Identification of risk factors of esophageal cancer with Chinese epidemiological data

• Project/Area Number: 16H05825
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Epidemiology and preventive medicine
• Research Institution: Niigata University
• Principal Investigator: Akazawa Kohei 新潟大学, 医歯学総合病院, 教授 (10175771)
• Co-Investigator(Kenkyū-buntansha): 石川 卓 新潟大学, 医歯学総合病院, 准教授 (70586940)
• Research Collaborator: Wakai Toshifumi
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 発癌リスク / 食道癌 / 水質 / 多変量解析 / 回帰モデル / 疫学調査 / 発癌リスク因子 / 水質調査 / 多変量回帰分析 / 疫学 / リスク因子 / 費用対効果分析 / 環境要因 / 発症リスク / 生活習慣 / 社会医学

Outline of Final Research Achievements

1.We gathered the epidemiological data of baseline characteristics, life style and circumustance for total 40,000 esophageal cancer patients and healthy people. Simultaneously, we investigated the indicators of water quality at 150 places in high incidence regions of esophageal cancer, and the other ones; 2. From the gathered data, we found the concentrations of nitrate nitrogen and ammonia and the other metal components in high incidence regions, which are seriously related with carcinogenesis, are higher than those in other regions two times or more; 3. The significant risk factors in life style were selected by means of comparing life style between cancer patitents and healthy persons. As the result, it was indicatd that intake of hot food and moldy food is identified as significant risk factors of incidence of esophageal cancer.

Academic Significance and Societal Importance of the Research Achievements

飲酒、喫煙、熱い食べ物の摂取は食道がんの発症リスクを高める生活習慣として知られているが、大規模な疫学データに基づきそのリスクの大きさを定量的に評価できた。また、飲料水の水質データを収集して、環境要因としての飲料水に含まれる窒素化合物が発癌リスクを高める可能性を示した。これらのリスクの定量的な評価は国際的にも重要なエビデンスとなりうるし、中国ならびに開発途上国での水質改善に資する科学的根拠を得ると期待される。また、水質改善や生活習慣の改善が食道癌発症の低下につながることから、その水質改善や啓発活動の費用対効果分析を行い、保健衛生上の有益性について検討する。

Research Products

• [Int'l Joint Research] 河北医科大学第四病院(中国)
• [Journal Article] Heterogeneity in esophageal and gastric cardia precursor progression during six-year endoscopic surveillance after population-based screening in a Chinese high-risk region (2017)
  • Author(s): Wen Denggui、Zhang Liwei、Wang Xiaoling、Wen Xiaoduo、Yang Yi、Chen Yuetong、Wang Guiying、Akazawa Kohei、Wang Shijie、Shan Baoen
  • Journal Title: Thoracic Cancer Volume: 8 Issue: 4 Pages: 328-336
  • DOI: 10.1111/1759-7714.12446
  • Open Access
• [Journal Article] Actionable gene-based classification toward precision medicine in gastric cancer (2017)
  • Author(s): Ichikawa H,Nagahashi M,Shimada Y,Hanyu T,Ishikawa T,Kameyama H,Kobayashi T,Sakata J,Yabusaki H,Nakagawa S,Sato N,Hirata Y,Kitagawa Y,Tanahashi T,Yoshida K,Nakanishi R,Oki E,Vuzman D,Lyle S,Takabe Ki,Ling Y,Okuda S,Akazawa K,Wakai T
  • Journal Title: Genome Medicine Volume: 9 Issue: 1
  • DOI: 10.1186/s13073-017-0484-3
  • Open Access
• [Journal Article] Cost-effectiveness of Paclitaxel + Ramucirumab Combination Therapy for Advanced Gastric Cancer Progressing After First-line Chemotherapy in Japan (2017)
  • Author(s): Saito Shota、Muneoka Yusuke、Ishikawa Takashi、Akazawa Kouhei
  • Journal Title: Clinical Therapeutics Volume: 39 Issue: 12 Pages: 2380-2388
  • DOI: 10.1016/j.clinthera.2017.10.017
  • Open Access
• [Journal Article] Five-year survival analysis of surgically resected gastric cancer cases in Japan: a retrospective analysis of more than 100,000 patients from the nationwide registry of the Japanese Gastric Cancer Association (2001-2007) (2017)
  • Author(s): Katai H, Ishikawa T, Akazawa K, Isobe Y, Miyashiro I, Oda I, Tsujitani S, Ono H, Tanabe S, Fukagawa T, Nunobe S, Kakeji Y, Nashimoto A; Registration Committee of the Japanese Gastric Cancer Association
  • Journal Title: Gastric Cancer Volume: 17 Issue: 1 Pages: 144-154
  • DOI: 10.1007/s10120-017-0716-7
  • NAID: 40021436651
  • Peer Reviewed / Open Access
• [Journal Article] Nomogram for 5-year relapse-free survival of a patient with advanced gastric cancer after surgery. (2016)
  • Author(s): Muneoka Y, Akazawa K, Ishikawa T, Ichikawa H, Nashimoto A, Yabusaki H, Tanaka N, Kosugi SI, Wakai T.
  • Journal Title: Int J Surg Volume: 35 Pages: 153-159
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Therapeutic or spontaneous Helicobacter pylori eradication can obscure magnifying narrow-band imaging of gastric tumors. (2016)
  • Author(s): Kobayashi M, Hashimoto S, Mizuno K, Takeuchi M, Sato Y, Watanabe G, Ajioka Y, Azumi M, Akazawa K, Terai S.
  • Journal Title: Endosc Int Open. Volume: 4
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Utility of comprehensive genomic sequencing for detecting HER2-positive colorectal cancer (2016)
  • Author(s): Shimada Y, Yagi R , Kameyama H , Nagahashi M, Ichikawa H, Tajima Y , Okamura T , Nakano M, Nakano M, Sato Y , Matsuzawa T , Sakata J, Kobayashi T, Nogami H, Maruyama S, Takii Y , Kawasaki T , Homma K, Izutsu H, Kodama K, Jennifer E. Ring, Alexei Protopopov , Stephen Lyle, Okuda S, Akazawa K, Wakai T,
  • Journal Title: Human PATHOLOGY Volume: -
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Recent trend of incidencee and survival rates in Japanese patients with gastric cancer (2018)
  • Author(s): Kohei Akazawa
  • Organizer: 12th Heibei cancer medical meeting
  • Int'l Joint Research / Invited