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Assessment of inhibition of root caries and hypermineralization using high concentration of fluoride and metal ions

Research Project

Project/Area Number 16H05515
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Tagami Junji  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (50171567)

Co-Investigator(Kenkyū-buntansha) 二階堂 徹  東京医科歯科大学, 歯学部, 非常勤講師 (00251538)
池田 正臣  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (20549927)
半場 秀典  東京歯科大学, 歯学部, 講師 (90634006)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords根面う蝕 / フッ化ジアンミン銀 / 象牙質の接着 / ABRZ / マイクロCT / 人工口腔装置 / フッ化ジアミン銀 / マイクロCT / 人口口腔装置 / 微小引張接着試験 / 抗菌性 / 変色 / フッ化物 / グルタチオン / フッ化物洗口 / 接着試験 / 歯学
Outline of Final Research Achievements

The purpose of this study was to evaluate the effect fluoride concentration on bonding performance, tooth discoloration and biofilm formation. The effect of fluoride concentration on bonding performance was to evaluate fluoride mouthrinses on dentin bonding performance of an adhesive system. Then, the surface analysis indicated different concentrations of fluoride might create different chemical compounds on the dentin surface, influencing the micro-TBS results. And then, the influence of glutathione on tooth discoloration was to evaluate the degree of discoloration after application of silver diammine fluoride (SDF). As a result, glutathione can effectively minimize color changes. Furthermore, effects of SDF preparations on cariogenic biofilm formation on dentin were investigated. Consequently, the amount of biofilms was minimum on the surface of dentin covered by 38%SDF.

Academic Significance and Societal Importance of the Research Achievements

高濃度フッ化物と各種金属イオンを組み合わせた根面う蝕抑制および変色抑制塗布材を製作し、高濃度フッ化物と歯との接着、歯の変色抑制法、歯面に対する細菌付着抑制効果、歯の脱灰と再石灰化を解析し評価した。研究の結果、フッ化物の濃度をコントロールし、抗酸化物を併用することで、歯との良好な接着が得られ、変色を抑制でき、さらに細菌付着を抑制できる歯面塗布材を開発することができた。また、フッ化物とリン酸カルシウムを含有した塗布材を歯に用いることにより高い再石灰化効果が得らえれた。以上から、より積極的な歯の保存とう蝕予防および治療法を選択することで、国民の健康長寿とQOLの向上に大きく寄与することができる。

Report

(5 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (23 results)

All 2021 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (10 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 10 results,  Open Access: 10 results) Presentation (11 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results)

  • [Int'l Joint Research] 香港大学歯学部(香港)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ワシントン大学歯学部(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Micro-CT assessment of the effect of silver diammine fluoride on inhibition of root dentin demineralization2021

    • Author(s)
      SHIMIZU Miyuki、MATSUI Naoko、SAYED Mahmoud、HAMBA Hidenori、OBAYASHI Sho、TAKAHASHI Motoi、TSUDA Yuka、TAKAGAKI Tomohiro、NIKAIDO Toru、TAGAMI Junji
    • Journal Title

      Dental Materials Journal

      Volume: 40 Issue: 4 Pages: 1041-1048

    • DOI

      10.4012/dmj.2020-290

    • NAID

      130008069746

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2021-07-25
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of silver diamine fluoride preparations on biofilm formation of <i>Streptococcus mutans </i>2021

    • Author(s)
      TAKAHASHI Motoi、MATIN Khairul、MATSUI Naoko、SHIMIZU Miyuki、TSUDA Yuka、UCHINUMA Shigeki、HIRAISHI Noriko、NIKAIDO Toru、TAGAMI Junji
    • Journal Title

      Dental Materials Journal

      Volume: 40 Issue: 4 Pages: 911-917

    • DOI

      10.4012/dmj.2020-341

    • NAID

      130008069848

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2021-07-25
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of silver diammine fluoride application on dentin bonding performance2020

    • Author(s)
      KO Aye KO、MATSUI Naoko、NAKAMOTO Ayako、IKEDA Masaomi、NIKAIDO Toru、BURROW Michael F.、TAGAMI Junji
    • Journal Title

      Dental Materials Journal

      Volume: 39 Issue: 3 Pages: 407-414

    • DOI

      10.4012/dmj.2019-057

    • NAID

      130007852201

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2020-05-27
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Morphological and elemental analysis of silver penetration into sound/demineralized dentin after SDF application.2019

    • Author(s)
      Sayed M, Matsui N, Uo M, Nikaido T, Oikawa M, Burrow MF, Tagami J.
    • Journal Title

      Dental Materials

      Volume: 35 Pages: 1718-1727

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of discoloration of sound/demineralized root dentin with silver diamine fluoride: In-vitro study.2019

    • Author(s)
      Sayed M, Matsui N, Hiraishi N, Inoue G, Nikaido T, Burrow MF, Tagami J.
    • Journal Title

      Dental Material Journal

      Volume: 38 Pages: 143-149

    • NAID

      130007592580

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of fluoride mouthrinse on bonding of a one-step self-etch adhesive to root dentin.2019

