Determination of hMSCs-derived neuroprotective factors on brain ischemia and the glial modulating mechanism

• Project/Area Number: 16H05443
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Showa University
• Principal Investigator: Ohtaki Hirokazu 昭和大学, 医学部, 准教授 (20349062)
• Co-Investigator(Kenkyū-buntansha): 荒田 悟 昭和大学, 教養部, 教授 (20159502) ; 渡邊 潤 昭和大学, 大学共同利用機関等の部局等, 兼任講師 (50649069) ; 吉川 輝 昭和大学, 医学部, 助教 (90737355)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000); Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 骨髄由来間葉系幹細胞 / ミクログリア / 脳虚血 / マクロファージ / 神経細胞死 / 骨髄間葉系幹細胞 / 脳神経疾患 / マイクログリア / 神経免疫学 / 脊髄損傷 / ケモカイン / 軸索伸長 / 細胞間相互作用 / 免疫学 / 再生医学 / 脳・神経 / 動物

Outline of Final Research Achievements

Bone marrow-derived mesenchymal stem/progenitor cells (MSCs) were focused on the suppression of tissue damages including central nervous system as well as the multipotency. The present project is to demonstrate the cross-talking between human MSCs (hMSCs) and the recipient mouse cells in vivo and in vitro.
hMSCs responded to ischemic/neuronal cell damaging homogenate, in particular, the inflammatory cytokines. It was reproduced transplanted hMSCs after ischemia and the hMSCs might mainly respond to macrophages. Transplanted hMSCs decreased spinal cord injury. The hMSCs increased CCL5 expression and the CCL5 contributed to macrophages/microglia polarization and axonal extension.

Academic Significance and Societal Importance of the Research Achievements

本研究計画の成果として，報告者らはマウス脳虚血および脊髄損傷モデルを用いてヒト間葉系幹・前駆細胞が生体内の炎症応答に応じてレシピエントの環境を制御し組織の修復や再生を促していることを明らかにした。これは，近年，本邦で承認された初の細胞治療薬が極めて早く有効性を示す根拠となりうる結果であり，将来このヒト間葉系幹・前駆細胞が様々な疾患に対して細胞治療薬となりうる可能性を示した。

Research Products

• [Int'l Joint Research] Tianjin University(中国)
• [Int'l Joint Research] University of Texas Rio Grande Valley(米国)
• [Int'l Joint Research] Texas A&M University(米国)
• [Int'l Joint Research] 天津中医薬大学(中国)
• [Int'l Joint Research] Tianjin University(中国)
• [Int'l Joint Research] University of Copenhagen(デンマーク)
• [Int'l Joint Research] University of Washington/Texas A&M Univ(アメリカ)
• [Int'l Joint Research] Texas A&M大学(米国)
• [Journal Article] A novel mouse model of heatstroke accounting for ambient temperature and relative humidity (2021)
  • Author(s): Miyamoto Kazuyuki、Suzuki Keisuke、Ohtaki Hirokazu、Nakamura Motoyasu、Yamaga Hiroki、Yagi Masaharu、Honda Kazuho、Hayashi Munetaka、Dohi Kenji
  • Journal Title: Journal of Intensive Care Volume: 9 Issue: 1 Pages: 35-35
  • DOI: 10.1186/s40560-021-00546-8
  • Peer Reviewed / Open Access
• [Journal Article] Entorhinal cortex and parahippocampus volume reductions impact olfactory decline in aged subjects (2021)
  • Author(s): izuka N, Masaoka Y, Kubota S, Sugiyama H, Yoshida M, Yoshikawa A, Koiwa N, Honma M, Watanabe K, Kamijo S, Kamimura S, Ida M, Ono K, Izumizaki M.
  • Journal Title: Brain and Behavior Volume: 11 Issue: 5
  • DOI: 10.1002/brb3.2115
  • Peer Reviewed / Open Access
• [Journal Article] The enhancement of CCL2 and CCL5 by human bone marrow-derived mesenchymal stem/stromal cells might contribute to inflammatory suppression and axonal extension after spinal cord injury (2020)
  • Author(s): Yagura Kazumichi、Ohtaki Hirokazu、Tsumuraya Tomomi、Sato Atsushi、Miyamoto Kazuyuki、Kawada Naoto、Suzuki Keisuke、Nakamura Motoyasu、Kanzaki Koji、Dohi Kenji、Izumizaki Masahiko、Hiraizumi Yutaka、Honda Kazuho
  • Journal Title: PLOS ONE Volume: 15 Issue: 3 Pages: 10-14
  • DOI: 10.1371/journal.pone.0230080
  • Peer Reviewed / Open Access
• [Journal Article] A simplified enriched environment increases body temperature and suppresses cancer progression in mice (2020)
  • Author(s): WATANABE Jun、KAGAMI Nobuyuki、KAWAZOE Mamiko、ARATA Satoru
  • Journal Title: Experimental Animals Volume: 69 Issue: 2 Pages: 207-218
  • DOI: 10.1538/expanim.19-0099
  • NAID: 130007835072
  • ISSN: 0007-5124, 1341-1357, 1881-7122
  • Peer Reviewed / Open Access
• [Journal Article] Heart Rate and Respiration Affect the Functional Connectivity of Default Mode Network in Resting-State Functional Magnetic Resonance Imaging (2020)
  • Author(s): Yoshikawa Akira、Masaoka Yuri、Yoshida Masaki、Koiwa Nobuyoshi、Honma Motoyasu、Watanabe Keiko、Kubota Satomi、Natsuko Iizuka、Ida Masahiro、Izumizaki Masahiko
  • Journal Title: Frontiers in Neuroscience Volume: 14 Pages: 631-631
  • DOI: 10.3389/fnins.2020.00631
  • Peer Reviewed / Open Access
• [Journal Article] Hippocampus and Parahippocampus Volume Reduction Associated With Impaired Olfactory Abilities in Subjects Without Evidence of Cognitive Decline (2020)
  • Author(s): Kubota Satomi、Masaoka Yuri、Sugiyama Haruko、Yoshida Masaki、Yoshikawa Akira、Koiwa Nobuyoshi、Honma Motoyasu、Kinno Ryuta、Watanabe Keiko、Iizuka Natsuko、Ida Masahiro、Ono Kenjiro、Izumizaki Masahiko
  • Journal Title: Frontiers in Human Neuroscience Volume: 14 Pages: 556519-556519
  • DOI: 10.3389/fnhum.2020.556519
  • Peer Reviewed / Open Access
• [Journal Article] PROGRESS OF MOTOR FUNCTIONS IN PATIENTS POST HEMATOPOIETIC STEM CELL TRANSPLANTATION (2020)
  • Author(s): 保坂 雄太郎、齋藤 文護、吉川 輝、柳沢 孝次、服部 憲路、中牧 剛、関屋 曻
  • Journal Title: Journal of The Showa University Society Volume: 80 Issue: 2 Pages: 169-180
  • DOI: 10.14930/jshowaunivsoc.80.169
  • NAID: 130007871294
  • ISSN: 2187-719X, 2188-529X
  • Peer Reviewed / Open Access
• [Journal Article] Luseogliflozin attenuates neointimal hyperplasia after wire injury in high-fat diet-fed mice via inhibition of perivascular adipose tissue remodeling (2019)
  • Author(s): Mori Yusaku、Terasaki Michishige、Hiromura Munenori、Saito Tomomi、Kushima Hideki、Koshibu Masakazu、Osaka Naoya、Ohara Makoto、Fukui Tomoyasu、Ohtaki Hirokazu、Tsutomu Hirano、Yamagishi Sho-ichi
  • Journal Title: Cardiovascular Diabetology Volume: 18 Issue: 1 Pages: 143-143
  • DOI: 10.1186/s12933-019-0947-5
  • Peer Reviewed / Open Access
• [Journal Article] Light-at-night exposure affects brain development through pineal allopregnanolone-dependent mechanisms (2019)
  • Author(s): Haraguchi S, Kamata M, Tokita T, Tashiro KI, Sato M, Nozaki M, Okamoto-Katsuyama M, Shimizu I, Han G, Chowdhury VS, Lei XF, Miyazaki T, Kim-Kaneyama JR, Nakamachi T, Matsuda K, Ohtaki H, Tokumoto T, Tachibana T, Miyazaki A, Tsutsui K.
