| Budget Amount *help |
¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Outline of Final Research Achievements |
The injection of glycogenolysis inhibitor into the rat brain revealed that brain glycogen contributes to exercise endurance through the production/supply of lactate, which is an important energy source for neurons, and its metabolic failure causes central fatigue. Furthermore, the mixed formulation of exercise and a high carbohydrate diet, "glycogen loading", increases glycogen levels not only in the skeletal muscle but also in the brain (hypothalamus and hippocampus) and enhances exercise endurance. In addition, metabolomics revealed that plasma tyrosine is a biomarker for brain glycogen loading. These findings should contribute to the development of a new strategy for athletes' higher endurance capacity called brain glycogen loading.
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