Analysis of latently infected HIV-1 circulating in Sub-Sahara Africa
| Project/Area Number |
16H05822
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Virology
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| Research Institution | Kumamoto University |
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Principal Investigator |
UENO Takamasa 熊本大学, ヒトレトロウイルス学共同研究センター, 教授 (10322314)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Keywords | HIV-1 / Sub-Sahara Africa / HIV / プロウイルス / HIV/AIDS / 潜伏感染 / タンザニア / ウイルス / ウィルス / 感染症 / ゲノム |
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| Outline of Final Research Achievements |
Understanding of latently infected HIV-1 variants circulating in developing countries has remained obscure. In this study, in collaboration with Muhimbili University of Health and Allied Sicences (Tanzania), we established a prospective HIV cohort in Dar es Salaam, Tanzania and recrutited HIV positive patients at Muhimbili National Hospital and surrounding Care and Treament Center. We analyzed virological and epidemiological characteristics as well as drug-resistance patter of latenly infected HIV-1 provirsus circulating in Tanzania. Results obtained in this study could provide useful information and insights into HIV control in resource-limiting settings such as Sub-Sahara Africa.
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| Academic Significance and Societal Importance of the Research Achievements |
抗ウイルス療法(ART)下で残存するHIV-1に関する途上国での情報は極めて乏しい。途上国においても多くの感染者がARTを受ける体制が整ってきており、本研究の成果はエイズが蔓延する地域におけるHIV医療の課題解決に貢献できる。
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Report
(5 results)
Research Products
(16 results)
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[Journal Article] Resistance of major histocompatibility complex class B (MHC-B) to Nef-mediated downregulation relative to that of MHC-A is conserved among primate lentiviruses and influences antiviral T cell responses in HIV-1-infected individuals.2018
Author(s)
F Mwimanzi, M Toyoda, M Mahiti, J Mann, J Martin, D Bangsberg, M Brockman, P Goulder, F Kirchhoff, Z Brumme, T Ndung’u, T Ueno
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Journal Title
Journal of Virology
Volume: 92
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Relative resistance of HLA-B to down-regulation by naturally occurring HIV-1 Nef sequences2016
Author(s)
61.Macdonald Mahiti, Mako Toyoda, Xiaofei Jia, Xiaomei T. Kuang, Francis Mwimanzi, Philip Mwimanzi, Bruce D Walker, Yong Xiong, Zabrina L Brumme, Mark A Brockman, Takamasa Ueno
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Journal Title
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Implications of circulating HIV drug resistance mutations in Tanzania’s ART program; analysis of virally suppressed, treatment failure and ART naïve subjects2019
Author(s)
G Barabona, G Judicate, M Mahiti, S Masoud, D Kamori, P Mbelele, AS Mgunya, L Minja, B Sunguya, U Shigemi, M Matsuda, A Hachiya, E Lyamuya, T Ueno
Organizer
第33回日本エイズ学会学術集会
Related Report
Invited
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