Isolation of pathogenic Entamoeba species from humans and macaques in Asia and analysis of host-parasite coevolution

• Project/Area Number: 16H05819
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Parasitology (including sanitary zoology)
• Research Institution: Tokai University
• Principal Investigator: TACHIBANA Hiroshi 東海大学, 医学部, 客員教授 (10147168)
• Co-Investigator(Kenkyū-buntansha): 牧内 貴志 東海大学, 医学部, 講師 (80587709)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
• Keywords: Entamoeba nuttalli / 赤痢アメーバ / マカク / 疫学 / 遺伝子多型 / ゲノム / 人獣共通感染症 / 進化 / 寄生虫 / 遺伝子 / 感染症

Outline of Final Research Achievements

Entamoeba nuttalli was detected in the feces of various macaques in Asia. The isolates showed genetic polymorphism reflecting geographical distance. On the other hand, no E. nuttalli infections were found in the survey of school children. Genotyping of E. histolytica and E. dispar suggested transmission of these amoebae within school classes. Whole genome analysis of E. nuttalli revealed a unique species-specific surface protein.

Academic Significance and Societal Importance of the Research Achievements

わが国ではニホンザルがヒトの生活圏に出没し、他のアジア諸国でもテンプルモンキーや飼育マカクにおいてヒトとの濃厚な接触がみられる。マカクの腸管寄生病原アメーバが人獣共通感染症の病原体なのかを明らかにすることは重要であるが、本研究の範囲ではヒトの感染例は確認されなかった。また、腸管寄生アメーバの遺伝的多型解析は、宿主マカクと寄生アメーバの地理的分布の解明やヒトにおける感染経路の解明に有用であった。

Research Products

• [Int'l Joint Research] 復旦大学/国立屏東科技大学(中国)
• [Int'l Joint Research] チュラロンコン大学(タイ)
• [Int'l Joint Research] チュラロンコン大学(タイ)
• [Int'l Joint Research] 国立屏東科技大学/復旦大学(中国)
• [Int'l Joint Research] チュラロンコン大学(タイ)
• [Int'l Joint Research] 復旦大学(中国)
• [Int'l Joint Research] エベレスト国際臨床研究センター(ネパール)
• [Int'l Joint Research] エベレスト国際臨床研究センター/トリブバン大学(ネパール)
• [Int'l Joint Research] 復旦大学(中国)
• [Journal Article] Analysis of D-A locus of tRNA-linked short tandem repeats reveals transmission of Entamoeba histolytica and E. dispar among students in the Thai-Myanmar border region of northwest Thailand (2021)
  • Author(s): Pattanawong U
  • Journal Title: PLoS Negl Trop Dis Volume: 15 Issue: 2 Pages: e0009188-e0009188
  • DOI: 10.1371/journal.pntd.0009188
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genotyping of Entamoeba nuttalli strains from the wild rhesus macaques of Myanmar and comparison with those from the wild rhesus macaques of Nepal and China (2021)
  • Author(s): Mon Hla Myat、Feng Meng、Pattanawong Urassaya、Kosuwin Rattiporn、Yanagi Tetsuo、Kobayashi Seiki、Putaporntip Chaturong、Jongwutiwes Somchai、Cheng Xunjia、Tachibana Hiroshi
  • Journal Title: Infection, Genetics and Evolution Volume: 92 Pages: 104830-104830
  • DOI: 10.1016/j.meegid.2021.104830
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification of Mamu-DRB1 gene as a susceptibility factor for Entamoeba nuttalli infection in Chinese Macaca mulatta (2021)
  • Author(s): Zijian Ling, Meng Feng, Jian Xu, Hiroshi Tachibana, Xunjia Cheng
  • Journal Title: Infection, Genetics and Evolution Volume: 93 Pages: 104952-104952
  • DOI: 10.1016/j.meegid.2021.104952
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A Novel TLR4-binding domain of peroxiredoxin from Entamoeba histolytica triggers NLRP3 inflammasome activation in macrophages (2021)
  • Author(s): Xia Li, Meng Feng, Yanqing Zhao, Yuhan Zhang, Ruixue Zhou, Hang Zho, Zhen Pang, Hiroshi Tachibana, Xunjia Cheng
  • Journal Title: Frontiers in Immunology Volume: 12 Pages: 758451-758451
  • DOI: 10.3389/fimmu.2021.758451
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation on elongation factor 1 alpha of Entamoeba histolytica interaction with the intermediate subunit of the Gal/GalNAc lectin and actin in phagocytosis (2020)
