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Establishment of a novel infertility treatment based on the technology of follicle activation

Research Project

Project/Area Number 16H05476
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionInternational University of Health and Welfare (2017-2019)
St. Marianna University School of Medicine (2016)

Principal Investigator

Kawamura Kazuhiro  国際医療福祉大学, 医学部, 教授 (10344756)

Co-Investigator(Kenkyū-buntansha) 佐藤 可野  国際医療福祉大学, 医学部, 助教 (00511073)
川島 一公  国際医療福祉大学, 医学部, 研究員 (40633946)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords卵胞 / 卵巣機能不全 / 早発閉経 / 生殖医学 / 不妊治療 / 卵胞活性化
Outline of Final Research Achievements

We have developed in vitro activation (IVA) treatment for patients with premature ovarian insufficiency and succeeded their pregnancies and deliveries by clinical application of IVA. To improve the clinical outcome of current IVA treatment and develop new treatment to expand susceptible diseases for IVA, we conducted 1) identification of new serum marker which reflect residual follicle numbers and development of its measurement system, 2) improvement of survival of grafted ovarian tissue, 3) development of cannula for ovarian tissue grafting, and 4) development of new IVA with suppression of Hippo signaling only.

Academic Significance and Societal Importance of the Research Achievements

IVAの臨床成績の向上とHippoシグナル抑制による新たなIVAの開発は、早発閉経や高齢の卵巣機能不全患者が自らの卵子での妊娠を可能とするパラダイムシフトとなる。さらに、本法は早発閉経まで至っていない若年の卵巣機能不全患者やFSH刺激に低反応の患者の不妊治療にも応用が可能と考えられる。また、これらの患者に妊娠の機会を与えることは、本邦の少子化対策、医療費削減など社会的にも非常に意義が高いと考えられる。また、詳細な卵巣機能の評価を可能とする血清マーカーの同定と測定系の開発は、本法の適応患者の選定のみならず、卵巣機能低下症例の閉経予測や不妊治療計画の策定にも有用となる。

Report

(4 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (118 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (4 results) Journal Article (33 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 11 results,  Open Access: 10 results,  Acknowledgement Compliant: 2 results) Presentation (66 results) (of which Int'l Joint Research: 54 results,  Invited: 61 results) Book (14 results) Remarks (1 results)

  • [Int'l Joint Research] Instituto Mexicano de Infertilidad (IMI)(メキシコ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Hacettepe University School of Medicine(トルコ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Medical Center Macierzynstwo(ポーランド)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] KK Women’s and Children’s Hospital(シンガポール)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Drug-free in-vitro activation of follicles for infertility treatment in poor ovarian response patients with decreased ovarian reserve2020

    • Author(s)
      Kawamura Kazuhiro、Ishizuka Bunpei、Hsueh Aaron J.W.
    • Journal Title

      Reproductive BioMedicine Online

      Volume: 40 Issue: 2 Pages: 245-253

    • DOI

      10.1016/j.rbmo.2019.09.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapamycin treatment maintains developmental potential of oocytes in mice and follicle reserve in human cortical fragments grafted into immune-deficient mice2020

    • Author(s)
      Yorino Sato, Kawamura K
    • Journal Title

      Mol Cell Endocrinol

      Volume: 504 Pages: 110694-110694

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinctive subpopulations of the intestinal microbiota are present in women with unexplained chronic anovulation.2019

    • Author(s)
      Sasaki H, Kawamura K, Kawamura T, Odamaki T, Katsumata N, Xiao JZ, Suzuki N, Tanaka M.
    • Journal Title

      Reprod Biomed Online.

