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Development of new drugs targeting receptor-associated protein system for ocular disorders

Research Project

Project/Area Number 16H05484
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionHokkaido University

Principal Investigator

Ishida Susumu  北海道大学, 医学研究院, 教授 (10245558)

Co-Investigator(Kenkyū-buntansha) 周東 智  北海道大学, 薬学研究院, 教授 (70241346)
神田 敦宏  北海道大学, 医学研究院, 特任講師 (80342707)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords受容体結合プロレニン系 / (プロ)レニン受容体 / レニン・アンジオテンシン系 / 血管新生 / 網脈絡膜疾患 / 受容体結合プロレニン / (プロ)レニン受容体
Outline of Final Research Achievements

The renin-angiotensin system (RAS) plays pivotal roles in homeostasis, but its abnormal activation has been proposed as a risk factor for several disorders including diabetes. Using animal models, we previously clarified the molecular mechanisms in which tissue RAS stimulates retinal angiogenesis and the critical roles of (pro)renin receptor [(P)RR] in retinal RAS activation and its concurrent intracellular signal transduction, i.e., the receptor-associated prorenin system (RAPS). RAPS is involved in the pathogenesis of several ocular disorders. However, its physiological functions remain unclear. The goal of this study is to develop a novel agent which can inhibit (P)RR functions, and determine its safety and efficacy in vitro and in vivo.

Academic Significance and Societal Importance of the Research Achievements

(プロ)レニン受容体は、網膜疾患のみならず腎臓や心血管系など生活習慣病の標的臓器の炎症病態にも関与することが明らかとなり、生活習慣病における臓器保護のための共通の創薬ターゲット分子としても注目されている。本研究計画により、眼科創薬が起点となって幅広い分野の研究が活性化され、我が国の医療水準の向上に貢献することが期待される。さらに、RAPSの阻害薬は予防医療的な介入戦略でもあるため、合併症が進行してから受ける費用の嵩む外科的治療や抗VEGF療法の減少につながることが予想され、医療費の削減から医療経済的にも有益と考えられる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (54 results)

All 2019 2018 2017 2016

All Journal Article (23 results) (of which Peer Reviewed: 20 results,  Open Access: 17 results,  Acknowledgement Compliant: 3 results) Presentation (29 results) (of which Int'l Joint Research: 10 results,  Invited: 14 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Increased plasma galectin-1 correlates with advanced glycation end products and interleukin-1 β in patients with proliferative diabetic retinopathy2019

    • Author(s)
      Hase K, Kanda A, Noda K, Ishida S
    • Journal Title

      International Journal of Ophthalmology

      Volume: 12 Issue: 4 Pages: 692-694

    • DOI

      10.18240/ijo.2019.04.28

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glucocorticoid receptor inhibits Muller glial galectin‐1 expression via DUSP1‐dependent and ‐independent deactivation of AP‐1 signalling2019

    • Author(s)
      Hirose Ikuyo, Kanda Atsuhiro, Noda Kousuke, Ishida Susumu
    • Journal Title

      Journal of Cellular and Molecular Medicine

      Volume: 23 Issue: 10 Pages: 6785-6796

    • DOI

      10.1111/jcmm.14559

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] (Pro)renin receptor: Involvement in diabetic retinopathy and development of molecular targeted therapy2019

    • Author(s)
      Kanda Atsuhiro, Ishida Susumu
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 10 Issue: 1 Pages: 6-17

    • DOI

      10.1111/jdi.12842

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TGF-β-SNAIL axis induces Muller glial-mesenchymal transition in the pathogenesis of idiopathic epiretinal membrane2019

    • Author(s)
      Kanda A, Noda K, Hirose I, Ishida S
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 673-673

    • DOI

      10.1038/s41598-018-36917-9

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suppression of choroidal neovascularization and fibrosis by a novel RNAi therapeutic agent against (pro)renin receptor.2019