  • Author(s): Hang Zhou, Yue Guan, Meng Feng, Yongfeng Fu, Hiroshi Tachibana, Xunjia Cheng
  • Journal Title: Pathogens Volume: 9 Issue: 9 Pages: 702-702
  • DOI: 10.3390/pathogens9090702
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Autophagy Activated by Peroxiredoxin of Entamoeba histolytica (2020)
  • Author(s): Li Xia、Zhang Yuhan、Zhao Yanqing、Qiao Ke、Feng Meng、Zhou Hang、Tachibana Hiroshi、Cheng Xunjia
  • Journal Title: Cells Volume: 9 Issue: 11 Pages: 2462-2462
  • DOI: 10.3390/cells9112462
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification and biochemical characterisation of Acanthamoeba castellanii cysteine protease 3 (2020)
  • Author(s): Wang Zhixin、Wu Duo、Tachibana Hiroshi、Feng Meng、Cheng Xun-jia
  • Journal Title: Parasites & Vectors Volume: 13 Issue: 1 Pages: 592-592
  • DOI: 10.1186/s13071-020-04474-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Single-Cell RNA Sequencing Reveals that the Switching of the Transcriptional Profiles of Cysteine-Related Genes Alters the Virulence of Entamoeba histolytica (2020)
  • Author(s): Feng Meng、Zhang Yuhan、Zhou Hang、Li Xia、Fu Yongfeng、Tachibana Hiroshi、Cheng Xunjia
  • Journal Title: mSystems Volume: 5 Issue: 6
  • DOI: 10.1128/msystems.01095-20
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Whole genome sequencing of Entamoeba nuttalli reveals mammalian host-related molecular signatures and a novel octapeptide-repeat surface protein (2019)
  • Author(s): Masayuki Tanaka, Takashi Makiuchi, Tomoyoshi Komiyama, Takashi Shiina, Ken Osaki, Hiroshi Tachibana
  • Journal Title: PLOS Neglected Tropical Diseases Volume: 13 Issue: 12 Pages: e0007923-e0007923
  • DOI: 10.1371/journal.pntd.0007923
  • Peer Reviewed / Open Access
• [Journal Article] Correlation between genotypes and geographic distribution of Entamoeba nuttalli isolates from wild long-tailed macaques in Central Thailand (2019)
  • Author(s): Feng Meng、Yanagi Tetsuo、Putaporntip Chaturong、Pattanawong Urassaya、Cheng Xunjia、Jongwutiwes Somchai、Tachibana Hiroshi
  • Journal Title: Infection, Genetics and Evolution Volume: 70 Pages: 114-122
  • DOI: 10.1016/j.meegid.2019.02.030
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Correlation of genetic diversity between hosts and parasites in <i>Entamoeba nuttalli</i> isolates from Tibetan and rhesus macaques in China (2018)
  • Author(s): Wei Miao、Feng Meng、Guan Yue、Guo Ce、Zhou Hang、Fu Yongfeng、Tachibana Hiroshi、Cheng Xunjia
  • Journal Title: BioScience Trends Volume: 12 Issue: 4 Pages: 375-381
  • DOI: 10.5582/bst.2018.01157
  • NAID: 130007485106
  • ISSN: 1881-7815, 1881-7823
  • Year and Date: 2018-08-31
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prevalence and genotypic diversity of Entamoeba species in inhabitants in Kathmandu, Nepal (2018)
  • Author(s): Feng Meng、Pandey Kishor、Yanagi Tetsuo、Wang Ting、Putaporntip Chaturong、Jongwutiwes Somchai、Cheng Xunjia、Sherchand Jeevan B.、Pandey Basu Dev、Tachibana Hiroshi
  • Journal Title: Parasitology Research Volume: 117 Issue: 8 Pages: 2467-2472
  • DOI: 10.1007/s00436-018-5935-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Naturally acquired IgG antibodies to thrombospondin-related anonymous protein of Plasmodium vivax (PvTRAP) in Thailand predominantly elicit immunological cross-reactivity (2018)
  • Author(s): Kosuwin Rattiporn、Feng Meng、Makiuchi Takashi、Putaporntip Chaturong、Tachibana Hiroshi、Jongwutiwes Somchai
  • Journal Title: Tropical Medicine & International Health Volume: 23 Issue: 8 Pages: 923-933
  • DOI: 10.1111/tmi.13083
