| Project/Area Number |
16H05823
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Virology
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| Research Institution | Kagoshima University |
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Principal Investigator |
Kubota Ryuji 鹿児島大学, 医歯学域医学系, 教授 (70336337)
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| Co-Investigator(Kenkyū-buntansha) |
出雲 周二 鹿児島大学, 医歯学域医学系, 客員研究員 (30143811)
蓮井 和久 鹿児島大学, 医歯学総合研究科, 客員研究員 (70198703)
吉満 誠 鹿児島大学, 医歯学域医学系, 准教授 (70404530)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Keywords | HTLV-1 / HAM / China / Taiwan / Japan / HTLV-1 subtype / ウイルス / 感染症 / 日本 / 中国 / 台湾 |
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| Outline of Final Research Achievements |
We conducted international joint research on HTLV-1-associated diseases in Fujian province in China, Taiwan, and southwest Japan. Japanese researchers visited China and Taiwan to give lectures to local researchers and clinicians and provided guidance for the diagnosis of HTLV-1 infection and HTLV-1-associated diseases. We found and reported the first HAM patient in China with Chinese researchers.We investigated the HTLV-1 subtype by analyzing the whole genome sequence of HTLV-1 in 15 Chinese, 26 Taiwanese, and 211 Japanese. The ratios of transcontinental subtype and Japanese subtype were 73%/27%, 58%/42%, and 18%/82%, respectively.It has become clear that HAM patients also exist in China and that HTLV-1 Japanese subtype exists at a certain rate in China.
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| Academic Significance and Societal Importance of the Research Achievements |
中国福建省にHTLV-1高感染地区あることが明らかとなった。中国で初めてのHAM患者を発見し、HTLV-1感染率が低い中国においても痙性脊髄麻痺患者においては抗HTLV-1抗体検査を行う必要性を指摘した。HTLV-1遺伝子の解析により、HTLV-1日本亜型が日本で82％、台湾で42％、福建省で27％存在することが明らかとなった。このことより、古代日本人の一部が西日本から海路によって南方に移動した可能性、または古代に中国東海岸に到達した人類の一部にHTLV-1が感染していた可能性が考えられた。
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