| Project/Area Number |
16H05834
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Hygiene and public health
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
角 大悟 徳島文理大学, 薬学部, 准教授 (30400683)
宮高 透喜 徳島文理大学, 薬学部, 助教 (50157658)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Keywords | ヒ素 / バングラデシュ / 免疫能 / 呼吸機能 / 曝露評価 |
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| Outline of Final Research Achievements |
In Bangladesh, groundwater is contaminated by arsenic that has melted out of the crust, and tens of millions of people living by relying on well water are suffering from arsenic health hazards such as skin pigmentation, keratosis, and skin cancer. In this study, we found that there are many cases of diabetes, asthma, cognitive decline in arsenic-contaminated areas by focusing on common diseases other than skin symptoms in arsenic-contaminated areas of Bangladesh. We also found that the higher the intake of arsenic, the stronger the effects. In addition, we revealed that infants are subjected to the same level of arsenic contamination as their mothers and that not only well water but also rice and vegetables are contaminated with arsenic.
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| Academic Significance and Societal Importance of the Research Achievements |
ヒ素による健康影響については、これまで皮膚症状や発がんを中心に検討されてきた。本研究は、糖尿病、喘息、認知機能低下などの一般疾患に注目し、ヒ素の曝露レベル依存的にこれらの影響が起こることを明らかにした。また、飲料水中のヒ素濃度のみならず、毛髪、爪のヒ素濃度を指標とすることで、個人レベルでの曝露評価に基づいて健康影響を明らかにした。さらに、ヒ素による糖尿病発症の機構に、筋肉量の低下を介したインスリン抵抗性の上昇が関与する可能性を世界で初めて示した。ヒ素は米にも含まれているため、バングラデッシュでの特殊な問題ではなく、米を常食する日本を含めた世界中に貢献できる研究成果である。
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