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Elucidation of interactions between cancer stem cells and their niche: Dual-targeted therapy in ovarian cancer patients

Research Project

Project/Area Number 16H05473
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKumamoto University

Principal Investigator

Katabuchi Hidetaka  熊本大学, 大学院生命科学研究部(医), 教授 (90224451)

Co-Investigator(Kenkyū-buntansha) 高石 清美  熊本大学, 医学部附属病院, 非常勤診療医師 (00601303)
本原 剛志  熊本大学, 大学院生命科学研究部(医), 助教 (10457591)
坂口 勲  熊本大学, 医学部附属病院, 講師 (40448527)
田代 浩徳  熊本大学, 大学院生命科学研究部(保), 教授 (70304996)
Research Collaborator Saito Fumitaka  
Tsuboki Junko  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords卵巣癌 / 癌幹細胞 / 癌幹細胞ニッチ / マクロファージ / 卵巣表層上皮 / 卵巣癌治療
Outline of Final Research Achievements

The tumor microenvironment represents a dynamic milieu that involves a complex network of interactions between cancer cells and various stromal components and plays a crucial role in cancer cell survival, proliferation, invasion, and metastasis. Considering the distinct biology of ovarian cancer, the elucidation of the cellular and molecular mechanisms underlying the reciprocal interplay between ovarian cancer stem cells and surrounding stromal cell types in the tumor microenvironment will provide further insights into the development of novel therapeutic approaches for patients with advanced ovarian cancer.
Our research group studied the biological mechanisms that regulate the highly orchestrated crosstalk between ovarian cancer stem cells and their niche in the tumor microenvironment.

Academic Significance and Societal Importance of the Research Achievements

実際の臨床の現場での卵巣癌診療において、われわれがしばしば経験する治療抵抗性あるいは寛解後の再発・転移など、既存の抗癌剤治療に限界を感じることも少なくない。卵巣癌患者のさらなる予後改善のためには、癌幹細胞あるいは癌幹細胞ニッチを中心とした組織発生や病態進展に関わる分子生物学的機序に着眼点を切り替えて研究を進めることが重要である。難治性卵巣癌の克服のためには、“種子”としての卵巣癌幹細胞と、それに対応する“土壌”としての癌幹細胞ニッチを標的としたDual-targeted therapyの開発が極めて重要な役割を果たしていくことが考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (19 results)

All 2019 2018 2017 2016

All Journal Article (7 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 7 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 1 results,  Invited: 8 results) Book (3 results)

  • [Journal Article] An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment.2019

    • Author(s)
      Motohara T, Masuda K, Morotti M, Zheng Y, El-Sahhar S, Chong KY, Wietek N, Alsaadi A, Karaminejadranjbar M, Hu Z, Artibani M, Gonzalez LS, Katabuchi H, Saya H, Ahmed AA.
    • Journal Title

      Oncogene

      Volume: 38 Issue: 16 Pages: 2885-2898

    • DOI

      10.1038/s41388-018-0637-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel therapeutic strategies for advanced ovarian cancer by using induced pluripotent stem cell-derived myelomonocytic cells producing interferon beta2018

    • Author(s)
      Imamura Yuko、Tashiro Hironori、Tsend-Ayush Gandolgor、Haruta Miwa、Dashdemberel Narantuya、Komohara Yoshihiro、Tsuboki Junko、Takaishi Kiyomi、Ohba Takashi、Nishimura Yasuharu、Katabuchi Hidetaka、Senju Satoru
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 11 Pages: 3403-3410

    • DOI

      10.1111/cas.13775

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum Prolactin Contributes to Enhancing Prolactin Receptor and pJAK2 in Type I Endometrial Cancer Cells in Young Women Without Insulin Resistance.2018

    • Author(s)
      Erdenebaatar C, Yamaguchi M, Monsur M, Saito F, Honda R, Tashiro H, Ohba T, Iyama KI, Katabuchi H.
    • Journal Title

      International Journal of Gynecological Pathology

      Volume: 印刷中 Issue: 4 Pages: 318-325

    • DOI

      10.1097/pgp.0000000000000527

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Radical resection of an endometrioid carcinoma arising from endometriosis in the round ligament within the right canal of Nuck: a case report and literature review.2018

