• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The new surgery for the treatment of glaucoma optic neuropathy

Research Project

Project/Area Number 16H05486
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionUniversity of Fukui

Principal Investigator

INATANI Masaru  福井大学, 学術研究院医学系部門, 教授 (40335245)

Co-Investigator(Kenkyū-buntansha) 高村 佳弘  福井大学, 学術研究院医学系部門, 准教授 (00283193)
松村 健大  福井大学, 学術研究院医学系部門, 助教 (40529369)
三宅 誠司  福井大学, 学術研究院医学系部門, 助教 (50572765)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords緑内障 / 外科
Outline of Final Research Achievements

We evaluated the effect and limitation of intraocular pressure-lowering of the new glaucoma surgeries in clinical studies, and conducted animal experiments to establish the technique of completely new glaucoma surgery. In clinical studies, filtration surgery using a short tube significantly reduces the frequency of postoperative complications. The filtration operation using the long tube exhibits the intraocular pressure reduction even in the case in which conventional trabeculectomy was not effective. The risk factors for corneal endothelial cell loss, which is a serious complication of the long tube, and the prognostic factors for postoperative intraocular pressure-lowering were identified. In animal studies, it was shown that filtration surgery with a novel device resulted in significant intraocular pressure reduction without serious adverse events.

Academic Significance and Societal Importance of the Research Achievements

従来の緑内障濾過手術であるトラベクレクトミーの問題点に対する改善策として、新たに登場した濾過手術であるミニチューブ及びロングチューブを用いた濾過手術の有効性と適応を明らかにすることができた。さらに、基礎研究と動物実験のデータから、眼圧が正常であるにもかかわらず、緑内障の進行する正常眼圧緑内障の視神経障害を抑制するために、新たに考案したデバイスを用いた濾過手術の術式の有効性を明らかにすることができた。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (29 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (17 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 17 results,  Open Access: 17 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Int'l Joint Research: 6 results,  Invited: 5 results) Remarks (4 results)

  • [Int'l Joint Research] カリフィルニア大学サンディエゴ校(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Evaluation of deep convolutional neural networks for glaucoma detection.2019

    • Author(s)
      Phan S, Satoh S, Yoda Y, Kashiwagi K, Oshika T, Japan Ocular Imaging Registry Research Group.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: Feb 24 Issue: 3 Pages: 276-283

    • DOI

      10.1007/s10384-019-00659-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prospective Cohort Study on Refractive Changes after Trabeculectomy.2019

    • Author(s)
      Iwasaki K, Takamura Y, Arimura S, Tsuji T, Matsumura T, Gozawa M, Inatani M.
    • Journal Title

      J Ophthalmol.

      Volume: 1 Pages: 4731653-4731653

    • DOI

      10.1155/2019/4731653

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between Vision-Related Quality of Life and Central 10° of the Binocular Integrated Visual Field in Advanced Glaucoma.2019

    • Author(s)
      Yamazaki Y, Sugisaki K, Araie M, Murata H, Kanamori A, Inoue T, Ishikawa S, Yoshikawa K, Maeda H, Yamada Y, Negi A, Inatani M, Tanihara H, Okinami S, Mizuki K, Mishima K, Uchida K, Matsumoto S.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 14990-14990

    • DOI

      10.1038/s41598-019-50677-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trabeculectomy followed by phacoemulsification versus trabeculectomy alone: The Collaborative Bleb-Related Infection Incidence and Treatment Study.2019

    • Author(s)
      Arimura S, Iwasaki K, Gozawa M, Takamura Y, Inatani M.
    • Journal Title

      PLoS One.

      Volume: 14 Issue: 10 Pages: e0223439-e0223439

    • DOI

      10.1371/journal.pone.0223439

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Microtubule Disruption on Dynamics of Acidic Organelles in the Axons of Primary Cultured Retinal Ganglion Cells2018

    • Author(s)
      Miyake Seiji、Takihara Yuji、Yokota Satoshi、Takamura Yoshihiro、Inatani Masaru
    • Journal Title

      Current Eye Research

      Volume: 43 Issue: 1 Pages: 77-83

    • DOI

      10.1080/02713683.2017.1370117

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Culture Systems of Dissociated Mouse and Human Pluripotent Stem Cell?Derived Retinal Ganglion Cells Purified by Two-Step Immunopanning2018

    • Author(s)
      Kobayashi Wataru、Onishi Akishi、Tu Hung-Ya、Takihara Yuji、Matsumura Michiru、Tsujimoto Kazuko、Inatani Masaru、Nakazawa Toru、Takahashi Masayo
    • Journal Title

      Investigative Opthalmology & Visual Science

      Volume: 59 Issue: 2 Pages: 776-776

    • DOI

      10.1167/iovs.17-22406

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of intravitreal triamcinolone acetonide injection at the end of vitrectomy for vitreous haemorrhage related to proliferative diabetic retinopathy.2018

    • Author(s)
      Takamura Y, Shimura M, Katome T, Someya H, Sugimoto M, Hirano T, Sakamoto T, Gozawa M, Matsumura T, Inatani M; writing committee of Japan-Clinical Retina Research Team (J-CREST)
    • Journal Title

      British Journal of Ophthalmology

      Volume: 102 Issue: 10 Pages: 1351-1357

    • DOI

      10.1136/bjophthalmol-2017-311377

    • NAID

      120006892813

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prospective cohort study of corneal endothelial cell loss after Baerveldt glaucoma implantation.2018

    • Author(s)
      Iwasaki K, Arimura S, Takihara Y, Takamura Y, Inatani M
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 7 Pages: e0201342-e0201342

    • DOI

      10.1371/journal.pone.0201342

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Randomised Clinical Trial for Postoperative Complications after Ex-PRESS Implantation versus Trabeculectomy with 2-Year Follow-Up2018

    • Author(s)
      Arimura Shogo、Miyake Seiji、Iwasaki Kentaro、Gozawa Makoto、Matsumura Takehiro、Takamura Yoshihiro、Inatani Masaru
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 16168-16168

    • DOI

      10.1038/s41598-018-34627-w

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of subconjunctival scarring after microincision vitrectomy surgery using 20-, 23-, 25- and 27-gauge systems in rabbits.2017

    • Author(s)
      Gozawa M, Takamura Y, Miyake S, Iwasaki K, Arimura S, Takihara Y, Inatani M.
    • Journal Title

      Acta Ophthalmol.

