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The development of surface-charged ceramics biomaterials for material-driven regenerative medicine

Research Project

Project/Area Number 16H05531
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Yamashita Kimihiro  東京医科歯科大学, 歯学部, 非常勤講師 (70174670)

Co-Investigator(Kenkyū-buntansha) 野崎 浩佑  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (00507767)
永井 亜希子  愛知学院大学, 歯学部, 准教授 (40360599)
中村 美穂  東京医科歯科大学, 生体材料工学研究所, 非常勤講師 (40401385)
堀内 尚紘  東京医科歯科大学, 生体材料工学研究所, 助教 (90598195)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywordsエレクトレット / バイオセラミックス / 表面電荷 / 電気分極 / 再生医療 / 生体材料 / 無機材料 / 生体と材料界面 / バイオインターフェイス / 表面改質 / 生体と材料間界面
Outline of Final Research Achievements

Although the medical and academic demands expect the progress of biomaterials for regenerative medicine, there are many difficulties to overcome before clinical use. The development of excellent biomaterials as scaffolds that support cell adhesion, proliferation, and differentiation is essential for regenerative medicine in addition to the cells and growth factors. There is a strong demand for further enhancement and development of existing biomaterials to regenerate large-scale defects in the fields of orthopedics and oral surgery. In this study, we established an application method to promote material-driven regenerative medicine that can control cell behavior by physical, chemical, or biological action. We further developed a universal theory describing material-cell interactions using in vitro and in vivo models.

Academic Significance and Societal Importance of the Research Achievements

我々は,バイオエレクトレットの外部作用力を勘案して,材料が自立的に発する相互作用力を用いて周辺環境を三次元的に制御する材料は生体内において骨再生や血管内皮細胞の修復や神経細胞の再生,あるいは創傷皮膚の修復を中心に有効で、これらの材料が持つ生物学的作用を起点にマテリアルバイオロジ―を提唱してきた.さらにこれらの作用力は未分化幹細胞や異種細胞間のシグナル伝達を制御できることも考えられ,その作用機序の解明は普遍的理論構築に至り,新たな再生医療への道が開拓されるものと期待できる.これらの成果は申請者らが他に先駆け発表し,世界的に評価を得てきている.

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (38 results)

All 2020 2019 2018 2017 2016

All Journal Article (18 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 18 results,  Open Access: 3 results) Presentation (20 results) (of which Int'l Joint Research: 7 results,  Invited: 8 results)

  • [Journal Article] Efficacy of electrical polarization on a rat femoral bone defect model with a custom-made external fixator2020

    • Author(s)
      Ohara Masato、Itoh Soichiro、Fujiwara Hiroyoshi、Oda Ryo、Tsuchida Shinji、Kohata Kazuhiro、Yamashita Kimihiro、Kubo Toshikazu
    • Journal Title

      Bio-Medical Materials and Engineering

      Volume: 30 Issue: 5-6 Pages: 475-486

    • DOI

      10.3233/bme-191068

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Antibacterial Property of Facet-Engineered TiO2 Nanosheet in Presence and Absence of Ultraviolet Irradiation2019

    • Author(s)
      Hayashi Kenichiro、Nozaki Kosuke、Tan Zhenquan、Fujita Kazuhisa、Nemoto Reina、Yamashita Kimihiro、Miura Hiroyuki、Itaka Keiji、Ohara Satoshi
    • Journal Title

      Materials

      Volume: 13 Issue: 1 Pages: 78-78

    • DOI

      10.3390/ma13010078

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An oriented hydroxyapatite film with arrayed plate‐like particles enhance chondrogenic differentiation of ATDC5 cells2019

    • Author(s)
      Komuro Hiroaki、Wint Wit Y.、Horiuchi Naohiro、Nozaki Kosuke、Sasano Tetsuo、Miyashin Michiyo、Yamashita Kimihiro、Nagai Akiko
    • Journal Title

      Journal of Biomedical Materials Research Part A

      Volume: 108 Issue: 3 Pages: 537-544

    • DOI

      10.1002/jbm.a.36834

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plate-like hydroxyapatite synthesized from dodecanedioic acid enhances chondrogenic cell proliferation2019

