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Molecular basis in endometrial cell differentiation induced by progesterone

Research Project

Project/Area Number 16H05469
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionThe University of Tokyo

Principal Investigator

Osuga Yutaka  東京大学, 医学部附属病院, 教授 (80260496)

Co-Investigator(Kenkyū-buntansha) 廣田 泰  東京大学, 医学部附属病院, 講師 (40598653)
平池 修  東京大学, 医学部附属病院, 准教授 (20529060)
甲賀 かをり  東京大学, 医学部附属病院, 准教授 (10396723)
平田 哲也  東京大学, 医学部附属病院, 登録研究員 (30431860)
原田 美由紀  東京大学, 医学部附属病院, 講師 (70451812)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywordsプロゲステロン / 着床 / 子宮 / 子宮腺筋症 / 子宮内膜 / リモデリング / 再生医療 / 胚浸潤 / 細胞増殖 / KRAS変異 / ゲノム / プロゲスチン / 黄体ホルモン / 子宮内膜症 / 妊娠 / 細胞老化 / マクロファージ / 子宮再生 / 脱細胞化 / STAT3 / ノックアウトマウス
Outline of Final Research Achievements

Uterine progesterone (P4) signaling has been investigated in this study. We found that stromal HIF2α acts on the detachment of the endometrial luminal epithelium from the stroma via hypoxia-related signals, which P4 does not affect (JCI 2018), and that P4 suppresses cell proliferation of the endometrial luminal epithelium and induces the fragmentation of epithelial cells and its trophoblast phagocytosis at the embryo attachment site. We also found that KRAS mutation in adenomyosis induces P4 resistance (Nat Commun 2019), and that P4 and STAT3 signaling is involved in the uterine remodeling (Endocrinology 2017, JCI Insight 2016).

Academic Significance and Societal Importance of the Research Achievements

本研究では、着床を可能にする胚受容能という視点でプロゲステロンの支配下にある着床の機構を明らかにし、子宮内環境と妊娠の科学的理解が可能になった。母体による初期胚発育に対する影響が明らかになったことで、不妊症の原因解明だけではなく、胎児発育不全や妊娠高血圧症候群などの妊娠中の合併症の解明、出生後の児生育との関連についての理解や生活習慣で起こる各種疾患の病因・病態の解明にまでつなげるための道筋ができた点で、学術的・社会的意義のある研究成果が得られたといえる。また、子宮腺筋症の薬物療法抵抗性の機序を明らかにすることができ、子宮腺筋症の新たな治療選択への基盤的知見が得られた点でも、社会的意義がある。

Report

(4 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (66 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (50 results) (of which Int'l Joint Research: 19 results,  Peer Reviewed: 48 results,  Open Access: 35 results,  Acknowledgement Compliant: 2 results) Presentation (13 results) (of which Int'l Joint Research: 10 results,  Invited: 11 results) Remarks (3 results)

  • [Journal Article] A National Survey of Umbilical Endometriosis in Japan2020

    • Author(s)
      Hirata Tetsuya,Koga Kaori,Kitade Mari,Fukuda Shinya,Neriishi Kazuaki,Taniguchi Fuminori,Honda Ritsuo,Takazawa Naoko,Tanaka Toshiaki,Kurihara Masatoshi,Nakajima Jun,Horie Shigeo,Nakai Hidekatsu,Enomoto Takayuki,Mandai Masaki,Narahara Hisashi,Kitawaki Jo,Harada Tasuku,Katabuchi Hidetaka,Yoshimura Kotaro,Osuga Yutaka
    • Journal Title

      Journal of Minimally Invasive Gynecology

      Volume: 27 Issue: 1 Pages: 80-87

    • DOI

      10.1016/j.jmig.2019.02.021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations2019

    • Author(s)
      Inoue Satoshi、Hirota Yasushi、Ueno Toshihide、十人省略、Tanaka Yosuke、Sakata Seiji、Takeuchi Kengo、Muraoka Ayako、Osuka Satoko、Saito Tsuyoshi、Oda Katsutoshi、Osuga Yutaka、Terao Yasuhisa、Kawazu Masahito、Mano Hiroyuki
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s41467-019-13708-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-tumor effect of inhibition of DNA damage response proteins, ATM and ATR, in endometrial cancer cells2019

