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Hybrid restortion of vision using electrical stimulation on retinitis pigmentosa

Research Project

Project/Area Number 16H05487
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionOsaka University

Principal Investigator

Fujikado Takashi  大阪大学, 生命機能研究科, 特任教授 (50243233)

Co-Investigator(Kenkyū-buntansha) 森本 壮  大阪大学, 医学系研究科, 寄附講座准教授 (00530198)
松下 賢治  大阪大学, 医学系研究科, 講師 (40437405)
神田 寛行  大阪大学, 医学系研究科, 助教 (50570248)
三好 智満  大阪大学, 医学系研究科, 助教 (70314309)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords視覚再生 / 網膜色素変性症 / 人工網膜 / ラマン分光 / 補償光学眼底カメラ / 視細胞 / 電気刺激 / 網膜電気刺激 / 網膜色素変性 / 遺伝子解析 / 視覚電気生理 / 神経保護 / 電気刺激治療 / ハイブリッド治療
Outline of Final Research Achievements

For retinitis pigmentosa (RP), we aimed to establish a treatment method by electrical stimulation according to the stage of the disease. By using Raman spectroscopy as an evaluation method for neuroprotection by electrical stimulation, the initial changes in neuronal cell death could be captured by the peak wavelength image of cytochrome c. Using the adaptive optics fundus camera, visual field defects in RP could be evaluated precisely over time by photoreceptor density. We have developed an STS type artificial retina with multiple electrode plates and demonstrated long-term safety in animal experiments. As a basic experiment of cortical stimulation type artificial vision, when a multipolar electrode placed in the cat retina was electrically stimulated, evoked potentials were recorded from the multipolar electrode placed in the visual cortex. By AI analysis, it was suggested that the spatial information corresponding to the retinal loci might be represented at visual cortex.

Academic Significance and Societal Importance of the Research Achievements

網膜色素変性症(RP)の進行度の評価として、補償光学眼底カメラを用いると、視野変化を視細胞数で定量的に評価できることが示され、電気刺激による神経保護治療の効果の判定に有効と考えられた。細胞死に至る前段階の神経細胞の状態は、ラマン分光画像で評価できることが示され、早期治療のバイオマーカーとなる可能性が示された。視野を拡大して歩行を可能にする2枚の電極板による人工網膜は、プロトタイプの装置の安全性、安定性が動物実験で示され、臨床試験に向けて一歩前進した。ネコ視覚皮質の局所誘発電位は、網膜刺激部位と一定の対応があることが示され、末期RPに対する、皮質刺激型人工視覚の刺激パターンを考える一助となった。

Report

(4 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (91 results)

All 2020 2019 2018 2017

All Journal Article (24 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 22 results,  Open Access: 11 results) Presentation (66 results) (of which Int'l Joint Research: 22 results,  Invited: 16 results) Book (1 results)

  • [Journal Article] Objective evaluation of visual fatigue in patients with intermittent exotropia2020

    • Author(s)
      Masakazu Hirota , Kozue Yada , Takeshi Morimoto , Takao Endo , Tomomitsu Miyoshi , Suguru Miyagawa , Yoko Hirohara , Tatsuo Yamaguchi , Makoto Saika , Takashi Fujikado
    • Journal Title

      PloS one

      Volume: 15 Issue: 3 Pages: 1-16

    • DOI

      10.1371/journal.pone.0230788

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Binocular Coordination during Smartphone Reading in Esophoric Patients2020

    • Author(s)
      Masakazu Hirota, Takeshi Morimoto, Tomomitsu Miyoshi, Takashi Fujikado.
    • Journal Title

      Journal of Binocular Vision and Ocular Motility

      Volume: 70 Issue: 1 Pages: 15

    • DOI

      10.1080/2576117x.2019.1690349

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electrophysiological evaluation of a chronically implanted electrode for suprachoroidal transretinal stimulation in rabbit eyes.2019

    • Author(s)
      Nishida K, Sakaguchi H, Kamei M, Saito T, Fujikado T, Nishida K.
    • Journal Title

      J Artif Organs.