  • Journal Title: eLife Volume: 8
  • DOI: 10.7554/elife.45306
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] マクロファージと骨髄間葉系幹細胞の中枢神経損傷抑制 (2019)
  • Author(s): 大滝 博和，矢倉 一道
  • Journal Title: 月刊細胞 Volume: 51 Pages: 33-36
• [Journal Article] Nesfatin-1 suppresses peripheral arterial remodeling without elevating blood pressure in mice (2019)
  • Author(s): Mori Yusaku、Shimizu Hiroyuki、Kushima Hideki、Saito Tomomi、Hiromura Munenori、Terasaki Michishige、Koshibu Masakazu、Ohtaki Hirokazu、Hirano Tsutomu
  • Journal Title: Endocrine Connections Volume: 印刷中 Issue: 5 Pages: 536-546
  • DOI: 10.1530/ec-19-0120
  • Peer Reviewed / Open Access
• [Journal Article] New function of PACAP on hematopoiesis through PACAP specific receptor (PAC1R) (2018)
  • Author(s): Ohtaki Hirokazu、Yagura Kazumichi、Xu Zhifang
  • Journal Title: Folia Pharmacologica Japonica Volume: 151 Issue: 6 Pages: 244-248
  • DOI: 10.1254/fpj.151.244
  • NAID: 130007394761
  • ISSN: 0015-5691, 1347-8397
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Left Posterior Orbitofrontal Cortex Is Associated With Odor-Induced Autobiographical Memory: An fMRI Study. Frontiers in Psychology (2018)
  • Author(s): Watanabe K, Masaoka Y, Kawamura M, Yoshida M, Koiwa N, Yoshikawa A, Kubota S, Ida M, Ono K, Izumizaki M
  • Journal Title: Frontiers in Psychology Volume: 9 Pages: 687-687
  • DOI: 10.3389/fpsyg.2018.00687
  • Peer Reviewed / Open Access
• [Journal Article] Oral rehydration solution increases SGLT1 and improves dehydration in a mouse heatstroke model. (2018)
  • Author(s): Miyamoto K, Ohtaki H, Takayasu H, Maeda A, Sasaki J, Honda K, Dohi K, Hayashi M.
  • Journal Title: Critical Care Medicine Volume: 46 Issue: 1 Pages: 252-252
  • DOI: 10.1097/01.ccm.0000528551.63676.f8
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• [Journal Article] New function of PACAP on hematopoiesis through PACAP specific receptor (PAC1R). (2018)
  • Author(s): Ohtaki H, Yagura K, Xu Z
  • Journal Title: 日本薬理学雑誌 Volume: -
  • NAID: 130007394761
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Intrapancreatic injection of human bone marrow-derived mesenchymal stem/stromal cells alleviates hyperglycemia and modulates the macrophage state in streptozotocin-induced type 1 diabetic mice. (2017)
  • Author(s): Murai N, Ohtaki H, Watanabe J, Xu Z, Sasaki S, Yagura K, Shioda S, Nagasaka S, Honda K, Izumizaki M.
  • Journal Title: PLoS One Volume: 12 Issue: 10 Pages: e0186637-e0186637
  • DOI: 10.1371/journal.pone.0186637
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide promotes eccrine gland sweat secretion. (2017)
  • Author(s): Sasaki S, Watanabe J, Ohtaki H, Matsumoto M, Murai N, Nakamachi T, Hannibal J, Fahrenkrug J, Hashimoto H, Watanabe H, Sueki H, Honda K, Miyazaki A, Shioda S.
  • Journal Title: Br J Dermatol. Volume: 176 Issue: 2 Pages: 413-422
  • DOI: 10.1111/bjd.14885
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Molecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration (2017)
  • Author(s): kenji Dohi, Kazue Satoh, Kazuyuki Miyamoto, Shunsuke Mommma, Kenichiro Fukuda, Ryo Higuchi, Hirokazu Ohtaki, Williams A Banks
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 61 Issue: 1 Pages: 1-5
  • DOI: 10.3164/jcbn.16-87
  • NAID: 130006847653
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Distinct Afatinib Resistance Mechanisms Identified in Lung Adenocarcinoma Harboring an EGFR Mutation. (2017)
  • Author(s): Yamaoka T, Ohmori T, Ohba M, Arata S, Murata Y, Kusumoto S, Ando K, Ishida H, Ohnishi T, Sasaki Y.
  • Journal Title: Mol Cancer Res. Volume: - Issue: 7 Pages: 915-928
  • DOI: 10.1158/1541-7786.mcr-16-0482
  • Peer Reviewed / Open Access
• [Journal Article] Coupling of dyspnea perception and occurrence of tachypnea during exercise. (2017)
  • Author(s): Tsukada S, Masaoka Y, Yoshikawa A, Okamoto K, Homma I, Izumizaki M.
  • Journal Title: J Physiol Sci. Volume: 67 Issue: 1 Pages: 173-180
  • DOI: 10.1007/s12576-016-0452-5
  • NAID: 40021064609
  • Peer Reviewed
• [Journal Article] Role of the autonomic nervous system in the tumor micro-environment and its therapeutic potential.(総説) (2017)
  • Author(s): Xu Z, Shioda S, Jinushi M, Kawakami Y, Ohtaki H, Wang S, Zhao X, Liu Y, Zhou D, Guo Y.
  • Journal Title: Curr Pharm Des Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Role of the autonomic nervous system in the tumor- micro-environment and its therapeutic potential. (2016)
  • Author(s): XU Z, SHIODA S, JINUSHI M, KAWAKAMI Y, OHTAKI H, WANG S, ZHAO X, LIU Y, ZHOU D, GUO Y.
