| Budget Amount *help |
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
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| Outline of Final Research Achievements |
In this study, we tried to clarify the relationship between phosphorylation of the myosin regulatory light chain that regulates the endogenous contractile force and cell morphology, contractile force generation, and motility. When the myosin regulatory light chain is put in a pseudo high phosphorylation state, the cells generate a force in a circular form and hardly move. Conversely, when the myosin regulatory light chain is put in a pseudo low phosphorylation state, the cell morphology became complicated and cell movement became active. In addition, it was revealed that the wild-type myosin regulatory light chain goes back and forth between the above two states.
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