International comparison of clinicopathological features in Japanese patients with diabetic nephropathy and nephrosclerosis with those in Asian countries

• Project/Area Number: 16H05837
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Kidney internal medicine
• Research Institution: Kanazawa University
• Principal Investigator: Wada Takashi 金沢大学, 医学系, 教授 (40334784)
• Co-Investigator(Kenkyū-buntansha): 古市 賢吾 金沢大学, 附属病院, 准教授 (50432125) ; 原 章規 金沢大学, 医学系, 准教授 (70507045)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 糖尿病性腎症 / 腎硬化症 / 国際比較 / バイオマーカー / 腎臓内科学

Outline of Final Research Achievements

This study was aimed to compare clinical outcomes and their related risk factors in patients with diabetic nephropathy and nephrosclerosis in Asian and Oceanian countries to our Japanese database. We have established international collaborative research team among Asian and Oceanian countries. International comparison of our results with Asian and Oceanian cohorts revealed that the presence of albuminuria and characteristic lesions in diseased kidneys was of importance for kidney prognosis. In addition, we have compared the prediction of prognosis using a novel biomarker candidate. In addition, prognostic risk factors from our Japanese database were closely relevant to those of Asian and Oceanian diabetic nephropathy patients. Taken together, these results suggested that the characteristic pathological lesions as well as the presence of albuminuria were clinically important to the long-term outcomes among Asian and Oceanian countries including Japan.

Academic Significance and Societal Importance of the Research Achievements

本邦では糖尿病性腎症は透析導入原疾患の第1位である。さらに、成長著しいアジア諸国においても、糖尿病の増加とともに、糖尿病性腎症の克服は重要な課題である。くわえて、超高齢社会を背景に、腎硬化症も重要な要素である。本研究の学術的な特色は、本邦の代表的なコホートから得られた成果をアジア諸国にて国際比較、検証を行った点にある。本研究により、アジア、オセアニア地域の糖尿病性腎症、腎硬化症の病態、予後、関連因子、本邦発の評価法の検証、国際比較を行えた。

Research Products

• [Int'l Joint Research] 国立台湾大学/高雄医学大学(その他の国・地域 （台湾）)
• [Int'l Joint Research] ニューサウスウェールズ州大学/ジョージ国際保健研究所(オーストラリア)
• [Int'l Joint Research] ハノイ医科大学(ベトナム)
• [Journal Article] Association of renal arteriosclerosis and hypertension with renal and cardiovascular outcomes in Japanese type?2 diabetes patients with diabetic nephropathy (2019)
  • Author(s): Shimizu M, et al
  • Journal Title: J Diabetes Investig Volume: 印刷中 Issue: 4 Pages: 1041-1049
  • DOI: 10.1111/jdi.12981
  • Peer Reviewed / Open Access
• [Journal Article] Effect of SGLT2 inhibitors on cardiovascular, renal and safety outcomes in patients with type 2 diabetes mellitus and chronic kidney disease: A systematic review and meta‐analysis (2019)
  • Author(s): Toyama Tadashi、Neuen Brendon L.、Jun Min、Ohkuma Toshiaki、Neal Bruce、Jardine Meg J.、Heerspink Hiddo L.、Wong Muh Geot、Ninomiya Toshiharu、Wada Takashi、Perkovic Vlado
  • Journal Title: Diabetes, Obesity and Metabolism Volume: 21 Issue: 5 Pages: 1237-1250
  • DOI: 10.1111/dom.13648
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Amplified Association Between Blood Pressure and Albuminuria in Overweight Patients With Biopsy-Proven Hypertensive Nephrosclerosis (2019)
  • Author(s): Kohagura Kentaro、Furuichi Kengo、Kochi Masako、Shimizu Miho、Yuzawa Yukio、Hara Akinori、Toyama Tadashi、Kitamura Hiroshi、Suzuki Yoshiki、Sato Hiroshi、Uesugi Noriko、Ubara Yoshifumi、Hoshino Junichi、Hisano Satoshi、Ueda Yoshihiko、Nishi Shinichi、Wada Takashi et al.