      Volume: 22 Pages: 237-245

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eleven-year follow-up of a Japanese retinitis pigmentosa patient with an HK1 gene mutation.2019

    • Author(s)
      Sato S, Morimoto T, Hotta K, Fujikado T, Nishida K
    • Journal Title

      Ophthalmic Genet.

      Volume: 40 Issue: 5 Pages: 466-469

    • DOI

      10.1080/13816810.2019.1678179

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An update on retinal prostheses2019

    • Author(s)
      Ayton Lauren N.、Barnes Nick、Dagnelie Gislin、Fujikado Takashi、Goetz Georges、Hornig Ralf、Jones Bryan W.、Muqit Mahiul M.K.、Rathbun Daniel L.、Stingl Katarina、Weiland James D.、Petoe Matthew A.
    • Journal Title

      Clinical Neurophysiology

      Volume: 131 Issue: 6 Pages: 1383-1398

    • DOI

      10.1016/j.clinph.2019.11.029

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The influence of visual field position induced by a retinal prosthesis simulator on mobility.2019

    • Author(s)
      Endo T, Hozumi K, Hirota M, Kanda H, Morimoto T, Nishida K, Fujikado T
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 257 Pages: 1765-1770

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel compound heterozygous mutation in TTC8 identified in a Japanese patient2019

    • Author(s)
      Sato S, Morimoto T, Hotta K, Fujikado T, Nishida K.
    • Journal Title

      Hum Genome Var

      Volume: 6 Issue: 1 Pages: 6-14

    • DOI

      10.1038/s41439-019-0045-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Using redox-sensitive mitochondrial cytochrome Raman bands for label-free detection of mitochondrial dysfunction.2019

    • Author(s)
      Morimoto T, Chiu LD, Kanda H, Kawagoe H, Ozawa T, Nakamura M, Nishida K, Fujita K, Fujikado T
    • Journal Title

      Analyst

      Volume: 144 Issue: 8 Pages: 25312540-25312540

    • DOI

      10.1039/c8an02213e

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Light localization with low-contrast targets in a patient implanted with a suprachoroidal–transretinal stimulation retinal prosthesis2018

    • Author(s)
      Endo Takao、Fujikado Takashi、Hirota Masakazu、Kanda Hiroyuki、Morimoto Takeshi、Nishida Kohji
    • Journal Title

      Graefe's Archive for Clinical and Experimental Ophthalmology

      Volume: 256 Issue: 9 Pages: 1723

    • DOI

      10.1007/s00417-018-3982-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative analyses of factors related to anxiety and depression in patients with retinitis pigmentosa2018

    • Author(s)
      Sainohira Mayumi、Yamashita Takehiro、Terasaki Hiroto、Sonoda Shozo、Miyata Kazunori、Murakami Yusuke、Ikeda Yasuhiro、Morimoto Takeshi、Endo Takao、Fujikado Takashi、Kamo Junko、Sakamoto Taiji
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 4 Pages: e0195983-e0195983

    • DOI

      10.1371/journal.pone.0195983

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Light localization with low-contrast targets in a patient implanted with a suprachoroidal-transretinal stimulation retinal prosthesis.2018

    • Author(s)
      Endo T、Fujikado T、Hirota M、Kanda H、Morimoto T、Nishida K
    • Journal Title

      Graefe's Arch Clin Experim Ophthalmol

      Volume: ()

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Objective evaluation of visual fatigue using binocular fusion maintenance2018

    • Author(s)
      Hirota Masakazu、Morimoto Takeshi、Kanda Hiroyuki、Endo Takao、Miyoshi Tomomitsu、Miyagawa Suguru、Hirohara Yoko、Yamaguchi Tatsuo、Saika Makoto、Fujikado Takashi
    • Journal Title

      Translational Vision Science & Technology

      Volume: 7 Issue: 2 Pages: 9-9

    • DOI

      10.1167/tvst.7.2.9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Asymmetric Electrical Pulse on Retinal Excitement for Retinal Prostheses.2018

    • Author(s)
      Nakano Yukari、Terasawa Y、Kanda H、Ohta J、Sawai H、Fujikado T
    • Journal Title

