• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Trigeminal nerve transection-induced neuroplastic changes in the somatosensory and insular cortices in a rat ectopic pain model

Research Project

Project/Area Number 16H05507
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionNihon University

Principal Investigator

KOBAYASHI Masayuki  日本大学, 歯学部, 教授 (00300830)

Co-Investigator(Kenkyū-buntansha) 藤田 智史  日本大学, 歯学部, 准教授 (00386096)
山本 清文  日本大学, 歯学部, 助教 (30609764)
崔 翼龍  国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー (60312229)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords疼痛 / 神経損傷 / 大脳皮質 / 島皮質 / 神経可塑性 / 光学計測 / カルシウム測光 / 抑制性シナプス後電流 / GABA / 局所神経回路 / グルタミン酸 / 可塑性 / 下歯槽神経 / 神経障害性疼痛 / シナプス伝達 / カルシウム・イメージング / 三叉神経損傷 / パッチ・クランプ記録 / 局所回路の改変 / 異常疼痛 / 機能再編 / 体性感覚野
Outline of Final Research Achievements

To elucidate the mechanisms of neuropathic pain and allodynia in the central nervous system, we focused on plastic changes of excitation in secondary somatosensory cortex and insular oral region (S2/IOR) of inferior alveolar nerve transection (IANX) model rats in which the mandibular but not maxillary nerve branch was cut. Optical imaging using VSD revealed contradictory excitatory responses 1 w after IANX between mandibular and maxillary molar pulp stimulation as follows: the loss of excitation following mandibular stimulation vs facilitated excitation following maxillary stimulation. At this stage, the neural activities in layer II/III excitatory and inhibitory neurons in S2/IOR in the IANX model rats were enhanced due to facilitated glutamatergic inputs. On the other hand, the inhibitory inputs onto the pyramidal neurons were reduced in the IANX model rats. These results suggest that IANX induces plastic changes in S2/IOR by changing the local excitatory and inhibitory circuits.

Academic Significance and Societal Importance of the Research Achievements

口腔領域は,触圧覚や味覚,歯根膜感覚など多様な感覚入力が同時に生じる点が,他の感覚と大きく異なる。本研究によって明らかになった現象,すなわち下顎からの感覚入力遮断による上顎歯髄刺激応答の増大は,味覚や温度感覚,筋感覚など島皮質が司っている他の感覚との相互作用を起こす可能性を示唆するものである。さらに,このような現象には大脳皮質の回路の再編が含まれていることから,末梢組織の損傷からの回復後に生じる慢性的な異常疼痛のメカニズムに中枢神経系が関与することが明らかとなった。この成果は,今後,臨床で生じる様々な感覚異常の治療法の開発に貢献すると期待できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (77 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (18 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 18 results,  Open Access: 5 results,  Acknowledgement Compliant: 4 results) Presentation (56 results) (of which Int'l Joint Research: 9 results,  Invited: 6 results) Remarks (2 results)

  • [Int'l Joint Research] 慶北国立大学(韓国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Trigeminal nerve transection-induced neuroplastic changes in the somatosensory and insular cortices in a rat ectopic pain model2019

    • Author(s)
      Fujita S, Yamamoto K, Kobayashi M
    • Journal Title

      eNeuro

      Volume: 6 Issue: 1 Pages: ENEURO.0462-18.2019

    • DOI

      10.1523/eneuro.0462-18.2019

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Orexin facilitates GABAergic IPSCs via postsynaptic OX1 receptors coupling to the intracellular PKC signalling cascade in the rat cerebral cortex2019

    • Author(s)
      Usui M, Kaneko K, Oi Y, Kobayashi M
    • Journal Title

      Neuropharmacology,

      Volume: 149 Pages: 97-112

    • DOI

      10.1016/j.neuropharm.2019.02.012

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular glucose-dependent IPSC enhancement by leptin in fast-spiking to pyramidal neuron connections via JAK2-PI3K pathway in the rat insular cortex2019

    • Author(s)
      Murayama S, Yamamoto K, Fujita S, Takei H, Inui T, Ogiso B, Kobayashi M
    • Journal Title

      Neuropharmacology,

      Volume: 149 Pages: 133-148

    • DOI

      10.1016/j.neuropharm.2019.02.021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Opposite roles in short-term plasticity for N-type and P/Q-type voltage-dependent calcium channels in GABAergic neuronal connections in the rat cerebral cortex.2018

