • Journal Title

      Nucleic Acids Research

      Volume: 47 Issue: D1 Pages: 1218-1224

    • DOI

      10.1093/nar/gky899

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix2018

    • Author(s)
      Fukuda Masatoshi、Yoshizawa Tatsuya et al.
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 2833-2833

    • DOI

      10.1038/s41467-018-05187-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isocitrate dehydrogenase gene mutations and 2-hydroxyglutarate accumulation in esophageal squamous cell carcinoma2018

    • Author(s)
      Miyake Keisuke、Baba Yoshifumi、Ishimoto Takatsugu、Hiyoshi Yukiharu、Iwatsuki Masaaki、Miyamoto Yuji、Yoshida Naoya、Watanabe Masayuki、Ogata Yoko、Nagayama Megumi、Silsirivanit Atit、Kobayashi Daiki、Araki Norie、Baba Hideo
    • Journal Title

      Medical Oncology

      Volume: 36 Issue: 1 Pages: 2-9

    • DOI

      10.1007/s12032-018-1229-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Artesunate and chloroquine induce cytotoxic activity on cholangiocarcinoma cells via different cell death mechanisms.2018

    • Author(s)
      Guragain D, Seubwai W, Kobayashi D, Silsinivanit A, Kulthida Vaeteewoottacharn K, Sawanyawisuth K, Wongkham C, Wongkham S, Araki N*, Cha`on U
    • Journal Title

      Cellular and Molecular Biology

      Volume: 64 Pages: 113-118

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ribosome Incorporation into Somatic Cells Promotes Lineage Transdifferentiation towards Multipotency2018

    • Author(s)
      Ito Naofumi、Katoh Kaoru、Kushige Hiroko、Saito Yutaka、Umemoto Terumasa、Matsuzaki Yu、Kiyonari Hiroshi、Kobayashi Daiki、Soga Minami、Era Takumi、Araki Norie、Furuta Yasuhide、Suda Toshio、Kida Yasuyuki、Ohta Kunimasa
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1634-1634

    • DOI

      10.1038/s41598-018-20057-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RBMX is a component of the centromere noncoding RNP complex involved in cohesion regulation2018

    • Author(s)
      Cho Yukiko、Ideue Takashi、Nagayama Megumi、Araki Norie、Tani Tokio
    • Journal Title

      Genes to Cells

      Volume: 23 Issue: 3 Pages: 172-184

    • DOI

      10.1111/gtc.12562

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical significance of GalNAcylated glycans in cholangiocarcinoma: Values for diagnosis and prognosis2018

    • Author(s)
      Saentaweesuk Waraporn、Silsirivanit Atit、Vaeteewoottacharn Kulthida、Sawanyawisuth Kanlayanee、Pairojkul Chawalit、Cha'on Ubon、Indramanee Somsiri、Pinlaor Somchai、Boonmars Thidarut、Araki Norie、Wongkham Chaisiri
    • Journal Title

      Clinica Chimica Acta

      Volume: 477 Pages: 66-71

    • DOI

      10.1016/j.cca.2017.12.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] jPOSTrepo: an international standard data repository for proteomes.2017

    • Author(s)
      Okuda S, Watanabe Y, Moriya Y, Kawano S, Yamamoto T, Matsumoto M, Takami T, Kobayashi D, Araki N, Yoshizawa AC, Tabata T, Sugiyama N, Goto S, Ishihama Y.
    • Journal Title

      Nucleic Acids Res.

      Volume: 45 Issue: D1 Pages: D1107-D1111

    • DOI

      10.1093/nar/gkw1080

    • NAID

      120006353864

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Activation of Vimentin is Critical to Promote a Metastatic Potential of Cholangiocarcinoma Cells2017

    • Author(s)
      Saentaweesuk Waraporn、Araki Norie、Vaeteewoottacharn Kulthida、Silsirivanit Atit、Seubwai Wunchana、Talabnin Chutima、Muisuk Kanha、Sripa Banchob、Wongkham Sopit、Okada Seiji、Wongkham Chaisiri
    • Journal Title

      Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

      Volume: 印刷中 Issue: 4 Pages: 605-616

    • DOI

      10.3727/096504017x15009778205068

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cellular biological validations of proteomics data.2016

    • Author(s)
      Kobayashi D, Araki N
    • Journal Title

      Proteome Letters

      Volume: 1(1) Pages: 37-43

    • NAID

      130006743371

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CXCL12/CXCR4 activation by cancer-associated fibroblasts promotes integrin β1 clustering and invasiveness in gastric cancer.2016