      SENSORS AND MATERIALS

      Volume: 30(2) Pages: 315-326

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bagolini red filter ladderによる融像維持能力の評価(原著論文)2018

    • Author(s)
      屋田 梢、広田 雅和 、森本 壮、三好 智満、遠藤 高生、宮川 雄、広原 陽子、山口 達夫、雑賀 誠、不二門 尚、西田 幸二
    • Journal Title

      眼科臨床紀要

      Volume: 11(1) Pages: 43-48

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 両眼波面センサーによる眼疲労の他覚的定量評価(原著論文)2017

    • Author(s)
      曽根原 寿明、井澤 康哲、祁 華、神津 和磨、向山 浩行、広田 雅和、遠藤 高生、神田 寛行、森本 壮 、不二門 尚
    • Journal Title

      視覚の科学

      Volume: 38(4) Pages: 114-121

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and Associated Factors of Segmentation Errors in the Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell Complex in Spectral-domain Optical Coherence Tomography Images2017

    • Author(s)
      Miki Atsuya、Kumoi Miho、Usui Shinichi、Endo Takao、Kawashima Rumi、Morimoto Takeshi、Matsushita Kenji、Fujikado Takashi、Nishida Kohji
    • Journal Title

      Journal of Glaucoma

      Volume: 26 Issue: 11 Pages: 995-1000

    • DOI

      10.1097/ijg.0000000000000771

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 入力型BMI:人工網膜2017

    • Author(s)
      神田 寛行 、不二門 尚
    • Journal Title

      精密工学会誌

      Volume: 83(11) Pages: 988-991

    • NAID

      130006855990

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 眼科領域におけるVideo-oculographyを用いた眼球運動解析の研究動向(解説)2017

    • Author(s)
      広田 雅和、不二門 尚
    • Journal Title

      視覚の科学

      Volume: 38(3) Pages: 76-79

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 脈絡膜上-経網膜刺激方式人工視覚における三角波と鋸波電流パルスの有効性(Effectiveness of triangular and saw-tooth pulses in a retinal prosthesis with suprachoroidal-transretinal stimulation(STS))(英語)(原著論文)2017

    • Author(s)
      中野 由香梨、寺澤 靖雄、神田 寛行、大澤 孝治、三好 智満、澤井 元、不二門 尚
    • Journal Title

      視覚の科学

      Volume: 38(3) Pages: 53-59

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The relationship between retinal damage and current intensity in a pre-clinical suprachoroidal-transretinal stimulation model using a laser-formed microporous electrode2017

    • Author(s)
      Kanda Hiroyuki、Nakano Yukari、Terasawa Yasuo、Morimoto Takeshi、Fujikado Takashi
    • Journal Title

      Journal of Neural Engineering

      Volume: 14 Issue: 5 Pages: 056013-056013

    • DOI

      10.1088/1741-2552/aa7d5c

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 調節麻痺薬の使用に関する施設基準および副作用に関する調査 多施設共同研究2017

    • Author(s)
      若槻 暁美、仁科 幸子 、三木 淳司、内海 隆、菅澤 淳、林 孝雄、佐藤 美保、木村 亜紀子、不二門 尚
    • Journal Title

      日本眼科学会雑誌

      Volume: 121(7) Pages: 529-534

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visual Performance and Optical Quality of Standardized Asymmetric Soft Contact Lenses in Patients With Keratoconus.2017

    • Author(s)
      Suzaki A、Maeda N、Fuchihata M、Koh S、Nishida K、Fujikado T
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 58(7) Issue: 7 Pages: 2899-2905

    • DOI

      10.1167/iovs.16-21296

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 強度近視眼のQualiy of lifeと白内障手術(原著論文)2017

    • Author(s)
      阿曽沼 早苗、広田 雅和、神田 寛行、芳賀 祥子、生野 恭司、松本 鉄也、不二門 尚、西田 幸二
    • Journal Title

      眼科臨床紀要

      Volume: 10(5) Pages: 373-379

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Automated measurements of human cone photoreceptor density in healthy and degenerative retina by region-based segmentation2017