    • Author(s)
      Takeuchi Makoto、Tanikawa Michihiro、Nagasaka Kazunori、Oda Katsutoshi、Kawata Yoshiko、Oki Shinya、Agapiti Chuwa、Sone Kenbun、Miyagawa Yuko、Hiraike Haruko、Wada-Hiraike Osamu、Kuramoto Hiroyuki、Ayabe Takuya、Osuga Yutaka、Fujii Tomoyuki
    • Journal Title

      Cancers

      Volume: 11 Issue: 12 Pages: 1913-1913

    • DOI

      10.3390/cancers11121913

    • URL

      https://pure.teikyo.jp/en/publications/5c41367b-5e04-4c85-98ed-26c93d8ab201

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Accumulation of advanced glycation end products in follicles is associated with poor oocyte developmental competence2019

    • Author(s)
      Takahashi Nozomi、Harada Miyuki、Azhary Jerilee M K、Kunitomi Chisato、Nose Emi、Terao Hiromi、Koike Hiroshi、Wada-Hiraike Osamu、Hirata Tetsuya、Hirota Yasushi、Koga Kaori、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Molecular Human Reproduction

      Volume: 25 Issue: 11 Pages: 684-694

    • DOI

      10.1093/molehr/gaz050

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endometriosis Triggers Excessive Activation of Primordial Follicles via PI3K-PTEN-Akt-Foxo3 Pathway2019

    • Author(s)
      Takeuchi Arisa、Koga Kaori、Satake Erina、Makabe Tomoko、Taguchi Ayumi、Miyashita Mariko、Takamura Masashi、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Yoshino Osamu、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      The Journal of Clinical Endocrinology & Metabolism

      Volume: 104 Issue: 11 Pages: 5547-5554

    • DOI

      10.1210/jc.2019-00281

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A survey of public attitudes toward uterus transplantation, surrogacy, and adoption in Japan2019

    • Author(s)
      Nakazawa Akari、Hirata Tetsuya、Arakawa Tomoko、Nagashima Natsuki、Fukuda Shinya、Neriishi Kazuaki、Harada Miyuki、Hirota Yasushi、Koga Kaori、Wada-Hiraike Osamu、Koizumi Yoshio、Fujii Tomoyuki、Irahara Minoru、Osuga Yutaka
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 10 Pages: 0223571-0223571

    • DOI

      10.1371/journal.pone.0223571

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Placental expression of lysophosphatidic acid receptors in normal pregnancy and preeclampsia2019

    • Author(s)
      Fujii Tatsuya、Nagamatsu Takeshi、Schust Danny J.、Ichikawa Mayuko、Kumasawa Keiichi、Yabe Shinichiro、Iriyama Takayuki、Hirota Yasushi、Osuga Yutaka、Aoki Junken、Yatomi Yutaka、Fujii Tomoyuki
    • Journal Title

      American Journal of Reproductive Immunology

      Volume: 82 Issue: 5

    • DOI

      10.1111/aji.13176

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Japanese nationwide survey on the cryopreservation of embryos, oocytes and ovarian tissue for cancer patients2019

    • Author(s)
      Sanada Yuko、Harada Miyuki、Kunitomi Chisato、Kanatani Mayuko、Izumi Gentaro、Hirata Tetsuya、Fujii Tomoyuki、Suzuki Nao、Morishige Ken‐ichirou、Aoki Daisuke、Irahara Minoru、Tsugawa Koichiro、Tanimoto Mitsune、Nishiyama Hiroyuki、Hosoi Hajime、Sugiyama Kazuhiko、Kawai Akira、Osuga Yutaka
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 45 Issue: 10 Pages: 2021-2028

    • DOI

      10.1111/jog.14073

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased LIGHT leading to sFlt-1 elevation underlies the pathogenic link between hydatidiform mole and preeclampsia2019

