New medical development of orthopedics area by drug repositioning strategy

• Project/Area Number: 16H05446
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Nagoya University
• Principal Investigator: ISHIGURO NAOKI 名古屋大学, 医学系研究科, 教授 (20212871)
• Co-Investigator(Kenkyū-buntansha): 高橋 伸典 名古屋大学, 医学部附属病院, 病院講師 (20570196) ; 鬼頭 浩史 名古屋大学, 医学系研究科, 准教授 (40291174) ; 今釜 史郎 名古屋大学, 医学部附属病院, 講師 (40467288) ; 水野 正明 名古屋大学, 医学部附属病院, 病院教授 (70283439) ; 酒井 忠博 名古屋大学, 医学部附属病院, 病院講師 (60378198)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
• Keywords: Drug repositioning / Runx II / Wnt/βcatenin / Sox9 / CD44断片化 / 希少疾患 / drug reposionning / 神経軸索伸長 / RunxII

Outline of Final Research Achievements

We adopted the drug repositioning strategy and obtained research results. 1. Runx II: Patented. The preclinical studies have been almost completed, and we are discussing clinical development with the company. 2. Wnt / β catenin: The candidate compound was examined and patented, but company approval was not obtained, and examination of the next candidate was started. 3. Sox 9: A candidate substance was obtained, but was promoted to promote ossification. Changing methodology and in progress. 4. Nerve axonal outgrowth agent: Obtained patent for use of peripheral neuropathy treatment. Start a clinical intervention study. 5. FGFG23 target: We tried to establish a primary screening system but did not achieve it.6. We confirmed that ADAM10 plays a role in CD44 fragmentation, and we started examining it as a target for the treatment of arthropathy.

Academic Significance and Societal Importance of the Research Achievements

治療薬開発の費用が経済的不事由から薬剤開発が進まない疾患がある。企業研究者は少なく、疾患を熟知した研究者が行う必要がある。市販薬のOff labelの薬剤効果を見出し、作用に関わる分子構造を明確にし、医療開発を行うのがDrug repositioningである。実績から安全性、製造工程の確立、薬剤の入手が容易等のメリットがある。医療開発が迅速に進められるという利点がある。標的分子・病態を定めて遺伝子導入細胞等でスクリーニングするシステムを確立した。候補化合物の発見から特許取得、企業との共同開発など着実に成果を挙げた。前臨床データ構築を達成することに成功し、複数の臨床研究を開始することが出来た。

Research Products

• [Journal Article] Physical, Mental, and Social Problems of Adolescent and Adult Patients with Achondroplasia (2019)
  • Author(s): Matsushita Masaki、Kitoh Hiroshi、Mishima Kenichi、Yamashita Satoshi、Haga Nobuhiko、Fujiwara Sayaka、Ozono Keiichi、Kubota Takuo、Kitaoka Taichi、Ishiguro Naoki
  • Journal Title: Calcified Tissue International Volume: 104 Issue: 4 Pages: 364-372
  • DOI: 10.1007/s00223-019-00518-z
  • Peer Reviewed / Open Access
• [Journal Article] Simvastatin promotes restoration of chondrocyte morphology and phenotype (2019)
  • Author(s): Terabe Kenya、Takahashi Nobunori、Cobb Michelle、Askew Emily B.、Knudson Cheryl B.、Knudson Warren
  • Journal Title: Archives of Biochemistry and Biophysics Volume: 665 Pages: 1-11
  • DOI: 10.1016/j.abb.2019.01.038
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Longitudinal changes in pulmonary function and respiratory impedance of rheumatoid arthritis (2019)
  • Author(s): Isobe Yoshitaka、Ito Satoru、Matsuda Toshiaki、Iwano Shingo、Uchida Akemi、Takahashi Nobunori、Kojima Toshihisa、Wakahara Keiko、Yamaguchi Etsuro、Hasegawa Yoshinori
  • Journal Title: Respiratory Physiology & Neurobiology Volume: 261 Pages: 1-8
  • DOI: 10.1016/j.resp.2018.12.008
  • Peer Reviewed / Open Access
• [Journal Article] An Open-Label, Single-Arm Study of a Patient-Specific Femoral Guide for Total Hip Arthroplasty via the Anterolateral Supine Approach, Linked with Three-Dimensional Surgical Support Software: Study Protocol (2018)
  • Author(s): KIDA DAIHEI、HASHIMOTO HIROYA、ITO NORIKO、KITO YUKARI、MORI KOUICHI、TAKAHASHI NOBUNORI、TOMITA YASUSHI
  • Journal Title: The Kurume Medical Journal Volume: 65 Issue: 2 Pages: 71-75
  • DOI: 10.2739/kurumemedj.MS652002
  • NAID: 130007650018
  • ISSN: 0023-5679, 1881-2090
  • Year and Date: 2018-06-30
  • Peer Reviewed / Open Access
• [Journal Article] A Novel Heterozygous Mutation in the T-box Protein 4 Gene in an Adult Case of Small Patella Syndrome. (2018)
  • Author(s): Oda T, Matsushita M, Ono Y, Kitoh H, Sakai T.
