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Muscle contraction and brain health: muscle-brain interaction and application for exercise prescription

Research Project

Project/Area Number 16H05919
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Sports science
Research InstitutionPhysical Fitness Research Institute, Meiji Yasuda Life Foundation of Health and Welfare

Principal Investigator

SUDO MIZUKI  公益財団法人明治安田厚生事業団体力医学研究所, その他部局等, 研究員(移行) (10585186)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Keywords豊かな環境 / 身体活動レベル / 情動 / 認知機能 / 骨格筋肥大 / 脳の健康 / 身体活動量 / BDNF / 筋収縮 / メンタルヘルス / 自発的な筋運動 / 感情 / 運動 / 筋肥大 / 脳科学 / 行動実験 / 豊かな環境飼育 / 脳 / エピジェネティクス
Outline of Final Research Achievements

The purpose of the present study was to examine that effects of an enrich environment (EE) on spontaneous locomotor activity, skeletal muscle and anxiety-like behavior compared with a standard environment (SE). We observed that increased exercise activity in the enriched environment improved anxiety-like behavior and spatial learning and memory. Moreover, all hindlimb muscle wet weights per BW were greater in the EE group compared with the SE group. The EE substantially increased locomotor activity and induced muscle hypertrophy in rats. An enriched environment used in the present study appeared to increase rat skeletal muscle volumes without increasing physiological and/or psychological stress.

Academic Significance and Societal Importance of the Research Achievements

本研究は,身体活動における重要な点である能動性と受動性に着目し,身体活動及び,運動を介した骨格筋から脳への求心的な応答が,メンタルヘルスや認知機能の変化に及ぼす機序を明らかにすることを大課題としている.そこで,能動・受動的な運動や身体活動モデルを確立し,これらの負荷がメンタルヘルスと認知機能に及ぼす影響と機序の解明を明らか目指した.本研究から得られる知見は,メンタルヘルスや認知機能の改善に対して,これまで画一的に提唱されてきた「身体活動は健康をもたらす」という漠然とした処方ではなく,健康増進を目的とした,骨格筋や脳に着目した生体を構成する各臓器の健康の重要性を明確にすることが可能となる.

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (14 results)

All 2019 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Int'l Joint Research: 4 results,  Invited: 4 results)

  • [Journal Article] Effects of Acute Stretching on Cognitive Function and Mood States of Physically Inactive Young Adults2019

    • Author(s)
      Sudo Mizuki、Ando Soichi
    • Journal Title

      Perceptual and Motor Skills

      Volume: 127 Issue: 1 Pages: 142-153

    • DOI

      10.1177/0031512519888304

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of enriched environment on rat skeletal muscle and plasma concentration of noradrenalin and cortisol.2017

    • Author(s)
      Mizuki Sudo, Soichi Ando, Yuko maher Nakanishi, Toshiya Nagamatsu
    • Journal Title

      体力研究

      Volume: 印刷中

    • NAID

      130007404246

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 異なる条件における豊かな環境暴露による身体活動量と不安様感情の関係性2019

    • Author(s)
      須藤みず紀,安藤創一
    • Organizer
      日本体力医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Spontaneous locomotor activity reduces anxiety-like behavior in environmental enrichment.2019

    • Author(s)
      Sudo M, Ando S
    • Organizer
      24th Annual Congress of the European College of Sport Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Environmental enrichment increases spontaneous locomotor activity in rats.2019

    • Author(s)
      Sudo M, Ando S
    • Organizer
      American College of Sports Medicine 66th Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 「骨格筋は『脳を守る』ための鍵となれるか?」2018

    • Author(s)
      須藤みず紀
    • Organizer
      第73回日本体力医学会 シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ラットにおける豊かな環境飼育は自発的な身体活動量と空間学習記憶能力を増加させる2018

    • Author(s)
      須藤みず紀, 安藤創一
    • Organizer
      第73回日本体力医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 環境による身体活動量の違いが脳機能に及ぼす影響2018

    • Author(s)
      須藤みず紀
    • Organizer
      第1回運動と脳の勉強会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] An enriched environment increases locomotor activity and induces skeletal muscle hypertrophy in rats2018

    • Author(s)
      Sudo M, Ando S
    • Organizer
      23rd European College of Sport Science
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Increased exercise activity in an enriched environment improves anxiety-like behavior and cognition.2018

    • Author(s)
      Sudo M, Ando S
    • Organizer
      65th Annual Congress of the American College of Sports Medicine
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 豊かな環境は心身の健康を促進する?-環境がもたらす筋と脳の関係-2017

    • Author(s)
      須藤みず紀
    • Organizer
      第1回スポーツニューロサイエンス研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 運動はメンタルヘルスと認知機能の向上に貢献できるのか?2017

    • Author(s)
      須藤みず紀
    • Organizer
      小の月の会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 発的な運動を促す豊かな環境は不安感情様の低下と骨格筋量の増加を惹起する2017

    • Author(s)
      須藤みず紀, 安藤創一, 永松俊哉
    • Organizer
      第72回日本体力医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 豊かな環境が骨格筋と生理的ストレス応答に及ぼす影響2017

    • Author(s)
      須藤みず紀, 安藤創一, 永松俊哉
    • Organizer
      第25回日本運動生理学会
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2021-02-19  

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