  • Journal Title: American Journal of Hypertension Volume: 32 Issue: 5 Pages: 486-491
  • DOI: 10.1093/ajh/hpz010
  • Peer Reviewed / Open Access
• [Journal Article] Nonproteinuric Versus Proteinuric Phenotypes in Diabetic Kidney Disease: A Propensity Score-Matched Analysis of a Nationwide, Biopsy-Based Cohort Study. (2019)
  • Author(s): Yamanouchi M, Furuichi K, Hoshino J, Toyama T, Hara A, Shimizu M, Kinowaki K, Fujii T, Ohashi K, Yuzawa Y, Kitamura H, Suzuki Y, Sato H, Uesugi N, Hisano S, Ueda Y, Nishi S, Yokoyama H, Nishino T, Samejima K, Kohagura K, Shibagaki Y, Mise K, Makino H, Matsuo S, Ubara Y, Wada T.
  • Journal Title: Diabetes Care Volume: - Issue: 5 Pages: 891-902
  • DOI: 10.2337/dc18-1320
  • Peer Reviewed / Open Access
• [Journal Article] Diabetic Nephropathy: A Comparison of the Clinical and Pathological Features between the CKD Risk Classification and the Classification of Diabetic Nephropathy 2014 in Japan (2018)
  • Author(s): Furuichi Kengo、Shimizu Miho、Hara Akinori、Toyama Tadashi、Wada Takashi
  • Journal Title: Internal Medicine Volume: 57 Issue: 23 Pages: 3345-3350
  • DOI: 10.2169/internalmedicine.1132-18
  • NAID: 130007539680
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-12-01
  • Peer Reviewed / Open Access
• [Journal Article] Uric acid-lowering and renoprotective effects of topiroxostat, a selective xanthine oxidoreductase inhibitor, in patients with diabetic nephropathy and hyperuricemia: a randomized, double-blind, placebo-controlled, parallel-group study (UPWARD study) (2018)
  • Author(s): Wada Takashi、Hosoya Tatsuo、Honda Daisuke、Sakamoto Ryusuke、Narita Kazutaka、Sasaki Tomomitsu、Okui Daisuke、Kimura Kenjiro
  • Journal Title: Clinical and Experimental Nephrology Volume: 22 Issue: 4 Pages: 860-870
  • DOI: 10.1007/s10157-018-1530-1
  • NAID: 120006490099
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathological predictors for progression of chronic kidney disease in nephrosclerosis: a biopsy-based cohort study (2018)
  • Author(s): Yamanouchi Masayuki、Hoshino Junichi、Ubara Yoshifumi、Takaichi Kenmei、Kinowaki Keiichi、Fujii Takeshi、Ohashi Kenichi、Mise Koki、Toyama Tadashi、Hara Akinori、Shimizu Miho、Furuichi Kengo、Wada Takashi
  • Journal Title: Nephrology Dialysis Transplantation Volume: - Issue: 7 Pages: 1182-1188
  • DOI: 10.1093/ndt/gfy121
  • Peer Reviewed / Open Access
• [Journal Article] Estimated glomerular filtration rate decline and risk of end-stage renal disease in type 2 diabetes (2018)
  • Author(s): Oshima Megumi、Toyama Tadashi、Haneda Masakazu、Furuichi Kengo、Babazono Tetsuya、Yokoyama Hiroki、Iseki Kunitoshi、Araki Shinichi、Ninomiya Toshiharu、Hara Shigeko、Nakamura Hiroyuki、Shimizu Miho、Hara Akinori、Makino Hirofumi、Wada Takashi et al.
  • Journal Title: PLOS ONE Volume: 13 Issue: 8 Pages: e0201535-e0201535
  • DOI: 10.1371/journal.pone.0201535
  • Peer Reviewed / Open Access
• [Journal Article] Gut microbiota-derived D-serine protects against acute kidney injury (2018)
  • Author(s): Yusuke Nakade, Yasunori Iwata, Takashi Wada, et al.