    • Author(s)
      Miyagawa Suguru、Fukuyama Hisashi、Hirota Masakazu、Yamaguchi Tatsuo、Kitamura Kazuo、Endo Takao、Kanda Hiroyuki、Morimoto Takeshi、Fujikado Takashi
    • Journal Title

      Clin Ophthalmol

      Volume: 11 Pages: 781

    • DOI

      10.2147/opth.s133070

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Difference of accommodative response between binocular and monocular viewing condition measured by binocular wavefront sensor.2019

    • Author(s)
      Takashi Fujikado; Hiroyuki Kanda; Takeshi Morimoto; Masakazu Hirota
    • Organizer
      ARVO meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Automatic discrimination of occult macular dystrophy by deep learning using fundus images of Adaptive Optics Scanning Laser Ophthalmoscopy2019

    • Author(s)
      Masakazu Hirota; Takeshi Morimoto; Suguru Miyagawa; Tomomitsu Miyoshi; Takashi Fujikado
    • Organizer
      ARVO meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel OPA1 gene mutations in Japanese patients with optic atrophy2019

    • Author(s)
      SHIGERU SATO; Noriyasu Hashida; Takeshi Morimoto; Kikuko Hotta; Takeshi Fujikado; Kohji Nishida
    • Organizer
      ARVO meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Surgical feasibility of newly developed suprachoroidal-transretinal stimulation (STS) prosthesis in healthy dogs2019

    • Author(s)
      Takeshi Morimoto; Tomomitsu Miyoshi; Toru Saito; Kunihiko Ito; Motoki Ozawa; Kohji Nishida; Takashi Fujikado
    • Organizer
      ARVO meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Starting point of visual rehabilitation for patients with retinitis pigmentosa based on visual function and vision-related quality of life2019

    • Author(s)
      Mayumi Sainohira; Takehiro Yamashita; Hiroto Terasaki; Shozo Sonoda; Kazunori Miyata; Junko Kamo; Takeshi Morimoto; Takao Endo; Takashi Fujikado; Yusuke Murakami; Yasuhiro Ikeda; Taiji Sakamoto
    • Organizer
      ARVO meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Survey of candidates of STS retinal prosthesis in RP patients with hand-motion or less vision2018

    • Author(s)
      Takashi Fujikado, Kenta Hozumi, et al
    • Organizer
      ARVO meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] Improvement of shape recognition associated with tactile sensation by visual learning using a retinal prosthesis simulator2018

    • Author(s)
      Kenta Hozumi, Takashi Fujikado, et al
    • Organizer
      ARVO meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] Re-Reading the Same Line in Intermittent Exotropia is Related to the Saccadic Disconjugacy2018

    • Author(s)
      Fujikado T
    • Organizer
      ISA + AAPOS 2018
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Binocular Coordination during Smartphone Reading in Patients with Intermittent Exotropia2018

    • Author(s)
      Hirota Masakazu、Kanda H、Endo T、Morimoto T、Miyoshi T、Fujikado T
    • Organizer
      ISA + AAPOS 2018
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Re-Reading the Same Line in Intermittent Exotropia is Related to the Saccadic Disconjugacy2018

    • Author(s)
      Fujikado T、Hirota M
    • Organizer
      ISA + AAPOS 2018
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 学童の近視をどうするか2018

    • Author(s)
      不二門 尚
    • Organizer
      第43回日本小児眼科学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 乳児期に外斜視を合併したCardio-facio-cutaneous症候群の一例2018

    • Author(s)
      穂積 健太、森本 壮、不二門 尚、西田 幸二
    • Organizer
      第43回日本小児眼科学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Visual performance of current retinal prosthesis.2018

    • Author(s)
      Takashi Fujikado
    • Organizer
      The 1st International Symposium on Systemus Intelligence Division
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel eye-tracking method for retinal prostheses.2018

    • Author(s)
      Hiroyuki Kanda
    • Organizer
      The 1st International Symposium on Systemus Intelligence Division
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of reaching movement and mobility with a prosthetic vision simulator.2018