  • Journal Title: Curr Pharm Des. Volume: 23 Issue: 11 Pages: 1687-1692
  • DOI: 10.2174/1381612822666161025152942
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• [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) is involved in adult mouse hippocampal neurogenesis after stroke. (2016)
  • Author(s): Matsumoto M, Nakamachi T, Watanabe J, Sugiyama K, Ohtaki H, Murai N, Sasaki S, Xu Z, Hashimoto H, Seki T, Miyazaki A, Shioda S.
  • Journal Title: J Mol Neurosci Volume: 10 Issue: 2 Pages: 1007-1007
  • DOI: 10.1007/s12031-016-0731-x
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor. (2016)
  • Author(s): Xu Z, Ohtaki H, Watanabe J, Miyamoto K, Murai N, Sasaki S, Matsumoto M, Hashimoto H, Hiraizumi Y, Numazawa S, Shioda S.
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 22373-22373
  • DOI: 10.1038/srep22373
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Therapeutic effects and mechanism of conditioned media from human mesenchymal stem cells on anti-GBM glomerulonephritis in WKY rats. (2016)
  • Author(s): Iseri K, Iyoda M, Ohtaki H, Matsumoto K, Wada Y, Suzuki T, Yamamoto Y, Saito T, Hihara K, Tachibana S, Honda K, Shibata T.
  • Journal Title: Am J Physiol Renal Physiol. Volume: 10 Issue: 11 Pages: 1152-1152
  • DOI: 10.1152/ajprenal.00165.2016
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] PACAP suppresses dry eye signs by stimulating tear secretion (2016)
  • Author(s): Nakamachi T, Ohtaki H, Seki T, Yofu S, Kagami N, Hashimoto H, Shintani N, Baba A, Mark L, Lanekoff I, Kiss P, Farkas J, Reglodi D, Shioda S.
  • Journal Title: Nat. Commun. Volume: 7 Issue: 1 Pages: 12034-12034
  • DOI: 10.1038/ncomms12034
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] マクロファージ調節を介したヒト骨髄間葉系幹細胞による炎症抑制作用（総説） (2016)
  • Author(s): 大滝博和
  • Journal Title: Bio Clinica Volume: 31 Pages: 63-68
  • Acknowledgement Compliant
• [Journal Article] Oral rehydration solution (OS-1) improves thermoregulation in a mouse heatstroke model. (2016)
  • Author(s): Miyamoto K, Ohtaki H, Takayasu H, Maeda A, Sasaki J, Honda K, Hayashi M, Dohi K.
  • Journal Title: Crit Care Med Volume: 44(12 Suppl 1) Pages: 402-402
  • Peer Reviewed
• [Journal Article] 神経発生学的な視点から再生医療のリハビリテーションについて考える : 神経の電気的な活動を摂動するニューロリハへの可能性． (2016)
  • Author(s): 熊田竜郎，吉川輝.
  • Journal Title: 常葉大学保健医療学部紀要 Volume: 7 Pages: 17-27
  • NAID: 40020785642
  • Peer Reviewed
• [Journal Article] Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice. (2016)
  • Author(s): Arata S, Watanabe J, Maeda M, Yamamoto M, Matsuhashi H, Mochizuki M, Kagami N, Honda K, Inagaki M.
  • Journal Title: Heliyon Volume: 2 Issue: 5 Pages: e00111-e00111
  • DOI: 10.1016/j.heliyon.2016.e00111
  • Peer Reviewed / Open Access
• [Presentation] The anti-inflammatory property of human bone marrow-derived mesenchymal stem/ stromal cells (hMSCs) is preserved in late-passage cultures (2021)
  • Author(s): Hirokazu Ohtaki, Dandan Song, Atsuko Ishii, Kazumichi Yagura, Akira Yoshikawa, Yutaka Hiraizumi, Kazuho Honda
  • Organizer: 第126回日本解剖学会総会・全国学術集会、第98回日本生理学会大会
• [Presentation] 長期間の感冒後嗅覚障害における脳形態変化 (2021)
  • Author(s): 上村 佐和 政岡 ゆり, 吉井 伸之, 村上 幸三, 吉川 輝, 吉田 正樹5 本間 元康, 上條 翔太郎, 﨑川 慶, 井田 正博, 小林 一女, 泉﨑 雅彦
  • Organizer: 第126回日本解剖学会総会・全国学術集会・第98回日本生理学会大会
• [Presentation] 高齢者における香りと自伝的記憶：眼窩前頭葉と側頭葉内側の機能的接続性の検証 (2021)
  • Author(s): 政岡 ゆり, 杉山 春子, 渡辺 慶子, 吉田 正樹, 吉川 輝, 小岩 信義, 本間 元康, 上條 翔太郎, 上村 佐和, 井田 正義, 小野 賢ニ郎, 泉崎 雅彦
  • Organizer: 第126回日本解剖学会総会・全国学術集会・第98回日本生理学会大会
• [Presentation] Pin1KOマウスにおける視床に増加するβアミロイド陽性反応の経時的解析. (2020)
  • Author(s): 大滝博和，田中優希，内田隆史，桐山恵介，本田一穂.
  • Organizer: 第125回日本解剖学会総会・全国学術集会
• [Presentation] Oral rehydration solution increases SGLT1 expression and improves dehydration in a mouse heatstroke model. (2020)
  • Author(s): Miyamoto K, Ohtaki H, Nakamura M ,Suzuki K, Sasaki J, Honda K, Dohi K and Hayashi M.
  • Organizer: SCCM2020
• [Presentation] 加齢に伴う皮膚ステロイド産生系の亢進は毛包幹細胞のタンパク質品質管理を障害する (2020)
  • Author(s): 原口 省吾、大滝 博和、杉浦 悠毅、嶋 雄一、宮崎 章
  • Organizer: 第93回日本内分泌学会学術集会
• [Presentation] Pin1KOマウスにおける視床に増加するβアミロイド陽性反応の経時的解析 (2020)
  • Author(s): 大滝博和，田中優希，内田隆史，桐山恵介，本田一穂
  • Organizer: 第125回日本解剖学会総会・全国学術集会
• [Presentation] マイクログリア/マクロファージの調節を介した骨髄由来幹/前駆細胞の神経保護能 (2020)
  • Author(s): 大滝 博和
  • Organizer: 第６３回日本神経化学会大会
  • Invited
• [Presentation] Pin1遺伝子欠損マウスは視床核にアミロイド封入体が増加する (2020)
  • Author(s): 大滝 博和, 田中 優希, 内田 隆史, 吉川 輝, 小野 賢二郎, 本田 一穂
  • Organizer: 第43回日本神経科学大会
• [Presentation] 在宅生活を送る要介護高齢者の自宅内転倒の調査 ~6年間のデータをもとにした自宅内転倒場所の詳細な検討~ (2020)
  • Author(s): 松本渉、吉川輝、大久保茂子
  • Organizer: 第7回日本地域理学療法学会学術大会
• [Presentation] 在宅で暮らす要介護者の自宅内での転倒時間帯と内服状況の実態調査 ~6年間の後方視的調査結果~ (2020)
  • Author(s): 松本渉、吉川輝、大久保茂子
  • Organizer: 第4回日本リハビリテーション医学会秋季学術集会
• [Presentation] Pin1 gene deficient mice impair spatial memory and show small brain volume. (2019)
  • Author(s): OHTAKI H, TANAKA Y, UCHIDA T, KIRIYAMA K, ONO K, HONDA K.
