Elucidation of interactions between cancer stem cells and their niche: Dual-targeted therapy in ovarian cancer patients
| Project/Area Number |
16H05473
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高石 清美 熊本大学, 医学部附属病院, 非常勤診療医師 (00601303)
本原 剛志 熊本大学, 大学院生命科学研究部(医), 助教 (10457591)
坂口 勲 熊本大学, 医学部附属病院, 講師 (40448527)
田代 浩徳 熊本大学, 大学院生命科学研究部(保), 教授 (70304996)
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| Research Collaborator |
Saito Fumitaka
Tsuboki Junko
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 卵巣癌 / 癌幹細胞 / 癌幹細胞ニッチ / マクロファージ / 卵巣表層上皮 / 卵巣癌治療 |
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| Outline of Final Research Achievements |
The tumor microenvironment represents a dynamic milieu that involves a complex network of interactions between cancer cells and various stromal components and plays a crucial role in cancer cell survival, proliferation, invasion, and metastasis. Considering the distinct biology of ovarian cancer, the elucidation of the cellular and molecular mechanisms underlying the reciprocal interplay between ovarian cancer stem cells and surrounding stromal cell types in the tumor microenvironment will provide further insights into the development of novel therapeutic approaches for patients with advanced ovarian cancer.
Our research group studied the biological mechanisms that regulate the highly orchestrated crosstalk between ovarian cancer stem cells and their niche in the tumor microenvironment.
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| Academic Significance and Societal Importance of the Research Achievements |
実際の臨床の現場での卵巣癌診療において、われわれがしばしば経験する治療抵抗性あるいは寛解後の再発・転移など、既存の抗癌剤治療に限界を感じることも少なくない。卵巣癌患者のさらなる予後改善のためには、癌幹細胞あるいは癌幹細胞ニッチを中心とした組織発生や病態進展に関わる分子生物学的機序に着眼点を切り替えて研究を進めることが重要である。難治性卵巣癌の克服のためには、“種子”としての卵巣癌幹細胞と、それに対応する“土壌”としての癌幹細胞ニッチを標的としたDual-targeted therapyの開発が極めて重要な役割を果たしていくことが考えられる。
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment.2019
Author(s)
Motohara T, Masuda K, Morotti M, Zheng Y, El-Sahhar S, Chong KY, Wietek N, Alsaadi A, Karaminejadranjbar M, Hu Z, Artibani M, Gonzalez LS, Katabuchi H, Saya H, Ahmed AA.
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Journal Title
Oncogene
Volume: 38
Issue: 16
Pages: 2885-2898
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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