The association between oral health and minor cognitive impairment (MCI): contribution of MCI prevention on dementia

• Project/Area Number: 16H05556
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Tohoku University
• Principal Investigator: Aida Jun 東北大学, 歯学研究科, 准教授 (80463777)
• Co-Investigator(Kenkyū-buntansha): 山本 龍生 神奈川歯科大学, 大学院歯学研究科, 教授 (20252984) ; 近藤 克則 千葉大学, 予防医学センター, 教授 (20298558) ; 坪谷 透 東北大学, 歯学研究科, 助教 (30650650) ; 小坂 健 東北大学, 歯学研究科, 教授 (60300935)
• Research Collaborator: KUSAMA Taro ; ARIMA Misaki
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2016: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
• Keywords: 歯科保健 / 軽度認知障害 / 認知症 / 口腔と全身の健康 / 口腔保健 / 疫学 / 歯 / MCI / 口腔の健康 / 認知機能 / 軽度認知障害（MCI）

Outline of Final Research Achievements

Determining the factors preventing minor cognitive impairment (MCI) is required. This study examined the association between oral health and MCI. In 2016, questionnaire was developed and epidemiological survey was conducted. In 2017, database was built and analysis had been started. In 2018, analysis had been continued. As the results, participants with better biting ability had significantly lower risk of MCI.

Academic Significance and Societal Importance of the Research Achievements

認知症は突然発症するのではなく、健常な状態から軽度認知障害(MCI)、そして認知症と段階を経て発症するため、認知症に至る前のMCIの状態を予防することが求めらてれている。本研究では交絡因子として現在歯数と義歯の使用の有無を調整した上でも噛み合わせが良いと認知機能が良い方向の有意な関連が認められた、主観的な噛み合わせが独立したファクターとして認知機能に関連している可能性が明らかにされた。これらの解析のほか、得られたデータからいくつかの疫学研究も実施し、口腔の健康が全身の健康悪化を予防する方向に機能していることを示唆する結果が得られた。これらは口腔の健康の様々な観点での重要性を示すものである。

Research Products

• [Journal Article] Cohort Study on Laryngeal Cough Reflex, Respiratory Disease, and Death: A Mediation Analysis. (2019)
  • Author(s): Yamamoto T, Aida J, Shinozaki T, Tsuboya T, Sugiyama K, Yamamoto T, Kondo K, Sasaki K, Osaka K
  • Journal Title: Journal of the American Medical Directors Association Volume: 1 Issue: 8 Pages: 1-6
  • DOI: 10.1016/j.jamda.2019.01.155
  • Peer Reviewed
• [Journal Article] Sleep duration and remaining teeth among older people (2018)
  • Author(s): Koyama Shihoko、Aida Jun、Cable Noriko、Tsuboya Toru、Matsuyama Yusuke、Sato Yukihiro、Yamamoto Tatsuo、Kondo Katsunori、Osaka Ken
  • Journal Title: Sleep Medicine Volume: 52 Pages: 18-22
  • DOI: 10.1016/j.sleep.2018.07.020
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Social and Behavioural Determinants of the Difference in Survival among Older Adults in Japan and England (2018)
  • Author(s): Aida Jun、Cable Noriko、Zaninotto Paola、Tsuboya Toru、Tsakos Georgios、Matsuyama Yusuke、Ito Kanade、Osaka Ken、Kondo Katsunori、Michael G. Marmot、 Richard G. Watt
  • Journal Title: Gerontology Volume: 64 Issue: 3 Pages: 266-277
  • DOI: 10.1159/000485797
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 主観的な噛み合わせと認知機能の関連性 (2018)
  • Author(s): 有馬実咲, 相田潤, 草間太郎, 杉山賢明, 坪谷透, 小山史穂子, 山本龍生, 近藤克則, 小坂健
  • Organizer: 日本口腔衛生学会総会
• [Presentation] Social determinants of oral health inequalities and challenges in Asia Pacific (2016)
  • Author(s): Jun Aida
  • Organizer: China-Japan-Korea Dental Science Symposium 2016
  • Int'l Joint Research
• [Book] Chapter 14. Tooth loss in Oral Epidemiology. A Textbook on Oral Health Conditions, Research Topics and Methods. (2019)
  • Author(s): Aida J
  • Publisher: Springer