Construction of evidence to prevent occupational exposure during intravenous administration of anticancer drugs
| Project/Area Number |
16H05580
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical nursing
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
Hirai Kazue 東京医科大学, 医学部, 教授 (10290058)
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| Co-Investigator(Kenkyū-buntansha) |
神田 清子 高崎健康福祉大学, 保健医療学部, 教授 (40134291)
飯野 京子 国立研究開発法人国立国際医療研究センター, その他部局等, 国立看護大学校 (00532350)
市川 智里 国立研究開発法人国立がん研究センター, 東病院, 看護師 (10588437)
野村 久祥 国立研究開発法人国立がん研究センター, 東病院, 薬剤師 (30774054)
平松 玉江 国立研究開発法人国立がん研究センター, 中央病院, 副看護部長 (30774187)
細川 舞 岩手県立大学, 看護学部, 准教授 (70760908)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 職業性曝露 / 抗がん剤 / 看護 / Hazardous drugs / Hazardous Drugs / 曝露 / 静脈内投与 / 静脈内注射 |
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| Outline of Final Research Achievements |
In order to clarify the contamination of environment and the nurse's personal protective equipment during intravenous administration of an anticancer drug, 1) as a fandamental study, when 3 nurses performed the administration procedure using an infusion bag prepared with Nyclin instead of an anticancer drug, (2) as a clinical study, when 5FU was administered using a general infusion set at 16 facilities, the residual amount was determined by LC/MS/MS method.In both cases (1) and (2), the contamination, especially on the environment and nurse's gloves, when using the general infusion set was clear.
Assuming urinary incontinence in patients within 48 hours after administration,linens intentionally contaminated with 5FU and CPA were washed by several methods, and the residual amount after washing was investigated. Perfect decontamination was confirmed by washing twice with a standard amount of water.
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| Academic Significance and Societal Importance of the Research Achievements |
抗がん剤静脈内投与時の看護師の職業性曝露を防ぐために、一般輸液セットではなくCSTD（閉鎖式接続器具）を使用する必要があること、CSTDを使用している場合も手袋・ガウンなどの個人防護具を着用する必要があることのエビデンスが確認できた。本結果により、調製のみならず投与にもCSTDを導入する必要性が明らかになった。
また、抗がん剤投与後の患者の体液・排泄物で汚染されたリネン類の取り扱いに関するエビデンスは世界的に例がなく、看護師、リネン類を取り扱う従事者の職業性曝露対策、また在宅で患者の世話をする家族の曝露対策の具体策が明らかになった。
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Report
(3 results)
Research Products
(16 results)
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[Presentation] Development of “Guidelines for safe handling of cancer chemotherapy drugs”in Japan2016
Author(s)
Kazue Hirai, Kiyoko Kanda, Keiko Iino, Taro Kano, Chisato Ichikawa, Sumiyo Iwamoto, Hisateru Yasui, Ayako Mitsuma, Hisanaga Nomura, Sumiko Hiura, Tomoko Morita, Hiroko Komatsu.
Organizer
International Conference on Cancer Nursing
Place of Presentation
香港
Year and Date
2016-09-04
Related Report
Int'l Joint Research
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[Presentation] Overview of JSCN/JSMO/JASPO Joint Guidelines for Safe Handling of Cancer Chemotherapy Drugs in Japan2016
Author(s)
Kiyoko Kanda, Kazue Hirai, Keiko Iino,Taro Kano,Chisato Ichikawa, Sumiyo Iwamoto, Hisateru Yasui, Ayako Mitsuma, Hisanaga Nomura, Sumiko Hiura, Tomoko Morita, Hiroko Komatsu.
Organizer
International Conference on Cancer Nursing
Place of Presentation
香港
Year and Date
2016-09-04
Related Report
Int'l Joint Research
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[Presentation] Survey of the safe handling of hazardous drugs by nurses in Japan2016
Author(s)
Keiko Iino, Kiyoko Kanda, Kazue Hirai, Taro Kano, Chisato Ichikawa, Sumiyo Iwamoto,Mari Watanabe ,Kazuko Nasu, Emi Fujii, Jun Kako, Ikuko Kazama , Hiroko Komatsu.
Organizer
International Conference on Cancer Nursing
Place of Presentation
香港
Year and Date
2016-09-04
Related Report
Int'l Joint Research
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