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The development of anti-inflammatory and regenerative medicine for periodontitis: application of Pannexin 3 signaling pathways.

Research Project

Project/Area Number 16H05514
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionTohoku University

Principal Investigator

Masaki Ishikawa  東北大学, 大学病院, 助教 (60432936)

Co-Investigator(Kenkyū-buntansha) 福本 敏  東北大学, 歯学研究科, 教授 (30264253)
齋藤 正寛  東北大学, 歯学研究科, 教授 (40215562)
Research Collaborator YAMADA yoshihiko  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords再生治療 / ギャップ ジャンクション / 骨形成 / 骨再生 / 骨芽細胞分化 / 軟骨細胞分化 / 抗炎症 / 2nd メッセンジャー / Pannexin / Gap junction / 骨芽細胞 / 炎症 / 歯周病 / カルシウム シグナル / 歯科保存 / 再生 / 再生医療 / 抗炎症作用 / 細胞・組織 / 再生医学 / 歯学 / 発現制御 / 発生・分化
Outline of Final Research Achievements

Coping with the hyper-aging society, an advanced treatment for periodontal disease is necessary in order to maintain the quality of life. Here, we show that Pannexin 3 (Panx3), a member of gap junction protein is a new regulator to switch from proliferation to differentiation of chondroprogenitors and osteoprogenitors via multiple Panx3 signaling pathways. We demonstrated that Panx3 has potentials for new medical treatment and drug application in periodontitis by promoting bone regeneration.

Academic Significance and Societal Importance of the Research Achievements

Panx3が軟骨細胞および骨芽細胞分化過程において、前駆細胞の増殖を抑制し、分化を促進するスイッチの役割を担っていること、小因子の細胞内外移動を調節していることが明らかになった。また、Panx3 KOマウスが骨形成不全を示すことからPanx3が新骨制御因子であることが示唆された。その結果、Panx3機能の制御機構を応用した再生療法開発および創薬に繋がる可能性が示された。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (21 results)

All 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (6 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 5 results) Remarks (5 results)

  • [Int'l Joint Research] NIH/NIDCR/Yoshihiko Yamada(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] NIDCR/NIH(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] NIDCR/National Institutes of Health(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Pannexin-3 Deficiency Delays Skin Wound Healing in Mice due to Defects in Channel Functionality2018

    • Author(s)
      Zhang Peipei、Ishikawa Masaki、Rhodes Craig、Doyle Andrew、Ikeuchi Tomoko、Nakamura Kuniyuki、Chiba Yuta、He Bing、Yamada Yoshihiko
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 139(4) Issue: 4 Pages: 909-918

    • DOI

      10.1016/j.jid.2018.08.033

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fibrillin-1 insufficiency alters periodontal wound healing failure in a mouse model of Marfan syndrome.2018

    • Author(s)
      Handa K, Abe S, Suresh VV, Fujieda Y, Ishikawa M, Orimoto A, Kobayashi Y, Yamada S, Yamaba S, Murakami S, Saito M.
    • Journal Title

      Arch Oral Biol.

      Volume: 90 Pages: 53-60

    • DOI

      10.1016/j.archoralbio.2018.02.017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene2017

    • Author(s)
      Yoshizaki Keigo、Hu Lizhi、Nguyen Thai、Sakai Kiyoshi、Ishikawa Masaki、Takahashi Ichiro、Fukumoto Satoshi、DenBesten Pamela K.、Bikle Daniel D.、Oda Yuko、Yamada Yoshihiko
    • Journal Title

      Journal of Biological Chemistry

      Volume: 292 Issue: 33 Pages: 13531-13540

    • DOI

      10.1074/jbc.m117.780866

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pannexin 3 regulates proliferation and differentiation of odontoblasts via its hemichannel activities2017

    • Author(s)
      Iwamoto Tsutomu、Nakamura Takashi、Ishikawa Masaki、Yoshizaki Keigo、Sugimoto Asuna、Ida-Yonemochi Hiroko、Ohshima Hayato、Saito Masahiro、Yamada Yoshihiko、Fukumoto Satoshi
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 5 Pages: 0177557-0177557

    • DOI

      10.1371/journal.pone.0177557

    • NAID

      120006534958

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] F-spondin negatively regulates dental follicle differentiation through the inhibition of TGF-beta activity.2017

    • Author(s)
      Orimoto A, Kurokawa M, Handa K, Ishikawa M, Nishida E, Aino M, Mitani A, Ogawa M, Tsuji T Saito M
    • Journal Title

      Arch Oral Biol

      Volume: 79 Pages: 7-13

    • DOI

      10.1016/j.archoralbio.2017.02.019

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Role of Pannexin 3 in Bone Biology2017

    • Author(s)
      Ishikawa M, Yamada Y
    • Journal Title

      J Dent Res

      Volume: Apr;96 Issue: 4 Pages: 372-379

    • DOI

      10.1177/0022034516678203

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Pannexin 3 ER Ca2+ channel gating is regulated by phosphorylation at Serine 68 residue to promote osteoblast differentiation2018

    • Author(s)
      Masaki ishikawa
    • Organizer
      Bones & Teeth Gordon Research conferences
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The role of gap junction protein skeletal biology: points of view from Pannexin 3 and Connexin 43.2018

    • Author(s)
      Masaki Ishikawa
    • Organizer
      Skeletal Biology Interest Group Special Seminar in NIDCR.
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Pannexin 3 ER Ca2+ channel gating is regulated by phosphorylation at Serine 68 residue to promote osteoblast differentiation.2018

    • Author(s)
      Masaki Ishikawa
    • Organizer
      Bones & Teeth Gordon Research conferences
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pannexin 3 is a new regulator for bone formation2017

    • Author(s)
      Masaki Ishikawa
    • Organizer
      The 49th Annual Meeting of the Japanese Society for Matrix Biology & Medicine
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] The role of gap junctin proteins in skeletal biology : points of view from Pannexin 3 and Connexin 432017

    • Author(s)
      Masaki Ishikawa
    • Organizer
      Consortium of Biological Sciences 2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Pannexin 3 is a new regulator for bone formation2017

    • Author(s)
      Masaki Ishikawa
    • Organizer
      The 49th Annual Meeting of the Japanese Society for Matrix Biology & Medicine
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] The role of gap junctin proteins in skeletal biology : points of view from Pannexin 3 and Connexin 432017

    • Author(s)
      Masaki ishikawa
    • Organizer
      Consortium of Biological Sciences 2017
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Remarks] Skeletal Science Retreat

    • URL

      http://jsbmr.umin.jp/ssr/report/index.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 骨代謝学会, 1st Author

    • URL

      http://www.jsbmr.jp/1st_author/170_mishikawa.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] Skeletal Science Retreatでの優秀discussion賞

    • URL

      http://jsbmr.umin.jp/ssr/report/index.html

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Remarks] 骨代謝学会、1st Author

    • URL

      http://www.jsbmr.jp/1st_author/170_mishikawa.html

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Remarks] From our sister journals,3月の注目論文

    • URL

      http://thenode.biologists.com/sister-journals-march-2016/research

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report

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Published: 2016-04-21   Modified: 2022-05-20  

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