  • Organizer: SFN2019
  • Int'l Joint Research
• [Presentation] Pin 1 gene deficient mice impair spatial cognitive function and increase amyloid formation in the brain. (2019)
  • Author(s): 大滝博和，田中優希，内田隆史，宮本和幸，鈴木恵輔，渡邊潤，本田一穂.
  • Organizer: 第92回日本生化学会大会
• [Presentation] 大脳皮質感覚運動領域における限局的脳梗塞モデルラットの運動学的な歩行分析． (2019)
  • Author(s): 吉川輝, 森下紗帆, 外村和也, 梅村和夫, 大滝博和, 泉﨑雅彦, 熊田竜郎．
  • Organizer: 第24回日本基礎理学療法学会学術大会．
• [Presentation] 血管特異的アクアポリン1遺伝子導入マウスの熱中症に対する効果 (2019)
  • Author(s): 大滝博和，宮本和幸，荒田悟，若山吉弘，鈴木恵輔，渡邊潤，本田一穂，土肥謙二
  • Organizer: 第124回日本解剖学会総会全国学術集会（新潟）
• [Presentation] PACAPによる神経幹細胞のラジアルグリアを介したアストロサイトへの分化誘導作用 (2019)
  • Author(s): 渡邊潤，大滝博和，本田一穂，荒田悟
  • Organizer: 第124回日本解剖学会総会全国学術集会（新潟）
• [Presentation] Pin1 gene deficient mice impaired spatial cognitive function and showed a decrease of frontotemporal lobar. (2019)
  • Author(s): Hirokazu Ohtaki, Keisuke Kiriyama, Kenjiro Ono, Katsuhiko Takahashi, Takafumi Uchida, Kazuho Honda
  • Organizer: 第42回日本神経科学大会・第62回日本神経化学会大会合同大会（NEURO2019）(新潟)
• [Presentation] 安静時機能的磁気共鳴画像における呼吸、心拍の影響. (2018)
  • Author(s): 吉川輝, 政岡ゆり, 吉田正樹, 小岩信義, 久保田怜美, 眞鍋亮, 飯塚奈都子, 井田正博,泉﨑雅彦
  • Organizer: 第25回脳機能とリハビリテーション研究会学術集会 (千葉)
• [Presentation] Default mode network and cognitive function: investigating into resting-state functional connectivity between hemisphere. (2018)
  • Author(s): Akira Yoshikawa, Masahiro Ida, Yuri Masaoka, Masaki Yoshida, Nobuyoshi Koiwa, Satomi Kubota, Ryo Manabe, Natsuko Iizuka, Masahiko Izumizaki.
  • Organizer: 第46 回日本磁気共鳴医学会大会 (金沢)
• [Presentation] Association between odor memory and prefrontal cortex: an fMRI study. (2018)
  • Author(s): Yuri Masaoka, Keiko Watanabe, Masahiro Ida, Masaki Yoshida, Nobuyoshi Koiwa, Akira Yoshikawa, Satomi Kubota, Natsuko Iizuka, Mitsuru Kawamura, Kenjirou Ono, Masahiko Izumizaki.
  • Organizer: 第46 回日本磁気共鳴医学会大会 (金沢)
• [Presentation] Amygdala reduction could be an early indication for cognitive impairment in elderly subjects. (2018)
  • Author(s): Satomi Kubota, Yuri Masaoka, Masaki Yoshida, Ryuta Kinno, Akira Yoshikawa, Ryo Manabe, Natsuko Iizuka, Masahiro Ida, Kenjirou Ono, Masahiko Izumizaki.
  • Organizer: 第46 回日本磁気共鳴医学会大会 (金沢)
• [Presentation] Cognitive function and morphological brain changes in chronic obstructive pulmonary disease. (2018)
  • Author(s): Ryo Manabe, Yuri Masaoka, Kentaro Okuda, Masaki Yoshida, Akira Yoshikawa, Satomi Kubota, Haruna Sato, Hitomi Ida, Masahiro Ida, Hironori Sagara, Masahiko Izumizaki.
  • Organizer: 第46 回日本磁気共鳴医学会大会 (金沢)
• [Presentation] Graph theoretical analysis of functional brain network for abnormal binocular function. (2018)
  • Author(s): Masaki Yoshida, Masahiro Ida, Yuri Masaoka, Nobuyuki Koiwa, Akira Yoshikawa.
  • Organizer: 第46 回日本磁気共鳴医学会大会 (金沢)
• [Presentation] Three-dimensional kinematic evaluation of motor deficit in a rat model of photochemically induced focal stroke. (2018)
  • Author(s): Akira Yoshikawa, Saho Morishita, Kazuya Hokamura, Kazuo Umemura, Masahiko Izumizaki, Tatsuro Kumada
  • Organizer: Neuroscience 2018 (San Diego, CA)
  • Int'l Joint Research
• [Presentation] Odor induced autobiographical memory associated with slow breathing and medial prefrontal activity: fMRI study. (2018)
  • Author(s): Yuri Masaoka, Keiko Watanabe, Mitsuru Kawamura, Masaki Yoshida, Nobuyoshi Koiwa, Akira Yoshikawa, Satomi Kubota, Masahiro Ida, Kenjirou Ono, Masahiko Izumizaki.
  • Organizer: Neuroscience 2018 (San Diego, CA)
  • Int'l Joint Research
• [Presentation] 胸髄損傷不全麻痺患者の片脚立位保持及び歩行特性 (2018)
  • Author(s): 金承革，吉川輝，栗田泰成，河戸誠司.
  • Organizer: 第40回臨床歩行分析研究会定例会 (札幌)
• [Presentation] 次元神経筋骨格モデルを用いた痙性歩行の治療評価. (2018)
  • Author(s): 的場斗吾, 小野智貴, 長谷和徳, 吉田真, 金承革，吉川輝.
  • Organizer: 第39回バイオメカニズム学術講演会 (つくば)
• [Presentation] COPD患者における脳の構造性変化について. (2018)
  • Author(s): 眞鍋亮, 政岡ゆり, 奥田健太郎, 吉田正樹, 吉川輝, 久保田怜美, 井田瞳, 井田正博, 相良博典, 泉崎雅彦.
  • Organizer: 第28回日本呼吸ケア・リハビリテーション学会学術集会 (幕張)
• [Presentation] 地域在住の健康高齢者を対象とした嗅覚機能と認知機能の関係性 -安静時機能的磁気共鳴画像法を用いた機能的接続性解析- (2018)
  • Author(s): 吉川輝, 政岡ゆり, 吉田正樹, 小岩信義, 久保田怜美, 眞鍋亮, 飯塚奈都子, 井田正博,泉﨑雅彦.