    • Author(s)
      Wint Wit Yee、Horiuchi Naohiro、Nozaki Kosuke、Nagai Akiko、Yamashita Kimihiro、Miyashin Michiyo
    • Journal Title

      Bio-Medical Materials and Engineering

      Volume: 30 Issue: 4 Pages: 375-386

    • DOI

      10.3233/bme-191060

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of glucose modification of hydroxyapatite nanoparticles on gene delivery2019

    • Author(s)
      Komuro H, Sasano T, Horiuchi N, Yamashita K, Nagai A
    • Journal Title

      J Biomed Mater Res A

      Volume: 107A Issue: 1 Pages: 61-66

    • DOI

      10.1002/jbm.a.36523

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrical conductivity of polycrystalline hydroxyapatite and its application to electret formation2018

    • Author(s)
      Horiuchi Naohiro、Madokoro Kazuki、Nozaki Kosuke、Nakamura Miho、Katayama Keiichi、Nagai Akiko、Yamashita Kimihiro
    • Journal Title

      Solid State Ionics

      Volume: 315 Pages: 19-25

    • DOI

      10.1016/j.ssi.2017.11.029

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcite Crystallization on Polarized Single Calcite Crystal Substrates in the Presence of Poly-Lysine2018

    • Author(s)
      Wada Norio、Horiuchi Naohiro、Nakamura Miho、Nozaki Kosuke、Nagai Akiko、Yamashita Kimihiro
    • Journal Title

      Crystal Growth & Design

      Volume: 18 Issue: 2 Pages: 872-878

    • DOI

      10.1021/acs.cgd.7b01364

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Size Control Synthesis of Hydroxyapatite Plates and Their Application in the Preparation of Highly Oriented Films2018

    • Author(s)
      Horiuchi Naohiro、Shibata Kotaro、Saito Hironori、Iwabuchi Yuki、Wada Norio、Nozaki Kosuke、Hashimoto Kazuaki、Tanaka Yumi、Nagai Akiko、Yamashita Kimihiro
    • Journal Title

      Crystal Growth & Design

      Volume: 18 Issue: 9 Pages: 5038-5044

    • DOI

      10.1021/acs.cgd.8b00480

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effectiveness of low-intensity pulsed ultrasound stimulation in unstable both radius and ulna diaphysis fractures in children to facilitate bone union2018

    • Author(s)
      S. Itoh, T. Ota, K. Yamashita
    • Journal Title

      The journal of the Japanese Bio-Electrical and Physical Stimulation Research Society

      Volume: 32 Pages: 11-15

    • NAID

      40021758517

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] セバシン酸を用いた板状水酸アパタイトの 合成2018

    • Author(s)
      堀内尚紘、斎藤弘憲、橋本和明、山下仁大
    • Journal Title

      J. Soc. Inorg. Mater. Jpn

      Volume: 25 Pages: 369-373

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Controlled crystallization of calcium carbonate via cooperation of poly-asparatic acid and poly-lysine under double-diffusion conditions in agar hydrogels2018

    • Author(s)
      Wada N, Horiuchi N, Nakamura M, Nozaki K, Nagai A, Yamashita K
    • Journal Title

      ACS Omega

      Volume: 3 Issue: 12 Pages: 16681-92

    • DOI

      10.1021/acsomega.8b02445

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and enhanced bone regeneration of carbonate substituted octacalcium phosphate2017

    • Author(s)
      Shen Donghe、Horiuchi Naohiro、Nozaki Sosuke、Miyashin Michiyo、Yamashita Kimihiro、Nagai Akiko
    • Journal Title

      Bio-Medical Materials and Engineering

      Volume: 28 Issue: 1 Pages: 9-21

    • DOI

      10.3233/bme-171651

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influences of osteoarthritis and osteoporosis on the electrical properties of human bones as in vivo electrets produced due to Wolff’s law2017