    • Author(s)
      Liu Y, Kanda A, Wu D, Ishizuka ET, Kase S, Noda K, Ichihara A, Ishida S
    • Journal Title

      Mol Ther Nucleic Acids

      Volume: 17 Pages: 113-125

    • DOI

      10.1016/j.omtn.2019.05.012

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unsaturated Aldehyde Acrolein Promotes Retinal Glial Cell Migration2019

    • Author(s)
      Murata Miyuki、Noda Kousuke、Yoshida Shiho、Saito Michiyuki、Fujiya Akio、Kanda Atsuhiro、Ishida Susumu
    • Journal Title

      Investigative Opthalmology & Visual Science

      Volume: 60 Issue: 13 Pages: 4425-4435

    • DOI

      10.1167/iovs.19-27346

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corneal hyperalgesia in patients with short tear film break-up time dry eye2019

    • Author(s)
      Tagawa Y, Noda K, Ohguchi T, Tagawa Y, Ishida S, Kitaichi N
    • Journal Title

      The Ocular Surface

      Volume: 17 Issue: 1 Pages: 55-59

    • DOI

      10.1016/j.jtos.2018.08.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Galectin-1 promotes choroidal neovascularization and subretinal fibrosis mediated via epithelial-mesenchymal transition2019

    • Author(s)
      Wu Di、Kanda Atsuhiro、Liu Ye、Kase Satoru、Noda Kousuke、Ishida Susumu
    • Journal Title

      The FASEB Journal

      Volume: 33 Issue: 2 Pages: 2498-2513

    • DOI

      10.1096/fj.201801227r

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Features of Japanese Patients With Anti-α-enolase Antibody?Positive Autoimmune Retinopathy: Novel Subtype of Multiple Drusen2018

    • Author(s)
      Ando Ryo、Saito Wataru、Kanda Atsuhiro、Kase Satoru、Fujinami Kaoru、Sugahara Michitaka、Nakamura Yosuke、Eguchi Shuichiro、Mori Shohei、Noda Kousuke、Shinoda Kei、Ishida Susumu
    • Journal Title

      American Journal of Ophthalmology

      Volume: 196 Pages: 181-196

    • DOI

      10.1016/j.ajo.2018.08.044

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteolytic cleavage of vascular adhesion protein-1 induced by vascular endothelial growth factor in retinal capillary endothelial cells2018

    • Author(s)
      Yoshida Shiho、Murata Miyuki、Noda Kousuke、Matsuda Takashi、Saito Michiyuki、Saito Wataru、Kanda Atsuhiro、Ishida Susumu
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 62 Issue: 2 Pages: 256-264

    • DOI

      10.1007/s10384-017-0555-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 眼内血管新生疾患の病態理解と治療の進歩2018

    • Author(s)
      石田 晋
    • Journal Title

      医学の歩み.266: 887,

      Volume: 266 Pages: 887-887

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 受容体結合プロレニン系を標的とした新規阻害薬の開発. ライフサイエンス2018

    • Author(s)
      石田 晋
    • Journal Title

      北海道大学研究シーズ集

      Volume: 5 Pages: 6-6

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 増殖糖尿病網膜症患者の血漿中における可溶型(プロ)レニン受容体に関連する全身的な要因. Best articles of the year2018

    • Author(s)
      長谷敬太郎、神田敦宏、廣瀬育代、野田航介、石田 晋
    • Journal Title

      北海道医学雑誌

      Volume: 93 Pages: 92-92

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Pathologic roles of receptor-associated prorenin system in idiopathic epiretinal membrane.2017

    • Author(s)
      Dong Y,Kanda A, Noda K, Saito W, Ishida S
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 44266-44266

    • DOI

      10.1038/srep44266

    • NAID

      120006219867

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Systemic factors related to soluble (pro)renin receptor in plasma of patients with proliferative diabetic retinopathy2017

    • Author(s)
      Hase Keitaro、Kanda Atsuhiro、Hirose Ikuyo、Noda Kousuke、Ishida Susumu
    • Journal Title