  • Journal Title: Journal of Orthopaedic Case Reports Volume: 8(1) Pages: 85-88
  • Peer Reviewed / Open Access
• [Journal Article] Activated FGFR3 prevents subchondral bone sclerosis during the development of osteoarthritis in transgenic mice with achondroplasia. (2018)
  • Author(s): 6.Okura T, Matsushita M, Mishima K, Esaki R, Seki T, Ishiguro N, Kitoh H.
  • Journal Title: J Orthop Res Volume: 36(1) Issue: 1 Pages: 300-308
  • DOI: 10.1002/jor.23608
  • Peer Reviewed / Open Access
• [Journal Article] Chronic lateral epiphyseal separation of the proximal tibia causes late-onset tibia vara. (2018)
  • Author(s): Hasegawa S, Kitoh H, Matsushita M, Mishima K, Kadono I, Sugiura H, Kitamura A, Ishiguro N
  • Journal Title: J Pediatr Orthop B. Volume: 27 Issue: 1 Pages: 31-34
  • DOI: 10.1097/bpb.0000000000000430
  • Peer Reviewed / Open Access
• [Journal Article] Changes in the range of motion of the lower limb joints during extensive tibial lengthening in achondroplasia (2018)
  • Author(s): Kadono Izumi、Kitoh Hiroshi、Mishima Kenichi、Matsushita Masaki、Sato Koji、Kako Masato、Ishiguro Naoki
  • Journal Title: Journal of Pediatric Orthopaedics B Volume: 27 Issue: 6 Pages: 535-540
  • DOI: 10.1097/bpb.0000000000000526
  • Peer Reviewed / Open Access
• [Journal Article] Congenital limb deficiency in Japan: a cross-sectional nationwide survey on its epidemiology (2018)
  • Author(s): Mano Hiroshi、Fujiwara Sayaka、Takamura Kazuyuki、Kitoh Hiroshi、Takayama Shinichiro、Ogata Tsutomu、Hashimoto Shuji、Haga Nobuhiko
  • Journal Title: BMC Musculoskeletal Disorders Volume: 19 Issue: 1 Pages: 262-262
  • DOI: 10.1186/s12891-018-2195-3
  • Peer Reviewed / Open Access
• [Journal Article] A Mouse Distraction Osteogenesis Model (2018)
  • Author(s): Fujio Masahito、Osawa Yusuke、Matsushita Masaki、Ogisu Kota、Tsuchiya Shuhei、Kitoh Hiroshi、Hibi Hideharu
  • Journal Title: Journal of Visualized Experiments Volume: 141 Issue: 141 Pages: 0-0
  • DOI: 10.3791/57925
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Extensive Bone Lengthening for a Patient with Linear Morphea (2018)
  • Author(s): Mishima K, Kitoh H, Matsushita M, Nagata T, Kamiya Y, Ishiguro N.