    • Author(s)
      Kenta Hozumi
    • Organizer
      The 1st International Symposium on Systemus Intelligence Division
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationships Between Spatial Contrast Sensitivity and Parafoveal Cone Density in Normal Subjects and Patients With Retinal Degeneration.2018

    • Author(s)
      Masakazu Hirota
    • Organizer
      The 1st International Symposium on Systemus Intelligence Division
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development and evaluation of a wide-field dual-array suprachoroidal-transretinal stimulation(STS) prosthesisu system.2017

    • Author(s)
      Takeshi Morimoto、H Kanda、K Hozumi、K Nishida、T Fujikado
    • Organizer
      Artificial Vision 2017
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Temporal ptterns of single-unit responses from on- and off-cells in the lateral geniculate nucleus elicited by suprachoroidal-transretinal stimulation.2017

    • Author(s)
      Hiroyuki Kanda、T Miyoshi 、T Morimoto、T Fujikado
    • Organizer
      Artificial Vision 2017
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Outcome measure of clinical traial of retinal prosthesis by suprachoroidal-transretinal stimulation(STS) for patients with hand-motion vision.2017

    • Author(s)
      Takashi Fujikado、T Endo、K Hozumi、H Kanda、T Morimoto、M Hirota、M Ozawa
    • Organizer
      Artificial Vision 2017
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of reaching movement and mobility with a prosthetic vision simulator.2017

    • Author(s)
      Kenta Hozumi、T Endo、M Hirota、H Kanda、T Morimoto、K Nishida、T Fujikado
    • Organizer
      Artificial Vision 2017
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Visual recovery from severe outer retinitis after tonsillitis.2017

    • Author(s)
      Rumi Kawashima、Kenji Matsushita、Takashi Fujikado、Kohji Nishida
    • Organizer
      第5回韓日合同臨床視覚電気生理学会 in Japan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 市販のERG測定機器を用いたL/M錐体比推定の試み2017

    • Author(s)
      穂積 健太、神田 寛行、山内 泰樹、森本 壮、広田 雅和、西田 幸二、不二門 尚
    • Organizer
      第65回日本臨床視覚電気生理学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 緑内障に抗アクアポリン4抗体陽性視神経炎を合併した2症例2017

    • Author(s)
      遠藤 高生、穂積 健太、森本 壮、臼井 審一、不二門 尚、西田 幸二
    • Organizer
      第55回日本神経眼科学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 人工網膜による視覚回復2017

    • Author(s)
      不二門 尚
    • Organizer
      第14回広島県眼科医会「第14回ロービジョンの集い」
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 人工網膜による視力回復2017

    • Author(s)
      不二門 尚
    • Organizer
      第12回水道橋眼科フォーラム
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 間欠性外斜視の融像破壊および再融像時における眼球運動速度2017

    • Author(s)
      広田 雅和、神田 寛行、森本 壮、三好 智満、宮川 雄、広原 陽子、山口 達夫、雑賀 誠、穂積 健太、不二門 尚
    • Organizer
      第71回日本臨床眼科学会総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 軸外収差理論に基づいた眼鏡レンズの近視進行抑制効果の検証2017

    • Author(s)
      神田 寛行、大鹿 哲郎、平岡 孝浩、長谷部 聡、大野 京子、森山 無価、石子 智士、稗田 牧 鳥居 秀成、Saulius Varnas、不二門 尚
    • Organizer
      第71回日本臨床眼科学会総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 網膜色素変性症患者における不安およびうつに関連する要因検討2017

    • Author(s)
      斉之平 真弓、加茂 純子、村上 祐介、遠藤 高生 、山下 高明、池田 康博、宮田 和典、不二門 尚、坂本 泰二
    • Organizer
      第71回日本臨床眼科学会総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 屈折矯正のコツ-眼科臨床の基本を深めよう-2017

    • Author(s)
      不二門 尚
    • Organizer
      日本眼科医会生涯教育講座札幌講座
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 斜視と屈折・調節2017

    • Author(s)
      不二門 尚
    • Organizer
      日本眼科医会生涯教育講座札幌講座
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 近視進行防止のアプローチ2017