    • Author(s)
      Yamamoto K and Kobayashi M
    • Journal Title

      J Neurosci

      Volume: 38 Issue: 46 Pages: 9814-9828

    • DOI

      10.1523/jneurosci.0337-18.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Menthol-induced facilitation of cerebrocortical excitatory propagation induced by air puff stimulation of the nasal cavity in the rat: An optical imaging study2018

    • Author(s)
      Fujita S, Zama M, Kaneko K, Murayama S, Ohtani S, Usui M, Noma D, Tsuda H, Yamamoto K, Kobayashi M
    • Journal Title

      Neurosci Lett

      Volume: 696 Pages: 87-92

    • DOI

      10.1016/j.neulet.2018.12.018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Experimental tooth movement temporally changes neural excitation and topographical map in rat somatosensory cortex2018

    • Author(s)
      Kaneko M, Fujita S, Shimizu N, Motoyoshi M, Kobayashi M
    • Journal Title

      Brain Res

      Volume: 1698 Pages: 62-69

    • DOI

      10.1016/j.brainres.2018.06.022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between the fluorescence intensity of rhodamine-labeled orexin A and the calcium responses in cortical neurons: An in?vivo two-photon calcium imaging study2018

    • Author(s)
      Ohtani Saori、Fujita Satoshi、Hasegawa Koki、Tsuda Hiromasa、Tonogi Morio、Kobayashi Masayuki
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 138 Issue: 1 Pages: 76-82

    • DOI

      10.1016/j.jphs.2018.09.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Application of unfolding transformation in the random matrix theory to analyze in vivo neuronal spike firing during awake and anesthetized conditions.2018

    • Author(s)
      Kato R, Yamanaka M, Kobayashi M
    • Journal Title

      J Pharmacol Sci

      Volume: 136 Issue: 3 Pages: 172-176

    • DOI

      10.1016/j.jphs.2018.01.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Somatotopic Organization and Temporal Characteristics of Cerebrocortical Excitation in Response to Nasal Mucosa Stimulation With and Without an Odor in the Rat: An Optical Imaging Study2018

    • Author(s)
      Zama Manabu、Hara Yaeko、Fujita Satoshi、Kaneko Tadayoshi、Kobayashi Masayuki
    • Journal Title

      Neuroscience

      Volume: 377 Pages: 77-86

    • DOI

      10.1016/j.neuroscience.2018.02.042

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracortical signal processing of periodontal ligament sensations in rat.2017

    • Author(s)
      Minoda A, Mizoguchi N, Kobayashi M, Suda N, Muramoto K
    • Journal Title

      Neuroscience

      Volume: 355 Pages: 212-224

    • DOI

      10.1016/j.neuroscience.2017.04.045

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physiological profiles of cortical responses to mechanical stimulation of the tooth in the rat: An optical imaging study.2017

    • Author(s)
      Kaneko M, Horinuki E, Shimizu N, Kobayashi M
    • Journal Title

      Neuroscience

      Volume: 358 Pages: 170-180

    • DOI

      10.1016/j.neuroscience.2017.06.042

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of C-fibers decreases quantal size of GABAergic synaptic transmission in the insular cortex.2017

    • Author(s)
      Murayama S, Yamamoto K, Kaneko M, Ogiso B, Kobayashi M
    • Journal Title

      Neuroscience

      Volume: 365 Pages: 179-191

    • DOI

      10.1016/j.neuroscience.2017.09.052

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histamine H3 Heteroreceptors Suppress Glutamatergic and GABAergic Synaptic Transmission in the Rat Insular Cortex2017

    • Author(s)
      Takei Hiroki、Yamamoto Kiyofumi、Bae Yong-Chul、Shirakawa Tetsuo、Kobayashi Masayuki
    • Journal Title

      Frontiers in neural circuit

      Volume: 11 Pages: 85-85

    • DOI

      10.3389/fncir.2017.00085

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Actions of Propofol on Neurons in the Cerebral Cortex2017

    • Author(s)
      Kobayashi M, Oi Y
    • Journal Title

      Journal of Nippon Medical School

      Volume: 84 Issue: 4 Pages: 165-169

    • DOI

      10.1272/jnms.84.165

    • NAID

      130006140096

    • ISSN
      1345-4676, 1347-3409
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal profiles of proprioception processed by the masseter muscle spindles in rat cerebral cortex: an optical imaging study.2017

    • Author(s)
      Fujita S, Kaneko M, Nakamura H, Kobayashi M
    • Journal Title

      Front Neural Circuit

      Volume: -

    • DOI

      10.3389/fncir.2017.00004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Neural mechanisms of nociception by orthodontic treatment.2017

