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Construction of comprehensive recovery system for peri-implantitis by selective radical application

Research Project

Project/Area Number 16H05520
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionTohoku University

Principal Investigator

Kanetaka Hiroyasu  東北大学, 歯学研究科, 准教授 (50292222)

Co-Investigator(Kenkyū-buntansha) 佐々木 啓一  東北大学, 歯学研究科, 教授 (30178644)
金子 俊郎  東北大学, 工学研究科, 教授 (30312599)
川下 将一  東北大学, 医工学研究科, 准教授 (70314234)
目代 貴之  東北大学, 金属材料研究所, 特任助教 (30466544)
工藤 忠明  東北大学, 歯学研究科, 助教 (50431606)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Keywords歯学 / 歯科インプラント / バイオマテリアル / 酸化チタン / 再活性化 / 大気圧プラズマ / ラジカル / 可視光応答
Outline of Final Research Achievements

Dental implants are widely used as highly predictive treatments, however, there is no fundamental solution to peri-implantitis. Therefore, in this research, we aimed to construct a completely new comprehensive implant recovery system for peri-implantitis by selecting the site and time and applying radicals using the latest engineering technology.
In this study, we first developed visible light responsive titanium oxide and atmospheric pressure plasma jet irradiation equipment that are most suitable for the implant recovery systems. Using these, we were able to acquire the basic technology to construct an implant recovery system that can be reliably and safely restored without removal in the oral cavity.

Academic Significance and Societal Importance of the Research Achievements

歯科インプラントの撤去を余儀なくされた場合、インプラントおよび周囲骨の喪失に伴う患者の身体的、心理的および経済的負担は著しく大きい。本研究成果により、口腔内リカバリーシステムが構築されれば、これら全ての問題を解決する可能性があり、臨床的・社会的意義は極めて大きいと考えられる。
口腔内環境といった厳しい条件下での、再活性化による新しいリカバリー法の確立は、生体内での変化に対して適応が難しい生体材料の生物学的、臨床的課題を解決する可能性を持つ。すなわち、人工関節治療など他の医療分野への応用展開として拡がる可能性も大きく、歯科医学分野からの技術発信として医学全体へ大きく貢献することが期待できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (10 results)

All 2018 2017 2016

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results)

  • [Journal Article] Surface structure and in vitro apatite-forming ability of titanium doped with various metals2018

    • Author(s)
      M. Kawashita, Y. Iwabuchi, K. Suzuki, M. Furuya, K. Yokota and H. Kanetaka
    • Journal Title

      Colloids and Surfaces A

      Volume: 555 Pages: 558-564

    • DOI

      10.1016/j.colsurfa.2018.07.027

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cold atmospheric plasma enhances osteoblast differentiation2017

    • Author(s)
      Tominami K, Kanetaka H, Sasaki S, Mokudai T, Kaneko T, Niwano Y
    • Journal Title

      PLoS One

      Volume: 12 Issue: 7 Pages: e0180507-e0180507

    • DOI

      10.1371/journal.pone.0180507

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Control of HAp formation and osteoconductivity on nitrogen-doped TiO2 scale formed by oxynitridation of Ti2017

    • Author(s)
      3.Masami Hashimoto, Satoshi Kitaoka, Yoshihiro Obata, Shunsuke Muto, Takafumi Ogawa, Maiko Furuya, Hiroyasu Kanetaka
    • Journal Title

      Key Engineering Materials

      Volume: 758 Pages: 86-89

    • DOI

      10.4028/www.scientific.net/kem.758.86

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of charged particles and reactive species on cell membrane permeabilization induced by atmospheric-pressure plasma irradiation2016

    • Author(s)
      S. Sasaki, M. Kanzaki, Y. Hokari, K. Tominami, T. Mokudai, H. Kanetaka, and T. Kaneko
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 55 Issue: 7S2 Pages: 07LG04-07LG04

    • DOI

      10.7567/jjap.55.07lg04

    • NAID

      210000146888

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Visible light-induced antimicrobial activity of N-doped TiO2 on Ti substrates2018

    • Author(s)
      M. Iwatsu, T. Ogawa, T. Mokudai, H. Kanetaka, M. Kawashita, T. Watanabe and K. Sasaki
    • Organizer
      27th Annual Scientific Meeting of the European Association for Osseointegration
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 銀または銅をドープしたチタンのアパタイト形成能と可視光照射による抗菌性の向上2018

    • Author(s)
      鈴木香苗、川下将一、岩津美里、目代貴之、金高弘恭
    • Organizer
      第40回日本バイオマテリアル学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Gas-liquid interfacial plasmas for enhancing gene transfer into living cells.2017

    • Author(s)
      Kaneko T, Sasaki S, Takashima K, Kanzaki M, Kanetaka H, Tachikawa M.
    • Organizer
      The 44th European Physical Society Conference on Plasma Physics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] HAp formation and osteoconductivity of nitrogen-doped TiO2 scale formed by oxynitridation of Ti exhibiting different surface charge.2017

    • Author(s)
      .Hashimoto M, Kitaoka S, Obata Y, Muto S, Furuya M, Kanetaka H.
    • Organizer
      The 15th Intetnational Conference on Advanced Materials
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Control of HAp formation and osteoconductivity on nitrogen-doped TiO2 scale formed by oxynitridation of Ti.2017

    • Author(s)
      Hashimoto M, Kitaoka S, Obata Y, Muto S, Ogawa T, Furuya M, Kanetaka H.
    • Organizer
      29th Symposium and Annual Meeting of the International Society for Ceramics in Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gas-Liquid Interfacial Atmospheric Pressure Plasmas for Medical Applications.2016

    • Author(s)
      Kaneko T, Sasaki S, Takashima K, Sato T, Kanetaka H, Tachikawa M, Kanzaki M.
    • Organizer
      The 3rd Japan-Taiwan Workshop on Plasma Life Science and Technology
    • Place of Presentation
      New Taipei City, Taiwan
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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