Applied research of periodontal disease therapeutics using osteogenic sugnal from osteoclasts
| Project/Area Number |
16H05508
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小出 雅則 松本歯科大学, 総合歯科医学研究所, 講師 (10367617)
中道 裕子 松本歯科大学, 総合歯科医学研究所, 講師 (20350829)
中村 美どり 松本歯科大学, 歯学部, 准教授 (90278177)
上原 俊介 松本歯科大学, 歯学部, 講師 (90434480)
溝口 利英 松本歯科大学, 総合歯科医学研究所, 講師 (90329475)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 破骨細胞 / 骨芽細胞 / 骨細胞 / オステオプロテゲリン / スクレロスチン / 白血病抑制因子 / 骨吸収 / 歯周病 / 骨代謝共役 / 骨形成 / RANKL / OPG / リバースシグナル / 骨リモデリング |
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| Outline of Final Research Achievements |
Osteoprotegerin (OPG) strongly inhibits osteoclast differentiation. We demonstrate that osteoprotegerin (OPG) and sclerostin produced by osteocytes is play an important role in the maintenance of cortical bone and alveolar bone, from experimental results using osteoprotegerin (OPG) gene-deficient mice. In addition, osteoclast-derived LIF (leukemia inhibitory factor) has been shown to reduce sclerostin expression in bone cells and to promote bone formation.
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| Academic Significance and Societal Importance of the Research Achievements |
破骨細胞と骨細胞間のシグナル伝達解析は、骨代謝研究の中で現在最も注目されている研究である。破骨細胞からの骨形成促進シグナルを解明するという視点は、独創的であると考える。本研究は、新しい歯周病治療薬へ応用開発する糸口を見出すことを目的として計画され、今回得られた知見は、歯周病および骨粗鬆症治療に新しい指針を提供するものである。
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Coupling of bone resorption and formation by RANKL reverse signalling.2018
Author(s)
Ikebuchi Y, Aoki S, Honma M, Hayashi M, Sugamori Y, Khan M, Kariya Y, Kato G, Tabata Y, Penninger JM, Udagawa N, Aoki K, Suzuki H
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Journal Title
Nature
Volume: 561
Issue: 7722
Pages: 195-200
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling.2017
Author(s)
Uehara S, Udagawa N, Mukai H, Ishihara A, Maeda K, Yamashita T, Murakami K, Nishita M, Nakamura T, Kato S, Minami Y, Takahashi N and Kobayashi Y
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Journal Title
Sci Signal
Volume: 10
Issue: 494
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Angiotensin II stimulation of cardiac hypertrophy and functional decompensation in osteoprotegerin-deficient mice.2016
Author(s)
Tsuruda T, Sekita-Hatakeyama Y, Hao Y, Sakamoto S, Kurogi S, Nakamura M, Udagawa N, Funamoto T, Sekimoto T, Hatakeyama K, Chosa E, Kato J, Asada Y, Kitamura K.
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Journal Title
Hypertension
Volume: 67
Issue: 5
Pages: 848-856
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Peptide drugs accelerate BMP-2-induced calvarial bone regeneration and stimulate osteoblast differentiation through mTORC1 signaling.2016
Author(s)
Sugamori Y, Mise-Omata S, Maeda C, Aoki S, Tabata Y, Murali R, Yasuda H, Udagawa N, Suzuki H, Honma M, Aoki K.
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Journal Title
Bioessays
Volume: 38
Issue: 8
Pages: 717-725
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) plays important roles in the induction of both bone-resorbing activity of osteoclasts and osteoblast differentiation2018
Author(s)
Udagawa N, Koide M, Uehara S, Arai A, Mizoguchi T, Yamashita T, Nakamura M, Kobayashi Y, Takahashi N, Kumakura S, Fukuda C, Tsuda E
Organizer
The American Society for Bone and Mineral Research (ASBMR) 2018 Annual Meeting
Related Report
Int'l Joint Research
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