      Volume: 95 Issue: 7

    • DOI

      10.1111/aos.13459

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circumpapillary Retinal Nerve Fiber Layer Thickness, Anterior Lamina Cribrosa Depth, and Lamina Cribrosa Thickness in Neovascular Glaucoma Secondary to Proliferative Diabetic Retinopathy: a cross-sectional study.2017

    • Author(s)
      Yokota S, Takihara Y, Takamura Y, Inatani M
    • Journal Title

      BMC Ophthalmology

      Volume: 17 Issue: 1 Pages: 57-57

    • DOI

      10.1186/s12886-017-0456-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Panretinal Photocoagulation Using Short-Pulse Laser Induces Less Inflammation and Macular Thickening in Patients with Diabetic Retinopathy.2017

    • Author(s)
      Takamura Y, Arimura S, Miyake S, Matsumura T, Gozawa M, Iwasaki K, Inatani M.
    • Journal Title

      J Ophthalmol.

      Volume: 2017 Pages: 8530261-8530261

    • DOI

      10.1155/2017/8530261

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of bleb fluid after Baerveldt glaucoma implantation using magnetic resonance imaging.2017

    • Author(s)
      Iwasaki K, Kanamoto M, Takihara Y, Arimura S, Takamura Y, Kimura H, Inatani M
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 11345-11345

    • DOI

      10.1038/s41598-017-11054-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Photocoagulation of the Retinal Nonperfusion Area Prevents the Expression of the Vascular Endothelial Growth Factor in an Animal Model.2017

    • Author(s)
      Gozawa M, Takamura Y, Miyake S, Matsumura T, Morioka M, Yamada Y, Inatani M.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 58 Issue: 13 Pages: 5946-5953

    • DOI

      10.1167/iovs.17-22739

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Randomized Clinical Trial for Early Postoperative Complications of Ex-PRESS Implantation versus Trabeculectomy: Complications Postoperatively of Ex-PRESS versus Trabeculectomy Study (CPETS)2016

    • Author(s)
      Arimura S, Takihara Y, Miyake S, Iwasaki K, Gozawa M, Matsumura T, Tomomatsu T, Takamura Y, Inatani M.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 26080-26080

    • DOI

      10.1038/srep26080

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comparing trabeculectomy outcomes between first and second operated eyes: A multicenter study.2016

    • Author(s)
      Iwasaki K, Takamura Y, Nishida T, Sawada A, Iwao K, Shinmura A, Kunimatsu-Sanuki S, Yamamoto T, Tanihara H, Sugiyama K, Nakazawa T, Inatani M.
    • Journal Title

      PLOS ONE

      Volume: 11 Issue: 9 Pages: e0162569-e0162569

    • DOI

      10.1371/journal.pone.0162569

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration.2016

    • Author(s)
      Shim MS, Takihara Y, Kim KY, Iwata T, Yue BY, Inatani M, Weinreb R, Perkin GA, Ju WK
    • Journal Title

      Scientific Reports

      Volume: 22 Issue: 1 Pages: 33830-33830

    • DOI

      10.1038/srep33830

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] iStentはどのくらい効果があるか?低侵襲緑内障手術(MIGS)に効果と適応2020

    • Author(s)
      稲谷 大
    • Organizer
      第43回日本眼科手術学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Axonal transport of mitochondria.2019

    • Author(s)
      Inatani M
    • Organizer
      The 33th APAO Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The complications of tube shunt surgery using Baerveldt glaucoma implant. -Prospective study-2018

    • Author(s)
      Inatani M
    • Organizer
      The 4th Asia-Pacific Glaucoma Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In vivo imaging of mitochondria in axonal transport.2017

    • Author(s)
      Inatani M
    • Organizer
      The 32th APAO Congress
    • Place of Presentation
      Singapore, Convention center
    • Year and Date
      2017-03-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical evidence for the most effective filtering surgery.2017

    • Author(s)
      Inatani M
    • Organizer
      the 58th annual meeting of the Ophthalmological Society of Taiwan
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In vivo imaging of mitochondrial axonal transport.2016

    • Author(s)
      Inatani M
    • Organizer
      32th Korean Glaucoma Society
    • Place of Presentation
      Korea, Seoul, JW Marriott Hotel
    • Year and Date
      2016-11-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Retinal ganglion cell imaging2016

    • Author(s)
      Inatani M
    • Organizer
      The 3rd Asia-Pacific Glaucoma Congress
    • Place of Presentation
      Thailand, Chiang Mai, Convention center
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 福井大学医学部眼科学教室

    • URL

      http://ganka-fukuimed.jp

    • Related Report
      2019 Annual Research Report
  • [Remarks] 福井大学眼科学教室 研究内容紹介

    • URL

      http://ganka-fukuimed.jp/class/pages/kenkyu.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 福井大学眼科学教室 研究内容紹介

    • URL

      http://ganka-fukuimed.jp/class/pages/kenkyu.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 福井大学医学部眼科学教室

    • URL

      http://www.med.u-fukui.ac.jp/GANKA/

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2022-01-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi