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Analysis of latently infected HIV-1 circulating in Sub-Sahara Africa

Research Project

Project/Area Number 16H05822
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Virology
Research InstitutionKumamoto University

Principal Investigator

UENO Takamasa  熊本大学, ヒトレトロウイルス学共同研究センター, 教授 (10322314)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
KeywordsHIV-1 / Sub-Sahara Africa / HIV / プロウイルス / HIV/AIDS / 潜伏感染 / タンザニア / ウイルス / ウィルス / 感染症 / ゲノム
Outline of Final Research Achievements

Understanding of latently infected HIV-1 variants circulating in developing countries has remained obscure. In this study, in collaboration with Muhimbili University of Health and Allied Sicences (Tanzania), we established a prospective HIV cohort in Dar es Salaam, Tanzania and recrutited HIV positive patients at Muhimbili National Hospital and surrounding Care and Treament Center. We analyzed virological and epidemiological characteristics as well as drug-resistance patter of latenly infected HIV-1 provirsus circulating in Tanzania. Results obtained in this study could provide useful information and insights into HIV control in resource-limiting settings such as Sub-Sahara Africa.

Academic Significance and Societal Importance of the Research Achievements

抗ウイルス療法(ART)下で残存するHIV-1に関する途上国での情報は極めて乏しい。途上国においても多くの感染者がARTを受ける体制が整ってきており、本研究の成果はエイズが蔓延する地域におけるHIV医療の課題解決に貢献できる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (16 results)

All 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (4 results) Journal Article (7 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 7 results,  Open Access: 4 results) Presentation (5 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results)

  • [Int'l Joint Research] Muhinbili University/Muhimbili National Hospital(タンザニア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ムヒンビリ医科学大学/国立ムヒンビリ病院(タンザニア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Muhimbili University/Muhimbili National Hospital(タンザニア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Muhimbili University/Muhimbili National Hospital(タンザニア)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Circulating HIV-1 Integrase Genotypes in Tanzania: Implication on the Introduction of Integrase Inhibitors-Based Antiretroviral Therapy Regimen2020

    • Author(s)
      Masoud Salim、Kamori Doreen、Barabona Godfrey、Mahiti Macdonald、Sunguya Bruno、Lyamuya Eligius、Ueno Takamasa
    • Journal Title

      AIDS Research and Human Retroviruses

      Volume: - Issue: 6 Pages: 539-543

    • DOI

      10.1089/aid.2020.0021

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pre-treatment and acquired HIV drug resistance in Dar es Salaam, Tanzania in the era of tenofovir and routine viral load monitoring2019

    • Author(s)
      Barabona Godfrey、Mahiti Macdonald、Masoud Salim、Mbelele Peter、Mgunya Amina Shaban、Minja Lilian、Sunguya Bruno、Shigemi Urara、Matsuda Masakazu、Hachiya Atsuko、Iwatani Yasumasa、Lyamuya Eligius、Ueno Takamasa
    • Journal Title

      Journal of Antimicrobial Chemotherapy

      Volume: 74 Issue: 10 Pages: 3016-3020

    • DOI

      10.1093/jac/dkz272

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Resistance of major histocompatibility complex class B (MHC-B) to Nef-mediated downregulation relative to that of MHC-A is conserved among primate lentiviruses and influences antiviral T cell responses in HIV-1-infected individuals.2018

    • Author(s)
      F Mwimanzi, M Toyoda, M Mahiti, J Mann, J Martin, D Bangsberg, M Brockman, P Goulder, F Kirchhoff, Z Brumme, T Ndung’u, T Ueno
    • Journal Title

      Journal of Virology

      Volume: 92 Issue: 1

    • DOI

      10.1128/jvi.01409-17

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Single blood transfusion induces the production of donor-specific alloantibodies and regulatory T cells mainly in the spleen.2018

    • Author(s)
      Ueta H, Kitazawa Y, Sawanobori Y, Ueno T, Ueha S, Matsushima K, Matsuno K.
    • Journal Title

      Int Immunol

      Volume: 30 Issue: 2 Pages: 53-67

    • DOI

      10.1093/intimm/dxx078

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HIV-1 Tat and Viral Latency: What We Can Learn from Naturally Occurring Sequence Variations2017

    • Author(s)
      Kamori Doreen、Ueno Takamasa
    • Journal Title

      Frontiers Microbiology

      Volume: 8 Pages: 80-80

    • DOI

      10.3389/fmicb.2017.00080

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of two unique naturally occurring Vpr sequence polymorphisms associated with clinical parameters in HIV-1 chronic infection2017

    • Author(s)
      Kamori Doreen、Hasan Zafrul、Ohashi Jun、Kawana-Tachikawa Ai、Gatanaga Hiroyuki、Oka Shinichi、Ueno Takamasa
    • Journal Title

      Journal of Medical Virology

      Volume: 89 Issue: 1 Pages: 123-129

    • DOI

      10.1002/jmv.24612

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relative resistance of HLA-B to down-regulation by naturally occurring HIV-1 Nef sequences2016

    • Author(s)
      61.Macdonald Mahiti, Mako Toyoda, Xiaofei Jia, Xiaomei T. Kuang, Francis Mwimanzi, Philip Mwimanzi, Bruce D Walker, Yong Xiong, Zabrina L Brumme, Mark A Brockman, Takamasa Ueno
    • Journal Title

      mBio

      Volume: 7

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Implications of circulating HIV drug resistance mutations in Tanzania’s ART program; analysis of virally suppressed, treatment failure and ART naïve subjects2019

    • Author(s)
      G Barabona, G Judicate, M Mahiti, S Masoud, D Kamori, P Mbelele, AS Mgunya, L Minja, B Sunguya, U Shigemi, M Matsuda, A Hachiya, E Lyamuya, T Ueno
    • Organizer
      第33回日本エイズ学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] HIV immune evasion mechanisms and disease association revealed by MUHAS graduates.2018

    • Author(s)
      Takamasa Ueno
    • Organizer
      6th MUHAS SCIENTIFIC CONFERENCE
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] CIRCULATING HIV-1 DRUG RESISTANCE MUTATIONS IN DAR ES SALAAM TANZANIA; IMPLICATION TO PRE EXPOSURE PROPHYLAXIS.2018

    • Author(s)
      Godfrey Barabona, Macdonald Mahiti, Salim Masoud, Peter Mbelele, Amina Shaban Mgunya, Lilian Minja, Bruno Sunguya, Eligius Lyamuya, Takamasa Ueno
    • Organizer
      HIVR4P2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relative resistance of HLA-B for downregulation by Nef is a fundamental property across lentiviral lineage2017

    • Author(s)
      Francis Mwimanzi, Macdonald Mahiti, Toyoda Mako, Jaclyn K Mann, Thumbi Ndung’u, Takamasa Ueno
    • Organizer
      9th International AIDS Society Conference on HIV Sciences
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MHCとHIV-1 Nefとの相互作用と免疫制御への影響2017

    • Author(s)
      上野貴将
    • Organizer
      第26回日本組織適合性学会大会
    • Related Report
      2017 Annual Research Report
    • Invited

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Published: 2016-04-21   Modified: 2022-10-20  

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