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Intestinal parasites in diarrhea children with or without HIV infection

Research Project

Project/Area Number 16H05842
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Infectious disease medicine
Research InstitutionKanazawa University

Principal Investigator

BI Xiuqiong  金沢大学, 医学系, 助教 (50565413)

Co-Investigator(Kenkyū-buntansha) 市村 宏  金沢大学, 医学系, 教授 (10264756)
所 正治  金沢大学, 先進予防医学研究センター, 准教授 (30338024)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
KeywordsHIV感染 / 腸管寄生原虫 / 免疫 / リスクファクター / 小児 / HIV / 感染危険因子 / 腸管寄生虫 / HIV,腸管寄生原虫 / ウイルス / 感染症 / 下痢症
Outline of Final Research Achievements

We investigated the prevalence and risk factors of Entamoeba species and Giardia intestinalis infections in Kenyan children with and without HIV infection. The rate of Entamoeba spp. infection in HIV-infected children [HIV(+)] was lower than in HIV-uninfected children [HIV(─)] (63.2% vs. 78.8%, P=0.02), and CD4/CD8 ratio was related with it (≧1 vs. <1, OR 3.3, P<0.01). For Giardia assemblage B infection, the rate in HIV(+) females was lower than in HIV(+) males and HIV(─) females (15.6% vs. 40.5% and 37.8%, P<0.01 and 0.02), no boiling drinking water (OR 3.8, P=0.04) and nursery care of siblings (OR 2.8, P=0.01) were risk factors. Entamoeba and Giardia assemblage B infections were incoherently correlated with HIV infection. Entamoeba infection maybe be an indicator of the children’s better immune status, whereas Giardia assemblage B infection was related to hygienic conditions. The hygienic quality of drinking water needs to be improved to prevent the Giardia infection.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果より、ケニアの小児では、アメーバとジアルジアBは、感染経路は共通しているにもかかわらず、HIV感染に及ぼす影響は異なっていた。HIV感染はアメーバ感染の危険因子ではなく、逆に、アメーバ感染は小児のよい免疫状態を示す指針であった。HIV感染は男児でジアルジアB感染の危険因子であるが、女児ではなかった。また、飲用水を煮沸しないことおよび兄弟の世話をすることがジアルジアB感染の危険因子であった。よって、ジアルジアBの感染は衛生状態と関係し、HIV感染との関係は男女で違う傾向であることが示唆された。飲用水の品質改善は小児のジアルジアBの感染予防において重要である。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (8 results)

All 2020 2019 2016 Other

All Int'l Joint Research (4 results) Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results)

  • [Int'l Joint Research] Kenya Medical Research Institute/Nyumbani Children' s home laboratory(ケニア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Kenya Medical Research Institute/Nyumbani Children's home laboratory(ケニア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ケニア国立医学研究所 (KEMRI))/ケニアニュンバニ子供センター(ケニア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] ケニア国立医学研究所 (KEMRI)/ケニアニュンバンニ子供センター(ケニア)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Newly emerged enterovirus-A71 C4 sublineage may be more virulent than B5 in the 2015?2016 hand-foot-and-mouth disease outbreak in northern Vietnam2020

    • Author(s)
      Chu Son T.、Kobayashi Kyousuke、Bi Xiuqiong、Ishizaki Azumi、Tran Tu T.、Phung Thuy T. B.、Pham Chung T. T.、Nguyen Lam V.、Ta Tuan A.、Khu Dung T. K.、Agoh Masanobu、Pham An N.、Koike Satoshi、Ichimura Hiroshi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 159-159

    • DOI

      10.1038/s41598-019-56703-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Extremely diversified haplotypes observed among assemblage B population of Giardia intestinalis in Kenya.2020

    • Author(s)
      Tetsushi Mizuno, Elizabeth J. Matey, Xiuqiong Bi, Hiroshi Ichimura, Masaharu Tokoro.
    • Journal Title

      Parasitology International

      Volume: 75 Pages: 102038-102038

    • DOI

      10.1016/j.parint.2019.102038

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Low concordance of oral and genital HPV infection among male patients with sexually transmitted infections in Vietnam2019

    • Author(s)
      Le HHL, Bi X, Ishizaki A, Le HV, Trung Vu Nguyen TV, Ichimura H
    • Journal Title

      BMC Infect Dis

      Volume: 19 Issue: 1 Pages: 578-578

    • DOI

      10.1186/s12879-019-4175-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Positive correlation of HIV infection with Giardia intestinal assemblage B but not assemblage A in asymptomatic Kenyan children2016

    • Author(s)
      畢 袖晴(Xiuqiong Bi)
    • Journal Title

      AIDS

      Volume: 30 Issue: 15 Pages: 2385-2387

    • DOI

      10.1097/qad.0000000000001216

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant

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Published: 2016-04-21   Modified: 2021-02-19  

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