      Volume: 38 Issue: 4 Pages: 570-578

    • DOI

      10.1016/j.rbmo.2018.12.026

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased effector regulatory T cells and increased activated CD4 + T cells in premature ovarian insufficiency2019

    • Author(s)
      Kobayashi Mutsumi、Nakashima Akitoshi、Yoshino Osamu、Yoshie Masanori、Ushijima Akemi、Ito Masami、Ono Yosuke、Shima Tomoko、Kawamura Kazuhiro、Ishizuka Bunpei、Saito Shigeru
    • Journal Title

      American Journal of Reproductive Immunology

      Volume: 81 Issue: 6 Pages: 13125-13125

    • DOI

      10.1111/aji.13125

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 卵胞活性化による新しい不妊治療2019

    • Author(s)
      河村和弘・河村七美
    • Journal Title

      月刊細胞

      Volume: Vol.51 No.5 Pages: 17-20

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 卵胞の活性化2019

    • Author(s)
      河村和弘・河村七美
    • Journal Title

      HORMONE FRONTIER IN GYNECOLOGY

      Volume: Vol. 26 No.2

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 不妊治療におけるプレシジョンメディシンの展開2019

    • Author(s)
      河村和弘
    • Journal Title

      Precision Medecine

      Volume: Vol.2 No.14

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Regulation of follicle growth through hormonal factors and mechanical cues mediated by Hippo signaling pathway.2018

    • Author(s)
      Kawashima I, Kawamura K.
    • Journal Title

      Syst Biol Reprod Med.

      Volume: 64 Issue: 1 Pages: 3-11

    • DOI

      10.1080/19396368.2017.1411990

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 卵胞発育2018

    • Author(s)
      河村和弘
    • Journal Title

      HORMONE FRONTIER IN GYNECOLOGY

      Volume: 25 Pages: 11-15

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Determination of Follicular Localization in Human Ovarian Cortex for Vitrification2018

    • Author(s)
      Haino Takayuki、Tarumi Wataru、Kawamura Kazuhiro、Harada Tohru、Sugimoto Kouhei、Okamoto Aikou、Ikegami Masahiro、Suzuki Nao
    • Journal Title

      J Adolesc Young Adult Oncol

      Volume: 7 Issue: 1 Pages: 46-53

    • DOI

      10.1089/jayao.2017.0028

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterosis extends the reproductive ability in aged female mice†2018

    • Author(s)
      Ozawa Yusuke、Watanabe Kenji、Toda Toshihiko、Shibuya Shuichi、Okumura Nobuaki、Okamoto Naoki、Sato Yorino、Kawashima Ikko、Kawamura Kazuhiro、Shimizu Takahiko
    • Journal Title

      Biology of Reproduction

      Volume: 100 Issue: 4 Pages: 1082-1089

    • DOI

      10.1093/biolre/ioy260

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 早発卵巣不全 卵胞活性化療法―腹腔鏡下卵巣組織移植術―2018

    • Author(s)
      河村和弘、河村七美
    • Journal Title

      産婦人科の実際

      Volume: 67 Pages: 405-409

    • Related Report
      2016 Annual Research Report
  • [Journal Article] isorganization of the germ cell pool leads to primary ovarian insufficiency.2017

    • Author(s)
      Kawashima I, Kawamura K
    • Journal Title

      Reproduction

      Volume: 印刷中 Issue: 6 Pages: R205-R213

    • DOI

      10.1530/rep-17-0015

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 早発閉経に対する新たな不妊治療「卵胞活性化療法」の開発と臨床応用2017

    • Author(s)
      河村和弘
    • Journal Title

      公益財団法人 山口内分泌疾患研究振興財団 内分泌に関する最新情報

      Volume: non

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 卵巣機能不全の新たな治療法の開発:卵胞活性化療法(IVA:in vitro activation)~   卵子再生2017

    • Author(s)
      河村和弘
    • Journal Title

      日本産科婦人科学会雑誌

      Volume: 69 Pages: 2233-2240

    • Related Report
      2017 Annual Research Report
  • [Journal Article] グラビア・目で見る遺伝子異常と婦人科内分泌疾患―早発卵巣不全―2017

    • Author(s)
      河村和弘・佐藤可野・鈴木直
    • Journal Title

      HORMONE FRONTIER IN GYNECOLOGY

      Volume: 24 Pages: 4-7

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 早発卵巣不全に対する低侵襲な不妊治療法の確立を目指した Hippo シグナル抑制剤による新たな卵胞発育誘導法の開発2017

    • Author(s)
      川越雄太・河村和弘・Aaron JW Hsueh
    • Journal Title

      日本受精着床学会雑誌

      Volume: 34 Pages: 1-4

    • Related Report
      2017 Annual Research Report
  • [Journal Article] POIの治療,薬物療法とIVAは?2017