      PLoS ONE

      Volume: 12 Issue: 12 Pages: e0189696-e0189696

    • DOI

      10.1371/journal.pone.0189696

    • NAID

      120006406688

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Novel Single-Strand RNAi Therapeutic Agent Targeting the (Pro)renin Receptor Suppresses Ocular Inflammation2017

    • Author(s)
      Kanda Atsuhiro、Ishizuka Erdal Tan、Shibata Atsushi、Matsumoto Takahiro、Toyofuku Hidekazu、Noda Kousuke、Namba Kenichi、Ishida Susumu
    • Journal Title

      Mol Ther Nucleic Acids

      Volume: 7 Pages: 116-126

    • DOI

      10.1016/j.omtn.2017.01.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel single-strand RNAi therapeutic agent targeting (pro)renin receptor suppresses ocular inflammation.2017

    • Author(s)
      Kanda A, Ishizuka ET, Shibata A, Matsumoto T, Toyofuku H, Noda K, Namba K, Ishida S
    • Journal Title

      Mol Ther Nucleic Acids

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Receptor-associated prorenin system contributes to development of inflammation and angiogenesis in proliferative diabetic retinopathy.2017

    • Author(s)
      Kanda A, Ishida S
    • Journal Title

      Inflamm Regen

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evaluation of the safety and tolerability of conjunctival ring for posterior segment of the eye.2017

    • Author(s)
      Kinoshita S, Ohguchi T, Noda K, Murata M, Yasueda S, Obata H, Matsunaga T, Fukushima T, Kanda A, Ishida S
    • Journal Title

      Curr Eye Res

      Volume: 印刷中 Issue: 8 Pages: 1149-1154

    • DOI

      10.1080/02713683.2017.1287277

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of alphaB-crystallin in epiretinal membrane of human proliferative diabetic retinopathy.2016

    • Author(s)
      Dong Y, Dong Z, Kase S, Ando R, Fukuhara J, Kinoshita S, Inafuku S, Tagawa Y, Ishizuka ET, Saito W, Murata M, Kanda A, Noda K, Ishida S
    • Journal Title

      Int J Ophthalmol

      Volume: 9 Pages: 1100-1105

    • DOI

      10.18240/ijo.2016.08.03

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of vascular endothelial growth factor-C by tumor necrosis factor-α in the conjunctiva and pterygium2016

    • Author(s)
      Dong Y, Kase S, Dong Z, Fukuhara J, Tagawa Y, Ishizuka ET, Murata M, Shinmei Y, Ohguchi T, Kanda A, Noda K, Ishida S
    • Journal Title

      Int J Mol Med

      Volume: 38 Issue: 2 Pages: 545-550

    • DOI

      10.3892/ijmm.2016.2647

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of geranylgeranylacetone on the protection of retinal ganglion cells in a mouse model of normal tension glaucoma.2016

    • Author(s)
      Dong Z, Shinmei Y, Dong Y, Inafuku S, Fukuhara J, Ando R, Kitaichi N, Kanda A, Tanaka K, Noda K, Harada T, Chin S, Ishida S.
    • Journal Title

      Heliyon

      Volume: 2 Issue: 10 Pages: e00191-e00191

    • DOI

      10.1016/j.heliyon.2016.e00191

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vitreous levels of vascular endothelial growth factor-B in proliferative diabetic retinopathy2016

    • Author(s)
      Kinoshita S, Noda K, Saito W, Kanda A, Ishida S
    • Journal Title

      Acta Ophthalmol

      Volume: - Issue: 6

    • DOI

      10.1111/aos.12969

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] TGF-β-SNAIL axis induces Muller Glial-Mesenchymal Transition (GMT) in the athogenesis of idiopathic epiretinal membrane2019

    • Author(s)
      Ishida S.
    • Organizer
      The 52nd Annual Retina Society Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anti-Enolase Drusen as a Subtype of Autoimmune Retinopathy2019

    • Author(s)
      Ishida S.
    • Organizer
      Macula Society 42th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] (プロ)レニン受容体特異的一本鎖RNA干渉による脈絡膜血管新生と線維化の抑制2019

    • Author(s)
      神田敦宏、劉 野、市原淳弘、石田 晋
    • Organizer
      第11回(プロ)レニン受容体フォーラム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 血管新生・線維化における新たな分子メカニズム~ガレクチン-1の病態関与~2019

    • Author(s)
      石田 晋
    • Organizer
      第104回鳥取大学眼科研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 受容体結合プロレニン系(receptor-associated prorenin system : RAPS)と眼疾患~糖尿病網膜症・ぶどう膜炎・加齢黄斑変性における病態形成~2019

    • Author(s)
      石田 晋
    • Organizer
      第4回眼科アップデートミーティングin北海道
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ガレクチン1は眼内血管新生・線維化を促進する2019

    • Author(s)
      石田 晋
    • Organizer
      第13回箱根ドライアイクラブ
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] (プロ)レニン受容体と糖尿病網膜症-受容体結合プロレニン系とミトコンドリア活性酸素の病態関与-2019

    • Author(s)
      石田 晋
    • Organizer
      第11回(プロ)レニン受容体フォーラム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 血管新生・線維化における新たな分子メカニズム~ガレクチン-1の病態関与~2019

    • Author(s)
      石田 晋
    • Organizer
      第38回神戸市立医療センター中央市民病院・神戸アイセンター病院 眼科オープンカンファレンス
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Advanced gycation endoproducts link inflammatory cues to upregulation of Galectin-1 in diabetic retinopathy2018

    • Author(s)
      Ishida S, Kanda A
    • Organizer
      The 31st Meeting of the Club Jules Gonin
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Increased plasma galectin-1 is correlated with advanced glycation end products and interleukin-1β in patients with proliferative diabetic retiopathy2018

    • Author(s)
      Hase K, Kanda A, Noda K, Ishida S
    • Organizer
      Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Therapeutic effect of novel single-stranded RNAi agent targeting (Pro) renin receptor in ocular inflammation2018

    • Author(s)
      Kanda A, Liu Y, Ishizuka ET, Noda K, Ishida S
    • Organizer
      33rd Asia-Pacific Academy of Ophthalmology Congress (APAO)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular mechanism of fibrosis in wAMD. Symposium: Update in Age-related Macular Degeneration 1: Neovascular AME & PCV2018

    • Author(s)
      Ishida S
    • Organizer
      The 12th Asia-Pacific Vitreo-retina Society Congress (APVRS)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] PshRNA against (pro)renin receptor as innovative drug development for diabetic retinopathy. Symposium: New dawn of ophthalmic pharmacologic therapy2018

    • Author(s)
      Ishida S
    • Organizer
      36th World Ophthalmology Congress (WOC) 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 受容体結合プロレニン系に対する核酸医薬による眼炎症病態の抑制2018

    • Author(s)
      神田敦宏、石田 晋
    • Organizer
      第38回日本眼薬理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 増殖糖尿病網膜症患者における血漿ガレクチン-1と炎症関連分子との相関解析2018

    • Author(s)
      長谷敬太郎、神田敦宏、野田航介、石田 晋
    • Organizer
      第122回日本眼科学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Systemic factors related to soluble (pro)renin receptor in plasma of patients with proliferative diabetic retinopathy2018

    • Author(s)
      長谷敬太郎、神田敦宏、石田 晋
    • Organizer
      第10回(プロ)レニン受容体フォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 受容体結合プロレニン系と糖尿病網膜症2018

    • Author(s)
      石田 晋
    • Organizer
      第3回糖尿病・眼合併症治療講演会 in 東名古屋
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 受容体結合プロレニン系と糖尿病網膜症ー 病態メカニズムの命名から創薬のチャレンジまで ー2018