    • Author(s)
      Kobayashi M, Horinuki E
    • Journal Title

      J Oral Science

      Volume: -

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Propofol-induced spike firing suppression is more pronounced in pyramidal neurons than in fast-spiking neurons in the rat insular cortex.2016

    • Author(s)
      Kaneko K, Koyanagi Y, Oi Y, Kobayashi M
    • Journal Title

      Neuroscience

      Volume: 339 Pages: 548-560

    • DOI

      10.1016/j.neuroscience.2016.10.016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Opioid subtype- and cell type-dependent regulation of inhibitory synaptic transmission in the rat insular cortex.2016

    • Author(s)
      Yokota E, Koyanagi Y, Yamamoto K, Oi Y, Koshikawa N, Kobayashi M
    • Journal Title

      Neuroscience

      Volume: 339 Pages: 478-490

    • DOI

      10.1016/j.neuroscience.2016.10.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 高次脳による口腔感覚情報処理機構2019

    • Author(s)
      小林真之
    • Organizer
      東京医科歯科大学大学院医歯学総合研究科セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 異所性異常疼痛モデルラットにおける大脳皮質の侵害刺激受容応答の亢進2019

    • Author(s)
      藤田智史,山本清文,小林真之
    • Organizer
      第92回日本薬理学会年会次世代の会主催シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 島皮質における口腔感覚情報の統合的理解-エビデンスに基づいた治療法の開発に向けて-2018

    • Author(s)
      小林真之
    • Organizer
      第70回日本大学歯学会学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 眼窩下神経結紮モデルの島皮質における興奮伝播の可塑的変化2018

    • Author(s)
      坐間学, 小林真之, 外木守雄
    • Organizer
      第70回日本大学歯学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] オレキシンはシナプス後細胞のタンパクキナーゼCを活性して島皮質抑制性シナプス伝達を促進する2018

    • Author(s)
      臼井緑,小林真之,大井良之
    • Organizer
      第70回日本大学歯学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cholinergic inputs to cortical cholinergic neurons facilitate disinhibition of excitatory neurons in the rat cerebral cortex2018

    • Author(s)
      Kaneko K, Matsumura S, Oi Y, Kobayashi M
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spike timing regularity depends on the firing time scale under propofol-induced anesthetic condition2018

    • Author(s)
      Kajiwara M, Kato R, Oi Y, Kobayashi M
    • Organizer
      18th World Congress of Basic and Clinical Pharmacology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 矯正力による皮質体性感覚野における体部位局在性の可塑的変化と振動性興奮の抑制2018

    • Author(s)
      金子茉莉,津田啓方,清水典佳,小林真之,本吉満
    • Organizer
      第77回東京矯正歯科学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 三叉神経脊髄路核尾側亜核の抑制性細胞→興奮性細胞間のシナプス特性の解明2018

    • Author(s)
      中谷有香,山本清文,小林真之
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ラット島皮質においてオレキシンはシナプス後細胞のPKC活性を介して抑制性シナプス伝達を促進する2018

    • Author(s)
      臼井緑, 大井良之, 小林真之
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 島皮質は口腔顔面における体性感覚および化学感覚を統合する2018

    • Author(s)
      小林真之
    • Organizer
      第60回歯科基礎医学会学術大会アップデートシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] メントールは鼻腔空気圧刺激に対する大脳皮質応答を増強する2018

    • Author(s)
      藤田智史,坐間学,小林真之
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 島皮質における興奮性ニューロンの三叉神経脊髄路核尾側亜核のI/II層における興奮性および抑制性ニューロンへの投射様式2018

    • Author(s)
      中谷有香,小林真之
    • Organizer
      第60回歯科基礎医学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Enhancement of responses to upper molar pulp stimulation in somatosensory and insular cortices in an ectopic pain model of the rat2018

    • Author(s)
      Fujita S, Yamamoto K, Kobayashi M
    • Organizer
      Oral Neuroscience 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Membrane potential responses of the excitatory and inhibitory neurons in layer Ⅱ/Ⅲ of the insular cortex by dental pulp stimulation: In vivo whole-cell targeting patch-clamp recording2018

    • Author(s)
      Murayama S, Ogiso B, Kobayashi M
    • Organizer
      Oral Neuroscience 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] メントールは鼻腔空気圧刺激による大脳皮質応答を増強する2018

    • Author(s)
      坐間学,小林真之,藤田智史,外木守雄
    • Organizer
      第52回日本味と匂学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 島皮質味覚応答ニューロンの文脈依存的活動2018

    • Author(s)
      梶原美絵,加藤梨紗子,小林真之
    • Organizer
      第52回日本味と匂学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ラット大脳皮質味覚野におけるレプチンの局所神経回路修飾作用2018

