| Budget Amount *help |
¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Outline of Final Research Achievements |
The integrity of genomic DNA that is challenged by various endogenous and exogenous sources is maintained by DNA repair mechanisms that remove and repair a wide variety of DNA damages. DNA double-stand breaks (DSBs) are one of the most deleterious type of DNA damage, which can be generated by ionizing radiation. DSBs are mainly repaired by either non-homologous end-joining or homologous recombination repair. In this study, we sought to reveal potential involvement of nuclear bodies in DSB repair. Among these, we focused on nuclear speckles that localize next to transcriptionally active regions. Mechanistically, we established that USP42, hitherto unidentified nuclear speckle factor, promoted homologous recombination repair.
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