• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of risk factors for systemic diseases in periodontitis patients based on the connection between oral and gut microbiomes

Research Project

Project/Area Number 16H05554
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontology
Research InstitutionTokyo Dental College (2018)
Niigata University (2016-2017)

Principal Investigator

Nakajima Takako  東京歯科大学, 歯学部, 非常勤講師 (40303143)

Co-Investigator(Kenkyū-buntansha) 山崎 和久  新潟大学, 医歯学系, 教授 (00182478)
齋藤 淳  東京歯科大学, 歯学部, 教授 (60266559)
森田 英利  岡山大学, 環境生命科学研究科, 教授 (70257294)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords歯周病 / 腸内細菌 / マイクロバイオーム / メタボローム / メタゲノム
Outline of Final Research Achievements

Periodontal disease is known to be associated with atherosclerotic vascular diseases, metabolic diseases, and autoimmune diseases. Gut dysbiosis is also implicated in these diseases. Based on our data in which swallowed periodontopathic bacteria induces gut dysbiosis, we aimed at clarifying these findings in fact take palce in human periodontitis patients. We demonstrated that gut microbiota composition of periodontitis patients is significantly different from that of healthy subjects, providing new insight into the causal mechanism of periodontitis for systemic diseases.

Academic Significance and Societal Importance of the Research Achievements

これまで歯周病が全身疾患のリスクを高めるメカニズムは解明されていなかった。本研究課題において、歯周病と関連する口腔細菌を多量、かつ継続的に嚥下することで腸内細菌が乱れることを実際の患者においてはじめて示した。腸内細菌叢は全身の健康と密接に関連しており、歯周病治療が腸内細菌叢の改善を介して健康長寿に貢献することの学術的基盤を提供した意義は大きい。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (20 results)

All 2018 2017 2016 Other

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (14 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results) Remarks (2 results)

  • [Journal Article] The anti-inflammatory effect of 10-oxo-trans-11-octadecenoic acid (KetoC) on RAW 264.7 cells stimulated with Porphyromonas gingivalis lipopolysaccharide2018

    • Author(s)
      Sulijaya B.、Takahashi N.、Yamada M.、Yokoji M.、Sato K.、Aoki-Nonaka Y.、Nakajima T.、Kishino S.、Ogawa J.、Yamazaki K.
    • Journal Title

      Journal of Periodontal Research

      Volume: 印刷中 Issue: 5 Pages: 777-784

    • DOI

      10.1111/jre.12564

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An orally administered oral pathobiont and commensal have comparable and innocuous systemic effects in germ-free mice2018

    • Author(s)
      Sato Keisuke、Yokoji Mai、Yamada Miki、Nakajima Takako、Yamazaki Kazuhisa
    • Journal Title

      Journal of Periodontal Research

      Volume: 53 Issue: 6 Pages: 950-960

    • DOI

      10.1111/jre.12593

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system.2017

    • Author(s)
      Sato K, Takahashi N, Kato T, Matsuda Y, Yokoji M, Yamada M, Nakajima T, Kondo N, Endo N, Yamamoto R, Noiri Y, Ohno H, Yamazaki K
    • Journal Title

      Sci. Rep.

      Volume: 7(1) Issue: 1 Pages: 6955-6955

    • DOI

      10.1038/s41598-017-07196-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The association of periodontitis and systemic responses, from the point of view of T-cell responses2016

    • Author(s)
      中島貴子
    • Journal Title

      Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)

      Volume: 58 Issue: 2 Pages: 51-57

    • DOI

      10.2329/perio.58.51

    • NAID

      130005164867

    • ISSN
      0385-0110, 1880-408X
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Porphyromonas gingivalis口腔投与が無菌マウスに与える影響の解析2018

    • Author(s)
      佐藤 圭祐,山田 実生,横地 麻衣,中島 貴子,山崎 和久
    • Organizer
      第61回春季日本歯周病学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Bioactive metabolite inhibits proinflammatory cytokines by macrophage treated with Porphyromonas gingivalis lipopolysaccharide via G-protein-coupled receptor 120.2018