    • Author(s)
      Kohata Kazuhiro、Itoh Soichiro、Horiuchi Naohiro、Yoshioka Taro、Yamashita Kimihiro
    • Journal Title

      Bio-Medical Materials and Engineering

      Volume: 28 Issue: 1 Pages: 65-74

    • DOI

      10.3233/bme-171657

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxyapatite with High Carbonate Substitutions Promotes Osteoclast Resorption through Osteocyte-like Cells2016

    • Author(s)
      Nakamura M, Hiratai R, Hentunen T, Salonen J, Yamashita K
    • Journal Title

      ACS Biomater Sci Eng

      Volume: 2 Issue: 2 Pages: 259-267

    • DOI

      10.1021/acsbiomaterials.5b00509

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Surface Free Energy Predominates in Cell Adhesion to Hydroxyapatite through Wettability2016

    • Author(s)
      2Nakamura M, Hori N, Ando H, Namba S, Toyama T, Nishimiya N, Yamashita K
    • Journal Title

      Mater Sci Eng C

      Volume: 62 Pages: 283-292

    • DOI

      10.1016/j.msec.2016.01.037

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electrostatic Induction Power Generator using Hydroxyapatite Ceramic Electrets2016

    • Author(s)
      Norio Wada, Naohiro Horiuchi, Katsuyuki Mukogawa, Kosuke Nozaki, Miho Nakamura, Akiko Nagai, Toshinori Okura and Kimihiro Yamashita
    • Journal Title

      Mater. Res. Bull.

      Volume: 74 Pages: 50-56

    • DOI

      10.1016/j.materresbull.2015.10.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Controlled in Vivo Nacre Formation in Flat Pearls with Hydroxyapatite Bioceramic Nuclei2016

    • Author(s)
      N. Wada, N. Horiuchi, K. Ohta, S. Urasaki, K. Yamauchi, K Yamashita
    • Journal Title

      Crystal Growth & Design

      Volume: 16 Issue: 1 Pages: 167-173

    • DOI

      10.1021/acs.cgd.5b01074

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Role of the Collaborative Functions of the Composite Structure of Organic and Inorganic Constituents and their Influence on the Electrical Properties of Human Bone2016

    • Author(s)
      Kohata K, Itoh S, Horiuchi N, Yoshioka T, Yamashita K
    • Journal Title

      Biomed Mater Eng

      Volume: 27 Issue: 2-3 Pages: 305-314

    • DOI

      10.3233/bme-161587

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] 高次構造制御チタニアナノシートによる暗所下における抗菌活性の向上2019

    • Author(s)
      野崎 浩佑,林 建一郎,譚 振権,山下 仁大,三浦 宏之,大原 智,位髙 啓史
    • Organizer
      第41回日本バイオマテリアル学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Antibacterial effect of highly oriented TiO2 nanosheet in dark conditions2019

    • Author(s)
      Kosuke Nozaki, Kenichiro Hayashi, Zhenquan Tan, Kimihiro Yamashita, Hiroyuki Miura, Satoshi Ohara, and Keiji Itaka
    • Organizer
      The 4th International Symposium on Biomedical Engineering (ISBE2019)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高次構造制御によるチタニアナノシートのレドックス活性と抗菌活性制御2019

    • Author(s)
      林建一郎,野崎浩佑,根本怜奈,山下仁大,三浦宏之
    • Organizer
      日本歯科理工学会平成31年度春季第73回学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Fundamentals of Hydroxyapatite-Electret-Based Biointerface Engineering2018

    • Author(s)
      Kimihiro Yamashita
    • Organizer
      THERMEC 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Introduction of Hydroxyapatite Electret for Novel Biointerface Engineering2018

    • Author(s)
      Kimihiro Yamashita
    • Organizer
      The International Symposium on Inorganic and Environmental Materials 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Calcium deficiency regulates surface charges of β-tricalcium phosphate2018

    • Author(s)
      Kosuke Nozaki, Kazuhisa Fujita, Naohiro Horiuchi, Kimihiro Yamashita, Kazuaki Hashimoto, Hiroyuki Miura, Akiko Nagai
    • Organizer
      6th General Session and Exhibition of the IADR
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 炭酸イオン含有量制御による吸収性骨補填材の骨伝導能の最適化2018

