| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
Traumatic spinal cord injury (SCI) brings numerous inflammatory cells, including macrophages, from the circulating blood to lesions, but the fate of these cells is unknown. We herein demonstrate that macrophages actively migrate toward the lesion epicenter after SCI, depending on the gradient of chemoattractant C5a. However, macrophages lacking interferon regulatory factor 8 (IRF8) can not migrate and remain widely scattered in the injured cord, resulting in a poor pathological and functional outcome. Conversely, pharmacological IRF8 activation promoted macrophage-autonomous migration with a significant increase in the purinergic receptors expression, thereby improving the functional recovery. Our findings revealed the importance of the bidirectional interaction between infiltrating macrophages and CNS cells, providing a novel therapeutic target for CNS injury.
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