  • Organizer: 第5回日本地域理学療法学会学術大会 (横浜)
• [Presentation] マウスにおける漸増運動負荷中の呼吸・代謝応答の加齢に伴う変化. (2018)
  • Author(s): 吉川輝, 金丸みつ子, 飯塚眞喜人, 大滝博和, 泉﨑雅彦.
  • Organizer: 第23回日本基礎理学療法学会学術大会 (京都)
• [Presentation] Relationship between Resting-State Functional Connectivity and cognitive function. (2018)
  • Author(s): Yoshikawa Akira, Masaoka Yuri, Yoshida Masaki, Koiwa Nobuyoshi, Kubota Satomi, Manabe Ryo, Natsuko Iizuka, Ida Masahiro, Izumizaki Masahiko.
  • Organizer: The 9th Federation of Asian and Oceanian Physiological Societies Congress (Kobe, Japan)
  • Int'l Joint Research
• [Presentation] Relation between Montreal Cognitive Assessment and amygdala-hippocampus volumes in the elderly. (2018)
  • Author(s): Satomi Kubota, Yuri Masaoka, Masaki Yoshida, Ryuta Kinno, Akira Yoshikawa, Ryo Manabe, Natsuko Iizuka, Masahiro Ida, Kenjiro Ono, Masahiko Izumizaki.
  • Organizer: The 9th Federation of Asian and Oceanian Physiological Societies Congress (Kobe, Japan)
  • Int'l Joint Research
• [Presentation] Effects of optogenetic inhibition of 5-HT neurons in the dorsal raphe nucleus on respiratory control. (2018)
  • Author(s): Mitsuko Kanamaru, Mana Tsukada, Akira Yoshikawa, Hiroshi Onimaru, Ayako Mochizuki, Masataka Sunagawa, Tomio Inoue, Masahiko Izumizaki.
  • Organizer: The 9th Federation of Asian and Oceanian Physiological Societies Congress (Kobe, Japan)
  • Int'l Joint Research
• [Presentation] 中枢神経障害時における移植骨髄由来間葉系幹細胞とグリア細胞の相互作用の解析 (2018)
  • Author(s): 大滝博和
  • Organizer: 第123回日本解剖学会総会・学術集会(東京)
  • Invited
• [Presentation] 脊髄損傷後のケモカインの局在とヒト間葉系幹細胞を用いた組織修復への関与 (2018)
  • Author(s): 矢倉一道、大滝博和、圓谷智海、佐藤敦、渡邊潤、宮本和幸、平泉裕、本田一穂
  • Organizer: 第123回日本解剖学会総会・学術集会(東京)
• [Presentation] 脊髄損傷後に増加するCCL5の役割とヒト骨髄間葉系幹細胞(hMSCs)の関与 (2018)
  • Author(s): 大滝博和，矢倉一道，渡邉潤，圓谷智海，宮本和幸，佐藤敦，平泉裕，本田一穂
  • Organizer: 第83回日本インターフェロン・サイトカイン学会学術集会 （東京）
• [Presentation] Proliferation of bone marrow hematopoietic progenitor cells by PACAP via the sympathetic nerve innervation. (2018)
  • Author(s): Ohtaki H, Xu Z, Watanabe J, Yagura K, Hiraizumi Y, Dohi K, Honda K
  • Organizer: 第41回日本神経科学大会（神戸）
• [Presentation] Increase of CCL5 after spinal cord injury might contributes to axonal regeneration. (2018)
  • Author(s): Hirokazu Ohtaki, Kazumichi Yagura, Tomomi Tsumuraya, Atsushi Sato, Jun Watanabe, Kazuyuki Miyamoto, Yutaka Hiraizumi, Kazuho Honda
  • Organizer: 第40回日本生物学的精神医学会・第61回日本神経化学会大会合同年会（神戸）
• [Presentation] マウス虚血脳における移植ヒト骨髄間葉系幹細胞（hMSCs）とマイクログリア・マクロファージの相互作用 (2018)
  • Author(s): 大滝博和, 矢倉一道, 渡邊潤, 宮本和幸, 土肥謙二, 本田一穂
  • Organizer: 第91回日本生化学会大会(京都）
• [Presentation] Effects of human mesenchymal stem/stromal cells on chemokines and microglia/macrophages after spinal cord injury in mic (2018)
  • Author(s): Kazumichi Yagura， Hirokazu Ohtaki, Jun Watanabe, Tomomi Tsumuraya, Atsushi Sato, Kazuyuki Miyamoto, Yutaka Hiraizumi, Koji Kanzaki, Kazuho Honda
  • Organizer: 14th International Congress of Neuroimmunology2018 (ISNI 2018) (Brisbane, Australia)
  • Int'l Joint Research
• [Presentation] Effect of human mesenchymal stromal cells (hMSCs) on CCL5 expression and macrophage polarization after spinal cord injury (2018)
  • Author(s): OHTAKI Hirokazu, YAGURA Kazumichi, TSUMURAYA Tomomi, SATO Atsushi, WATANABE Jun, MIYAMOTO Kazuyuki, HIRAIZUMI Yutaka, HONDA Kazuho
  • Organizer: Neuroscience 2018 (San Diego, CA)
  • Int'l Joint Research
• [Presentation] 中枢神経損傷に対する神経ペプチドPACAPの有用性とその機構 (2018)
  • Author(s): 大滝博和
  • Organizer: 第33回日本酸化ストレス学会関東支部会(東京)
  • Invited
• [Presentation] マウス頭部外傷モデルにおけるエダラボンのtherapeutic time windowについて (2018)
  • Author(s): 宮本和幸，大滝博和，鈴木恵輔，本田一穂，林宗貴，土肥謙二
  • Organizer: 第33回日本酸化ストレス学会関東支部会(東京)
• [Presentation] 急性期脳損傷とneuroinflammationの軽減化を目指した酸化ストレス制御を目的としたアプローチ (2018)
  • Author(s): 土肥謙二，鈴木恵輔，宮本和幸，大滝博和，本田一穂
  • Organizer: 第33回日本酸化ストレス学会関東支部会(東京)
• [Presentation] 簡易型環境エンリッチメント飼育マウスにおけるがん増殖抑制効果. (2018)
  • Author(s): 渡邊潤, 松橋秀人, 加賀美信幸, 荒田悟.
  • Organizer: 第65回日本実験動物学会総会 (富山)
• [Presentation] PACAP induces differentiation of neural progenitor cells into glial lineage via radial glia (2018)
  • Author(s): Jun Watanabe, Hirokazu Ohtaki, Satoru Arata, Seiji Shioda.