    • Author(s)
      Iriyama Takayuki、Wang Guan、Yoshikawa Midori、Mimura Nobuko、Matsui Haruka、Sayama Seisuke、Kumasawa Keiichi、Nagamatsu Takeshi、Koga Kaori、Kotani Tomomi、Niimi Kaoru、Yamamoto Eiko、Kellems Rodney E.、Xia Yang、Osuga Yutaka、Fujii Tomoyuki
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 01017-01017

    • DOI

      10.1038/s41598-019-46660-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of oxidative stress in follicular fluid on embryos of patients undergoing assisted reproductive technology treatment2019

    • Author(s)
      Terao Hiromi、Wada‐Hiraike Osamu、Nagumo Aiko、Kunitomi Chisato、Azhary Jerilee M. K.、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Koga Kaori、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 45 Issue: 9 Pages: 1884-1891

    • DOI

      10.1111/jog.14040

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uterine receptivity, embryo attachment, and embryo invasion: Multistep processes in embryo implantation2019

    • Author(s)
      Fukui Yamato、Hirota Yasushi、Matsuo Mitsunori、Gebril Mona、Akaeda Shun、Hiraoka Takehiro、Osuga Yutaka
    • Journal Title

      Reproductive Medicine and Biology

      Volume: 18 Issue: 3 Pages: 234-240

    • DOI

      10.1002/rmb2.12280

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum Brain-derived Neurotrophic Factor Levels Mirror Bone Mineral Density in Amenorrheic and Eumenorrheic Athletes.2019

    • Author(s)
      Nose S, Yoshino O, Nomoto K, Harada M, Dohi M, Kawahara T, Osuga Y, Fujii T, Saito S.
    • Journal Title

      Int J Sports Med.

      Volume: 40(4) Issue: 04 Pages: 276-282

    • DOI

      10.1055/a-0835-6119

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sphingosine 1 Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells.2019

    • Author(s)
      Yoshino O, Yamada-Nomoto K, Kano K, Ono Y, Kobayashi M, Ito M, Yoneda S, Nakashima A, Shima T, Onda T, Osuga Y, Aoki J, Saito S.
    • Journal Title

      Reprod Sci.

      Volume: 1933719119828112 Issue: 11 Pages: 1460-1467

    • DOI

      10.1177/1933719119828112

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary2019

    • Author(s)
      Akino Nana、Wada-Hiraike Osamu、Isono Wataru、Terao Hiromi、Honjo Harunori、Miyamoto Yuichiro、Tanikawa Michihiro、Sone Kenbun、Hirano Mana、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Koga Kaori、Oda Katsutoshi、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Reproductive Biology and Endocrinology

      Volume: 17 Issue: 1 Pages: 2323-2323

    • DOI

      10.1186/s12958-019-0466-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mdm2-p53-SF1 pathway in ovarian granulosa cells directs ovulation and fertilization by conditioning oocyte quality2019

    • Author(s)
      Haraguchi Hirofumi、Hirota Yasushi、Saito-Fujita Tomoko、Tanaka Tomoki、Shimizu-Hirota Ryoko、Harada Miyuki、Akaeda Shun、Hiraoka Takehiro、Matsuo Mitsunori、Matsumoto Leona、Hirata Tetsuya、Koga Kaori、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      The FASEB Journal

      Volume: 33 Issue: 2 Pages: 2610-2620

    • DOI

      10.1096/fj.201801401r

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 薬物療法 漢方,GnRH製剤の使い方 経口剤レルゴリクスを含めて2019

    • Author(s)
      大須賀穣
    • Journal Title

      臨床婦人科産科

      Volume: 73 Pages: 959-964

    • Related Report
      2018 Annual Research Report
  • [Journal Article] GnRHアナログ製剤の種類と特徴2019

    • Author(s)
      大須賀穣
    • Journal Title

      産科と婦人科

      Volume: 86 Pages: 6-12

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Endoplasmic Reticulum Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS2018