    • Author(s)
      村山翔太,小林真之
    • Organizer
      第52回日本味と匂学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 矯正力負荷による大脳皮質ニューロンの歯根膜刺激に対する興奮応答の時系列解析2018

    • Author(s)
      堀貫恵利,小林真之,本吉満
    • Organizer
      第77回日本矯正歯科学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 眼窩下神経半結紮モデルラットの島皮質における興奮伝播の可塑的変化の検討2018

    • Author(s)
      坐間学, 金子忠良, 原八重子, 外木守雄
    • Organizer
      第63回日本口腔外科学会総会・学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cholinergic interneurons facilitate disinhibition of pyramidal neurons in the rat cerebral cortex2018

    • Author(s)
      Kaneko K, Matsumura S, Oi Y, Kobayashi M
    • Organizer
      Society for Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 電位依存性カルシウムチャネルによる抑制性シナプス伝達の短期可塑性調節2018

    • Author(s)
      小林真之
    • Organizer
      第2回新潟神経懇話会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cholinergic inputs to cortical cholinergic interneurons facilitate disinhibition of excitatory neurons in the rat cerebral cortex2018

    • Author(s)
      Kaneko K, Matsumura S, Fujita S, Kobayashi M
    • Organizer
      第12回三叉神経領域の感覚―運動統合機構研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 光遺伝学的手法による島皮質から三叉神経脊髄路核尾側亜核への投射経路の機能解明.2018

    • Author(s)
      中谷有香,山本清文,小林真之
    • Organizer
      第95回日本生理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 島皮質における口腔顔面感覚の制御機構解明に向けて.2017

    • Author(s)
      小林真之
    • Organizer
      第59回歯科基礎医学会学術大会ライオン賞受賞講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 蛍光標識ペプチドの集積を利用した受容体と細胞応答の相関解明に向けた新規アプローチ.2017

    • Author(s)
      大谷紗織,藤田智史,外木守雄,小林真之
    • Organizer
      第69回日本大学歯学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラット大脳皮質に存在するコリン作動性ニューロンの役割.2017

    • Author(s)
      金子啓介,大井良之,小林真之
    • Organizer
      第69回日本大学歯学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 歯の実験的移動は大脳皮質の体部位局在地図を変化させる.2017

    • Author(s)
      金子茉莉,堀貫恵利,小林真之,清水典佳
    • Organizer
      第69回日本大学歯学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Ablation of unmyelinated C-fibers modulates of GABAergic transmission in insular cortex.2017

    • Author(s)
      村山翔太,小木曽文内,小林 真之
    • Organizer
      第69回日本大学歯学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 無髄神経欠損モデルラットにおける島皮質の抑制性神経伝達機構の変化.2017

    • Author(s)
      村山翔太,林誠,小林真之,小木曽文内
    • Organizer
      第146回日本歯科保存学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラット島皮質における抑制性シナプス伝達に対するオレキシンの作用.2017

    • Author(s)
      臼井緑,横田英子,大井良之,小林真之
    • Organizer
      第64回日本麻酔学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラット無顆粒島皮質における錐体細胞および抑制性介在ニューロンの電気生理学的膜特性に及ぼすプロポフォールの影響.2017

    • Author(s)
      金子啓介,小柳裕子,大井良之,小林真之
    • Organizer
      第64回日本麻酔学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Orexin facilitates GABAergic inhibitory synaptic transmission in the rat insular cortex.2017

    • Author(s)
      Usui M, Oi Y, Kobayashi M
    • Organizer
      第40回日本神経科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] N- and P/Q- type calcium channels differentially regulate short-term plasticity in rat cortical inhibitory synapses.2017

    • Author(s)
      Yamamoto K, Kobayashi M
    • Organizer
      第40回日本神経科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 舌乾燥に起因する三叉神経脊髄路核尾側亜核のAMPA受容体のリン酸化.2017

    • Author(s)
      中谷有香,岩田幸一,小林真之
    • Organizer
      第136回日本薬理学会関東部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Orexin facilitates GABAergic inhibitory synaptic transmission in the rat insular cortex.2017

    • Author(s)
      臼井緑,大井良之,小林真之
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Infraorbital nerve injury facilitates the excitatory propagation evoked by the stimulation of orofacial regions in insular cortex.2017

    • Author(s)
      坐間学,堀貫恵利,金子忠良,小林真之
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 三叉神経脊髄路核尾側亜核第Ⅰ/Ⅱ層に存在する興奮性及びおよび抑制性ニューロンの膜特性.2017