  • Journal Title: JCI Insight Volume: 18;3(20) Issue: 20 Pages: 97957-97957
  • DOI: 10.1172/jci.insight.97957
  • NAID: 120006733372
  • Peer Reviewed / Open Access
• [Journal Article] Erythropoietin signal protected HUVEC from high glucose induced injury (2018)
  • Author(s): Yasuda Haruka、Iwata Yasunori、Nakajima Satoshi、Furuichi Kengo、Miyake Taito、Sakai Norihiko、Kitajima Shinji、Toyama Tadashi、Shinozaki Yasuyuki、Sagara Akihiro、Miyagawa Taro、Hara Akinori、Shimizu Miho、Kamikawa Yasutaka、Sato Kouichi、Oshima Megumi、Yoneda-Nakagawa Shiori、Kaneko Shuichi、Wada Takashi
  • Journal Title: Nephrology Volume: in press Issue: 7 Pages: 767-774
  • DOI: 10.1111/nep.13518
  • Peer Reviewed / Open Access
• [Journal Article] Decline in estimated glomerular filtration rate is associated with risk of end-stage renal disease in type 2 diabetes with macroalbuminuria: an observational study from JDNCS. (2018)
  • Author(s): Shimizu M, Furuichi K, Toyama T, Funamoto T, Kitajima S, Hara A, Ogawa D, Koya D, Ikeda K, Koshino Y, Kurokawa Y, Abe H, Mori K, Nakayama M, Konishi Y, Samejima K, Matsui M, Yamauchi H, Gohda T, Fukami K et al
  • Journal Title: Clin Exp Nephrol Volume: 22 Issue: 2 Pages: 377-387
  • DOI: 10.1007/s10157-017-1467-9
  • Peer Reviewed / Open Access
• [Journal Article] Value of adding the renal pathological score to the kidney failure risk equation in advanced diabetic nephropathy (2018)
  • Author(s): Yamanouchi Masayuki、Hoshino Junichi、Ubara Yoshifumi、Takaichi Kenmei、Kinowaki Keiichi、Fujii Takeshi、Ohashi Kenichi、Mise Koki、Toyama Tadashi、Hara Akinori、Kitagawa Kiyoki、Shimizu Miho、Furuichi Kengo、Wada Takashi
  • Journal Title: PLoS One Volume: 13 Issue: 1 Pages: e0190930-e0190930
  • DOI: 10.1371/journal.pone.0190930
  • NAID: 120006460354
  • Peer Reviewed / Open Access
• [Journal Article] A new pathological scoring system by the Japanese classification to predict renal outcome in diabetic nephropathy (2018)
  • Author(s): Hoshino Junichi、Furuichi Kengo、Yamanouchi Masayuki、Toyama Tadashi、Shimizu Miho、Takaichi Kenmei、Ubara Yoshifumi、Wada Takashi et al.
  • Journal Title: PLoS One Volume: 13 Issue: 2 Pages: e0190923-e0190923
  • DOI: 10.1371/journal.pone.0190923
  • Peer Reviewed / Open Access
• [Journal Article] Clinico-pathological features of kidney disease in diabetic cases (2018)
  • Author(s): Furuichi Kengo、Shimizu Miho、Okada Hirokazu、Narita Ichiei、Wada Takashi
  • Journal Title: Clin Exp Nephrol Volume: - Issue: 5 Pages: 1046-1051
  • DOI: 10.1007/s10157-018-1556-4
  • Peer Reviewed / Open Access
• [Journal Article] Rationale and study design of a clinical trial to assess the effects of LDL apheresis on proteinuria in diabetic patients with severe proteinuria and dyslipidemia (2017)
  • Author(s): Wada T, Muso E, Maruyama S, Hara A, Furuichi K, Yoshimura K, Miyazaki M, Sato E, Abe M, Shibagaki Y, Narita I, Yokoyama H, Mori N, Yuzawa Y, Matsubara T, Tsukamoto T, Wada J, Ito T, Masutani K, Tsuruya K, Fujimoto S, Tsuda A, Suzuki H, Kasuno K, Terada Y, Nakata T, Iino N, Kobayashi S.
  • Journal Title: Clin Exp Nephrol Volume: 22 Issue: 3 Pages: 591
  • DOI: 10.1007/s10157-017-1488-4
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathological analysis of biopsy-proven diabetic nephropathy based on the Japanese classification of diabetic nephropathy (2017)
  • Author(s): Furuichi Kengo、Research Group of Diabetic Nephropathy, Ministry of Health, Labour and Welfare of Japan, and Japan Agency for Medical Research and Development、Shimizu Miho、Yuzawa Yukio、Hara Akinori、Toyama Tadashi、Wada Takashi et al.
  • Journal Title: Clin Exp Nephrol Volume: - Issue: 3 Pages: 570-582
  • DOI: 10.1007/s10157-017-1485-7
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and pathological significance of autoantibodies to erythropoietin receptor in type 2 diabetic patients with chronic kidney disease (2017)
  • Author(s): Hara A, Furuichi K, Koshino A, Yasuda H, Tran T, Iwata Y, Sakai N, Shimizu M, Kaneko S, Nakamura H, Wada T.