    • Author(s)
      Azhary Jerilee M K、Harada Miyuki、Takahashi Nozomi、Nose Emi、Kunitomi Chisato、Koike Hiroshi、Hirata Tetsuya、Hirota Yasushi、Koga Kaori、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Endocrinology

      Volume: 160 Issue: 1 Pages: 119-132

    • DOI

      10.1210/en.2018-00675

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A survey of public attitudes towards third-party reproduction in Japan in 20142018

    • Author(s)
      Yamamoto Naoko、Hirata Tetsuya、Izumi Gentaro、Nakazawa Akari、Fukuda Shinya、Neriishi Kazuaki、Arakawa Tomoko、Takamura Masashi、Harada Miyuki、Hirota Yasushi、Koga Kaori、Wada-Hiraike Osamu、Fujii Tomoyuki、Irahara Minoru、Osuga Yutaka
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 10 Pages: 198499-198499

    • DOI

      10.1371/journal.pone.0198499

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of Nerve Injury-Induced Protein1 (Ninj1) in Endometriosis2018

    • Author(s)
      Miyashita Mariko、Koga Kaori、Takeuchi Arisa、Makabe Tomoko、Taguchi Ayumi、Urata Yoko、Izumi Gentaro、Takamura Masashi、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Wada-Hiraike Osamu、Yoshino Osamu、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Reproductive Sciences

      Volume: in press Issue: 8 Pages: 368-375

    • DOI

      10.1177/1933719118806395

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] HIF2α in the uterine stroma permits embryo invasion and luminal epithelium detachment2018

    • Author(s)
      Matsumoto Leona、Hirota Yasushi、Saito-Fujita Tomoko、Takeda Norihiko、Tanaka Tomoki、Hiraoka Takehiro、Akaeda Shun、Fujita Hidetoshi、Shimizu-Hirota Ryoko、Igaue Shota、Matsuo Mitsunori、Haraguchi Hirofumi、Saito-Kanatani Mayuko、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Journal of Clinical Investigation

      Volume: 128 Issue: 7 Pages: 3186-3197

    • DOI

      10.1172/jci98931

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Japanese GWAS identifies variants for bust-size, dysmenorrhea, and menstrual fever that are eQTLs for relevant protein-coding or long non-coding RNAs2018

    • Author(s)
      Hirata Tetsuya、Koga Kaori、Johnson Todd A.、Morino Ryoko、Nakazono Kazuyuki、Kamitsuji Shigeo、Akita Masanori、Kawajiri Maiko、Kami Azusa、Hoshi Yuria、Tada Asami、Ishikawa Kenichi、Hine Maaya、Kobayashi Miki、Kurume Nami、Fujii Tomoyuki、Kamatani Naoyuki、Osuga Yutaka
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 8502-8502

    • DOI

      10.1038/s41598-018-25065-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD11c+ M1-like macrophages (MΦs) but not CD206+ M2-like MΦ are involved in folliculogenesis in mice ovary2018

    • Author(s)
      Ono Yosuke、Nagai Miwako、Yoshino Osamu、Koga Kaori、Nawaz Allah、Hatta Hideki、Nishizono Hirofumi、Izumi Gentaro、Nakashima Akitoshi、Imura Johji、Tobe Kazuyuki、Fujii Tomoyuki、Osuga Yutaka、Saito Shigeru
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 8171-8171

    • DOI

      10.1038/s41598-018-25837-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of Nrf2 might reduce oxidative stress in human granulosa cells2018

    • Author(s)
      Akino Nana、Wada-Hiraike Osamu、Terao Hiromi、Honjoh Harunori、Isono Wataru、Fu Houju、Hirano Mana、Miyamoto Yuichiro、Tanikawa Michihiro、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Koga Kaori、Oda Katsutoshi、Kawana Kei、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Mol Cell Endocrinol

      Volume: 470 Pages: 96

    • DOI

      10.1016/j.mce.2017.10.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adenomyosis and adverse perinatal outcomes: increased risk of second trimester miscarriage, preeclampsia, and placental malposition2017

    • Author(s)
      Hashimoto A, Iriyama T, Sayama S, Nakayama T, Komatsu A, Miyauchi A, Nishii O, Nagamatsu T, Osuga Y, Fujii T1
    • Journal Title