  • Journal Title: Case Rep Orthop. Volume: - Pages: 1-5
  • DOI: 10.1155/2018/4535804
  • Peer Reviewed / Open Access
• [Journal Article] HPPにおける骨折リスクについて. HPP Frontier (2018)
  • Author(s): 鬼頭浩史
  • Journal Title: HPP Frontier Volume: 1 Pages: 40-41
  • Open Access
• [Journal Article] 思春期を診る・四肢や体幹の痛み (2018)
  • Author(s): 鬼頭浩史
  • Journal Title: 小児科 Volume: 59(5) Pages: 543-548
  • Open Access
• [Journal Article] 骨系統疾患の治療-現状と展望- (2018)
  • Author(s): 鬼頭浩史
  • Journal Title: 日整会誌 Volume: 92(12) Pages: 977-986
  • Open Access
• [Journal Article] Clinical effectiveness and long-term retention of abatacept in elderly rheumatoid arthritis patients: Results from a multicenter registry system (2018)
  • Author(s): Takahashi N、Kojima T、Kida D、Kaneko A、Hirano Y、Fujibayashi T、Yabe Y、Takagi H、Oguchi T、Hanabayashi M、Kato T、Funahashi K、Hayashi M、Tsuboi S、Kanayama Y、Sobue Y、Asai N、Matsumoto T、Watanabe T、Asai S、Ishiguro N
  • Journal Title: Modern Rheumatology Volume: 15 Issue: 6 Pages: 1-23
  • DOI: 10.1080/14397595.2018.1525019
  • Peer Reviewed / Open Access
• [Journal Article] Association between chest computed tomography findings and respiratory adverse events in rheumatoid arthritis patients undergoing long-term biological therapy (2018)
  • Author(s): Matsumoto Takuya、Iwano Shingo、Takahashi Nobunori、Asai Shuji、Watanabe Tatsuo、Asai Nobuyuki、Sobue Yasumori、Ito Satoru、Ishiguro Naoki、Kojima Toshihisa
  • Journal Title: International Journal of Rheumatic Diseases Volume: November Issue: 4 Pages: 1-10
  • DOI: 10.1111/1756-185x.13434
  • Peer Reviewed / Open Access
• [Journal Article] An Open-label Single-arm Trial of a Novel Extramedullary Guide Coordinated with 3D Surgical Assistive Software for Total Knee Arthroplasty (2018)
  • Author(s): Kida D1, Hashimoto H, Saito AM, Kito Y, Mori K, Terabe K, Takahashi N, Tomita Y.
  • Journal Title: Acta Medica Okayama Volume: 72 Issue: 4 Pages: 441-445
  • DOI: 10.18926/AMO/56186
  • NAID: 120006501294
  • URL: https://ousar.lib.okayama-u.ac.jp/56186
  • Peer Reviewed / Open Access
• [Journal Article] Influence of methotrexate on gastrointestinal symptoms in patients with rheumatoid arthritis (2018)
  • Author(s): Asai Shuji、Nagai Kaoru、Takahashi Nobunori、Watanabe Tatsuo、Matsumoto Takuya、Asai Nobuyuki、Sobue Yasumori、Ishiguro Naoki、Kojima Toshihisa
  • Journal Title: International Journal of Rheumatic Diseases Volume: 22 Issue: 2 Pages: 207-213
  • DOI: 10.1111/1756-185x.13380
  • NAID: 120006648041
  • Peer Reviewed / Open Access
• [Journal Article] Effects of a self-assembling peptide as a scaffold on bone formation in a defect (2018)
  • Author(s): Ando Kei、Imagama Shiro、Kobayashi Kazuyoshi、Ito Kenyu、Tsushima Mikito、Morozumi Masayoshi、Tanaka Satoshi、Machino Masaaki、Ota Kyotaro、Nishida Koji、Nishida Yoshihiro、Ishiguro Naoki
  • Journal Title: PLOS ONE Volume: 13 Issue: 1 Pages: e0190833-e0190833
  • DOI: 10.1371/journal.pone.0190833
  • Peer Reviewed / Open Access
• [Journal Article] Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters (2018)
  • Author(s): Ito Kenyu、Ohkawara Bisei、Yagi Hideki、Nakashima Hiroaki、Tsushima Mikito、Ota Kyotaro、Konishi Hiroyuki、Masuda Akio、Imagama Shiro、Kiyama Hiroshi、Ishiguro Naoki、Ohno Kinji
  • Journal Title: Sceintific Reports Volume: 8 Issue: 1 Pages: 434-434
  • DOI: 10.1038/s41598-017-18753-5
  • Peer Reviewed / Open Access
• [Journal Article] Early radiographic risk factors for rigid relapse in idiopathic clubfoot treated with the Ponseti method. (2017)
  • Author(s): Mishima K, Kitoh H, Matsushita M, Sugiura H, Hasegawa S, Kitamura A, Nishida Y, Ishiguro N.
