| Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2016: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
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| Outline of Final Research Achievements |
Optical imaging technology is a reliable tool for biomedical research filed and clinical diagnostics in various diseases. We developed and evaluated own microscopy system for biomedical applications in the field of orthopedic surgery. Osteoporosis is a major bone disease that connotes the risk of fragility fractures. Bone strength arises from both bone quantity and quality. Assessment of bone quality and bone quantity is important for prediction of fracture risk. Bone mineral density is used to determine the bone strength in the current diagnosis of osteoporosis. However, there is no practical method to measure chemical composition of bone tissue including hydroxyapatite and collagen non-invasively. Raman spectroscopy is a powerful technique to analyze chemical composition and material properties of bone matrix non-invasively. Here, we successfully obtained Raman spectral data of bone matrix to evaluate the bone quality in the osteoporosis model.
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