    • Author(s)
      河村和弘・河村七美
    • Journal Title

      産婦人科の実際

      Volume: 69 Pages: 1537-1543

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 喫煙と早発卵巣不全の関連性に関するアンケート調査2017

    • Author(s)
      川越雄太、佐藤可野、河村和弘
    • Journal Title

      日本受精着床学会雑誌

      Volume: 34 Pages: 247-250

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Infertility Treatment in Primary Ovarian Insufficiency: Fertility Preservation and?In Vitro?Activation2017

    • Author(s)
      Yorino Sato, Nanami Kawamura, Kazuhiro Kawamura
    • Journal Title

      Journal of Gynecology and Womens Health

      Volume: 7 Issue: 1 Pages: 1-4

    • DOI

      10.19080/jgwh.2017.07.555704

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 卵巣機能不全の新たな不妊治療法の開発:卵胞活性化療法(IVA:in vitro activation)~卵子再生2017

    • Author(s)
      河村和弘
    • Journal Title

      日本産科婦人科学会雑誌

      Volume: 69 Pages: 2233-2240

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 目で見る遺伝子異常と婦人科内分泌疾患―早発卵巣不全―2017

    • Author(s)
      河村和弘
    • Journal Title

      Hormone Frontier in Gynecology

      Volume: 24 Pages: 4-7

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 卵巣性無月経の診断と対応2017

    • Author(s)
      河村和弘、河村七美
    • Journal Title

      ホルモンと臨床

      Volume: 63 Pages: 463-467

    • Related Report
      2016 Annual Research Report
  • [Journal Article] POIの治療、薬物療法とIVAは?2017

    • Author(s)
      河村和弘、河村七美
    • Journal Title

      産婦人科の実際

      Volume: 66 Pages: 1537-1543

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 妊娠成立過程における最新のトピックス 排卵2017

    • Author(s)
      河村和弘
    • Journal Title

      Hormone Frontier in Gynecology

      Volume: 25 Pages: 11-15

    • Related Report
      2016 Annual Research Report
  • [Journal Article] In Vitro Activation of Follicles and Fresh Tissue Auto-transplantation in Primary Ovarian Insufficiency Patients.2016

    • Author(s)
      Zhai J, Yao G, Dong F, Bu Z, Cheng Y, Sato Y, Hu L, Zhang Y, Wang J, Dai S, Li J, Sun J, Hsueh AJ, Kawamura K, Sun Y
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 101 Issue: 11 Pages: 4405-4412

    • DOI

      10.1210/jc.2016-1589

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Activation of dormant follicles: a new treatment for premature ovarian failure?2016

    • Author(s)
      Kawamura K, Kawamura Nanami, Hsueh AJ
    • Journal Title

      Curr Opin Obstet Gynecol

      Volume: in press Issue: 3 Pages: 217-222

    • DOI

      10.1097/gco.0000000000000268

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 早発卵巣不全(早発閉経)の新たな不妊治療2016

    • Author(s)
      河村和弘
    • Journal Title

      日本医師会雑誌

      Volume: 144 Pages: 2096-2097

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 卵胞活性化療法2016

    • Author(s)
      河村和弘
    • Journal Title

      Hormone Frontier in Gynecology

      Volume: 23 Pages: 63-67

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 早発閉経の治療2016

    • Author(s)
      河村和弘
    • Journal Title

      産科と婦人科

      Volume: 83 Pages: 1184-1189

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 早発閉経2016

    • Author(s)
      河村和弘
    • Journal Title

      臨床 婦人科産科

      Volume: 70 Pages: 1137-1142

    • Related Report
      2016 Annual Research Report
  • [Journal Article] がん治療後の卵巣機能不全と妊娠2016

    • Author(s)
      河村和弘
    • Journal Title

      日本産科婦人科学会雑誌

      Volume: 68 Pages: 3029-3033

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 卵胞発育を理解するー知っておくべき基礎知識(卵胞発育異常の病態と治療) 早発閉経2016

    • Author(s)
      河村和弘
    • Journal Title

      臨床婦人科産科

      Volume: 70 Pages: 1137-1142

    • Related Report
      2016 Annual Research Report
  • [Presentation] Drug Free In-vitro Activation for Diminished Ovarian Reserve in State of the Art in 2020 of In Vitro Activation2020

    • Author(s)
      Kawamura K
    • Organizer
      8th ASPIRE Masterclass
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Drug-free in vitro activation for diminished ovarian reserve2020

    • Author(s)
      Kawamura K
    • Organizer
      The 5 th symposium of MFI
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Disinctive subpopulations of the intestinal microbiota are present in women with unexplained chronic novulation2019

    • Author(s)
      Sasaki H, Kawamura K,Jinno Y, Kobanawa M,Nakagawa R,Iwai M,Kamijo S,Yamada M,Hamatani T,Suzuki N,Tanaka M,Aoki D
    • Organizer
      第71回日本産科婦人科学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Precongress course of 8th International Congress of the Jordanian Society for Fertility2019

    • Author(s)
      Kawamura K
    • Organizer
      8th International PreCongress of the Jordanian Society for Fertility
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In Vitro activation : Development of novel infertility treatment for ovarian dysfunction"2019

    • Author(s)
      Kawamura K
    • Organizer
      8th International Congress of the Jordanian Society for Fertility
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of smoking in infertile women with ovarian dysfunction2019

    • Author(s)
      Kawamura K
    • Organizer
      8th International Congress of the Jordanian Society for Fertility
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IVA: What is New?2019

    • Author(s)
      Kawamura K
    • Organizer
      The 9th Congress of the Asia Pacific Initiative on Reproduction
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In vitro activation : new infertility treatments in patients with Primary Ovarian Insufficiency (POI)2019

    • Author(s)
      Kawamura K
    • Organizer
      Scientific and practical conference : New ever news in Reproductive Technology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In vitro activation for infertility treatment of ovarian2019

    • Author(s)
      Kawamura K
    • Organizer
      the XXXII International Congress with Endoscopic Course
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Ovarian Activation as Treatment of Premature Ovarian Failure2019

    • Author(s)
      Kawamura K
    • Organizer
      The 2019 Midwest Reproductive Symposium international
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 加齢による卵巣機能不全の早期診断・治療のための新たなバイオマーカー2019

    • Author(s)
      河村和弘
    • Organizer
      第19回日本抗加齢医学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Development of In vitro activation (IVA) as a treatment for premature ovarian insufficiency Drug-free IVA as a new treatment for ovarian dysfunction2019

    • Author(s)
      Kawamura K
    • Organizer
      XVII Conference of Armenian Society for Reproductive Medicine
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In-vitro Activation of Follicles in Reduced Ovarian Reserve2019

    • Author(s)
      Kawamura K
    • Organizer
      27th International Congress of the Obstetrical & Gynaecological Society of Malaysia
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Options in Reduced Ovarian Reserve; What Works and What Doesn’t?2019

    • Author(s)
      Kawamura K
    • Organizer
      27th International Congress of the Obstetrical & Gynaecological Society of Malaysia
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In Vitro Activation: New Infertility Treatments in Patients with Primary Ovarian Insufficiency2019

    • Author(s)
      Kawamura K
    • Organizer
      XXIX ежегодной международной
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In vitro activation for treatment of ovarian dysfunction, current and future2019

    • Author(s)
      Kawamura K
    • Organizer
      "XXIX ежегодной международной
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Children after in vitro activation of ovarian follicles2019

    • Author(s)
      Kawamura K
    • Organizer
      NOVELTIES IN THE IN VITRO FERTILIZATION LAB: WHERE WE ARE AND WHERE
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A challenge for in vitro follicle development in human2019

    • Author(s)
      Kawamura K
    • Organizer
      DIPARTIMENTO DI BIOLOGIA Università degli Studi di NAPOLI Federico II
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In vitro activation (IVA) for treatment of ovarian dysfunction: Current and Future2019

    • Author(s)
      Kawamura K
    • Organizer
      Nankai China-Japan Gynecology Specialist Workshop 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In vitro activation for primary ovarian insuffiency2018