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Development of a sensitive immunochromatographic kit using fluorescent silica nanoparticles for rapid serodiagnosis of amebiasis (2018)
  • Author(s): Tachibana Hiroshi、Kakino Azumi、Kazama Makoto、Feng Meng、Asai Satomi、Umezawa Kazuo、Nozaki Tsukasa、Makiuchi Takashi、Kamada Takayuki、Watanabe Hideki、Horiki Noriyuki、Cheng Xunjia、Masuda Gohta
  • Journal Title: Parasitology Volume: 145 Issue: 14 Pages: 1890-1895
  • DOI: 10.1017/s0031182018000690
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Molecular and biochemical characterization of key enzymes in the cysteine and serine metabolic pathways of Acanthamoeba castellanii (2018)
  • Author(s): Wu Duo、Feng Meng、Wang Zhi-xin、Qiao Ke、Tachibana Hiroshi、Cheng Xun-jia
  • Journal Title: Parasites & Vectors Volume: 11 Issue: 1 Pages: 604-604
  • DOI: 10.1186/s13071-018-3188-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influence of Heterologous Transplant of DNA-lacking Mitochondria from Entamoeba histolytica on Proliferation of Entamoeba invadens (2018)
  • Author(s): Kazama Makoto、Yoshida Kazuhiro、Ogiwara Sanae、Makiuchi Takashi、Tachibana Hiroshi
  • Journal Title: Journal of Eukaryotic Microbiology Volume: 0 Issue: 3 Pages: 1-11
  • DOI: 10.1111/jeu.12693
  • Peer Reviewed
• [Journal Article] Characteristics of inflammatory reactions during development of liver abscess in hamsters inoculated with Entamoeba nuttalli (2018)
  • Author(s): Guan Y, Feng M, Min X, Zhou H, Fu Y, Tachibana H, Cheng X
  • Journal Title: PLoS Negl. Trop. Dis. Volume: 12 Issue: 2 Pages: e0006216-e0006216
  • DOI: 10.1371/journal.pntd.0006216
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Apoptosis of Acanthamoeba castellanii trophozoites induced by oleic acid (2018)
  • Author(s): Wu D, Qiao K, Feng M, Fu Y, Cai J, Deng Y, Tachibana H, Cheng X
  • Journal Title: J. Eukaryot. Microbiol. Volume: 65 Issue: 2 Pages: 191-199
  • DOI: 10.1111/jeu.12454
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Comparison of hemolytic activity of the intermediate subunit of Entamoeba histolytica and Entamoeba dispar lectins (2017)
  • Author(s): Kentaro Kato, Takashi Makiuchi, Xunjia Cheng, Hiroshi Tachibana
  • Journal Title: PLOS ONE Volume: 12 Issue: 7 Pages: e0181864-e0181864
  • DOI: 10.1371/journal.pone.0181864
  • NAID: 120006987440
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hetero-oligomer of dynamin-related proteins participates in the fission of highly divergent mitochondria from Entamoeba histolytica (2017)
  • Author(s): Makiuchi T, Santos HJ, Tachibana H, Nozaki T
  • Journal Title: Sci. Rep. Volume: 7 Issue: 1
  • DOI: 10.1038/s41598-017-13721-5
  • Peer Reviewed / Open Access
• [Journal Article] 再発を繰返したアメーバ性大腸炎のパロモマイシンによる１治療例 (2017)
  • Author(s): 坪川大悟、高山陽子、東納重隆、道田知樹、石田康生、八田岳士、橘 裕司、辻 尚利
  • Journal Title: Clin. Parasitol. Volume: 28 Pages: 80-83
  • Peer Reviewed
• [Journal Article] Behavior of DNA-lacking mitochondria in Entamoeba histolytica revealed by organelle transplant. (2017)
  • Author(s): Kazama M, Ogiwara S, Makiuchi T, Yoshida K, Nakada-Tsukui K, Nozaki T, Tachibana H
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 44273-44273
  • DOI: 10.1038/srep44273
  • Peer Reviewed / Open Access
• [Journal Article] 人獣共通感染症としてのアメーバ症 (2016)
  • Author(s): 橘 裕司、小林正規
  • Journal Title: 病原微生物検出情報 Volume: 37 Pages: 249-250
  • Open Access
• [Journal Article] Identification of Entamoeba polecki with unique 18S rRNA gene sequences from Celebes crested macaques and pigs in Tangkoko Nature Reserve, North Sulawesi, Indonesia. (2016)
  • Author(s): Tuda, J., Feng, M., Imada, M., Kobayashi, S., Cheng, X. and Tachibana, H.
  • Journal Title: J. Euk. Microbiol. Volume: 63 Issue: 5 Pages: 1-6
  • DOI: 10.1111/jeu.12304
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] IUD使用者で認めた歯肉アメーバと放線菌の子宮内感染から生じた腹腔内膿瘍の１例 (2016)
  • Author(s): 横田恭子、渡邊直樹、根ヶ山清、真嶋允人、嶌村将志、伊吹英美、串田吉生、橘 裕司、新井明治
  • Journal Title: Clin. Parasitol. Volume: 27 Pages: 93-95
• [Presentation] わが国に分布するマカクにおけるEntamoeba nuttalliの感染状況と分離株の遺伝的多様性 (2021)
  • Author(s): 橘 裕司, 小林正規, 柳 哲雄, 松岡史朗, 辻 大和, 垣野あずみ、金田良雅, 松林清明
  • Organizer: 第90回日本寄生虫学会大会
• [Presentation] 赤痢アメーバのPeroxiredoxinにおけるアイソフォーム間の性状比較 (2021)
  • Author(s): 今井達也, 牧内貴志, 佐々木亜由美, 福西菜穂子, 良原栄策, 橘 裕司
  • Organizer: 第90回日本寄生虫学会大会
• [Presentation] Entamoeba nuttalliの全ゲノム解析によって明らかになったEntamoeba種間の共通遺伝子群と種特異的な新規表面タンパク質 (2020)
  • Author(s): 田中政之, 牧内貴志, 橘 裕司
  • Organizer: 第89回日本寄生虫学会大会
• [Presentation] ライブイメージングによる赤痢アメーバPeroxiredoxinの動態解析 (2020)
  • Author(s): 今井達也, 牧内貴志, 橘 裕司
  • Organizer: 第89回日本寄生虫学会大会
• [Presentation] Prevalence and genotypic diversity of Entamoeba histolytica and Entamoeba dispar in schoolchildren from the Thai-Myanmar border region in northwest Thailand (2019)
  • Author(s): Hiroshi Tachibana, Urassaya Pattanawong, Azumi Kakino, Seiki Kobayashi, Naoko Yoshida, Chaturong Putaporntip, Somchai Jongwutiwes
  • Organizer: 29th European Congress of Clinical Microbiology and Infectious Diseases
  • Int'l Joint Research
• [Presentation] Intestinal parasitic infections among humans and macaques in Nepal (2019)
  • Author(s): Kishor Pandey, Naoko Yoshida, Azumi Kakino, Takashi Makiuchi, Seiki Kobayashi, Mukesh Chalise, Basu Pandey, Hiroshi Tachibana
  • Organizer: 29th European Congress of Clinical Microbiology and Infectious Diseases
  • Int'l Joint Research
• [Presentation] タイ中央部に生息する野生カニクイザルから分離した腸管寄生アメーバEntamoeba nuttalliのDNA型と地理的分布の相関 (2019)
  • Author(s): 橘 裕司, 馮 萌, 柳 哲雄, Chaturong Putaporntip, Urassaya Pattanawong, 程 訓佳, Somchai Jongwutiwes
  • Organizer: 第35回日本霊長類学会大会
• [Presentation] ライブイメージングによる赤痢アメーバPeroxiredoxinの動態解析 (2019)
  • Author(s): 今井達也, 牧内貴志, 橘 裕司
  • Organizer: 第79回日本寄生虫学会東日本支部大会
• [Presentation] ライブイメージング法による赤痢アメーバ抗酸化タンパク質の動態解析 (2019)
  • Author(s): 今井達也, 牧内貴志, 橘 裕司
  • Organizer: 日本原生生物学会第52回大会
• [Presentation] 赤痢アメーバ症の迅速血清診断のための蛍光イムノクロマト法の評価 (2019)