  • Journal Title: Foot Ankle Surg. Volume: ー Issue: 6 Pages: 30126-1
  • DOI: 10.1016/j.fas.2017.06.003
  • Peer Reviewed / Open Access
• [Journal Article] High rate of improvement in serum matrix metalloproteinase-3 levels at 4 weeks predicts remission at 52 weeks in RA patients treated with adalimumab (2017)
  • Author(s): Hattori Yosuke、Kojima Toshihisa、Kaneko Atsushi、Kida Daihei、Hirano Yuji、Fujibayashi Takayoshi、Yabe Yuichiro、Oguchi Takeshi、Kanayama Yasuhide、Miyake Hiroyuki、Kato Takefumi、Takagi Hideki、Hayashi Masatoshi、Ito Takayasu、Shioura Tomone、Takahashi Nobunori、Ishikawa Hisato、Funahashi Koji、Ishiguro Naoki
  • Journal Title: Mod Rheumatol Volume: 28 Issue: 1 Pages: 119-125
  • DOI: 10.1080/14397595.2017.1317320
  • Peer Reviewed / Open Access
• [Journal Article] Predictors of biologic discontinuation due to insufficient response in patients with rheumatoid arthritis who achieved clinical remission with biologic treatment: A multicenter observational cohort study (2017)
  • Author(s): Asai S, Fujibayashi T, Oguchi T, Hanabayashi M, Hayashi M, Matsubara H, Ito T, Yabe Y, Watanabe T, Hirano Y, Kanayama Y, Kaneko A, Kato T, Takagi H, Takahashi N, Funahashi K, Takemoto T, Asai N, Watanabe T, Ishiguro N, Kojima T
  • Journal Title: Mod Rheumatol. Volume: 28(2) Issue: 2 Pages: 221-226
  • DOI: 10.1080/14397595.2017.1332558
  • NAID: 120006648042
  • Peer Reviewed / Open Access
• [Journal Article] Maternal administration of meclozine for the treatment of foramen magnum stenosis in transgenic mice with achondroplasia (2017)
  • Author(s): Matsushita M, Mishima K, Esaki R, Ishiguro N, Ohno K, Kitoh H
  • Journal Title: J Neurosurg Pediatr Volume: 19 Issue: 1 Pages: 91-95
  • DOI: 10.3171/2016.7.peds16199
  • Peer Reviewed / Open Access
• [Journal Article] Is the timing of surgery associated with avascular necrosis after unstable slipped capital femoral epiphysis? A multicenter study. (2017)
  • Author(s): Kohno Y, Nakashima Y, Kitano T, Irie T, Kita A, Nakamura T, Endo H, Fujii Y, Kuroda T, Mitani S, Kitoh H, Matsushita M, Hattori T, Iwata K, Iwamoto Y.
  • Journal Title: J Orthop Sci. Volume: 22 Issue: 1 Pages: 112-115
  • DOI: 10.1016/j.jos.2016.08.012
  • Peer Reviewed / Open Access
• [Journal Article] Percutaneous pinning after prolonged skeletal traction with the hip in a flexed position for unstable slipped capital femoral epiphysis: A case series of 11 patients. (2017)
  • Author(s): Matsushita M, Mishima K, Iwata K, Hattori T, Ishiguro N, Kitoh H.
  • Journal Title: Medicine (Baltimore). Volume: 96 Issue: 19 Pages: e6662-e6662
  • DOI: 10.1097/md.0000000000006662
  • Peer Reviewed / Open Access
• [Journal Article] Activated FGFR3 promotes bone formation via accelerating endochondral ossification in mouse model of distraction osteogenesis (2017)
  • Author(s): Osawa Yusuke、Matsushita Masaki、Hasegawa Sachi、Esaki Ryusaku、Fujio Masahito、Ohkawara Bisei、Ishiguro Naoki、Ohno Kinji、Kitoh Hiroshi
  • Journal Title: Bone Volume: 105 Pages: 42-49
  • DOI: 10.1016/j.bone.2017.05.016
  • Peer Reviewed / Open Access
• [Journal Article] Clinical dosage of meclozine promotes longitudinal bone growth, bone volume, and trabecular bone quality in transgenic mice with achondroplasia. (2017)
  • Author(s): Matsushita M, Esaki R, Mishima K, Ishiguro N, Ohno K, Kitoh H.
