| Budget Amount *help |
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2016: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
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| Outline of Final Research Achievements |
It is known that abnormalities in lipid biosynthesis, distribution, metabolism, and excretion, are associated with various diseases, similar to the genetic mutations and protein dysfunction. In this study, for the treatment of arteriosclerosis and inflammatory diseases, we evaluated the effects of acid-labile polyrotaxanes (PRXs) that can directly interact to the intracellular lipids and cholesterol on the inflammatory responses and metabolic functions of macrophages. It was clarified that PRX suppressed the accumulation of cholesterol in LPS-stimulated macrophages and suppresses the gene expression of inflammatory cytokines and the activation of transcription factors. Accordingly, PRXs would be applied for the treatment of inflammatory diseases through the modulation of cholesterol metabolism.
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