| Budget Amount *help |
¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
An RNA sequence (transcript) folds upon itself into a tertiary structure while being synthesized out of its template DNA sequence on a gene. This phenomenon is called cotranscriptional folding (CF). Geary et al. demonstrated a design of template sequence whose transcript cotranscriptionally folds into a target RNA tile structure highly likely.
In this research project, we proposed the oritatami system (OS) as a mathematical model of CF, and studied the potential of OS to yield structures as well as the computational complexity of several problems on the OS design. One of the important result is the design and implementation of OS that counts in binary. This counter OS is of use to control the size of the target structure to be folded. It turned out to be quite useful also to generate a fractal-like structure, whose folding requires a simple computation like counting inherently.
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