  • Organizer: International GPCR symposium (Kyoto, Japan)
  • Int'l Joint Research
• [Presentation] Optogenetic analysis of nociceptive mechanism mediated by 5-HT neurons in the nucleus raphe magnus. (2018)
  • Author(s): Mitsuhashi M, Kanamaru M, Tanaka FK, Yoshikawa A, Hisamitsu T, Sunagawa M, Izumizaki M.
  • Organizer: 第95回日本生理学会大会
• [Presentation] Amygdala reduction could be an early indication for cognitive impairment in elderly subjects. (2018)
  • Author(s): Kubota S, Masaoka Y, Yoshida M, Kinno R, Yoshikawa A, Manabe R, Ida M, Ono K, Izumizaki M.
  • Organizer: 第95回日本生理学会大会
• [Presentation] Relationship between the Functional Connectivity during resting-state fMRI and Cognitive Assessment Battery in elderly subjects. (2018)
  • Author(s): Yoshikawa A, Masaoka Y, Yoshida M, Koiwa N, Kubota S, Manabe R, Ida M, Izumizaki M.
  • Organizer: 第95回日本生理学会大会
• [Presentation] Effect of different exercises on the differentiation of neural stem cells and motor recovery in rats with motor cortex infarction. (2018)
  • Author(s): Morishita S, Hokamura K, Yoshikawa A, Agata N, Umemura K, Tsutsui Y, Kumada T.
  • Organizer: 第95回日本生理学会大会
• [Presentation] Cognitive function and hippocampus volume in chronic obstructive pulmonary disease. (2018)
  • Author(s): Manabe R, Masaoka Y, Okuda K, Yoshida M, Yoshikawa A, Kubota S, Sato H, Yamagami H, Ida M, Sagara H, Izumizaki M.
  • Organizer: 第95回日本生理学会大会
• [Presentation] マウス熱中症モデルにおける経口補水液(OS-1)の有用性について (2018)
  • Author(s): 宮本和幸, 大滝博和, 髙安弘美, 前田敦雄, 佐々木純, 本田一穂, 土肥謙二, 林宗貴.
  • Organizer: 第45回日本集中治療医学会学術集会
• [Presentation] 中枢神経障害時における移植骨髄由来間葉系幹細胞とグリア細胞の相互作用の解析 (2018)
  • Author(s): 大滝博和
  • Organizer: 第123回日本解剖学会総会・学術集会
  • Invited
• [Presentation] 脊髄損傷後のケモカインの局在とヒト間葉系幹細胞を用いた組織修復への関与 (2018)
  • Author(s): 矢倉一道、大滝博和、圓谷智海、佐藤敦、渡邊潤、宮本和幸、平泉裕、本田一穂
  • Organizer: 第123回日本解剖学会総会・学術集会
• [Presentation] 腎内血管内皮の多様性の検討：低真空SEMによる腎生検パラフィン切片の三次元的解析． (2017)
  • Author(s): 本田一穂，南雲佑，種田積子，舟橋久幸，大滝博和，澤智華，渡邊潤，瀧本雅文，小田秀明，新田孝作，大塚成人
  • Organizer: 第122回日本解剖学会総会・全国学術集会
  • Place of Presentation: 長崎大学坂本キャンパス（長崎）
  • Year and Date: 2017-03-28
• [Presentation] 骨髄間葉系幹細胞（MSCs）は頭部外傷モデルマウスの血液脳関門破綻を抑制する． (2017)
  • Author(s): 渡邊 潤，大滝 博和，矢倉 一道，本田 一穂，荒田 悟．
  • Organizer: 第122回日本解剖学会総会・全国学術集会
  • Place of Presentation: 長崎大学坂本キャンパス（長崎）
  • Year and Date: 2017-03-28
• [Presentation] 脊髄損傷マウスにおける慢性的なケモカインとその受容体の発現の変動． (2017)
  • Author(s): 矢倉一道，大滝博和，圓谷智海，佐藤 敦，渡邊 潤，宮本和幸，平泉 裕，本田一穂
  • Organizer: 第122回日本解剖学会総会・全国学術集会
  • Place of Presentation: 長崎大学坂本キャンパス（長崎）
  • Year and Date: 2017-03-28
• [Presentation] MRIによるPin1遺伝子欠損マウスの脳の容量の解析． (2017)
  • Author(s): 大滝博和，渡邊 潤，矢倉一道，宮本和幸，土肥謙二，内田隆史，本田一穂．
  • Organizer: 第122回日本解剖学会総会・全国学術集会
  • Place of Presentation: 長崎大学坂本キャンパス（長崎）
  • Year and Date: 2017-03-28
• [Presentation] PACAP KOマウスにおける加齢に伴う脳内酸化傷害の増加と記憶学習行動の異常． (2017)
  • Author(s): 中町智哉，大滝博和，渡邊潤，松田恒平，塩田清二
  • Organizer: 第122回日本解剖学会総会・全国学術集会
  • Place of Presentation: 長崎大学坂本キャンパス（長崎）
  • Year and Date: 2017-03-28
• [Presentation] Altered functional connectivity of resting state fMRI by eliminating of physiological fluctuation. (2017)
  • Author(s): Yoshikawa A, Yoshida M, Masaoka Y, Koiwa N, Watanabe K, Ida M, Izumizaki M.
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松（浜松)
  • Year and Date: 2017-03-28
• [Presentation] Effect of different exercises on neurogenesis and motor recovery in rats with motor cortex infarction. (2017)
  • Author(s): Morishita S, Hokamura K, Yoshikawa A, Agata N, Umemura K, Tsutsui Y, Kumada T.
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松（浜松)
  • Year and Date: 2017-03-28
• [Presentation] Activating dorsal raphe nucleus serotonin neurons affects control of vigilance state switch. (2017)
  • Author(s): Moriya R, Kanamaru M, Okuma N, Yoshikawa A, Tanaka FK, Hokari S, Oshima Y, Onimaru H, Izumizaki M.
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松（浜松)
  • Year and Date: 2017-03-28
• [Presentation] Relationship between anxiety behavior and respiration control as determined using optogenetics. (2017)
  • Author(s): Okuma N, Kanamaru M, Moriya R, Tanaka FK, Arata S, Watanabe J, Endou T, Yoshikawa A, Iizuka M, Izumizaki M.
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松（浜松)
  • Year and Date: 2017-03-28
• [Presentation] PACAP increases hematopoietic stem/progenitor cellar proliferation in murine bone marrow via nerve innervation. (2017)
  • Author(s): Ohtaki H.
  • Organizer: 第90回日本薬理学会年会
  • Place of Presentation: 長崎ブリックホールおよび長崎新聞文化ホール（長崎）
  • Year and Date: 2017-03-15
  • Invited
• [Presentation] マウス熱中症モデルにおける経口補水液(OS-1)の効果について. (2017)
  • Author(s): 宮本和幸, 大滝博和, 髙安弘美, 前田敦雄, 佐々木純, 本田一穂, 土肥謙二, 林宗貴.
