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International comparison study between Japan and Korea aiming at paradigmshift from 8020 to 8028

Research Project

Project/Area Number 16H05850
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Social dentistry
Research InstitutionKyushu University

Principal Investigator

Yamashita Yoshihisa  九州大学, 歯学研究院, 教授 (20192403)

Co-Investigator(Kenkyū-buntansha) 三浦 宏子  国立保健医療科学院, その他部局等, 部長 (10183625)
古田 美智子  九州大学, 歯学研究院, 講師 (20509591)
二宮 利治  九州大学, 医学研究院, 教授 (30571765)
竹下 徹  九州大学, 歯学研究院, 准教授 (50546471)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords歯周病 / 生活環境因子 / 口腔マイクロバイオーム / 韓国 / 国際比較 / 生活環因子 / 口腔マイクロバオーム
Outline of Final Research Achievements

Comparing the data of the national health survey in Korea with those of the medical examination of Hisayama inhabitants, more significant prevalence of periodontal disease was found in Japanese than Korean, even when the numbers of the present teeth, of the decayed teeth, and of the filled teeth, visiting at a dental clinic, smoking, age, sex, and presence of the metabolic syndrome were adjusted. Having checked a periodontal disease-related nutrient, prevalence of the disease tended to increase in subjects with fewer intakes of the total dietary fiber in both the countries, but the kinds of the nutrient in conjunction with periodontal disease were different among the two countries. When internationally comparing the salivary microbiota in adult subjects between both countries, a difference was detected in the microbiota constitution of the two countries, and additional bacterial species characteristic to identify each nation were detected by applying machine learning (Light GBM).

Academic Significance and Societal Importance of the Research Achievements

成人で歯を失う原因の多くは歯周病であり、歯周病関連の生活環境因子についてはこれまでに莫大な数の疫学研究がある。しかし、現実な予防法はプラークコントロールと禁煙指導に限られている。本研究では、日本と韓国の国際比較に基づき、より幅広い観点から歯周疾患の発症に影響する社会環境因子の解明を目指す。歯周疾患の発症および進行に関与する改善可能な生活環境因子を特定して、地域歯科保健活動などを介して歯周病の発症や進行を劇的に抑制できれば、我が国の口腔保健状態を大きく改善することができる。その結果、口腔保健の目標を8020から8028に大きく前進させて、口腔管理を中心とした歯科保健医療を推進させることができる。

Report

(5 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (47 results)

All 2019 2018 2017 2016

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (36 results) (of which Int'l Joint Research: 7 results,  Invited: 16 results)

  • [Journal Article] Periodontitis Is Associated with Chronic Obstructive Pulmonary Disease2019

    • Author(s)
      Takeuchi K.、Matsumoto K.、Furuta M.、Fukuyama S.、Takeshita T.、Ogata H.、Suma S.、Shibata Y.、Shimazaki Y.、Hata J.、Ninomiya T.、Nakanishi Y.、Inoue H.、Yamashita Y.
    • Journal Title

      Journal of Dental Research

      Volume: 98 Issue: 5 Pages: 534-540

    • DOI

      10.1177/0022034519833630

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periodontal status and lung function decline in the community: the Hisayama study2018

    • Author(s)
      Takeuchi Kenji、Matsumoto Koichiro、Furuta Michiko、Fukuyama Satoru、Takeshita Toru、Ogata Hiroaki、Suma Shino、Shibata Yukie、Shimazaki Yoshihiro、Hata Jun、Ninomiya Toshiharu、Nakanishi Yoichi、Inoue Hiromasa、Yamashita Yoshihisa
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 13354-13354

    • DOI

      10.1038/s41598-018-31610-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tongue Microbiota and Oral Health Status in Community-Dwelling Elderly Adults2018

    • Author(s)
      Asakawa M, Takeshita T, Furuta M, Kageyama S, Takeuchi K, Hata J, Ninomiya T, Yamashita Y
    • Journal Title

      mSphere

      Volume: 3(4) Issue: 4

    • DOI

      10.1128/msphere.00332-18

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Periodontitis modifies the association between smoking and chronic obstructive pulmonary disease in Japanese men2018