    • Author(s)
      野崎浩佑,藤田和久,林 建一郎,山下仁大,三浦宏之,永井亜希子
    • Organizer
      第71回日本歯科理工学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 分極ゼオライトの電気特性評価2018

    • Author(s)
      中村美穂,米山祥平,吉田直哉,大倉利典,山下仁大
    • Organizer
      日本セラミックス協会 2018年年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Banked bone intended for clinical use as an electrical energy resourvoir2017

    • Author(s)
      M. Nakamura, K. Yamashita, J. Tuukkanen, P. Lehenkari
    • Organizer
      Finnish Bone bank meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Understanding of cell-biomaterial interactions in terms of surface and materials science2017

    • Author(s)
      M. Nakamura, K. Yamashita
    • Organizer
      International Symposium on Biomedical and Environmental Materials
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Interfacial polarization caused by proton conduction in hydroxyapatite and its application for electret formation2017

    • Author(s)
      N. Horiuchi, K. Nozaki, M. Nakamura, A. Nagai, K. Yamashita
    • Organizer
      20th International Conference on Solid State Ionics
    • Related Report
      2017 Annual Research Report
  • [Presentation] 新規材料合成法からバイオ分野応用をターゲットにしたセラミックエレクトレットの表面静電場による固体析出反応の制御2017

    • Author(s)
      山下仁大
    • Organizer
      日本セラミックス協会 2017 年年会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] カルボン酸を用いた板状水酸アパタイトの合成2017

    • Author(s)
      堀内尚紘,野崎浩佑,中村美穂,永井亜希子,山下仁大
    • Organizer
      無機マテリアル学会第 134 回学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 水酸アパタイトエレクトレットの特性に与える焼結条件の影響2017

    • Author(s)
      大塚啓介, 堀内尚紘, 野崎浩佑, 中村美穂, 永井亜希子, 山下仁大
    • Organizer
      日本セラミックス協会 第30回秋季シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] ポーリングアパタイトの開発2017

    • Author(s)
      山下仁大
    • Organizer
      日本セラミックス協会 第30回秋季シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 溶解性を制御するナトリウムイオン固溶β型リン酸三カルシウムを用いた分極バイオセラミックスの開発2016

    • Author(s)
      遠藤敬幸,野崎浩佑,堀内尚紘,橋本和明,山下仁大,永井亜希子
    • Organizer
      第 20 回生体関連セラミックス討論会
    • Place of Presentation
      大阪大学銀杏会館(大阪府吹田市)
    • Year and Date
      2016-12-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] 細胞足場材料のためのハイドロキシアパタイト薄膜作成2016

    • Author(s)
      野副菜摘,堀内尚紘,野崎浩佑,橋本和明,山下仁大,永井亜希子
    • Organizer
      第20回生体関連セラミックス討論会 .12.02
    • Place of Presentation
      大阪大学銀杏会館(大阪府吹田市)
    • Year and Date
      2016-12-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] 破骨細胞吸収特性に対するアパタイトの炭酸含有量の影響2016

    • Author(s)
      中村美穂, 平体留美, 田熊孝子, Hentunen T, Salonen J, Tuukkanen J, 山下仁大.
    • Organizer
      日本バイオマテリアル学会シンポジウム
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-11-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] Osteocyte-Mediated Osteoclastogenesis Stimulated by Carbonate Apatite2016

    • Author(s)
      Nakamura M
    • Organizer
      The 28th Annual Meeting of the International Society for Ceramics in Medicine (Bioceramics 28)
    • Place of Presentation
      Charlotte, North Carolina (USA)
    • Year and Date
      2016-10-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Surface Science and Biocompatibility of Electrically Polarized Bioceramics2016

    • Author(s)
      Yamashita K
    • Organizer
      The 9th International Symposium on Inorganic Phosphate Materials (ISIPM-9)
    • Place of Presentation
      Tokyo (Japan)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2021-02-19  

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