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 7371-7371
  • DOI: 10.1038/s41598-017-07044-8
  • Peer Reviewed / Open Access
• [Journal Article] Longitudinal study of the activities of daily living and quality of life in Japanese patients with fibrodysplasia ossificans progressiva. (2017)
  • Author(s): 9.Nakahara Y, Kitoh H, Nakashima Y, Toguchida J, Haga N.
  • Journal Title: Disabil Rehabil Volume: 16 Issue: 6 Pages: 1-6
  • DOI: 10.1080/09638288.2017.1405083
  • Peer Reviewed / Open Access
• [Journal Article] Simvastatin inhibits CD44 fragmentation in chondrocytes. (2016)
  • Author(s): Terabe K, Takahashi N, Takemoto T, Knudson W, Ishiguro N, Kojima T.
  • Journal Title: Archives of Biochemistry and Biophysics Volume: 604 Pages: 1-10
  • DOI: 10.1016/j.abb.2016.05.019
  • NAID: 120005868236
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mechanical stress loading induces CD44 cleavage in human chondrocytic HCS-2/8 cells. (2016)
  • Author(s): Kobayakawa T, Takahashi N, Sobue Y, Terabe K, Ishiguro N, Kojima T.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 478(3) Issue: 3 Pages: 1230-1235
  • DOI: 10.1016/j.bbrc.2016.08.099
  • NAID: 120006305561
  • Peer Reviewed
• [Journal Article] Longterm Retention Rate and Risk Factors for Adalimumab Discontinuation Due To Efficacy and Safety in Japanese Patients with Rheumatoid Arthritis: An Observational Cohort Study. (2016)
  • Author(s): Hattori Y, Kojima T, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Terabe K, Yabe Y, Miyake H, Kato T, Takagi H, Hayashi M, Ito T, Kanayama Y, Oguchi T, Takahashi N, Ishikawa H, Funahashi K, Ishiguro N.
  • Journal Title: The Journal of Rheumatology Volume: 43(8) Issue: 8 Pages: 1475-9
  • DOI: 10.3899/jrheum.151006
  • Peer Reviewed
• [Journal Article] Low bone mineral density in achondroplasia and hypochondroplasia (2015)
  • Author(s): Matsushita M, Kitoh H, Mishima K, Kadono I, Sugiura H, Hasegawa S, Nishida Y, Ishiguro N
  • Journal Title: Pediatr Int. Volume: 印刷中 Issue: 8 Pages: 705-708
  • DOI: 10.1111/ped.12890
  • Peer Reviewed
• [Presentation] エイロプレートによる大転子骨端線抑制術の短期術後成績 (2018)
  • Author(s): 三島健一、鬼頭浩史、松下雅樹、門野泉、長田侃、西田佳弘、石黒直樹
  • Organizer: 第33回東海小児整形外科懇話会
• [Presentation] 先天性下腿偽関節症に対し早期髄内釘固定を施行した1例 (2018)
  • Author(s): 長田侃、鬼頭浩史、三島健一、松下雅樹、石黒直樹
  • Organizer: 第33回東海小児整形外科懇話会
• [Presentation] FGFR3は変形性関節症マウスモデルにおける軟骨下骨の骨硬化を抑制する (2018)
  • Author(s): 大倉俊昭、松下雅樹、三島健一、関泰輔、石黒直樹、鬼頭浩史
  • Organizer: 第31回日本軟骨代謝学会
• [Presentation] 骨系統疾患の治療-現状と展望- (2018)
  • Author(s): 鬼頭浩史、三島健一、松下雅樹、石黒直樹
  • Organizer: 第91回日本整形外科学会
• [Presentation] MAC創外固定器による下腿変形矯正 (2018)
  • Author(s): 松下雅樹、鬼頭浩史、三島健一、長田侃、金子浩史、岩田浩志、服部義、石黒直樹
  • Organizer: 第91回日本整形外科学会
• [Presentation] ペルテス病に対する装具療法とソルター骨盤骨切り術の比較 (2018)
  • Author(s): 金子浩史、服部義、鬼頭浩史、三島健一、松下雅樹、吉橋裕治、則竹耕治、石黒直樹
  • Organizer: 第91回日本整形外科学会
• [Presentation] 軟骨無形成症患者における思春期以降のQOLの検討 (2018)
  • Author(s): 松下雅樹、鬼頭浩史、三島健一、長田侃、石黒直樹、藤原清香、芳賀信彦、北岡太一、窪田拓生、大薗恵一
  • Organizer: 第36回日本骨代謝学会
• [Presentation] Transplantation of autologous culture-expanded bone marrow cells and PRP during lower limb lengthening. (2018)
  • Author(s): Kitoh H.