    • Author(s)
      Harland Jane、Furuta Michiko、Takeuchi Kenji、Tanaka Shunichi、Yamashita Yoshihisa
    • Journal Title

      Journal of Oral Science

      Volume: 60 Issue: 2 Pages: 226-231

    • DOI

      10.2334/josnusd.17-0225

    • NAID

      130007398363

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationships of variations in the tongue microbiota and pneumonia mortality in nursing home residents2018

    • Author(s)
      Kageyama S, Takeshita T, Furuta M, Tomioka M, Asakawa M, Suma S, Takeuchi K, Shibata Y, Iwasa Y, Yamashita Y
    • Journal Title

      J Gerontol A Biol Sci Med Sci

      Volume: - Issue: 8 Pages: 1097-1102

    • DOI

      10.1093/gerona/glx205

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔微生物叢と感染症リスク2018

    • Author(s)
      山下喜久
    • Journal Title

      最新医学

      Volume: 73 Pages: 523-529

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Tooth Loss and Risk of Dementia in the Community: the Hisayama Study2017

    • Author(s)
      Takeuchi K, Ohara T, Furuta M, Takeshita T, Shibata Y, Hata J, Yoshida D, Yamashita Y, Ninomiya T
    • Journal Title

      J Am Geriatr Soc

      Volume: 印刷中 Issue: 5

    • DOI

      10.1111/jgs.14791

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The oral microbiome and human health2017

    • Author(s)
      Yamashita Y, Takeshita T
    • Journal Title

      Journal of Oral Science

      Volume: 59 Issue: 2 Pages: 201-206

    • DOI

      10.2334/josnusd.16-0856

    • NAID

      130006882396

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral mycobiome in community-dwelling elderly and its relation to oral and general health conditions2017

    • Author(s)
      Zakaria MN, Furuta M, Takeshita T, Shibata Y, Sundari R, Eshima N, Ninomiya T, Yamashita Y
    • Journal Title

      Oral Dis

      Volume: 23 Issue: 7 Pages: 973-982

    • DOI

      10.1111/odi.12682

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 口腔マイクロバイオーム2017

    • Author(s)
      山下喜久
    • Journal Title

      ザ・クインテッセンス

      Volume: 36(5) Pages: 84-89

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 口腔ケアの重要性2017

    • Author(s)
      柴田幸江、山下喜久
    • Journal Title

      教育と医学

      Volume: 65 Pages: 544-553

    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔環境保健と口腔細菌叢2018

    • Author(s)
      山下喜久
    • Organizer
      第15回日本口腔ケア協会学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 誤嚥性肺炎は口腔ケアで予防できるか2018

    • Author(s)
      山下喜久
    • Organizer
      第15回日本口腔ケア協会学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] メタボリックシンドロームの発症と歯科健診受診との関連:5年間の後ろ向きコホート研究2018

    • Author(s)
      田中照彦、竹内研時、古田美智子、須磨紫乃、竹下 徹、嶋﨑義浩、品川 隆、山下喜久
    • Organizer
      第67回日本口腔衛生学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 地域在住高齢者における咀嚼機能と低栄養の関連性の男女差の検討2018

    • Author(s)
      須磨紫乃、古田美智子、竹内研時、竹下 徹、柴田幸江、嶋﨑義浩、二宮利治、山下喜久
    • Organizer
      第67回日本口腔衛生学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 口腔の健康と健康寿命の関連性 を示すエビデンス2018

    • Author(s)
      山下喜久
    • Organizer
      口腔医学シンポジウム「口腔医学」-歯科の将来象
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 舌苔細菌叢の構成と高齢者の肺炎死亡リスクとの関連2018

    • Author(s)
      竹下徹、影山伸哉、須磨紫乃、古田美智子、竹内研時、朝川美加李、岩佐康行、山下喜久
    • Organizer
      第48日本嫌気性菌感染症学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Oral Microbiota Related to Pneumonia Mortality in Nursing Home Residents2018

