| Project/Area Number |
16H05492
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川上 和義 東北大学, 医学系研究科, 教授 (10253973)
菅野 恵美 東北大学, 医学系研究科, 准教授 (10431595)
丹野 寛大 東北大学, 医学系研究科, 助教 (10755664)
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| Co-Investigator(Renkei-kenkyūsha) |
KAZAMA itsurou 宮城大学, 看護学群(部), 教授 (60593978)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | 創傷治癒 / ナチュラルキラー（NKT）細胞 / α-Galactosylceramide / 免疫 / NKT細胞 / 緑膿菌 / 緑膿菌感染 |
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| Outline of Final Research Achievements |
In chronic wounds, the inflammatory responses are prolonged with persistent neutrophil infiltration. Recently, we showed that skin wound healing was delayed and the healing process was impaired under conditions lacking invariant natural killer T (iNKT) cells, an innate immune lymphocyte with potent immuno-regulatory activity.
In the present study, to identify the possible contribution of NKT cells activation, the effects of α-Galactosylceramide (α-GalCer) administration on wound healing, specific activator of iNKT cells, were examined. Administration of a-GalCer at the wound sites significantly promoted wound closure, granulation tissue formation, angiogenesis compared with vehicle treatment. In addition, the inflammatory cells were rapidly decreased and granulation tissue were enhanced in α-GalCer administered mice.
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| Academic Significance and Societal Importance of the Research Achievements |
現在、慢性創傷における炎症遷延に対する治療法としては、抗菌薬などを用いた病原微生物に対する治療法が主流となっており、宿主免疫をターゲットとした治療法は存在しない。
本研究により、α-Galactosylceramide (α-GalCer)によるNKT細胞の活性化が炎症反応を速やかに収束させ、創傷治癒を促進することが明らかになり、新規治療法の可能性が高まった。
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