  • Organizer: 第44回日本集中治療医学会総会・学術集会
  • Place of Presentation: 札幌市教育文化会館 (札幌)
  • Year and Date: 2017-03-09
• [Presentation] Oral rehydration solution (Os-1) improves thermoregulation in a mouse heatstroke model. (2017)
  • Author(s): Miyamoto K, Ohtaki H, Takayasu H, Maeda A, Sasaki J, Honda K, Hayashi M, Dohi K.
  • Organizer: 46th Critical Care Congress
  • Place of Presentation: Hawaii Convention Center (Honolulu, HI)
  • Year and Date: 2017-01-21
  • Int'l Joint Research
• [Presentation] Effects of enriched environment on suppression of cancer progression in mice. (2017)
  • Author(s): Arata S, Watanabe J, Matsuhashi H, Kagami N.
  • Organizer: 第64回日本実験動物学会総会
• [Presentation] 片側大脳皮質損傷後の運動機能回復に関与する神経回路網の再編成~神経回路網の再編成を調節する遺伝子の探索~ (2017)
  • Author(s): 吉川輝，中町智哉，Rakwal Randeep，柴藤淳子，大滝博和，塩田清二，泉﨑雅彦．
  • Organizer: 第52回日本理学療法学術大会
• [Presentation] PACAP38の外傷性脳損傷抑制効果と抗酸化能向上作用について (2017)
  • Author(s): 宮本和幸, 大滝博和, 髙安弘美, 前田敦雄, 佐々木純, 本田一穂, 林宗貴, 土肥謙二.
  • Organizer: 第70回日本酸化ストレス学会学術集会
• [Presentation] Three-dimensional neuro-musculo-skeltal model with mechanical charcteristics of stretch reflex. (2017)
  • Author(s): Matoba T, Hase K, Kim SH, Yoshikawa A.
  • Organizer: XXVI Congress of the International Society of Biomechanics
  • Int'l Joint Research
• [Presentation] Production of MCP-1 (CCL2) from human mesenchymal stem/stromal cells in ischemic brain (2017)
  • Author(s): Ohtaki H, Yagura K, Tanaka Y, Watanabe J, Miyamoto K, Hiraizumi Y, Dohi K, Honda K.
  • Organizer: 第40回日本神経科学大会
• [Presentation] Administration of TSG-6 form MSCs improves memory after traumatic brain injury in mice. (2017)
  • Author(s): Watanabe J, Ohtaki H, Yagura K, Honda K, Arata S.
  • Organizer: 第40回日本神経科学大会
• [Presentation] 各測定方法から見た健康・運動について ーヒト及びモデル動物を用いて運動生理学的観点から見た運動と健康ー (2017)
  • Author(s): 吉川輝．
  • Organizer: 第5回日本スポーツ健康科学会
  • Invited
• [Presentation] Sleep disorder or deficit in olfaction provide an early indication of neurodegeneration. (2017)
  • Author(s): Masaoka Y, Ida M, Yoshida M, Koiwa N, Yoshikawa A, Kubota S, Kawamura M, Ono K, Izumizaki M.
  • Organizer: 第45回日本磁気共鳴医学会大会
• [Presentation] Graph theoretical analysis of white matter network for abnormal binocular function. (2017)
  • Author(s): Yoshida M, Ida M, Masaoka Y, Yoshikawa A.
  • Organizer: 第45回日本磁気共鳴医学会大会
• [Presentation] The Influence of Physiological Noise on Default Mode Network - resting state fMRI Study - (2017)
  • Author(s): Yoshikawa A, Ida M, Yoshida M, Masaoka Y, Koiwa N, Watanabe K, Kubota S, Manabe R, Izumizaki M.
  • Organizer: 第45回日本磁気共鳴医学会大会
• [Presentation] Effects of enriched environment on suppression of cancer progression in mice. (2017)
  • Author(s): Arata S, Watanabe J, Matsuhashi H, Kagami N.
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Human mesenchymal stem/stromal cells express CCL2 (MCP-1) on ischemic hippocampal homogenate exposure (2017)
  • Author(s): Ohtaki H, Watanabe J, Yagura K, Miyamoto K, Iwakura Y, Dohi K, Honda K.
  • Organizer: The 5th Annual Meeting of the International Cytokine and Interferon Society (ICIS2017)
  • Int'l Joint Research
• [Presentation] Expression patterns and distributions of chemokines and their receptors after spinal cord injury (SCI) in mice. (2017)
  • Author(s): Yagura K, Ohtaki H, Tsumuraya T, Sato A, Watanabe J, Hiraizumi Y, Honda K.
  • Organizer: The 5th Annual Meeting of the International Cytokine and Interferon Society (ICIS2017)
  • Int'l Joint Research
• [Presentation] Effects of various exercises on motor recovery through gating and neuro/gliogenesis in motor cortex infarction in rats. (2017)
  • Author(s): Kumada T, Morishita S, Hokamura K, Yoshikawa A, Agata N, Tsutsui Y, Umemura
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Suppression of nitric oxide level from microglia by co-culturing with human mesenchymal stem/progenitor cells. (2017)
  • Author(s): Ohtaki H, Watanabe J, Yagura K, Miyamoto K, Hiraizumi Y, Honda K, Dohi K.
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Olfactory impairment and sleep disorder may provide early indication of neurodegeneration. (2017)
  • Author(s): Masaoka Y, Kawamura M, Yoshida M, Koiwa N, Yoshikawa A, Ida M, Ono K, Phillips A, Izumizaki M.
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Administrations of mesenchymal stem/stromal cells (MSCs) produced beneficial effects in models of traumatic brain injury via prevention of blood brain barrier leakage. (2017)
  • Author(s): Watanabe J, Ohtaki H, Yagura K, Honda K, Arata S.
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Gene and cellular localizations of chemokines and their receptors after spinal cord injury(SCI) in mice. (2017)
  • Author(s): Yagura K, Ohtaki H, Tsumuraya T, Sato A, Watanabe J, Miyamoto K, Tanaka S, Hiraizumi Y, Kanzaki K, Honda K.
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Cardiac and Respiratory Physiological Noise Corrections Improved Resting-State Functional Connectivity in the Limbic Areas. (2017)
  • Author(s): Yoshikawa A, Yoshida M, Masaoka Y, Koiwa N, Watanabe K, Ida M, Izumizaki M.
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] 痙性歩行の再現を目指した3次元神経筋骨格モデルの構築． (2017)
  • Author(s): 的場斗吾、長谷和徳、林祐一郎、金承革、吉川輝．
  • Organizer: 第38回バイオメカニズム学術講演会
• [Presentation] 脊髄損傷マウスにおけるケモカインの変動と役割 (2017)
  • Author(s): 矢倉一道，大滝博和，圓谷智海，佐藤敦，渡邊潤，宮本和幸，平泉裕，本田一穂
  • Organizer: 第64回昭和大学学士会総会
• [Presentation] PACAP promotes sweat secretion in eccrine gland via PAC1R. (2017)
  • Author(s): Watanabe J, Sasaki S, Ohtaki H, Arata S Honda K, Shioda S.