    • Author(s)
      中谷有香,山本清文,小林真之
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラット皮質における咬筋筋紡錘刺激に応答する興奮伝播の時空間的特徴.2017

    • Author(s)
      藤田智史,小林真之
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Experimental tooth movement increases the excitability of excitatory and inhibitory neurons in the insular cortex.2017

    • Author(s)
      堀貫恵利,清水典佳,小林真之
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The agranular insular cortical fast-spiking interneurons receive excitatory inputs from the piriform cortex.2017

    • Author(s)
      山本清文,小林真之
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 歯の実験的移動にともなう大脳皮質の体部位局在の変化. Orthodontic treatment induces plastic changes of somatotopic organization in the cerebral cortex.2017

    • Author(s)
      金子茉莉,小林真之,清水典佳
    • Organizer
      第76回日本矯正歯科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 矯正力は大脳皮質ニューロンの歯根膜電気刺激に対する応答を増大させる.2017

    • Author(s)
      堀貫恵利,清水典佳,小林真之
    • Organizer
      第76回日本矯正歯科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 蛍光標識オレキシン投与時の蛍光輝度変化と皮質神経細胞のカルシウム応答の相関.2017

    • Author(s)
      大谷紗織,外木守雄
    • Organizer
      第62回日本口腔外科学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Rhodamine標識オレキシンの蛍光強度とニューロンのカルシウム応答との相関.2017

    • Author(s)
      大谷紗織,藤田智史,小林真之,長谷川功紀,外木守雄
    • Organizer
      第16回日本睡眠歯科学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ローダミン標識オレキシンを用いた島皮質ニューロンの受容体数とカルシウム応答の相関の解析.2017

    • Author(s)
      藤田智史,小林真之
    • Organizer
      第11回三叉神経領域の感覚―運動統合機構研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Differences in cortical excitation profiles between mechanical and electrical stimulation of the periodontal ligament.2017

    • Author(s)
      Kaneko M, Horinuki E, Shimizu N, Kobayashi M
    • Organizer
      Neuropathic Pain 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Orexin facilitates GABAergic inhibitory synaptic transmission in the rat insular cortex.2017

    • Author(s)
      Usui M, Oi Y, Kobayashi M
    • Organizer
      Neuropathic Pain 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Driving dynamics of membrane potential response to dental pulp stimulation in vivo targeted patch clamp recording in the rat insular cortex.2017

    • Author(s)
      Murayama S, Ogiso B, Kobayashi M
    • Organizer
      Oral Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nociceptive input imbalance mediated by ablation of C-fibers causes plastic change of GABAergic neuronal circuits in the insular cortex.2017

    • Author(s)
      Murayama S, Yamamoto K, Ogiso B, Kobayashi M
    • Organizer
      Society for Neuroscience Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Correlation between fluorescent intensity of rhodamine-labeled orexin and calcium responses of neurons in the insular cortex.2017

    • Author(s)
      Ohtani S, Fujita S, Kobayashi M, Hasegawa K, Tonogi M
    • Organizer
      The 11th Sleep Respiration Forum in Hawaii combined with Hawaii Sleep Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Orthodontic force changes response properties of excitatory and inhibitory neurons in the somatosensory and insular cortices.2017

    • Author(s)
      Horinuki E, Shimizu N, Kobayashi M
    • Organizer
      30th Taiwan Association of Orthodontists annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] What happens in the cerebral cortex of the trigeminal nerve-injured animals?¬ -Pathophysiological mechanisms and a pharmacological approach-2017

    • Author(s)
      小林真之
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール(長崎県長崎市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 矯正力負荷下の歯根膜刺激に対する大脳皮質の神経応答.2016

    • Author(s)
      堀貫恵利,小林真之,越川憲明,清水典佳
    • Organizer
      第58回歯科基礎医学会学術大会・総会
    • Place of Presentation
      札幌国際会議場(北海道札幌市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 矯正力負荷によって生じる大脳皮質における興奮伝播の変化2016

    • Author(s)
      小林真之
    • Organizer
      第58回歯科基礎医学会サテライトシンポジウム
    • Place of Presentation
      札幌国際会議場(北海道札幌市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] コリン作動性ニューロンによる側坐核の機能調節2016

    • Author(s)
      小林真之
    • Organizer
      第58回歯科基礎医学会サテライトシンポジウム
    • Place of Presentation
      札幌国際会議場(北海道札幌市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Remarks] 日本大学歯学部薬理学講座

    • URL

      http://www2.dent.nihon-u.ac.jp/pharmacology/

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] http://www2.dent.nihon-u.ac.jp/pharmacology/

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi