The new surgery for the treatment of glaucoma optic neuropathy
| Project/Area Number |
16H05486
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | University of Fukui |
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Principal Investigator |
INATANI Masaru 福井大学, 学術研究院医学系部門, 教授 (40335245)
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| Co-Investigator(Kenkyū-buntansha) |
高村 佳弘 福井大学, 学術研究院医学系部門, 准教授 (00283193)
松村 健大 福井大学, 学術研究院医学系部門, 助教 (40529369)
三宅 誠司 福井大学, 学術研究院医学系部門, 助教 (50572765)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Keywords | 緑内障 / 外科 |
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| Outline of Final Research Achievements |
We evaluated the effect and limitation of intraocular pressure-lowering of the new glaucoma surgeries in clinical studies, and conducted animal experiments to establish the technique of completely new glaucoma surgery. In clinical studies, filtration surgery using a short tube significantly reduces the frequency of postoperative complications. The filtration operation using the long tube exhibits the intraocular pressure reduction even in the case in which conventional trabeculectomy was not effective. The risk factors for corneal endothelial cell loss, which is a serious complication of the long tube, and the prognostic factors for postoperative intraocular pressure-lowering were identified. In animal studies, it was shown that filtration surgery with a novel device resulted in significant intraocular pressure reduction without serious adverse events.
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| Academic Significance and Societal Importance of the Research Achievements |
従来の緑内障濾過手術であるトラベクレクトミーの問題点に対する改善策として、新たに登場した濾過手術であるミニチューブ及びロングチューブを用いた濾過手術の有効性と適応を明らかにすることができた。さらに、基礎研究と動物実験のデータから、眼圧が正常であるにもかかわらず、緑内障の進行する正常眼圧緑内障の視神経障害を抑制するために、新たに考案したデバイスを用いた濾過手術の術式の有効性を明らかにすることができた。
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Report
(5 results)
Research Products
(29 results)
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[Journal Article] Relationship between Vision-Related Quality of Life and Central 10° of the Binocular Integrated Visual Field in Advanced Glaucoma.2019
Author(s)
Yamazaki Y, Sugisaki K, Araie M, Murata H, Kanamori A, Inoue T, Ishikawa S, Yoshikawa K, Maeda H, Yamada Y, Negi A, Inatani M, Tanihara H, Okinami S, Mizuki K, Mishima K, Uchida K, Matsumoto S.
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Journal Title
Sci Rep.
Volume: 9
Issue: 1
Pages: 14990-14990
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comparing trabeculectomy outcomes between first and second operated eyes: A multicenter study.2016
Author(s)
Iwasaki K, Takamura Y, Nishida T, Sawada A, Iwao K, Shinmura A, Kunimatsu-Sanuki S, Yamamoto T, Tanihara H, Sugiyama K, Nakazawa T, Inatani M.
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Journal Title
PLOS ONE
Volume: 11
Issue: 9
Pages: e0162569-e0162569
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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