    • Author(s)
      Benso Sulijaya, Naoki Takahashi, Miki Yamada, Mai Yokoji, Keisuke Sato, Yukari Aoki-Nonaka, Takako Nakajima, Kazuhisa Yamazaki.
    • Organizer
      第61回春季日本歯周病学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Impact of Local Drug Delivery of Minocycline on the Subgingival Microbiota during Supportive Periodontal Therapy: A Pilot Study.2017

    • Author(s)
      Nakajima T, Miyazawa H, Horimizu M, Li L, Okada Y, Arita T, Inoue M, Nishida M, Yamazaki K, Genco RJ
    • Organizer
      UNCPERIO 2017EXPO
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Periodontopathic bacteria increases the severity of collagen-induced arthritis by affecting gut microbiota.2017

    • Author(s)
      Yamazaki K, Sato K, Takahashi N, Kato T, Matsuda Y, Yokoji M, Yamada M, Yamazaki K, Nakajima T, OhnoH
    • Organizer
      PgMelbourne
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 歯周炎患者における腸内細菌叢の解析2017

    • Author(s)
      中島貴子,高橋直紀,皆川高嘉,宮沢春菜,伊藤晴江,佐藤圭祐,山崎和久
    • Organizer
      第60回春季日本歯周病学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Impact of Local Drug Delivery of Minocycline on the Subgingival Microbiota during Supportive Periodontal Therapy: a Pilot Study2017

    • Author(s)
      Nakajima T, Miyazawa H, Horimizu M, Li L, Okada Y, Arita T, Inoue M, Nishida M, Yamazaki K, Genco R
    • Organizer
      12th Asian Pacific Society of Periodontology Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of the association between alveolar bone resorption and atherosclerosis risk.2017

    • Author(s)
      Yonezawa D, Koide H, Aruga A, Takahasji S, Tsutsumi T, Kumagai S, Nakajima T and Yamazaki K
    • Organizer
      12th Asian Pacific Society of Periodontology Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 塩酸ミノサイクリン局所投与がサポーティブペリオドンタルセラピー(SPT)期歯周炎患者の歯肉縁下細菌叢に及ぼす影響(第Ⅰ報)2017

    • Author(s)
      中島貴子,宮沢春菜,堀水慎,杉田典子,奥田一博,山崎和久
    • Organizer
      第147回日本歯科保存学会秋季学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Porphyromonas gingivalis口腔投与のコラーゲン誘導性関節炎増悪メカニズムの解析2017

    • Author(s)
      佐藤圭祐,高橋直紀,中島麻由佳,松田由実,山田実生,横地麻衣,中島貴子,山崎和久
    • Organizer
      第147回日本歯科保存学会秋季学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 歯周炎患者腸内細菌叢における口腔内由来細菌の比率2017

    • Author(s)
      山崎恭子,中島貴子,高橋直紀,宮沢春菜,皆川高嘉,佐藤圭祐,伊藤晴江,山崎和久
    • Organizer
      第147回日本歯科保存学会秋季学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 歯周病と動脈硬化性疾患の関連2017

    • Author(s)
      中島貴子
    • Organizer
      日本歯周病学会60周年記念京都大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 塩酸ミノサイクリン局所投与がサポーティブペリオドンタルセラピー(SPT)期歯周炎患者の歯肉縁下細菌叢に及ぼす影響(第Ⅱ報)2017

    • Author(s)
      宮沢春菜,中島貴子,堀水慎,杉田典子,奥田一博,山崎和久
    • Organizer
      日本歯周病学会60周年記念京都大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 成人健診データにおける歯槽骨吸収量と動脈硬化症リスクの関連解析2016

    • Author(s)
      米澤大輔、小出浩貴、有賀彩乃、高橋駿介、堤 武志、熊谷 信平、中島貴子、山崎和久.
    • Organizer
      第59回秋季日本歯周病学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] T細胞免疫応答解析を基盤とした歯周炎と全身応答の関連解明2016

    • Author(s)
      中島貴子
    • Organizer
      第59回春季日本歯周病学会学術大会
    • Place of Presentation
      かごしま県民交流センター(鹿児島県鹿児島市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Remarks] 山崎研究室

    • URL

      http://www.dent.niigata-u.ac.jp/yamazaki_labo/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 歯周‐全身プロジェクト 山崎研究室

    • URL

      http://www.dent.niigata-u.ac.jp/yamazaki_labo/

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi