The skeletal muscle characteristics and strategy of intervention at each stage of sarcopenia

• Project/Area Number: 16H05921
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: University of Tsukuba
• Principal Investigator: Yamada Minoru 筑波大学, 人間系, 准教授 (30525572)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥20,800,000 (Direct Cost: ¥16,000,000、Indirect Cost: ¥4,800,000); Fiscal Year 2018: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
• Keywords: サルコペニア / ダイナペニア / 骨格筋 / 筋量 / 筋力 / 筋質 / 老化 / リハビリテーション / 運動処方 / アミノ酸

Outline of Final Research Achievements

The aim of this study was to compare the skeletal muscle characteristics at each stage of sarcopenia (normal, pre-sarcopenia, dynapenia, and sarcopenia) in older adults, and to investigate the synergistic effects of resistance exercise and a protein supplement on skeletal muscle in sarcopenic and dynapenic older adults. Our results found that muscle strength and quality indicators were lower in the sarcopenia and dynapenia groups than in the other groups, and the synergistic effect of resistance exercise and protein supplementation on muscle quality and strength in sarcopenic and dynapenic older adults.

Academic Significance and Societal Importance of the Research Achievements

サルコペニアは、転倒や入院、要介護や死亡などの有害健康転帰を招くリスクファクターである。本研究では、サルコペニアだけでなくダイナペニアも同様の骨格筋特性を有していることを明確にし、さらには両者に対する有益な介入方法を示すことができた。このことは学術的価値を有するだけでなく、汎用性の高い社会的意義のある成果であると考えられた。

Research Products

• [Journal Article] Synergistic effect of bodyweight resistance exercise and protein supplementation on skeletal muscle in sarcopenic or dynapenic older adults (2019)
  • Author(s): Yamada Minoru、Kimura Yosuke、Ishiyama Daisuke、Nishio Naohito、Otobe Yuhei、Tanaka Tomoya、Ohji Shunsuke、Koyama Shingo、Sato Atsushi、Suzuki Mizue、Ogawa Hideyuki、Ichikawa Takeo、Ito Daisuke、Arai Hidenori
  • Journal Title: Geriatrics & Gerontology International Volume: 印刷中 Issue: 5 Pages: 429-437
  • DOI: 10.1111/ggi.13643
  • Peer Reviewed / Open Access
• [Journal Article] Phase angle is a useful indicator for muscle function in older adults. (2019)
  • Author(s): Yamada M, Kimura Y, Ishiyama D, Nishio N, Otobe Y, Tanaka T, Ohji S, Koyama S, Sato A, Suzuki M, Ogawa H, Ichikawa T, Ito D, Arai H.
  • Journal Title: J Nutr Health Aging Volume: 23 Pages: 251-255
  • Peer Reviewed
• [Journal Article] Social frailty predicts incident disability and mortality among community-dwelling Japanese older adults. (2018)
  • Author(s): Yamada M, Arai H
  • Journal Title: Journal of American Medical Directors Association Volume: 19(12) Issue: 12 Pages: 1099-1103
  • DOI: 10.1016/j.jamda.2018.09.013
  • Peer Reviewed
• [Journal Article] Effects of active learning on health literacy and behavior in older adults: a randomized controlled trial (2018)
  • Author(s): Uemura Kazuki、Yamada Minoru、Okamoto Hiroshi
  • Journal Title: Journal of the American Geriatrics Society Volume: 印刷中 Issue: 9 Pages: 1721-1729
  • DOI: 10.1111/jgs.15458
  • Peer Reviewed
• [Journal Article] Relationship between characteristics of skeletal muscle and oral function in community-dwelling older women (2018)
  • Author(s): Suzuki Mizue、Koyama Shingo、Kimura Yosuke、Ishiyama Daisuke、Otobe Yuhei、Nishio Naohito、Ichikawa Takeo、Kunieda Yota、Ohji Shunsuke、Ito Daisuke、Yamada Minoru
  • Journal Title: Archives of Gerontology and Geriatrics Volume: 79 Pages: 171-175
  • DOI: 10.1016/j.archger.2018.09.003
  • Peer Reviewed
• [Journal Article] Chapter 4 Treatment of sarcopenia (2018)
  • Author(s): Arai Hidenori、Wakabayashi Hidetaka、Yoshimura Yoshihiro、Yamada Minoru、Kim Hunkyung、Harada Atsushi
  • Journal Title: Geriatrics & Gerontology International Volume: 18 Issue: S1 Pages: 28-44
  • DOI: 10.1111/ggi.13322
  • Peer Reviewed
• [Journal Article] Is grip strength adjustment necessary for sarcopenia diagnosis? (2018)
  • Author(s): Yamada Minoru、Arai Hidenori
  • Journal Title: Geriatr Gerontol Int Volume: 18 Issue: 3 Pages: 511-512
  • DOI: 10.1111/ggi.13232
  • Peer Reviewed
• [Journal Article] Prevalence of frailty among community-dwellers and outpatients in Japan as defined by the Japanese version of the Cardiovascular Health Study criteria (2017)
  • Author(s): Satake Shosuke、Shimada Hiroyuki、Yamada Minoru、Kim Hunkyung、Yoshida Hideyo、Gondo Yasuyuki、Matsubayashi Kozo、Matsushita Eiji、Kuzuya Masafumi、Kozaki Koichi、Sugimoto Ken、Senda Kazuyoshi、Sakuma Mayumi、Endo Naoto、Arai Hidenori
  • Journal Title: Geriatr Gerontol Int Volume: 17 Issue: 12 Pages: 2629-2634
  • DOI: 10.1111/ggi.13129
  • Peer Reviewed / Open Access
• [Journal Article] Self-Management Group Exercise Extends Healthy Life Expectancy in Frail Community-Dwelling Older Adults (2017)
  • Author(s): Yamada Minoru、Arai Hidenori
  • Journal Title: Int J Environ Res Public Health Volume: 14 Issue: 5 Pages: 531-531
  • DOI: 10.3390/ijerph14050531
  • NAID: 120007128928
  • Peer Reviewed / Open Access
• [Journal Article] Differential Characteristics of Skeletal Muscle in Community-Dwelling Older Adults (2017)
  • Author(s): Yamada Minoru、Kimura Yosuke、Ishiyama Daisuke、Nishio Naohito、Abe Yuki、Kakehi Tomohiro、Fujimoto Junko、Tanaka Tomoya、Ohji Shunsuke、Otobe Yuhei、Koyama Shingo、Okajima Yukiko、Arai Hidenori
  • Journal Title: J Am Med Dir Assoc Volume: 18 Issue: 9 Pages: 807.e9-807.e16
  • DOI: 10.1016/j.jamda.2017.05.011
  • Peer Reviewed
• [Journal Article] The association between fear of falling and smoothness of lower trunk oscillation in gait varies according to gait speed in community-dwelling older adults (2017)
  • Author(s): Asai Tsuyoshi、Misu Shogo、Sawa Ryuichi、Doi Takehiko、Yamada Minoru
  • Journal Title: J Neuroeng Rehabil Volume: 14 Issue: 1 Pages: 1-9
  • DOI: 10.1186/s12984-016-0211-0
  • NAID: 120007134975
  • Peer Reviewed
• [Journal Article] Interventions for Treating Sarcopenia: A Systematic Review and Meta-Analysis of Randomized Controlled Studies (2017)
  • Author(s): Yoshimura Yoshihiro、Wakabayashi Hidetaka、Yamada Minoru、Kim Hunkyung、Harada Atsushi、Arai Hidenori
  • Journal Title: J Am Med Dir Assoc Volume: 18 Issue: 6 Pages: 553.e1-553.e16
  • DOI: 10.1016/j.jamda.2017.03.019
  • Peer Reviewed
• [Journal Article] The severity and number of musculoskeletal pain associated with gait in community-dwelling elderly individuals (2017)
  • Author(s): Sawa Ryuichi、Doi Takehiko、Misu Shogo、Saito Takashi、Sugimoto Taiki、Murata Shunsuke、Asai Tsuyoshi、Yamada Minoru、Ono Rei
  • Journal Title: Gait Posture Volume: 54 Pages: 242-247
  • DOI: 10.1016/j.gaitpost.2017.03.013
  • Peer Reviewed
• [Journal Article] The extracellular to intracellular water ratio in upper legs is negatively associated with skeletal muscle strength and gait speed in older people. (2017)
  • Author(s): Yosuke Yamada, T Yoshida, K Yokoyama, Y Watanabe, M Miyake, E Yamagata, M Yamada, M Kimura, Kyoto-Kameoka Study
  • Journal Title: Journal of Gerontology A Biological Science and Medical Science Volume: 72 Pages: 293-298
  • DOI: 10.1093/gerona/glw125
  • Peer Reviewed
• [Journal Article] Combination of low body mass index and low serum albumin level leads to poor functional recovery in stroke patients (2016)
  • Author(s): Kimura Y, Yamada M, Kakehi T, Itagaki A, Tanaka N, Muroh Y
  • Journal Title: J Stroke Cerebrovasc Dis Volume: - Issue: 2 Pages: 448-453
  • DOI: 10.1016/j.jstrokecerebrovasdis.2016.10.008
  • Peer Reviewed
• [Journal Article] Comparability of two representative devices for bioelectrical impedance data acquisition (2016)
  • Author(s): M Yamada, Yosuke Yamada, H Arai
  • Journal Title: Geriatrics & Gerontology International Volume: 16 Issue: 9 Pages: 1087-8
  • DOI: 10.1111/ggi.12647
  • Peer Reviewed
• [Journal Article] Systematic review of the Kihon Checklist: is it a reliable assessment of frailty? (2016)
  • Author(s): Priscila Yukari Sewo Sampaio, Yamada M, Arai H
  • Journal Title: Geriatr Gerontol Int. Volume: - Issue: 8 Pages: 893-902
  • DOI: 10.1111/ggi.12833
  • Peer Reviewed / Int'l Joint Research