| Project/Area Number |
16H05488
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
SOTOZONO CHIE 京都府立医科大学, 医学(系)研究科(研究院), 教授 (30216585)
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| Co-Investigator(Kenkyū-buntansha) |
木下 茂 京都府立医科大学, 医学(系)研究科(研究院), 教授 (30116024)
上田 真由美 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (60398386)
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| Research Collaborator |
NISHIGAKI HIROMI
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | Stevens-Johnson症候群 / SJS/TEN / Stevens-Johnson症候群（SJS） / 中毒性表皮壊死融解症（TEN） / 視力障害 / 遺伝素因 / 病態解明 / 薬疹 / 病態 / 微生物感染 / 臨床サンプル / 遺伝子 / プロテオミクス / 中毒性表皮壊死症 / 臨床研究 |
|---|
| Outline of Final Research Achievements |
Analysis of lipid mediators of SJS / TEN patients with severe ocular complications showed that there were less glycerine lipids and higher in oxidized PC in the SJS / TEN patients. In proteomics analysis of tears of the SJS / TEN patients, IL-6, IL-8, IFN-g, eotaxin, RANTES, and MIP-1b were elevated in the SJS / TEN patients. In exhaustive protein expression analysis in ocular surface tissues , expression of PIGR, HEPACAM2 and ADH1C decreased significantly and ODZ2 (teneurin-2) increased significantly. In genetic analysis, REC114 and several new related genes were able to identify.
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| Academic Significance and Societal Importance of the Research Achievements |
新規の疾患関連遺伝子REC114の発見や、患者組織・細胞や涙液の遺伝子ならびにタンパクの変化の発見は、病態把握につながり、今後の治療方針の決定や、新規治療法の開発に役立つものと期待される
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