      J Mater Fetal Neonata Med

      Volume: 31 Issue: 3 Pages: 364

    • DOI

      10.1080/14767058.2017.1285895

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ジエノゲストの子宮腺筋症患者における臨床評価 - 多施設共同ランダム化プラセボ対照二重盲検並行群間用量反応比較試験 -2017

    • Author(s)
      大須賀穣, 渡邉学, 萩野篤司
    • Journal Title

      薬理と治療

      Volume: 45 Pages: 907-920

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oil-Soluble Contrast Medium (OSCM) for Hysterosalpingography Modulates Dendritic Cell and Regulatory T Cell Profiles in the Peritoneal Cavity: A Possible Mechanism by Which OSCM Enhances Fertility2017

    • Author(s)
      Izumi Gentaro、Koga Kaori、Takamura Masashi、Bo Wang、Nagai Miwako、Miyashita Mariko、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Yoshino Osamu、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      J Immunol

      Volume: 198 Issue: 11 Pages: 4277-4284

    • DOI

      10.4049/jimmunol.1600498

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] F4/80+ macrophages contribute to clearance of senescent cells in the mouse postpartum uterus.2017

    • Author(s)
      Egashira M, Hirota Y, Shimizu-Hirota R, Saito-Fujita T, Haraguchi H, Matsumoto L, Matsuo M, Hiraoka T, Tanaka T, Akaeda S, Takehisa C, Saito-Kanatani M, Maeda K, Fujii T, Osuga Y.
    • Journal Title

      Endocrinology

      Volume: 印刷中 Issue: 7 Pages: 2344-2353

    • DOI

      10.1210/en.2016-1886

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Autotaxin–lysophosphatidic acid–LPA<sub>3</sub> signaling at the embryo-epithelial boundary controls decidualization pathways2017

    • Author(s)
      Aikawa Shizu、Kano Kuniyuki、Inoue Asuka、Wang Jiao、Saigusa Daisuke、Nagamatsu Takeshi、Hirota Yasushi、Fujii Tomoyuki、Tsuchiya Soken、Taketomi Yoshitaka、Sugimoto Yukihiko、Murakami Makoto、Arita Makoto、Kurano Makoto、Ikeda Hitoshi、Yatomi Yutaka、Chun Jerold、Aoki Junken
    • Journal Title

      EMBO J

      Volume: 36 Issue: 14 Pages: 2146

    • DOI

      10.15252/embj.201696290

    • URL

      https://pure.teikyo.jp/en/publications/9eff2a14-8b59-4329-98bc-70cc556391fc

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nomenclature of primary amenorrhea: A proposal document of the Japan Society of Obstetrics and Gynecology committee for the redefinition of primary amenorrhea2017

    • Author(s)
      Shozu Makio、Ishikawa Hiroshi、Horikawa Reiko、Sakakibara Hideya、Izumi Shun-ichiro、Ohba Takashi、Hirota Yasushi、Ogata Tsutomu、Osuga Yutaka、Kugu Koji
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 43 Issue: 11 Pages: 1738-1742

    • DOI

      10.1111/jog.13442

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis2017

    • Author(s)
      Takahashi Nozomi、Harada Miyuki、Hirota Yasushi、Nose Emi、Azhary Jerilee MK、Koike Hiroshi、Kunitomi Chisato、Yoshino Osamu、Izumi Gentaro、Hirata Tetsuya、Koga Kaori、Wada-Hiraike Osamu、Chang R. Jeffrey、Shimasaki Shunichi、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 10824-10824

    • DOI

      10.1038/s41598-017-11252-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhanced HIF2α expression during human trophoblast differentiation into syncytiotrophoblast suppresses transcription of placental growth factor2017

    • Author(s)
      Fujii Tatsuya、Nagamatsu Takeshi、Morita Kazuki、Schust Danny J.、Iriyama Takayuki、Komatsu Atsushi、Osuga Yutaka、Fujii Tomoyuki
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 12455-12455