    • Author(s)
      Kawamura K
    • Organizer
      Updates in Infertility Treatment Madrid2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 卵巣機能不全の新たな治療戦略-予知、予防、治療-2018

    • Author(s)
      河村和弘
    • Organizer
      厚木市産婦人科医会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] IVA as a new hope for infertility treatment in POI Patients2018

    • Author(s)
      Kawamura K
    • Organizer
      IMI Mexico congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A Wake-up call fir resting follicles2018

    • Author(s)
      Kawamura K
    • Organizer
      39th Belgian Society for Reproductive Medicine Scientific Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IVA as a new hope for infertility treatment in POI Patients.2018

    • Author(s)
      Kawamura K
    • Organizer
      IMI Mexico congress
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In vitro activation for primary ovarian insufficiency.2018

    • Author(s)
      Kawamura K
    • Organizer
      Update In Infertility Treatment 2018
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 早発閉経の不妊治療戦略2017

    • Author(s)
      河村和弘
    • Organizer
      第74回九州・沖縄生殖医学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 卵巣機能不全の新たな不妊治療法の開発:卵胞活性化療法(IVA:in vitro activation)~卵子再生2017

    • Author(s)
      河村和弘
    • Organizer
      第69回日本産科婦人科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] In vitro activation: A novel approach to treat infertility2017

    • Author(s)
      Kawamura K
    • Organizer
      International Congress on CINTEMPORARY and FUTURE PERSPECTIVES In PERSONARIZED REPRODUCTIVE MEDICINE & CARE
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Video demonstrations ad patients’ follow up protocols2017

    • Author(s)
      Kawamura K
    • Organizer
      7th International IVI Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IVA as infertility therapy for patients with primary ovarian insufficiency: in vitro drug treatment and two-step surgery2017

    • Author(s)
      Kawamura K
    • Organizer
      7th International IVI Congress
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 超音波からわかる卵巣機能不全2017

    • Author(s)
      河村和弘
    • Organizer
      日本超音波医学会第90回学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 卵巣機能不全に対する新たな不妊治療「卵胞活性化療法」の開発2017

    • Author(s)
      河村和弘
    • Organizer
      公益財団法人 神澤医学研究振興財団 第19回講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Infertility Treatment Through In Vitro Activation of Follicles2017

    • Author(s)
      Kawamura K
    • Organizer
      Gordon Research Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Improving ovarian response through ovarian tissue activation2017

    • Author(s)
      Kawamura K
    • Organizer
      European Society of Human Reproduction and Embryology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Update of In Vitro Activation treatment for patients with primary ovarian insufficiency2017

    • Author(s)
      Kawamura K
    • Organizer
      European Society of Human Reproduction and Embryology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 喫煙と早発卵巣機能不全:喫煙は早発卵巣機能不全の発症因子、増悪因子となりうるか2017

    • Author(s)
      河村和弘、佐藤可野
    • Organizer
      第32回 平成28年度助成研究発表会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Regeneration of ovarian follicle growth in patients with primary ovarian insufficiency:from bench to clinical practice2017

    • Author(s)
      Kawamura K
    • Organizer
      The International Research Symposium on Regulation of Germ Cell Development in vivo and in vitro
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In vitro activation in IVF2017

    • Author(s)
      Kawamura K
    • Organizer
      ART FOCUS assisted reproductive technology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 基礎研究から臨床応用へ:卵胞活性化療法の開発2017

    • Author(s)
      河村和弘
    • Organizer
      東京医科歯科大学 大学院特別講義
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] IVA(in vitro activation)の臨床応用2017

    • Author(s)
      河村和弘
    • Organizer
      第20回日本IVF学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] In Vitro Activation: A New Infertility Treatment for Patients with Primary Ovarian Insufficiency (POI)2017

    • Author(s)
      Kawamura K
    • Organizer
      ART World Congless2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hippoシグナル抑制によるDORの治療戦略2017

    • Author(s)
      河村和弘
    • Organizer
      第62回日本生殖医学会学術講演会・総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Ovarian factors in IVM2017

