| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Outline of Final Research Achievements |
Msx1 is known as a causative gene for tooth agenesis and is also important for tooth development in mice. Its functional domains have been well studied using cultured cells, on the other hand, the analysis using mice has not been performed because the problem of the gene disruption technology and the cost. Then, we have tried functional analysis of each domain of the Msx1 gene in mice using the genome editing technology that has been developed in recent years. We found that the MH5 and MH6 domains downstream of the homeodomain are important for tooth and bone formation.
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