    • Author(s)
      Yamashita Yoshihisa
    • Organizer
      The 4th Microbiome R&D and Business Collaboration Congress
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Identification of transition of bacterial diversity and composition in the early postnatal development of oral microbiota2018

    • Author(s)
      Shinya Kageyama, Mikari Asakawa, Toru Takeshita, Kenji Takeuchi, Rie Matsumi, Yukie Shibata, Michiko Furuta, Shino Suma, Yoshihisa Yamashita
    • Organizer
      The 4th Microbiome R&D and Business Collaboration Congress
    • Related Report
      2017 Annual Research Report
  • [Presentation] デンタルプラーク形成に関わる初期付着細菌群の特定2018

    • Author(s)
      竹下徹、井原由佳理、影山伸哉、松見理恵、山下喜久
    • Organizer
      第91回日本細菌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Characteristics of salivary microbiome in orally-healthy Japanese adults2017

    • Author(s)
      Toru Takeshita, Shinya Kageyama, Mikari Asakawa, Michiko Furuta, Kenji Takeuchi, Toshiharu Ninomiya, Yoshihisa Yamashita
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 唾液マイクロバイオームにおけるIgA結合細菌の探索2017

    • Author(s)
      影山伸哉、竹下徹、朝川美加李、柴田幸江、松見理恵、古田美智子、竹内研時、山下喜久
    • Organizer
      第11回日本ゲノム微生物学会年会
    • Place of Presentation
      東京
    • Year and Date
      2017-03-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] Diagnostic value of salivary microbiome to grasp periodontal health condition and susceptibility to periodontal disease2017

    • Author(s)
      Yoshihisa Yamashita
    • Organizer
      3rd Microbiome R&D and Business Collaboration Congress: Asia
    • Place of Presentation
      Hong Kong
    • Year and Date
      2017-03-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Exploration of IgA-binding bacteria in salivary microbiome2017

    • Author(s)
      Shinya Kageyama, Toru Takeshita, Mikari Asakawa, Yukie Shibata, Rie Matusmi, Michiko Furuta, Kenji Takeuchi, Yoshihisa Yamashita
    • Organizer
      Kyudai Oral Bioscience 2017
    • Place of Presentation
      Fukuoka
    • Year and Date
      2017-02-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 口腔マイクロバイオーム をめぐる最近の話題2017

    • Author(s)
      山下喜久
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 舌苔マイクロバイオームの細菌構成と口腔の健康状態との関連2017

    • Author(s)
      朝川美加李、竹下徹、影山伸哉、古田美智子、竹内研時、須磨紫乃、山下喜久
    • Organizer
      第66回日本口腔衛生学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 舌苔マイクロバイオームが高齢者の発熱に及ぼす影響2017

    • Author(s)
      影山伸哉、竹下徹、須磨紫乃、古田美智子、竹内研時、朝川美加李、岩佐康行、山下喜久
    • Organizer
      第66回日本口腔衛生学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔マイクロバイオーム解析から見えるヒトの健康2017

    • Author(s)
      山下喜久
    • Organizer
      第66回日本口腔衛生学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 口から美味しく食べられる 生涯の幸せのために2017

    • Author(s)
      山下喜久
    • Organizer
      第2回西日本子ども歯科保健・健康会議
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 高齢者の肺炎死亡リスクを高める舌苔マイクロバイオームの特徴2017

    • Author(s)
      影山伸哉、竹下徹、須磨紫乃、古田美智子、竹内研時、朝川美加李、岩佐康行、山下喜久
    • Organizer
      第11回細菌学若手コロッセウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] コーヒーが口腔常在細菌の生育に及ぼす影響に関する研究2017

    • Author(s)
      緒方康二、竹下徹、柴田幸江、山下喜久
    • Organizer
      第39回九州口腔衛生学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高齢者の肺炎死亡リスクを高める舌苔マイクロバイオームの同定2017