    • Author(s)
      Izumi D, Ishimoto T, Miyake K, Sugihara H, Eto K, Sawayama H, Yasuda T, Kiyozumi Y, Kaida T, Kurashige J, Imamura Y, Hiyoshi Y, Iwatsuki M, Iwagami S, Baba Y, Sakamoto Y, Miyamoto Y, Yoshida N, Watanabe M, Takamori H, Araki N, Tan P, Baba H.
    • Journal Title

      Int J Cancer

      Volume: 1;138(5) Issue: 5 Pages: 1207-19

    • DOI

      10.1002/ijc.29864

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] NF1の融合プロテオシステムズバイオロジーによる病態メカニズム治療標的の解析2020

    • Author(s)
      荒木令江
    • Organizer
      第11回フォンレックリングハウゼン病学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] プロテオミクスを基盤とした統合的システムズバイオロジーの腫瘍研究への応用2019

    • Author(s)
      荒木令江
    • Organizer
      第43回 蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Functional integrated-omics coupled with interactome analyses identified a novel target signaling of the NF1-associated tumor2019

    • Author(s)
      荒木令江
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Integrated phospho-glycomics identified the target signaling of cancer stem cells2019

    • Author(s)
      Norie Araki*, Akiko Niibori-Nambu, Atit Silsirivanit, Yuki Nishiyama-Ikedat, Daiki Kobayashi
    • Organizer
      25th Human Proteome Organization World Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] シンポジウム: インフォマティクスに支えられるプロテオーム解析 インフォマティクスに支えられるプロテオーム解析 Proteome analysis supported by informatics2019

    • Author(s)
      小林 大樹 ・ 荒木 令江
    • Organizer
      日本プロテオーム学会2019年大会 第70回日本電気泳動学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] クロスリンキング質量分析(XL-MS)によるNF1関連病態因子TCTPと翻訳伸長因子群の相互作用形式の解明2019

    • Author(s)
      椋木 浩太 ・ 小林 大樹 ・ 徳田 高穂 ・ 荒木 令江
    • Organizer
      日本プロテオーム学会2019年大会 第70回日本電気泳動学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Identification of the O-GalNAc glycoproteomes related to the malignancy of Cholangiocarcinoma2019

    • Author(s)
      Detarya Marutpong・ 小林 大樹・ Sawanyawisuth Kanlayanee・ Wongkham Sopit Silsirivanit Atit ・ Wongkham Chaisiri・ 荒木 令江
    • Organizer
      日本プロテオーム学会2019年大会 第70回日本電気泳動学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Methyloproteomics of the maintenance and differentiation of glioma cancer stem cells2019

    • Author(s)
      Baron Byron・ 小林 大樹・ 仁科 由美・ 池田(西山) 友貴 ・ 荒木 令江
    • Organizer
      日本プロテオーム学会2019年大会 第70回日本電気泳動学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 特別企画「使ってみようバイオデータベース―つながるデータ、広がる世界(BioDB)」 プロテオーム統合データベースjPOST2019

    • Author(s)
      石濱 泰,五斗 進,奥田 修二郎,松本 雅記,荒木 令江
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] jPOST統合環境の機能深化と連携基盤強化2019

    • Author(s)
      守屋勇樹、河野信、奥田修二郎、渡辺由、松本雅記、高見知代、小林大樹、 山ノ内祥訓、荒木令江、吉沢明康、田畑剛、岩崎未央、杉山直幸、田中聡、五斗進、石濱泰
    • Organizer
      トーゴーの日シンポジウム2019
    • Related Report
      2018 Annual Research Report
  • [Presentation] Integrated proteo-glyco-genomics Identification of the potential clinical target of cancer stem cells2018

    • Author(s)
      Norie Araki, Akiko Niibori-Nambu, Atit Silsirivanit1, Yoshimune Yamasaki, Hiroki Okanishi, Daiki Kobayashi, Kiyohiko Angata, Atsushi Kuno, Hisashi Narimatsu.
    • Organizer
      International meeting of "Current Glycosciences and Glycotechnology: Application for Medicine"
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cancer systems biology by integrated proteomics2018

    • Author(s)
      Norie Araki
    • Organizer
      The 3th e-Asia Glyco Biomarker Workshop
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] jPOST統合環境の開発2018