  • Organizer: Asia Pacific Stem Cells and Cartilage Repair Symposium.
  • Int'l Joint Research
• [Presentation] 骨再生の足場となる新規自己集合体ペプチドの検証 家兎腰椎固定、脛骨骨孔モデル (2018)
  • Author(s): 安藤 圭, 今釜 史郎, 小林 和克, 大田 恭太郎, 町野 正明, 田中 智史, 両角 正義, 伊藤 定之, 神原 俊輔, 西田 佳弘, 石黒 直樹
  • Organizer: 第33回日本整形外科学会基礎学術集会
• [Presentation] Zonisamideは頸髄症の進行を抑制する (2018)
  • Author(s): 神原 俊輔, 大河原 美静, 大田 恭太郎, 小清水 宏行, 井上 太郎, 今釜 史郎, 石黒 直樹, 大野 欽司
  • Organizer: 第33回日本整形外科学会基礎学術集会
• [Presentation] ポリグルタミン鎖が伸長した変異アンドロゲン受容体が骨格筋や神経筋接合部に与える影響 球脊髄性筋萎縮症の病態解明 (2018)
  • Author(s): 田中 智史, 伊藤 卓治, 今釜 史郎, 石黒 直樹, 岡田 洋平
  • Organizer: 第33回日本整形外科学会基礎学術集会
• [Presentation] 抗てんかん薬ゾニサミドは脊髄損傷モデルマウスの下肢運動機能を改善させる (2018)
  • Author(s): 大田 恭太郎, 大河原 美静, 神原 俊輔, 井上 太郎, 小清水 宏行, 都島 幹人, 安藤 圭, 小林 和克, 今釜 史郎, 石黒 直樹, 大野 欽司
  • Organizer: 第33回日本整形外科学会基礎学術集会
• [Presentation] 骨再生の足場となる新規自己集合体ペプチドの検証 (2018)
  • Author(s): 藤 圭, 今釜 史郎, 小林 和克, 両角 正義, 田中 智史, 町野 正明, 大田 恭太郎, 伊藤 定之, 神原 俊輔, 石黒 直樹
  • Organizer: 第36回日本骨代謝学会
• [Presentation] 運動神経細胞の細胞死を抑制する既認可薬の網羅的探索-Pindololは細胞死を抑制し、脊髄損傷による運動機能障害を改善する- (2017)
  • Author(s): 都島幹人,大河原美静,伊藤研悠,大田恭太郎,神原俊輔,井上太郎,小清水宏行,今釜史郎,石黒直樹,大野欽司
  • Organizer: 第32回日本整形外科学会基礎学術集会
• [Presentation] Drug X can inhibit apoptotic cell death induced by oxidative stress in vitro and improve locomotor function of lower limbs in spinal cord injury model mice in vivo. (2017)
  • Author(s): M Tsushima, B Ohkawara, S Imagama, K Ando, K Kobayashi, N Ishiguro, K Ohno
  • Organizer: Eurospine 2017
  • Int'l Joint Research
• [Presentation] 抗てんかん薬ゾニサミドは脊髄損傷モデルマウスの運動機能を改善する (2017)
  • Author(s): 大田恭太郎,大河原美静,伊藤研悠,大田恭太郎,神原俊輔,井上太郎,小清水宏行,今釜史郎,石黒直樹,大野欽司
  • Organizer: 第46回日本脊椎脊髄病学会
• [Presentation] Characteristics of functional impairment in patients with long-standing rheumatoid arthritis based on range of motion of joints: multicenter prospective cohort study for evaluation of joint surgery on physical function (2016)
  • Author(s): Toshihisa Kojima, Hajime Ishikawa, Sakae Tanaka, Nobuhiko Haga, Keiichiro Nishida, Masao Yukioka, Jun Hashimoto, Hisaaki Miyahara, Yasuo Niki, Tomoatu Kimura, Hiromi Oda, Masayo Kojima, Naoki Ishiguro
  • Organizer: American College of Rheumatology
  • Place of Presentation: ワシントン、アメリカ
  • Year and Date: 2016-11-11
  • Int'l Joint Research