  • Journal Title: Kidney Int Rep Volume: 3 Issue: 1 Pages: 133-141
  • DOI: 10.1016/j.ekir.2017.08.017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nationwide multicenter kidney biopsy study of Japanese patients with hypertensive nephrosclerosis (2017)
  • Author(s): Furuichi Kengo、Research Group of Diabetic Nephropathy and Nephrosclerosis, Ministry of Health, Labour and Welfare of Japan, and Japan Agency for Medical Research and Development、Shimizu Miho、Yuzawa Yukio、Hara Akinori、Toyama Tadashi、Wada Takashi et al.
  • Journal Title: Clin Exp Nephrol Volume: - Issue: 3 Pages: 629-637
  • DOI: 10.1007/s10157-017-1496-4
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic value of proteinuria and glomerular filtration rate on Taiwanese patients with diabetes mellitus and advanced chronic kidney disease: a single center experience. (2017)
  • Author(s): Chen PM, Wada T, Chiang CK.
  • Journal Title: Clin Exp Nephrol Volume: 21 Issue: 2 Pages: 307-315
  • DOI: 10.1007/s10157-016-1290-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nationwide multicentre kidney biopsy study of Japanese patients with type 2 diabetes. (2017)
  • Author(s): Furuichi K, Yuzawa Y, Shimizu M, Hara A, Toyama T, Kitamura H, Suzuki Y, Sato H, Uesugi N, Ubara Y, Hisano S, Ueda Y, Nishi S, Yokoyama H, Nishino T, Kohagura K, Ogawa D, Mise K, Shibagaki Y, Kimura K, Haneda M, Makino H, Matsuo S, Wada T.
  • Journal Title: Nephrol Dial Transplant Volume: 印刷中 Issue: 1 Pages: 138-148
  • DOI: 10.1093/ndt/gfw417
  • NAID: 120006460355
  • Peer Reviewed / Open Access
• [Journal Article] 糖尿病性腎症：最近の進歩 (2016)
  • Author(s): 和田 隆志
  • Journal Title: 日本内科学会雑誌 Volume: 105 Pages: 1870-1876
• [Journal Article] 糖尿病性腎症の臨床 (2016)
  • Author(s): 和田 隆志
  • Journal Title: 日本内科学会雑誌 Volume: 105 Pages: 482-487
• [Presentation] 糖尿病性腎症と運動療法 (2019)
  • Author(s): 和田隆志・清水美保・遠山直志・原章規・北島信治・岩田恭宜・坂井宣彦・櫻井吾郎・古市賢吾
  • Organizer: 第9回日本腎臓リハビリテーション学会学術集会
• [Presentation] Kidney diseases and related organ-cross talk - pathogenesis, therapy and biomarkers- (2019)
  • Author(s): Takashi Wada
  • Organizer: Kick-Off Symposium of the Double Degree Programs Between Hanoi Medical University and Kanazawa University
• [Presentation] 糖尿病性腎症の進展マーカー候補としての抗エリスロポエチン受容体抗体 (2018)
  • Author(s): 原章規・古市賢吾・和田隆志
  • Organizer: 第61回日本腎臓学会学術総会
• [Presentation] キラルアミノ酸の可能性 (2018)
  • Author(s): 中出祐介・岩田恭宜・和田隆志
  • Organizer: 第61回日本腎臓学会学術総会
• [Presentation] 糖尿病性腎臓病と糖尿病性腎症：腎病変の不均一性と病態 (2018)
  • Author(s): 和田隆志・清水美保・遠山直志・原章規・湯澤由紀夫・古市賢吾
  • Organizer: 第61回日本腎臓学会学術総会
  • Invited
• [Presentation] 糖尿病腎生検コホートの最新知見 (2018)
  • Author(s): 古市賢吾・和田隆志
  • Organizer: 第61回日本腎臓学会学術総会
• [Presentation] 細菌遺伝子情報の病態への関与 (2018)
  • Author(s): 岩田恭宜・中出祐介・和田隆志
  • Organizer: 第61回日本腎臓学会学術総会
• [Presentation] 腎臓病におけるバイオマーカー (2018)
  • Author(s): 和田隆志
  • Organizer: 第58 回日本臨床化学会年次学術集会
  • Invited
• [Presentation] DKD・高血圧性腎硬化症の病理と臨床 (2018)
  • Author(s): 遠山直志・原章規・清水美保・古市賢吾・和田隆志
  • Organizer: 第41回日本高血圧学会総会