  • Organizer: 13th International Symposium on VIP, PACAP and Related Peptides
  • Int'l Joint Research
• [Presentation] Therapeutic time-window for edaravone treatment of traumatic brain injury in mice. (2017)
  • Author(s): Miyamoto K, Ohtaki H, Dohi, K, Sitho H, Maeda A, Sasaki J, Honda K, Hayashi M.
  • Organizer: 8th Joint Meeting of Society for Free Radical Research Australasia and Japan with International Symposium on Coenzyme Q10
  • Int'l Joint Research
• [Presentation] 神経筋骨格モデルを用いた筋の力学特性と歩容の関係性の分析. (2016)
  • Author(s): 的場斗吾，長谷和徳，林祐一郎，金承革，吉川輝.
  • Organizer: 第37回バイオメカニズム学術講演会.
  • Place of Presentation: 富山大学（射水，富山）
  • Year and Date: 2016-11-12
• [Presentation] Responses of human mesenchymal stem/stromal cells on brain ischemia. (2016)
  • Author(s): Ohtaki H, Taniguchi S, Tanaka Y, Watanabe J, Miyamoto K, Yoshikawa A, Dohi K, Honda K.
  • Organizer: SFN2016
  • Place of Presentation: San Diego Convention Center (San Diego, CA)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Behavioral, Neuroanatomical, and DNA microarray Study after Neonatal and Adult Unilateral Brain Hemisuction Mice. (2016)
  • Author(s): Yoshikawa A, Nakamachi T, Ohtaki H, Izumizaki M.
  • Organizer: SFN2016
  • Place of Presentation: San Diego Convention Center (San Diego, CA)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Respiratory synchronizes activation of olfactory processing in the limbic system. (2016)
  • Author(s): Masaoka Y, Yoshida M, Koiwa N, Watanabe K, Yoshikawa A, Ida M, Homma I, Izumizaki M.
  • Organizer: SFN2016
  • Place of Presentation: San Diego Convention Center (San Diego, CA)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Communication between microglia and hMSCs on CNS disease. (2016)
  • Author(s): Ohtaki H.
  • Organizer: Texas A &M Invited Seminar
  • Place of Presentation: Texas A & M Univ. IRM (Collage Station, TX)
  • Year and Date: 2016-11-10
  • Int'l Joint Research / Invited
• [Presentation] 運動皮質梗塞ラットの運動機能回復と神経新生を促がす運動負荷法の検討. (2016)
  • Author(s): 森下紗帆，外村和也，縣信秀，吉川輝，梅村和夫，筒井祥博，熊田竜郎.
  • Organizer: 第135回日本薬理学会関東部会.
  • Place of Presentation: アクトシティ浜松 (浜松)
  • Year and Date: 2016-10-08
• [Presentation] 脳虚血マウスにおける移植ヒト骨髄間葉系幹・前駆細胞（hMSCs）の応答. (2016)
  • Author(s): 大滝博和，渡邊潤，宮本和幸，平泉裕，本田一穂.
  • Organizer: 第８９回日本生化学会大会
  • Place of Presentation: 仙台国際センター/東北大学川内北キャンパス（仙台）
  • Year and Date: 2016-09-25
• [Presentation] Transiently altered brain connectivity after cataract surgery -resting fMRI study-. (2016)
  • Author(s): Yoshida M, Ida M, Masaoka Y, Koiwa N, Yoshikawa A, Watanabe K.
  • Organizer: 第44回日本磁気共鳴医学会大会
  • Place of Presentation: 大宮ソニックシティー (大宮)
  • Year and Date: 2016-09-09
• [Presentation] Odor induced autographical memory associated with activity in the posterior parts of the brain as well as limbic olfactory areas. (2016)
  • Author(s): Watanabe K, Masaoka Y, Yoshida M, Koiwa N, Yoshikawa A, Ida M, Kawamura M, Ono K, Izumizaki M.
  • Organizer: 第44回日本磁気共鳴医学会大会
  • Place of Presentation: 大宮ソニックシティー (大宮)
  • Year and Date: 2016-09-09
• [Presentation] Respiratory-related neural activities in medulla and limbic system during resting and olfactory states -fMRI study-. (2016)
  • Author(s): Masaoka Y, Ida M, Yoshida M, Koiwa N, Watanabe K, Yoshikawa A, Homma I, Izumizaki M.
  • Organizer: 第44回日本磁気共鳴医学会大会
  • Place of Presentation: 大宮ソニックシティー (大宮)
  • Year and Date: 2016-09-09
• [Presentation] Optogenetic silencing of selected serotonin neurons in the control of CO2-induced arousal. (2016)
  • Author(s): Moriya R, Kanamaru M, Ookuma N, Yoshikawa A, Tanaka FK, Hokari S, Ohshima Y, Izumizaki M.
  • Organizer: 26th International Congress of the European Respiratory Society
  • Place of Presentation: ExCeL Conference Centre (London UK)
  • Year and Date: 2016-09-03
  • Int'l Joint Research
• [Presentation] Suppression of Spinal Cord Injury by Human Mesenchymal Stem/Stromal Cells (hMSCs) via Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Mice. (2016)
  • Author(s): Ohtaki H, Tsumuraya T, Sato A, Miyamoto K, Yoshikawa A, Watanabe J, Hiraizumi Y, Dohi K, Hashimoto H, Honda K.
  • Organizer: The 39th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: PACIFICO Yokohama (Yokohama,Japan)
  • Year and Date: 2016-07-20
  • Int'l Joint Research
• [Presentation] Activities of the medulla and the limbic system synchronized with respiration during olfactory stimuli－fMRI study－. (2016)
  • Author(s): Masaoka Y, Yoshida M, Koiwa N, Watanabe K, Yoshikawa A, Ida M, Homma I, Izumizaki M.
  • Organizer: 17th International Symposium on Olfaction and Taste (ISOT2016)
  • Place of Presentation: PACIFICO Yokohama (Yokohama,Japan)
  • Year and Date: 2016-06-05
  • Int'l Joint Research
• [Presentation] エクリン汗腺におけるPACAPの汗分泌促進作用． (2016)
  • Author(s): 渡邊潤，佐々木駿，中町智哉，大滝博和，荒田悟，本田一穂，塩田清二．
  • Organizer: 第13回GPCR研究会
  • Place of Presentation: 未来科学館（東京）
  • Year and Date: 2016-05-13
• [Presentation] PACAPはアクアポリン5を介して涙液分泌を促進する． (2016)
  • Author(s): 中町智哉，大滝博和，関保，渡邊潤，塩田清二
  • Organizer: 第13回GPCR研究会
  • Place of Presentation: 未来科学館（東京）
  • Year and Date: 2016-05-13
• [Book] Pituitary Adenylate Cyclase Activating Polypeptide - PACAP, (Eds. Reglodi D and Tamas A) (2016)
  • Author(s): Ohtaki H and Shioda S.
  • Total Pages: 840
  • Publisher: Springer International Publishing