    • Author(s)
      不二門 尚
    • Organizer
      第13回Eye Care Strategy Seminar
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 眼科矯正(眼鏡による屈折矯正の総論)2017

    • Author(s)
      不二門 尚
    • Organizer
      第53回日本眼光学学会総会セッション
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 両眼波面センサーによる多角的調節検査2017

    • Author(s)
      神田  寛行
    • Organizer
      第53回日本眼光学学会総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] いまさら聞けない屈折矯正の基本2017

    • Author(s)
      不二門 尚
    • Organizer
      第53回日本眼光学学会総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヘッドマウントディスプレイによるバーチャルリアリティの視覚への影響:眼疲労の評価2017

    • Author(s)
      広田 雅和、神田  寛行、森本 壮、三好 智満、穂積 健太、宮川 雄、広原 陽子、山口 達夫、雑賀 誠、不二門 尚
    • Organizer
      第53回日本眼光学学会総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 眼光学にこだわったコンタクトレンズ2017

    • Author(s)
      不二門 尚
    • Organizer
      第53回日本眼光学学会総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 眼鏡矯正(眼鏡による屈折矯正の総論)2017

    • Author(s)
      不二門 尚
    • Organizer
      第53回日本眼光学学会総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 両眼波面センサーによる両眼視を加味した近見眼鏡処方の検討2017

    • Author(s)
      広原 陽子、雑賀 誠、宮川 雄、広田 雅和、神田 寛行、不二門 尚
    • Organizer
      第53回日本眼光学学会総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 両眼波面センサーによる眼疲労の他覚的定量評価2017

    • Author(s)
      曽根原 寿明、井澤 康哲、祁 華、神津 和磨、向山 浩行、広田 雅和、遠藤 高生、神田 寛行、森本 壮、不二門 尚
    • Organizer
      第53回日本眼光学学会総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 斜視と屈折・調節2017

    • Author(s)
      不二門 尚
    • Organizer
      日本眼科医会第73回生涯教育講座
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] スマホ時代の目の健康について2017

    • Author(s)
      不二門 尚
    • Organizer
      第33回目の健康講座
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 医学的立場から見た立体視-小児の斜視と立体視障害、成人の斜視と眼の疲労ー2017

    • Author(s)
      不二門 尚
    • Organizer
      認知科学研究センター
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Development of a Second-Generation Device for Suprachoroidal-Transretinal Stimulation2017

    • Author(s)
      Kanda H、Kamei M、Sakaguchi H、Endo T、Hirota M、Morimoto T、Nishida K、Kishima H、Miyoshi T、Terasawa Y、Osawa K、Ozawa M、Fujikado T
    • Organizer
      39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 人工網膜の現状と今後2017

    • Author(s)
      不二門 尚
    • Organizer
      岐阜県網膜色素変性症協会創立10周年記念式典
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 加齢変化は術後成績に影響するか?眼光学的立場から(白内障術後の飛蚊症、複視)2017

    • Author(s)
      不二門 尚
    • Organizer
      第32回JSCRS学術総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 間欠性外斜視の読書時の視線解析2017

    • Author(s)
      広田 雅和、神田 寛行、森本 壮、三好 智満、遠藤 高生、不二門 尚
    • Organizer
      第73回日本弱視斜視学会総会・第42回日本小児眼科学会総会合同学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Bagolini red filter ladderによる融像維持能力の評価2017

    • Author(s)
      屋田 梢、広田 雅和、神田 寛行、森本 壮、三好 智満、遠藤 高生、宮川 雄、広原 陽子、山口 達夫、雑賀 誠、不二門 尚、、
    • Organizer
      第73回日本弱視斜視学会総会・第42回日本小児眼科学会総会合同学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 両眼開放下の調節反応の動的特性に対する視覚負荷の影響2017

    • Author(s)
      神田 寛行、曽根原 寿明、広田 雅和、遠藤 高生、森本 壮、不二門 尚
    • Organizer
      第73回日本弱視斜視学会総会・第42回日本小児眼科学会総会合同学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Relationship between reading performance and saccadic disconjugacy in patients with convergence insufficiency type intermittent exotropia.2017