    • Author(s)
      奥田修二郎、渡辺由、守屋勇樹、河野信、松本雅記、高見知代、小林大樹、山ノ内祥訓、 荒木令江、吉沢明康、田畑剛、岩崎未央、杉山直幸、田中聡、五斗進、石濱泰
    • Organizer
      トーゴーの日シンポジウム2018
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] プロテオミクスを基盤としたプロテオゲノム情報の疾患研究への橋渡しとその応用「プロテオゲノミクスが解き明かす新たな分子ネットワークと次世代創薬研究への応用」2018

    • Author(s)
      荒木令江、南部新堀 晶子, 山崎吉宗, 山ノ内祥訓, 當房浩一, 小林大樹
    • Organizer
      第41回日本分子生物学会年会(横浜)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] jPOST: 質量分析生データを最大限に活用するためのメタデータキュレーション2018

    • Author(s)
      小林大樹・ 荒木令江・ 奥田修二郎・ 渡辺由・ 守屋勇樹・ 河野信・ 山本格・ 松本雅記・ 高見知代・ 吉沢明康・ 田畑剛・ 岩崎未央・ 杉山直幸・ 田中聡・ 五斗進・ 石濱泰
    • Organizer
      アジアオセアニアプロテオーム学会/日本プロテオーム学会/質量分析学会合同MSP2018年大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Integrated phospho-glyco-proteogenomics identified the potential clinical target signals against glioma stem cells2018

    • Author(s)
      Norie Araki, Akiko Niibori-Nambu, Atit Silsirivanit, Daiki Kobayashi, Takuichiro Hide, Hideo Namakumra, Junichi Kuratsu
    • Organizer
      第78回日本癌学会学術総会 Interantional Session
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] SWATH定量によるNF1関連因子TCTP2量体型と翻訳伸長因子群の相互作用の解析2018

    • Author(s)
      徳田高穂・ 小林大樹・ 岡西広樹・ 荒木令江
    • Organizer
      アジアオセアニアプロテオーム学会/日本プロテオーム学会/質量分析学会合同MSP2018年大会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] プロテオミクスを基盤とした融合オミクスによる腫瘍特異的ネットワーク解析2018

    • Author(s)
      荒木令江
    • Organizer
      第69回日本電気泳動学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ショットガンプロテオミクスとネットワーク解析「大規模に同定された分子群から如何に注目すべきネットワークを抽出するか」2018

    • Author(s)
      荒木令江
    • Organizer
      プロテオミクス・タンパク分析基礎講座プロテオミクス研究会2018
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Systems biology of cancer stem cells by integrated proteomics and glycomics2018

    • Author(s)
      Norie Araki, Akiko Niibori-Nambu, Atit Silsirivanit, Yoshimune Yamasaki, Hirokazu Toubou, Hiroki Okanishi, Daiki Kobayashi
    • Organizer
      the 5th Asia Pacific Protein Association Conference and 12th International Symposium of the Protein Society of Thailand
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cancer systems biology by integrated proteomics2018

    • Author(s)
      Norie Araki
    • Organizer
      The 3th e-Asia Glyco Biomarker Workshop (Khon Kaen, Thailand)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Integrated proteo-glyco-genomics identified the potential clinical target of cancer stem cells2017

    • Author(s)
      Norie Araki, Akiko Niibori-Nambu, Atit Silsirivanit, Yoshimune, Yamasaki, Hiroki Okanishi, Daiki Kobayashi, Kiyohiko Angata, Atsushi Kuno, Hisashi Narimatsu.
    • Organizer
      The 15th Inthernational Human Proteome Organization Congress (HUPO201 Dublin, IRELAND
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Proteomics of post-translational lysine acetylation in glioma-derived stem cells2017

    • Author(s)
      Okanishi, H., Akiko Niibori-Nambu, Kobayashi, D., Araki, N
    • Organizer
      16th Human Proteome Organization World Conference (HUPO2017), (Dublin Convention Center, Ireland Dublin)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Studies of key signals related to the maintenance and differentiation of glioma initiating cells by integrated-omics2017

    • Author(s)
      Norie Araki, Akiko Niibori-Nambu, Atit Silsirivanit, Hiroki Okanishi, Daiki Kobayashi, Takuichiro Hide, Hideo Namakumra
    • Organizer
      第75回日本癌学会学術総会, パシフィコ横浜(横浜)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] グリオーマ幹細胞における翻訳後修飾アセチル化の分化変動プロテオミクス2017

    • Author(s)
      岡西広樹,鷲頭朋之,南部晶子,小林大樹,荒木令江.
    • Organizer
      日本プロテオーム学会2017年会 (JHUPO2017) (大阪)
    • Related Report
      2017 Annual Research Report
  • [Presentation] プロオミクスを基盤とした統合オミクスによる新規腫瘍マーカーと治療標的の同定2017