    • Author(s)
      Motooka Y, Motohara T, Honda R, Tashiro H, Mikami Y, Katabuchi H.
    • Journal Title

      Gynecologic Oncology Reports

      Volume: 24 Pages: 61-64

    • DOI

      10.1016/j.gore.2018.01.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Administration of Cabergoline Contributes to Preserving Fertility in Young Hyperprolactinemic Patients With Endometrial Cancer Treated With Medroxyprogesterone Acetate.2018

    • Author(s)
      Erdenebaatar C, Yamaguchi M, Saito F, Monsur M, Honda R, Tashiro H, Ohba T, Katabuchi H
    • Journal Title

      International journal of gynecological cancer

      Volume: 2018 Issue: 3 Pages: 539-544

    • DOI

      10.1097/igc.0000000000001196

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer.2017

    • Author(s)
      Tayama S, Motohara T, Narantuya D, Li C, Fujimoto K, Sakaguchi I, Tashiro H, Saya H, Nagano O, Katabuchi H
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 27 Pages: 44312-44325

    • DOI

      10.18632/oncotarget.17871

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CD44 Variant 6 as a Predictive Biomarker for Distant Metastasis in Patients With Epithelial Ovarian Cancer.2016

    • Author(s)
      Motohara T, Fujimoto K, Tayama S, Narantuya D, Sakaguchi I, Tashiro H, Katabuchi H.
    • Journal Title

      Obstet Gynecol.

      Volume: 127 Issue: 6 Pages: 1003-11

    • DOI

      10.1097/aog.0000000000001420

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] What we have learned from neoadjuvant chemotherapy for epithelial ovarian cancer: cancer stem cells and their niche as its therapeutic targets2018

    • Author(s)
      Hidetaka Katabuchi
    • Organizer
      The 20th Seminar of Standardized Treatment and Progress of Gynecologic Cancers & Symposium of Precision Medicine in Gynecological Oncology
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 卵巣癌治療シーズの探索 考える臨床、科学的な病理2018

    • Author(s)
      片渕秀隆
    • Organizer
      第10回関西婦人科腫瘍・病理懇話会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 卵巣癌を管窺する2018:OSEとSTICの間で揺れる卵巣癌2018

    • Author(s)
      片渕秀隆
    • Organizer
      熊本産科婦人科学会第228回学術講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Treatment of epithelial ovarian cancer: Looking from he JSGO guideline Version 2015 toward next-generation strategies2018

    • Author(s)
      Hidetaka Katabuchi
    • Organizer
      The Shandong Gynecologic Oncology Forum 2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 卵巣癌研究の符丁2017

    • Author(s)
      片渕秀隆
    • Organizer
      平成29年度医歯薬学班 研究発表
    • Related Report
      2017 Annual Research Report
  • [Presentation] Treatment of epithelial ovarian cancer: Looking from the JSGO guideline version 2015 toward next-generation strategies2017

    • Author(s)
      片渕秀隆
    • Organizer
      24th Asia Pacific Cancer Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] OSEとSTICの間で揺れる卵巣癌2017

    • Author(s)
      片渕秀隆
    • Organizer
      第48回日本婦人科病理学会学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 顕微鏡のレンズの向こう側2017

    • Author(s)
      片渕秀隆
    • Organizer
      第59回日本婦人科腫瘍学会学術講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 変化する卵巣癌の概念とその治療2017

    • Author(s)
      片渕秀隆
    • Organizer
      第29回つきじ放射線研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Book] Emerging role of CD44 variant 6 in driving the metastatic journey of ovarian cancer stem cells. Cell Biology of the Ovary.2018

    • Author(s)
      Motohara T, Katabuchi H
    • Total Pages
      166
    • Publisher
      Springer
    • ISBN
      9789811079405
    • Related Report
      2018 Annual Research Report
  • [Book] Molecular targeted therapy for epithelial ovarian cancer. Cell Biology of the Ovary.2018

    • Author(s)
      Tashiro H, Katabuchi H.
    • Total Pages
      166
    • Publisher
      Springer
    • ISBN
      9789811079405
    • Related Report
      2018 Annual Research Report
  • [Book] Frontiers in Ovarian Cancer Science2017

    • Author(s)
      片渕秀隆
    • Total Pages
      441
    • Publisher
      Springer
    • ISBN
      9789811041594
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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