    • Author(s)
      河村和弘
    • Organizer
      第62回日本生殖医学会学術講演会・総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] IVA (in vitro activation) As a new Hope for Infertility Treatment in POI Patients2017

    • Author(s)
      Kawamura K
    • Organizer
      Innovations in the World of IVF Treatments
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Laboratory and Clinical Tips for IVA Collaborations2017

    • Author(s)
      Kawamura K,Okamoto N
    • Organizer
      Innovations in the World of IVF Treatments
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IN VITRO ACTIVATION OF OVARIAN TISSUE FROM THEORY TO PRACTICE2017

    • Author(s)
      Kawamura K
    • Organizer
      International Conference MODERN REPRODUCTOLOGY: FROM SCIENTIFIC OPENINGS TO PRACTICE IMPLEMENTATION
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Clinical Management of POI and the Role of in Vitro Activation2017

    • Author(s)
      Kawamura K
    • Organizer
      3rd Jakarta Infertility Update 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Clinical Management of POI and the role of in vitro activation.2017

    • Author(s)
      Kawamura K
    • Organizer
      3rd Jakarta Infertility Update 2017
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In Vitro Activation of ovarian tissue-from theory to practice.2017

    • Author(s)
      Kawamura K
    • Organizer
      International Conference Modern Reproductology: from Scientific Openings to Practice Implemention
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IVA (In Vitro Activation) as a new hope for infertility treatment in POI Patients.2017

    • Author(s)
      Kawamura K
    • Organizer
      Innovations in the World of IVF treatments
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] n Vitro Activation: A New Infertility Treatment for Patients with Primary Ovarian Insufficiency (POI)2017

    • Author(s)
      Kawamura K
    • Organizer
      2017 ART World Congress
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In vitro activation in IVF2017

    • Author(s)
      Kawamura K
    • Organizer
      ART Focus 2017
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of ovarian follicle growth in patients with primary ovarian insufficiency: from bench to clinical practice2017

    • Author(s)
      Kawamura K
    • Organizer
      The International Research Symposium on Regulation of Germ Cell Development in vivo and in vitro
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Update of in vitro activation treatment for patients with primary ovarian insufficiency.2017

    • Author(s)
      Kawamura K
    • Organizer
      The 33rd Annual Meeting of ESHRE
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Improving ovarian response through ovarian tissue activation.2017

    • Author(s)
      Kawamura K
    • Organizer
      The 33rd Annual Meeting of ESHRE
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Infertility treatment through in vitro activation of follicles.2017

    • Author(s)
      Kawamura K
    • Organizer
      Gordon Research Conference
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Video demonstration and patients’ follow up protocols.2017

    • Author(s)
      Kawamura K
    • Organizer
      The 7th International IVI Congress-Reproductive Medicine and Beyond
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IVA as infertility therapy for patients with primary ovarian insufficiency: in vitro drug treatment and two-step surgery.2017

    • Author(s)
      Kawamura K
    • Organizer
      The 7th International IVI Congress-Reproductive Medicine and Beyond
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In vitro activation: A novel approach to treat infertility.2017

    • Author(s)
      Kawamura K
    • Organizer
      II nd International EXPERMED congress
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IVA as a new infertility treatments of patients wit POI.2017

    • Author(s)
      Kawamura K
    • Organizer
      The 29th conference of the Korean Society for Assisted Reproduction
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Establishment of Novel Infertility Treatment for Patients with Primary Ovarian Insufficiency: In Vitro Activation [IVA].2017

    • Author(s)
      Kawamura K
    • Organizer
      Upper Egypt Assisted Reproductive Conference
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In vitro follicle activation.2016

    • Author(s)
      Kawamura K
    • Organizer
      Turkish Society Reproductive Medicine Congress 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New fertility treatments (IVA) In vitro activation: A new infertility treatment for patients with primary ovarian insufficiency (POI).2016

    • Author(s)
      Kawamura K
    • Organizer
      Ovarian Club VIII
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] PI3K regulation of dormant follicle activation.2016

    • Author(s)
      Kawamura K
    • Organizer
      Annual Conference 2016 Society for Reproduction and Fertility
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Fertility preservation in patients with primary ovarian insufficiency.2016