    • Author(s)
      Hirota Masakazu、Kanda H、Endo T、T K Lohmann、Miyoshi T、Morimoto T、Fujikado T
    • Organizer
      第73回日本弱視斜視学会総会・第42回日本小児眼科学会総会合同学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 人工網膜の現状と今後2017

    • Author(s)
      不二門 尚
    • Organizer
      JRPS第5回総会・医療講演会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 眼科視機能研究の面白さ2017

    • Author(s)
      不二門 尚
    • Organizer
      大阪大学眼科同窓会100周年記念講演会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 人工網膜の現状と今後の展望2017

    • Author(s)
      不二門 尚
    • Organizer
      JRPS京都定期総会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] スマートフォン・ヘッドマウントディスプレー時代の斜視診療2017

    • Author(s)
      不二門 尚
    • Organizer
      第87回九州眼科学会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 近視進行防止のアプローチ2017

    • Author(s)
      不二門 尚
    • Organizer
      第5回大田区眼科臨床懇話会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ロービジョンケアの未来:人工網膜埋植後の視覚リハビリテーション2017

    • Author(s)
      不二門 尚
    • Organizer
      第18回日本ロービジョン学会総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Objective Assessment of Visual Fatigue by Ability to Maintain Binocular Fusion.2017

    • Author(s)
      Hirota M、Morimoto T、Kanda H、Endo T、Miyoshi T、Miyagawa S、Hirohara Y、Yamaguchi T、Saika M、Fujikado T
    • Organizer
      ARVO2017
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chronic Implantation of a wide-field dual-array suprachoroidaltransretinal stimulation (STS) prosthesis in dogs.2017

    • Author(s)
      Morimoto T、Kanda H、Endo T、Nishida K、Fujikado T
    • Organizer
      ARVO2017
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel eye-tracking method for retinal prostheses.2017

    • Author(s)
      Kanda H、Satonaka S、Morimoto T、Miyoshi T、Fujikado T
    • Organizer
      ARVO2017
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optimized position of dualarray STS retinal prosthesis for mobility examined by retinal prosthesis simulator.2017

    • Author(s)
      Hozumi K、Endo T、Hirota、Kanda H、Morimoto T、Fujikado T、Nishida K
    • Organizer
      ARVO2017
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳腫瘍に起因した microcystic macular edema の一例2017

    • Author(s)
      広田 雅和
    • Organizer
      第2回関西眼科画像研究会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 人工網膜シミュレータを用いた歩行試験2017

    • Author(s)
      遠藤 高生、穂積 健太、広田 雅和、神田 寛行、森本 壮、不二門 尚、西田 幸二
    • Organizer
      第121回日本眼科学会総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 人工網膜の視機能評価を目的とした歩行テストの開発2017

    • Author(s)
      神田 寛行、広田 雅和、遠藤 高生、森本 壮、不二門 尚
    • Organizer
      第121回日本眼科学会総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 2枚電極板-脈絡膜上ー経網膜電気刺激型人工網膜装置のイヌへの埋植述と生体適合性2017

    • Author(s)
      森本 壮、神田 寛行、遠藤 高生、西田 幸二、不二門 尚
    • Organizer
      第121回日本眼科学会総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高次視機能の解明と治療2017

    • Author(s)
      不二門 尚
    • Organizer
      第121回日本眼科学会総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 両眼視と輻湊・調節2017

    • Author(s)
      不二門 尚
    • Organizer
      第121回日本眼科学会総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 間欠性外斜視患者における易眼疲労性の他覚的評価2017

    • Author(s)
      広田 雅和、神田 寛行、森本 壮、三好 智満、遠藤 高生、宮川 雄、広原 陽子、山口 達夫、雑賀 誠、不二門 尚
    • Organizer
      第121回日本眼科学会総会
    • Related Report
      2016 Annual Research Report
  • [Book] 1336専門家による私の治療 2017-2018年度版:【59】眼精疲労2017

    • Author(s)
      遠藤 高生、不二門 尚
    • Total Pages
      1734
    • Publisher
      日本医事新報社
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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