    • DOI

      10.1038/s41598-017-12685-w

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of the efficacy and safety of dienogest in the treatment of painful symptoms in patients with adenomyosis: a randomized, double-blind, multicenter, placebo-controlled study2017

    • Author(s)
      Osuga Yutaka、Fujimoto-Okabe Haruka、Hagino Atsushi
    • Journal Title

      Fertil Steril

      Volume: 108 Issue: 4 Pages: 673-678

    • DOI

      10.1016/j.fertnstert.2017.07.021

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term use of dienogest in the treatment of painful symptoms in adenomyosis2017

    • Author(s)
      Osuga Yutaka、Watanabe Manabu、Hagino Atsushi
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 43 Issue: 9 Pages: 1441-1448

    • DOI

      10.1111/jog.13406

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of endometrioma after cervical conization2017

    • Author(s)
      Takahashi Nozomi、Koga Kaori、Arakawa Ichiro、Harada Miyuki、Oda Katsutoshi、Kawana Kei、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Gynecol Endocrinol

      Volume: 34 Issue: 4 Pages: 1-4

    • DOI

      10.1080/09513590.2017.1393660

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drospirenone reduces inflammatory cytokines, vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) expression in human endometriotic stromal cells.2017

    • Author(s)
      Makabe T, Koga K, Miyashita M, Takeuchi A, Sue F, Taguchi A, Urata Y, Izumi G, Takamura M, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y.
    • Journal Title

      J Reprod Immunol

      Volume: 119 Pages: 44-48

    • DOI

      10.1016/j.jri.2016.12.002

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Potential Role for Endoplasmic Reticulum Stress in Progesterone Deficiency in Obese Women.2017

    • Author(s)
      Takahashi N, Harada M, Hirota Y, Zhao L, Azhary JM, Yoshino O, Izumi G, Hirata T, Koga K, Wada-Hiraike O, Fujii T, Osuga Y.
    • Journal Title

      Endocrinology

      Volume: 158 Pages: 84-97

    • DOI

      10.1210/en.2016-1511

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Emerging Role of FOXL2 in Regulating the Transcriptional Activation Function of Estrogen Receptor β: An Insight into Ovarian Folliculogenesis2017

    • Author(s)
      Hirano M, Wada-Hiraike O, Fu H, Akino N, Isono W, Sakurabashi A, Fukuda T, Morita Y, Tanikawa M, Miyamoto Y, Nishi Y, Yanase T, Harada M, Oishi H, Yano T, Koga K, Oda K, Kawana K, Fujii T, Osuga Y.
    • Journal Title

      Reprod Sci

      Volume: 24 Issue: 1 Pages: 133

    • DOI

      10.1177/1933719116651150

    • URL

      https://pure.teikyo.jp/en/publications/a510e310-ad12-45f7-ba18-ee76722a91a0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] STAT3 accelerates uterine epithelial regeneration in a mouse model of decellularized uterine matrix transplantation.2016

    • Author(s)
      Hiraoka T, Hirota Y, Saito-Fujita T, Matsuo M, Egashira M, Matsumoto L, Haraguchi H, Dey SK, Furukawa KS, Fujii T, Osuga Y.
    • Journal Title

      JCI Insight

      Volume: 1 Issue: 8

    • DOI

      10.1172/jci.insight.87591

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The assessment of myometrium perfusion in patients with uterine fibroid by arterial spin labeling MRI.2016

    • Author(s)
      Takahashi N, Yoshino O, Hiraike O, Maeda E, Nakamura M, Hori M, Harada M, Koga K, Saito S, Fujii T, Osuga Y.
    • Journal Title

      Springerplus

      Volume: 5 Issue: 1 Pages: 1907-1907

    • DOI

      10.1186/s40064-016-3596-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dienogest reduces proliferation, NGF expression and nerve fiber density in human adenomyosis.2016

    • Author(s)
      Takeuchi A, Koga K, Miyashita M, Makabe T, Sue F, Harada M, Hirata T, Hirota Y, Fujii T, Osuga Y.
    • Journal Title

      Eur J Obstet Gynecol Reprod Biol

      Volume: 207 Pages: 157-161

    • DOI

      10.1016/j.ejogrb.2016.10.053

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Assisted reproductive technology pregnancy complications are significantly associated with endometriosis severity before conception: a retrospective cohort study.2016

    • Author(s)
      Fujii T, Wada-Hiraike O, Nagamatsu T, Harada M, Hirata T, Koga K, Fujii T, Osuga Y.
    • Journal Title

      Reprod Biol Endocrinol

      Volume: 14 Issue: 1 Pages: 73-73

    • DOI

      10.1186/s12958-016-0209-2

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mannose receptor is highly expressed by peritoneal dendritic cells in endometriosis.2016

    • Author(s)
      Izumi G, Koga K, Takamura M, Makabe T, Nagai M, Urata Y, Harada M, Hirata T, Hirota Y, Fujii T, Osuga Y.
    • Journal Title

      Fertil Steril

      Volume: 107 Issue: 1 Pages: 167-173

    • DOI

      10.1016/j.fertnstert.2016.09.036

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of ovarian cancer after excision of endometrioma.2016

    • Author(s)
      Haraguchi H, Koga K, Takamura M, Makabe T, Sue F, Miyashita M, Urata Y, Izumi G, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Oda K, Kawana K, Fujii T, Osuga Y.
    • Journal Title

      Fertil Steril

      Volume: 106 Issue: 6 Pages: 1432-1437

    • DOI

      10.1016/j.fertnstert.2016.07.1077

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophil depletion reduces endometriotic lesion formation in mice.2016

    • Author(s)
      Takamura M, Koga K, Izumi G, Urata Y, Nagai M, Hasegawa A, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y.
    • Journal Title

      Am J Reprod Immunol

      Volume: 76 Issue: 3 Pages: 193-198

    • DOI

      10.1111/aji.12540

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Usefulness of T2 star-weighted imaging in ovarian cysts and tumors.2016

    • Author(s)
      Takahashi N, Yoshino O, Maeda E, Naganawa S, Harada M, Koga K, Hiraike O, Nakamura M, Tabuchi T, Hori M, Saito S, Fujii T, Osuga Y.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 42 Issue: 10 Pages: 1336-1342

    • DOI

      10.1111/jog.13056

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Where are oncofertility and fertility preservation treatments heading in 2016?2016

    • Author(s)
      Harada M, Osuga Y.
    • Journal Title

      Future Oncol

      Volume: 12 Issue: 20 Pages: 2313-2321

    • DOI

      10.2217/fon-2016-0161

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of 1,25-dihydroxy vitamin D3 on endometriosis.2016

    • Author(s)
      Miyashita M, Koga K, Izumi G, Sue F, Makabe T, Taguchi A, Nagai M, Urata Y, Takamura M, Harada M, Hirata T, Hirota Y, Wada-Hiraike O, Fujii T, Osuga Y.
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 101 Issue: 6 Pages: 2371-2379

    • DOI

      10.1210/jc.2016-1515

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A potential role of endoplasmic reticulum stress in development of ovarian hyperstimulation syndrome.2016

    • Author(s)
      Takahashi N, Harada M, Hirota Y, Zhao L, Yoshino O, Urata Y, Izumi G, Takamura M, Hirata T, Koga K, Wada-Hiraike O, Fujii T, Osuga Y.
    • Journal Title

      Mol Cell Endocrinol

      Volume: 428 Pages: 161-169

    • DOI

      10.1016/j.mce.2016.03.032

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells.2016

    • Author(s)
      Taguchi, A., Koga, K., Kawana, K., Makabe, T., Sue, F., Miyashita, M., Yoshida, M., Urata, Y., Izumi, G., Takamura, M., Harada, M., Hirata, T., Hirota, Y., Wada-Hiraike, O., Fujii, T., Osuga, Y
    • Journal Title

      American Journal of Reproductive Immunology

      Volume: 75 Issue: 4 Pages: 486-492

    • DOI

      10.1111/aji.12489

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 子宮筋腫の薬物治療Update2019

    • Author(s)
      大須賀穣
    • Organizer
      第59回日本産科婦人科内視鏡学会学術講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 生殖医療-近未来へのイノベーション-2019

