| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Outline of Final Research Achievements |
In order to clarify the genetic background of adolescent idiopathic scoliosis (AIS), we have conducted genetic study for AIS by using genome-wide association study (GWAS) which is a genetic statistical method. We have performed a total of three GWASs and identified 20 AIS susceptibility genes. The total number of samples exceeds 5000 samples and this is the largest cohort worldwide. And we have also identified a gene involved in severity and a gene involved in progression by stratification analyses of GWAS. Furthermore, we have conducted international meta-analysis with American, Swedish and Chinese research groups using GWAS data and replicated these susceptibility genes among other races.
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