    • Author(s)
      Nakamoto A, Sato T, Matsui N, Ikeda M, Nikaido T, Burrow MF, Tagami J.
    • Journal Title

      Journal of Oral Science

      Volume: 61 Pages: 125-132

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of Glutathione Bio-Molecule on Tooth Discoloration Associated with Silver Diammine Fluoride2018

    • Author(s)
      Sayed Mahmoud、Matsui Naoko、Hiraishi Noriko、Nikaido Toru、Burrow Michael、Tagami Junji
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 5 Pages: 1322-1322

    • DOI

      10.3390/ijms19051322

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Micro-computed tomography assessment of root dentin around fluoride-releasing restorations after demineralization/remineralization.2018

    • Author(s)
      Zan KW, Nakamura K, Hamba H, Sadr A, Nikaido T, Tagami J.
    • Journal Title

      Eur J Oral Sci.

      Volume: 126(5) Issue: 5 Pages: 390-399

    • DOI

      10.1111/eos.12558

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of fluoride mouthrinse on adhesion to bovine root dentin.2018

    • Author(s)
      Nakamoto A, Ikeda M, Hiraishi N, Nikaido T, Uo M, Tagami J.
    • Journal Title

      Dental Material Journal

      Volume: 37 Pages: 919-927

    • NAID

      130007538095

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of zinc fluoride on inhibiting dentin demineralization and collagen degradation <i>in vitro</i>: A comparison of various topical fluoride agents2016

    • Author(s)
      Thanatvarakorn O, MD. Islam SMDS, Nakashima S, Sadr A, Nikaido T, Tagami J.
    • Journal Title

      Dental Materials Journal

      Volume: 35 Issue: 5 Pages: 769-775

    • DOI

      10.4012/dmj.2015-388

    • NAID

      130005598488

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] フッ化ジアンミン銀系材料塗布後の歯根面におけるバイオフィルム形成の評価.2018

    • Author(s)
      高橋基、松井七生子、マティン・カイルール、清水美透、平石典子、二階堂徹、田上順次.
    • Organizer
      日本歯科保存学会2018年度秋季学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Micro-CTを用いたフッ化ジアンミン銀系材料の歯根面象牙質脱灰抑制効果の評価.2018

    • Author(s)
      清水美透、松井七生子、半場秀典、大林翔、マハムド サイド、高橋基、二階堂徹、田上順次.
    • Organizer
      日本歯科保存学会2018年度秋季学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Assessment of a Zinc-Containing Desensitizer for Prevention of Dentin Demineralization.2018

    • Author(s)
      Saad Amr, Nikaido Toru, Abdou Ahmed, Tagami Junji.
    • Organizer
      IADR/PER General Session
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Fluoride Mouthrinse on Adhesion to Bovine Root Dentin.2018

    • Author(s)
      Nakamoto Ayako, Ikeda Masaomi, Hiraishi Noriko, Nikaido Toru, Uo Motohiro, Tagami Junji.
    • Organizer
      2018 IADR/PER General Session
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Glutathione on Tooth Discoloration With Silver Diamine Fluoride.2018

    • Author(s)
      Sayed Mahmoud, Matsui Naoko, Hiraishi Noriko, Nikaido Toru, Tagami Junji.
    • Organizer
      IADR/PER General Session
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Silver Diamine Fluoride Application on Dentin Bonding Performance.2018

    • Author(s)
      Ko Ko Aye, Matsui Naoko, Nikaido Toru, Nakamoto Ayako, Ikeda Masaomi, Tagami Junji.
    • Organizer
      IADR/PER General Session
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Efficacy of Experimental Fluoride-containing Caries-detector Dye Liquids on Dentin Remineralization.2018

    • Author(s)
      Zan Khine Win, Hamba Hidenori, Nikaido Toru, Ikeda Masaomi, Tagami Junji.
    • Organizer
      IADR/PER General Session
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ライフステージに応じた歯の保存と修復法2018

    • Author(s)
      二階堂徹
    • Organizer
      秩父郡市歯科医師会学術講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] フッ化ジアンミン銀による奪回象牙質の変色の評価2017

    • Author(s)
      2.マハムド サイド、松井七生子、平石典子、井上剛、二階堂徹、田上順次
    • Organizer
      日本歯科保存学会2017年度秋季学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] フッ化カリウム及びナトリウムの濃度が微小せん断接着強さ及び脱灰抑制効果に及ぼす影響2017

    • Author(s)
      アルカタニ アリ、井上剛、二階堂徹、田上順次
    • Organizer
      日本歯科保存学会2017年度秋季学術大会(第147回)
    • Related Report
      2017 Annual Research Report
  • [Presentation] フッ化ジアンミン銀の塗布が象牙質引張り接着強さに及ぼす影響2016

    • Author(s)
      エイ コー コー,松井七生子,中元絢子,二階堂徹,田上順次
    • Organizer
      第35回日本接着歯学会学術大会
    • Place of Presentation
      北海道大学学術交流会館(札幌)
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2022-08-05  

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