    • Author(s)
      荒木令江
    • Organizer
      熊本震災復興フォーラム(東京)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] プロテオームデータにある生物学的な重要性を見出すための“Computational”ツール2017

    • Author(s)
      小林 大樹、荒木 令江
    • Organizer
      日本プロテオーム学会2017年会 (JHUPO2017) (大阪)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 多彩な質量分析方法論の融合による癌の悪性化・薬剤耐性メカニズムの解析2017

    • Author(s)
      荒木 令江
    • Organizer
      質量分析フォーラム2017 (東京/大阪)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Identification of a novel translation machinery regulating NF1-associated tumors by affinity purification and SWATH (AP-SWATH)2017

    • Author(s)
      Daiki Kobayashi, Takaho Tokuda, Kyosuke Sato, Hiroki Okanishi, Sumio Ohtsuki, Norie Araki
    • Organizer
      16th Human Proteome Organization World Conference (HUPO2017), (Ireland Dublin)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] jPOST: メタデータのキュレーション2017

    • Author(s)
      小林大樹、荒木令江、奥田修二郎、渡辺由、守屋勇樹、河野信、山本格、松本雅記、高見知代、吉沢明康、田畑剛、杉山直幸、田中聡、岩崎未央、五斗進、石濱泰
    • Organizer
      トーゴーの日シンポジウム2017 (東京)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Basics and Application of Disease Proteomics2017

    • Author(s)
      荒木令江
    • Organizer
      歯科口腔ブレインサイエンスセミナー2017 (九州大学)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] TCTP-EF1A2-翻訳伸長因子複合体を介した神経線維腫症1型腫瘍特異的な翻訳機構の解析2017

    • Author(s)
      小林 大樹、徳田 高穂、岡西 広樹、大槻 純男、荒木 令江
    • Organizer
      2017年度生命科学系学会合同年次大会(Conbio2017)(兵庫県神戸市)
    • Related Report
      2017 Annual Research Report
  • [Presentation] データベース検索エンジンを用いたタンパク質同定における特異性向上2017

    • Author(s)
      吉沢明康, 田畑剛, 守屋勇樹, 河野信, 奥田修二郎, 渡辺由, 山本格, 松本雅記, 高見知代, 小林大樹, 荒木令江, 杉山直幸, 田中聡, 五斗進, 石濱泰 質量分析総合討論会
    • Organizer
      質量分析総合討論会2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] jPOST: メタデータのキュレーション2017

    • Author(s)
      小林大樹、荒木令江、奥田修二郎、渡辺由、守屋勇樹、河野信、山本格、松本雅記、高見知代、吉沢明康、田畑剛、杉山直幸、田中聡、岩崎未央、五斗進、石濱泰
    • Organizer
      トーゴーの日シンポジウム2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] jPOST:プロテオーム統合データベースプロジェクト2017

    • Author(s)
      奥田修二郎, 渡辺由, 守屋勇樹, 河野信, 山本格, 松本雅記, 高見知代, 小林大樹, 荒木令江, 吉沢明康, 田畑剛, 杉山直幸, 田中聡, 五斗進, 石濱泰
    • Organizer
      第90回日本生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] jPOST:プロテオームデータベースの開発2017

    • Author(s)
      守屋勇樹, 河野信, 奥田修二郎, 渡辺由, 山本格, 松本雅記, 高見知代, 小林大樹, 荒木令江, 吉沢明康, 田畑剛, 杉山直幸, 田中聡, 五斗進, 石濱泰
    • Organizer
      日本生化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] jPOST:プロテオーム統合データベースの開発2017

    • Author(s)
      守屋勇樹, 河野信, 奥田修二郎, 渡辺由, 山本格, 松本雅記, 高見知代, 小林大樹, 荒木令江, 吉沢明康, 田畑剛, 杉山直幸, 田中聡, 五斗進, 石澤泰
    • Organizer
      日本プロテオーム学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] jPOST 同定結果のFDR改善を目指す再解析プロトコルの開発2017

    • Author(s)
      吉沢 明康, 田畑 剛, 守屋 勇樹, 河野 信, 奥田 修二郎, 渡辺 由, 山本 格, 松本 雅記, 高見 知代, 小林 大樹, 荒木 令江, 杉山 直幸, 田中 聡, 五斗 進, 石濱 泰
    • Organizer
      生命科学系学会合同年次大会生化学会2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 細胞分裂の制御に関わるSatellite I ncRNP複合体構成因子候補YB-1の機能解析2017

    • Author(s)
      河野 貴亮, 井手上 賢, 荒木 令江, 谷 時雄
    • Organizer
      生命科学系学会合同年次大会生化学会2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] TCTP-EF1A2-翻訳伸長因子複合体を介した神経線維腫症1型腫瘍特異的な翻訳機構の解析2017

    • Author(s)
      小林 大樹、徳田 高穂、岡西 広樹、大槻 純男、荒木 令江
    • Organizer
      2017年度生命科学系学会合同年次大会(Conbio2017)
    • Related Report
      2017 Annual Research Report
  • [Presentation] プロオミクスを基盤とした統合オミクスによる新規腫瘍マーカーと治療標的の同定2017

    • Author(s)
      荒木令江
    • Organizer
      熊本震災復興フォーラム
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] プロテオームデータにある生物学的な重要性を見出すための“Computational”ツール2017

    • Author(s)
      小林 大樹、荒木 令江
    • Organizer
      日本プロテオーム学会2017年会
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 多彩な質量分析方法論の融合による癌の悪性化・薬剤耐性メカニズムの解析2017

    • Author(s)
      荒木 令江
    • Organizer
      質量分析フォーラム2017
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Systems biology of cancer stem cells by integrated proteomics and glycomics2017

    • Author(s)
      Norie Araki
    • Organizer
      the 5th Asia Pacific Protein Association Conference and 12th International Symposium of the Protein Society of Thailand
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Integrated proteo-glyco-genomics identified the potential clinical target of cancer stem cells2017

    • Author(s)
      NORIE ARAKI, Akiko Nambu-Niibori, Atit Silsirivanit, Yoshimune Yamasaki, Hirokazu Toubou, Hiroki Okanishi, Daiki Kobayashi, Kiyohiko Angata, Atsushi Kuno, Hisashi Narimatsu
    • Organizer
      The 15th Inthernational Human Proteome Organization Congress (HUPO2017)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Interactome Analysis Identified a Novel Binding Manner of TCTP-Translation Elongation Factors in Neurofibromatosis Type 12017

    • Author(s)
      DAIKI KOBAYASHI, Takaho Tokuda, Kyosuke Sato, Megumi Nagayama, Sumio Ohtsuki, Norie Araki
    • Organizer
      The 15th Inthernational Human Proteome Organization Congress (HUPO2017)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 融合プロテオミクスを基盤としたシステムズバイオロジーの腫瘍研究への応用2016

    • Author(s)
      荒木令江
    • Organizer
      日本プロテオーム学会2016年会(学会賞受賞講演)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional integrated proteomics identified "glyco-niche" signalings as a regulator of the maintenance and differentiation of cancer stem cells2016

    • Author(s)
      NORIE ARAKI, Akiko Nambu-Niibori, Atit Silsirivanit, Yoshimune Yamasaki, Hirokazu Toubou, Hiroki Okanishi, Daiki Kobayashi
    • Organizer
      HUPO2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A Novel "Glyco-Niche" Signaling As a Regulator of the Maintenance and Differentiation of Cancer Stem Cells Was Identified by Integrated Proteomics2016

    • Author(s)
      NORIE ARAKI, Akiko Nambu-Niibori, Atit Silsirivanit, Yoshimune Yamasaki, Hirokazu Toubou, Hiroki Okanishi, Daiki Kobayashi
    • Organizer
      AOHUPO2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 融合的オミクス解析とシステムズバイオロジーによるNF1 腫瘍の新規治療ターゲットシグナルの同定と機能解析2016

    • Author(s)
      荒木令江、小林大樹、新堀(南部) 晶子、中村英夫、尹浩信、倉津純一
    • Organizer
      第74回日本癌学会学術総会
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] O-GlcNAcylation regulates stemness-maintenance and differentiation of glioma stem cells2016

    • Author(s)
      Silsirivanit A, Akiko Niibori-Nambu, Nagai M, Kobayashi D, Nagayama M, Araki N
    • Organizer
      The 5th International Biochemistry and Molecular Biology Conference 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Remarks] 熊本大学大学院生命科学研究部腫瘍医学分野

    • URL

      http://srv02.medic.kumamoto-u.ac.jp/dept/tumor/index.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 日本プロテオームデータベース(jPOST)

    • URL

      https://repository.jpostdb.org/

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2022-08-22  

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