| Budget Amount *help |
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2017: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2016: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
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| Outline of Final Research Achievements |
How animals learn an association between certain sensory stimuli and a reward remains unclear. In this study, we focused on cortico-cortical projection neurons in the primary sensory cortex which is the early branch point of the signal pathway that conveys reward-related sensory stimuli. We revealed that, upon learning, layer 2/3 neurons bi-directionally change their sensitivity to reward-associated sensory stimuli in a projection-specific manner. We further analyzed the anatomical patterns of layer 2/3 projection neurons and revealed that the projection targets of dorsal and ventral pathways are significantly overlapped at this early stage. In addition, our recordings from layer 5 neurons suggested that synaptic computation by layer 5 neurons during active behavior is different from that of layer 2/3 neurons. Thus, our data uncovered the basic properties of cortico-cortical projection neurons of primary sensory cortex.
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