• [Presentation] DKDにおける臨床と病理の相互理解 (2018)
  • Author(s): 清水美保・古市賢吾・和田隆志
  • Organizer: 第48回日本腎臓学会西部学術大会
• [Presentation] 糖尿病性腎臓病update (2018)
  • Author(s): 和田隆志
  • Organizer: 第59回日本内科学会 信越支部主催生涯教育講演会
  • Invited
• [Presentation] 糖尿病性腎症・糖尿病性腎臓病の病態と治療 (2018)
  • Author(s): 和田隆志
  • Organizer: 第33回日本糖尿病合併症学会
  • Invited
• [Presentation] 糖尿病性腎症に対するLDLアフェレシス療法 (2018)
  • Author(s): 北島信二・原章規・古市賢吾・和田隆志
  • Organizer: 第39回日本アフェレシス学会学術大会
• [Presentation] Long-term outcome of biopsy-proven lupus nephritis and novel insight of autoantibodies to erythropoietin receptor for prognosis. (2018)
  • Author(s): Takashi Wada
  • Organizer: The 62nd Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology
  • Int'l Joint Research / Invited
• [Presentation] Diabetic Kidney Diseases with Type 2 Diabetes. (2018)
  • Author(s): Takashi Wada
  • Organizer: CSN Annual General Meeting 2018
  • Int'l Joint Research / Invited
• [Presentation] Nationwide Clinicopathological Study & Related Biomarkers in Diabetic Nephropathy. (2018)
  • Author(s): Takashi Wada
  • Organizer: Dynamo Townhall
• [Presentation] Diabeticnephropathy and diabetic kidney disease: Clinicopathological aspects and biomarkers. (2018)
  • Author(s): Takashi Wada
  • Organizer: Advanced Course on Renal Pathology and Nephrology
• [Presentation] 糖尿病性腎症と血圧管理 (2017)
  • Author(s): 和田隆志
  • Organizer: 第6回臨床高血圧フォーラム
  • Invited
• [Presentation] 糖尿病性腎症の予後関連病理因子 (2017)
  • Author(s): 古市賢吾・和田隆志
  • Organizer: 第60回日本腎臓学会学術総会
• [Presentation] 糖尿病性腎症: 病態解明・予後改善と連携推進 (2017)
  • Author(s): 和田隆志・清水美保・原章規・遠山直志・古市賢吾
  • Organizer: 第60回日本腎臓学会学術総会
• [Presentation] 日本と海外の血液透析の状況と国際比較 (2017)
  • Author(s): 和田隆志
  • Organizer: 第62回日本透析医学会学術集会・総会
  • Invited
• [Presentation] Clinicopathological characteristics and related biomarkers in diabetic nephropathy. (2017)
  • Author(s): Takashi Wada, Miho Shimizu, Tadashi Toyama, Akinori Hara, Kengo Furuichi
  • Organizer: The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM2017)
  • Int'l Joint Research
• [Presentation] 腎領域のデータベースの整備と活用：糖尿病性腎症レジストリーJDNCS (2017)
  • Author(s): 和田隆志
  • Organizer: 第64回日本臨床検査医学会学術集会
• [Presentation] 糖尿病性腎症：最近の進歩 (2016)
  • Author(s): 和田隆志
  • Organizer: 第113回日本内科学会総会・講演会
  • Place of Presentation: 東京国際フォーラム(東京）
  • Invited
• [Presentation] Clinicopathological characteristics and related biomarkers of diabetic nephropathy (2016)
  • Author(s): Takashi Wada
  • Organizer: The 36th Annual Meeting of the Korean Society of Nephrology（KSN 2016)
  • Place of Presentation: ソウル（韓国）
  • Int'l Joint Research / Invited
• [Presentation] Diabetic nephropathy (2016)
  • Author(s): Takashi Wada
  • Organizer: Advanced Course on Renal Pathology and Nephrology
  • Place of Presentation: ハノイ（ベトナム）
  • Invited
• [Book] 糖尿病性腎臓病の診かた、考えかた (2018)
  • Author(s): 和田 隆志、柏原 直樹
  • Total Pages: 224
  • Publisher: 中外医学社
  • ISBN: 4498224361
• [Book] AKI急性腎障害治療の実際 (2018)
  • Author(s): 迫恵輔・和田隆志・阿部 雅紀（編集）
  • Total Pages: 262
  • Publisher: 日本医事新報社
  • ISBN: 4784944877