    • Author(s)
      影山伸哉、竹下徹、須磨紫乃、古田美智子、竹内研時、朝川美加李、岩佐康行、山下喜久
    • Organizer
      第11回日本ゲノム微生物学会若手の会研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 唾液マイクロバイオームに対するIgAの認識2017

    • Author(s)
      影山伸哉、竹下徹、朝川美加李、柴田幸江、山下喜久
    • Organizer
      第59回歯科基礎医学会学術大会 日本学術会議シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 口腔マイクロバイオームの病原性の解明へのアプローチ2017

    • Author(s)
      山下喜久
    • Organizer
      第59回歯科基礎医学会学術大会 日本学術会議シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 口腔マイクロバイオームのバランスと高齢者の呼吸器疾患の関連性2017

    • Author(s)
      山下喜久
    • Organizer
      第87回日本感染症学会西日本地方会学術集会・第60回日本感染症学会中日本地方会学術集会・第65回日本化学療法学会西日本支部総会(合同開催)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 8028を具現化するための 口腔管理を中心とした 歯科医療システムの確立を考える2017

    • Author(s)
      山下喜久
    • Organizer
      第60回東海口腔衛生学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Identification of IgA-binding bacteria in salivary microbiome2016

    • Author(s)
      Shinya Kageyama, Toru Takeshita, Mikari Asakawa, Yukie Shibata, Rie Matusmi, Michiko Furuta, Kenji Takeuchi, Yoshihisa Yamashita
    • Organizer
      6th International Human Microbiome Congress
    • Place of Presentation
      Houston
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of salivary microbiome in orally-healthy Japanese adults2016

    • Author(s)
      Toru Takeshita, Shinya Kageyama, Mikair Asakawa, Michiko Furuta, Kenji Takeuchi, Toshiharu Ninomiya, Yoshihisa Yamashita
    • Organizer
      6th International Human Microbiome Congress
    • Place of Presentation
      Houston
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 口腔バイオフィルムの網羅的解析から見える次世代の歯科医療2016

    • Author(s)
      山下喜久
    • Organizer
      第23回日本歯科医学総会
    • Place of Presentation
      福岡
    • Year and Date
      2016-10-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Characteristics of bacterial composition in saliva of edentulous adults2016

    • Author(s)
      Yoshihisa Yamashita, Toru Takeshita, Michiko Furuta, Kenji Takeuchi, Yukie Shibata, Toshiharu Ninomiya
    • Organizer
      4th World Congress on Targeting Microbiota
    • Place of Presentation
      Paris
    • Year and Date
      2016-10-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 口腔マイクロバオームと口腔疾患2016

    • Author(s)
      山下喜久
    • Organizer
      日本ヘルスケア歯科学会ヘルスケアミーティング2016
    • Place of Presentation
      東京
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Development of oral indigenous microbiota and factors associated with maturation in early childhood2016

    • Author(s)
      Midair Asakawa, Toru Takeshita, Shinya Kageyama, Yoshihisa Yamashita
    • Organizer
      第58回歯科基礎医学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 唾液マイクロバイオームは歯周病の重症度を反映する2016

    • Author(s)
      影山伸哉、竹下徹、朝川美加李、柴田幸江、山下喜久
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Succession of tongue microbiota in early childhood and its related factors2016

    • Author(s)
      Toru Takeshita, Midair Asakawa, Shinya Kageyama, Yoshihisa Yamashita Succession of tongue microbiota in early childhood and its related factors
    • Organizer
      ISME16
    • Place of Presentation
      Montreol
    • Year and Date
      2016-08-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Oral microbiota representing oral health conditions and host susceptibility to periodontitis2016

    • Author(s)
      Yoshihisa Yamashita
    • Organizer
      2016 IADR/APR General Session & Exhibition
    • Place of Presentation
      Seoul
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 口腔マイクロバイオームの評価に基づく健康管理2016

    • Author(s)
      山下喜久
    • Organizer
      第16回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 加齢と口腔マイクロバイオームの変化2016

    • Author(s)
      山下喜久
    • Organizer
      第11回日本アンチエイジング歯科学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
    • Invited

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Published: 2016-04-21   Modified: 2022-01-27  

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