    • Author(s)
      石田 晋
    • Organizer
      岐阜薬科大学薬効解析学研究室セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 眼科の研究して自分の世界を持ってみませんか! ~受容体結合プロレニン系の命名から創薬のチャレンジまで~2017

    • Author(s)
      石田 晋
    • Organizer
      The 12th Tohoku University Ophthalmic Research and Clinical Seminar
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 受容体結合プロレニン系と眼の関わり2017

    • Author(s)
      石田 晋
    • Organizer
      Basic Research Forum in Sendai
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Analysis of ocular phenolype in RPE-specific Atp6ap2 conditional knockout mice2017

    • Author(s)
      Ishizuka ET, Kanda A, Noda K, Ichihara A, Ishida S
    • Organizer
      第9回(プロ)レニン受容体フォーラム
    • Place of Presentation
      東京慈恵医科大学(東京都港区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Roles of (Pro)renin receptor in the pathogenesis of diabetic retinopathy.2016

    • Author(s)
      Ishida S
    • Organizer
      2016 Autumn Meeting of Ophthalmological Society of Taiwan (TOS)
    • Place of Presentation
      Kaohsiung Medical University Chung-Ho Memorial Hospital(高雄、台湾)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Receptor-associated prorenin system in the pathogenesis of diabetic retinopathy.2016

    • Author(s)
      石田 晋
    • Organizer
      第70回 日本臨床眼科学会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 糖尿病網膜症における血管新生因子ガレクチン-1による病態形成への関与2016

    • Author(s)
      石田 晋、董 陽子、野田航介、齋藤 航、神田敦宏
    • Organizer
      第22回日本糖尿病眼学会総会
    • Place of Presentation
      仙台国際センター(仙台市青葉区)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Relationship between choroidal blood flow velocity and choroidal thickness during systemic corticosteroid therapy for Vogt-Koyanagi-Harada disease2016

    • Author(s)
      石田 晋
    • Organizer
      第41回日本微小循環学会総会
    • Place of Presentation
      コクヨホール(東京都港区)
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Galectin-1と糖尿病網膜症2016

    • Author(s)
      石田 晋
    • Organizer
      第18回Japan Macula Club
    • Place of Presentation
      蒲郡クラシックホテル(愛知県蒲郡)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Aflibercept traps Galectin-1, an angiogenic factor in diabetic retinopathy2016

    • Author(s)
      Ishida S, Kanda A, Noda K, Saito W
    • Organizer
      30th Meeting of the Club Jules Gonin
    • Place of Presentation
      Palais des Congres de Bordeaux(フランス、ボルドー)
    • Year and Date
      2016-07-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ATP6AP2/ (pro)renin receptor contributes to glucose metabolism via stabilizing the pyruvate dehydrogenase E1 β subunit.2016

    • Author(s)
      Ishida S
    • Organizer
      XXⅡ Biennial Meeting of the International Society for Eye Research(ISER)
    • Place of Presentation
      京王プラザホテル東京(東京都新宿区)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] AMDの線維化はなぜ起こるのか?-次世代の治療標的-2016

    • Author(s)
      石田 晋
    • Organizer
      第19回信濃町網膜研究会
    • Place of Presentation
      ホテルグランドパレス(東京都千代田区)
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] プロレニン受容体リガンド及びアンタゴニスト2016

    • Inventor(s)
      石田 晋、神田敦宏他
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Rights Type
      特許
    • Patent Publication Number
      2017-141185
    • Filing Date
      2016
    • Acquisition Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] プロレニン遺伝子またはプロレニン受容体遺伝子の発現を抑制する一本鎖核酸分子およびその用途2016

    • Inventor(s)
      石田 晋、神田敦宏他
    • Industrial Property Rights Holder
      北大、東京医大、(株)ボナック
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016
    • Acquisition Date
      2017
    • Related Report
      2017 Annual Research Report
    • Overseas

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Published: 2016-04-21   Modified: 2021-02-19  

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