    • Author(s)
      大須賀穣
    • Organizer
      第71回日本産科婦人科学会学術講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 稀少部位子宮内膜症診療ガイドラインの解説2018

    • Author(s)
      大須賀穣
    • Organizer
      第23回日本生殖内分泌学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] STAT3: A Key Transcriptional Factor Not Only in Embryo Implantation but also in Endometrial Regeneration2018

    • Author(s)
      Yasushi Hirota
    • Organizer
      Society for Reproductive Investigation, 65th Annual Scientific Meeting, Endometrium Satellite Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Levonorgestrel Inhibits Embryo Implantation by Downregulation of Uterine LIF Expression2018

    • Author(s)
      Mitsunori Matsuo, Yasushi Hirota, Tomoko Saito-Fujita, Hirofumi Haraguchi, Shota Igaue, Leona Matsumoto, Takehiro Hiraoka, Shun Akaeda, Tomoki Tanaka, Tomoyuki Fujii, Yutaka Osuga
    • Organizer
      Society for Reproductive Investigation, 65th Annual Scientific Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diet and Supplements for Endometriosis2017

    • Author(s)
      Yutaka Osuga
    • Organizer
      6 th Asian Congress of Endometriosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel immune mechanism in the development of endometriosis2017

    • Author(s)
      Yutaka Osuga
    • Organizer
      19th World Congress on In Vitro Fertilization in conjunction with VI. Society of Reproductive Medicine and Surgery Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Novel strategies for ART in patients with endometriosis, adenomyosis, and uterine fibroid.2017

    • Author(s)
      Yutaka Osuga
    • Organizer
      The 11th Congress of the Pacific Society for Reproductive Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Current problems in infertile women associated with endometriosis.2017

    • Author(s)
      Yutaka Osuga
    • Organizer
      7th Congress of the Asia Pacific Initiative on Reproduction
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Results from a phase 2 study of Relugolix, an oral gonadotropin-releasing hormone receptor antagonist, VS. placebo in women with endometriosis-associated pain.2017

    • Author(s)
      Yutaka Osuga
    • Organizer
      World Congress of Endometriosis 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Activated IL6-STAT3 pathway in adenomyosis2017

    • Author(s)
      Yasushi Hirota、Takehiro Hiraoka、Tomoko Saito-Fujita、Tomoyuki Fujii、Yutaka Osuga
    • Organizer
      World Congress of Endometriosis 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Uterine hypoxia inducible factor contributes to blastocyst invasion by clearance of luminal epithelium at the site of blastocyst attachment2017

    • Author(s)
      Yasushi Hirota, Tomoko Saito-Fujita, Leona Matsumoto, Hirofumi HaraguchiMitsunori Matsuo, Takehiro Hiraoka, Shun Akaeda, Tomoki Tanaka, Norihiko Takeda, Yutaka Osuga, Tomoyuki Fujii
    • Organizer
      Society for the Study of Reproduction, 50th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Medical and Surgical Treatment in Adenomyosis2017

    • Author(s)
      Yasushi Hirota
    • Organizer
      18th APAGE Annual Congress 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Remarks] 【プレスリリース】転写因子STAT3を介した子宮内膜の再構築と子宮の再生の仕組み

    • URL

      http://www.h.u-tokyo.ac.jp/vcms_lf/release_20160603-1.pdf

    • Related Report
      2018 Annual Research Report
  • [Remarks] 【プレスリリース】胚が子宮内膜に浸潤する着床のメカニズムを解明

    • URL

      http://www.h.u-tokyo.ac.jp/vcms_lf/release_20180619.pdf

    • Related Report
      2018 Annual Research Report
  • [Remarks] 【プレスリリース】子宮腺筋症と子宮内膜症併発に関連する遺伝子変異を発見―発症機構の解明に期待―

    • URL

      https://www.ncc.go.jp/jp/information/pr_release/2019/1219/20191219.pdf

    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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