Creation of elastic gel platform through the rational design of self-assembling polypeptides
| Project/Area Number |
16H05911
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2018: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2017: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2016: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
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| Keywords | ナノバイオ / 生体材料 / ポリペプチド / エラスチン / ゲル |
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| Outline of Final Research Achievements |
This study aimed to create new biomaterials as a platform for life science research through the development of easy-to-use elastin materials. The elastin-like block polypeptide GPGs developed by us are found to exhibit following characteristics. 1) GPGs form hydrogels at a concentration of two orders of magnitude lower than that of those existing elastin-based materials. 2) The fusion of a cell-adhesive sequence to GPG results in a nanofibers showing cell adhesive and proliferation properties equivalent to fibronectin toward fibroblast cells. 3) GPG nanofibers without the cell adhesion sequence are excellent in low platelet adhesion property.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究によって、エラスチン類似ブロックポリペプチドGPGは、ハンドリング性、堅牢な自己集合性による分子設計の自由度の高さ、ファイバー表面への機能性モチーフ提示による高い生理活性等に優れる材料であることが示された。GPG類は、細胞のメカノトランスダクション研究や、細胞プリンティング用基材、人工血管や人工皮膚の創製など、ライフサイエンス研究のための新しいプラットフォームとして幅広い活用が期待される。
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Report
(4 results)
Research Products
(28 results)