• [Presentation] FGFR3-targetted therapy for short stature in achondroplasia. (2016)
  • Author(s): Hiroshi Kitoh
  • Organizer: The 60th Anniversary Congress of the Korean Orthopaedic Association
  • Place of Presentation: 仁川広域市、韓国
  • Year and Date: 2016-10-19
  • Int'l Joint Research / Invited
• [Presentation] 変形性関節症に対する新規治療薬の探索－Wnt/β-カテニンシグナル経路の制御－ (2016)
  • Author(s): 酒井忠博,宮本健太郎,大河原美静,高松晃,大野欽司,平岩秀樹,濱田恭,小田智之,山下暁士,石黒直樹
  • Organizer: 第31回日本整形外科学会基礎学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-10-13
• [Presentation] 腱細胞における腱関連遺伝子と血管新生関連遺伝子の検討 (2016)
  • Author(s): 土谷早穂,酒井忠博,平岩秀樹,濱田恭,小田智之,山下暁士,宮本健太郎,岸本烈純,石黒直樹
  • Organizer: 第31回日本整形外科学会基礎学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-10-13
• [Presentation] Wnt/β-カテニンシグナル経路は腱関連遺伝子発現に影響を与える (2016)
  • Author(s): 岸本烈純,大河原美静,酒井忠博,平岩秀樹,濱田恭,小田智之,山下暁士,宮本健太郎,土谷早穂,大野欽司,石黒直樹
  • Organizer: 第31回日本整形外科学会基礎学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-10-13
• [Presentation] 骨再生の足場となる新規自己集合体ペプチド (2016)
  • Author(s): 安藤圭、今釜史郎、小林和克、飛田哲朗、伊藤研悠、都島幹人、石川喜資、松本明之、西田佳弘、石黒直樹
  • Organizer: 第31回日本整形外科学会基礎学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-10-13
• [Presentation] ヒトiPS細胞を用いたニューロマスキュラーモデルの構築 (2016)
  • Author(s): 田中智史、下門大祐、伊藤卓治、今釜史郎、西田佳弘、道勇学、大野欽司、岡野栄之、石黒直樹、岡田洋平
  • Organizer: 第31回日本整形外科学会基礎学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-10-13
• [Presentation] 脊髄において特異的発現パターンを有するFgf18の神経筋接合部に対する役割 (2016)
  • Author(s): 伊藤研悠、大河原美静、今釜史郎、飛田哲朗、都島幹人、田中智史、大田恭太郎、西田佳弘、石黒直樹、大野欽司
  • Organizer: 第31回日本整形外科学会基礎学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-10-13
• [Presentation] Zonisamideaはマウスの坐骨神経切断・自家移植モデルにおいて、軸索延長に寄与し、末梢神経再生を促進する (2016)
  • Author(s): 都島幹人、八木秀樹、大河原美静、伊藤研悠、田中智史、大田恭太郎、石井久雄、能登公俊、今釜史郎、西田佳弘、石黒直樹、大野欽司
  • Organizer: 第31回日本整形外科学会基礎学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-10-13
• [Presentation] 遺伝性神経筋疾患に関するＣＲＩＳＰＲ／Ｃａｓ9によるゲノム編集治療の可能性 (2016)
  • Author(s): 田中智史、伊藤卓治、太田明伸、今釜史郎、西田佳弘、細川好孝、道勇学、大野欽司、石黒直樹、岡田洋平
  • Organizer: 第31回日本整形外科学会基礎学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-10-13
• [Presentation] 骨系統疾患の診断と治療の進歩 「軟骨無形成症の低身長に対する治療」 (2016)
  • Author(s): 鬼頭浩史
  • Organizer: 第34回日本骨代謝学会学術集会 第３回アジア太平洋骨代謝学会議
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2016-07-20