    • Author(s)
      Kawamura K
    • Organizer
      The XII th Scientific Meeting of the GRECOT
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] New infertility treatments (IVA: in vitro activation) of patients with primary ovarian insufficiency (POI).2016

    • Author(s)
      Kawamura K
    • Organizer
      The XI th Turkish German Gynecologic Congress
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] Textbook of Oncofertility Research and Practice2019

    • Author(s)
      Iwahata H, Takae S, Kawamura K, Suzuki N
    • Total Pages
      4
    • Publisher
      Springer
    • ISBN
      9783030028671
    • Related Report
      2018 Annual Research Report
  • [Book] 今すぐ知りたい! 不妊治療Q&A2019

    • Author(s)
      河村和弘
    • Total Pages
      2
    • Publisher
      医学書院
    • ISBN
      9784260038263
    • Related Report
      2018 Annual Research Report
  • [Book] 産科婦人科臨床 生殖生理2019

    • Author(s)
      河村和弘
    • Total Pages
      10
    • Publisher
      中山書店
    • ISBN
      9784521747613
    • Related Report
      2018 Annual Research Report
  • [Book] 不妊症・不育症診療 : その伝承とエビデンス2019

    • Author(s)
      河村和弘
    • Total Pages
      7
    • Publisher
      中外医学社
    • ISBN
      9784498160002
    • Related Report
      2018 Annual Research Report
  • [Book] 女性内分泌クリニカルクエスチョン902017

    • Author(s)
      河村和弘
    • Total Pages
      6
    • Publisher
      診断と治療社
    • Related Report
      2017 Annual Research Report
  • [Book] 先端医療シリーズ48 臨床医のための最新産科婦人科2017

    • Author(s)
      河村和弘・鈴木直
    • Total Pages
      4
    • Publisher
      先端医療技術研究所
    • Related Report
      2017 Annual Research Report
  • [Book] 産婦人科の実際 ガイドラインの隙間を埋める!臨床医マエストロの技2017

    • Author(s)
      河村和弘・河村七美
    • Total Pages
      7
    • Publisher
      金原出版株式会社
    • Related Report
      2017 Annual Research Report
  • [Book] 女性内分泌クリニカルクエスチョン90, Q37 卵巣機能不全に影響する抗がん剤はどのようなものがある?2017

    • Author(s)
      河村和弘、河村七美
    • Total Pages
      3
    • Publisher
      中外医学社
    • Related Report
      2016 Annual Research Report
  • [Book] 女性内分泌クリニカルクエスチョン90, Q38 POIに対する排卵誘発法を成功させるには2017

    • Author(s)
      河村和弘、河村七美
    • Total Pages
      3
    • Publisher
      中外医学社
    • Related Report
      2016 Annual Research Report
  • [Book] がん治療後の卵巣機能不全の不妊治療2017

    • Author(s)
      河村和弘、鈴木直
    • Total Pages
      4
    • Publisher
      先端医療技術研究所
    • Related Report
      2016 Annual Research Report
  • [Book] ガイドラインのすき間を埋める!臨床マエストロの技, GQ29 POIの治療、薬物療法とIVAは?2017

    • Author(s)
      河村和弘
    • Total Pages
      7
    • Publisher
      金原出版株式会社
    • Related Report
      2016 Annual Research Report
  • [Book] 基礎からわかる女性内分泌 (早発卵巣不全の病態と診断)2016

    • Author(s)
      河村和弘
    • Total Pages
      3
    • Publisher
      診断と治療社
    • Related Report
      2016 Annual Research Report
  • [Book] 基礎からわかる女性内分泌 (早発卵巣不全の治療)2016

    • Author(s)
      河村和弘
    • Total Pages
      3
    • Publisher
      診断と治療社
    • Related Report
      2016 Annual Research Report
  • [Book] 不妊・不育診療指針The perfect Guide for Infertility, 早発卵巣不全(POI)2016

    • Author(s)
      河村和弘
    • Total Pages
      5
    • Publisher
      中外医学社
    • Related Report
      2016 Annual Research Report
  • [Remarks] IVA Fertility

    • URL

      http://www.ivafertility.com/IVA/index.html

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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