  • Author(s): 橘 裕司, Urassaya Pattanawong, 垣野あずみ, Napaporn Kuamsab, Chaturong Putaporntip, Somchai Jongwutiwes
  • Organizer: 第60回日本熱帯医学会大会
• [Presentation] タイ北西部ミャンマー国境地帯の学校における赤痢アメーバとEntamoeba disparの分布および遺伝子多型の解析 (2019)
  • Author(s): 橘 裕司、Urassaya Pattanawong、垣野あずみ、小林正規、吉田菜穂子、Chaturong Putaporntip、Somchai Jongwutiwes
  • Organizer: 第88回日本寄生虫学会大会
• [Presentation] タイ北西部ミャンマー国境地帯の学校における腸管寄生アメーバの感染状況調査 (2018)
  • Author(s): Urassaya Pattanawong、垣野あずみ、小林正規、吉田菜穂子、Chaturong Putaporntip、Somchai Jongwutiwes、橘 裕司
  • Organizer: 第78回日本寄生虫学会東日本支部大会
• [Presentation] タイ北西部ターク県の学校における腸管寄生アメーバの感染状況調査 (2018)
  • Author(s): 橘 裕司、Urassaya Pattanawong、垣野あずみ、小林正規、吉田菜穂子、Chaturong Putaporntip、Somchai Jongwutiwes
  • Organizer: 第59回日本熱帯医学会大会
• [Presentation] 嫌気性アメーバにおける縮退ミトコンドリア（マイトソーム）の異種間移植 (2018)
  • Author(s): 風間 真、吉田和弘、荻原早苗、牧内貴志、橘 裕司
  • Organizer: 日本共生生物学会第２回大会
• [Presentation] Comparison of hemolytic activity of the intermediate subunit of Entamoeba histolytica and Entamoeba dispar lectins (2018)
  • Author(s): Kentaro Kato、Takashi Makiuchi、Xunjia Cheng、Hiroshi Tachibana
  • Organizer: 第87回日本寄生虫学会大会
• [Presentation] 赤痢アメーバ症迅速血清診断のための蛍光イムノクロマト法の開発と評価 (2018)
  • Author(s): 橘 裕司、垣野あずみ、風間 真、馮 萌、浅井さとみ、梅澤和夫、野崎 司、牧内貴志、堀木紀行、程 訓佳、増田剛太
  • Organizer: 第87回日本寄生虫学会大会
• [Presentation] ロングリードおよびショートリードハイスループットシーケンサーを用いたEntamoeba nuttalliの全ゲノムシークエンシング解析 (2018)
  • Author(s): 田中政之、牧内貴志、小見山智義、椎名 隆、橘 裕司
  • Organizer: 第87回日本寄生虫学会大会
• [Presentation] ネパールのヒトとマカクにおける腸管寄生アメーバの探索 (2017)
  • Author(s): Pandey K、吉田菜穂子、垣野あずみ、牧内貴志、小林正規、Chalise M、Pandey B、岩田 敏、橘 裕司
  • Organizer: 第86回日本寄生虫学会大会
  • Place of Presentation: 北海道大学学術交流会館（北海道札幌市）
  • Year and Date: 2017-05-28
• [Presentation] ネパールのヒトとマカクにおける腸管寄生アメーバの探索 (2017)
  • Author(s): Kishor Pandey、吉田菜穂子、垣野あずみ、牧内貴志、小林正規、Mukesh Chalise、Basu Pandey、岩田 敏、橘 裕司
  • Organizer: 第86回日本寄生虫学会大会
• [Presentation] Entamoeba histolyticaとEntamoeba disparのIglレクチンの溶血活性比較研究 (2017)
  • Author(s): 加藤健太郎、牧内貴志、Xunjia Cheng、橘 裕司
  • Organizer: 第86回日本寄生虫学会大会
• [Presentation] 赤痢アメーバの特殊化ミトコンドリアにおける分裂機構の解析 (2017)
  • Author(s): 牧内貴志、Santos Herbert、野崎智義、橘 裕司
  • Organizer: 第86回日本寄生虫学会大会
• [Presentation] タイの三日熱マラリア患者におけるPvMSP-9の組換え断片抗原に対する血清抗体の反応性解析 (2017)
  • Author(s): Sunisa Songsaigath、牧内貴志、Chaturong Putaporntip、Somchai Jongwutiwes、橘 裕司
  • Organizer: 第86回日本寄生虫学会大会
• [Presentation] Sequence diversity and naturally acquired IgG antibodies against the merozoite surface protein 3 gamma of Plasmodium vivax in Thailand (2017)
  • Author(s): Napaporn Kuamsab、Chaturong Putaporntip、牧内貴志、垣野あずみ、Somchai Jongwutiwes、橘 裕司
  • Organizer: 第86回日本寄生虫学会大会
• [Presentation] 中国に生息する野生チベットモンキーからの腸管寄生アメーバEntamoeba nuttalliの分離と遺伝的多型解析 (2017)
  • Author(s): 橘 裕司、Yue Guan、Meng Feng、Junlong Cai、Xiangyang Min、Xingyu Zhou、Qing Xu、Ning Tan、Xunjia Cheng
  • Organizer: 第33回日本霊長類学会大会
• [Presentation] Entamoeba属のIglレクチンの溶血活性比較研究 (2017)
  • Author(s): 加藤健太郎、牧内貴志、Xunjia Cheng、橘 裕司
  • Organizer: 第36回日本糖質学会年会
• [Presentation] 赤痢アメーバ症の診断 - 知っておきたい近縁種 - (2017)
  • Author(s): 橘 裕司
  • Organizer: 第77回日本寄生虫学会東日本支部大会
  • Invited
• [Presentation] ネパールのヒトとマカクにおける病原アメーバEntamoeba nuttalli感染の探索と分離株の遺伝的多型解析 (2017)
  • Author(s): 橘 裕司、小林正規、垣野あずみ、牧内貴志、吉田菜穂子、Kishor Pandey、Mukesh Chalise、Basu Pandey
  • Organizer: 第58回日本熱帯医学会大会・第32回日本国際保健医療学会学術大会・第21回日本渡航医学会学術集会合同大会
• [Presentation] 赤痢アメーバにおけるレクチンサブユニット (Igl) の機能解析 (2017)
  • Author(s): 牧内貴志、加藤健太郎、Xunjia Cheng、橘 裕司
  • Organizer: 第50回日本原生生物学会・第1回日本共生生物学会合同大会
• [Presentation] EntamoebaレクチンのIglサブユニットが有する溶血活性に関する研究 (2017)
  • Author(s): 加藤健太郎、牧内貴志、Xunjia Cheng、橘 裕司
  • Organizer: 第40回日本分子生物学会年会
• [Presentation] Entamoeba histolyticaとEntamoeba disparのIglレクチンの活性比較研究 (2016)
  • Author(s): 加藤健太郎、牧内貴志、橘 裕司
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-12-01
• [Presentation] 赤痢アメーバにおけるペルオキシレドキシンの局在と機能 (2016)
  • Author(s): 吉田和弘、牧内貴志、風間 真、福西菜穂子、橘 裕司
  • Organizer: 第49回日本原生生物学会大会
  • Place of Presentation: 岡山大学津島キャンパス（岡山県岡山市）
  • Year and Date: 2016-10-09
• [Presentation] 赤痢アメーバにおけるオルガネラ移植法確立と退縮ミトコンドリアの品質管理機構 (2016)
  • Author(s): 風間 真、荻原早苗、牧内貴志、吉田和弘、津久井久美子、野崎智義、橘 裕司
  • Organizer: 第49回日本原生生物学会大会
  • Place of Presentation: 岡山大学津島キャンパス（岡山県岡山市）
  • Year and Date: 2016-10-09
• [Presentation] Entamoeba histolyticaとEntamoeba disparレクチンの活性比較研究 (2016)
  • Author(s): 加藤健太郎、橘 裕司
  • Organizer: 第35回日本糖質学会年会
  • Place of Presentation: 高知市文化プラザかるぽーと（高知県高知市）
  • Year and Date: 2016-09-03
• [Presentation] スラウェシ島のクロザルにおける腸管寄生アメーバの感染状況 (2016)
  • Author(s): 橘 裕司、Tuda J、馮 萌、今田美穂子、小林正規、程 訓佳
  • Organizer: 第32回日本霊長類学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島県鹿児島市）
  • Year and Date: 2016-07-16