| Budget Amount *help |
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2016: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
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| Outline of Final Research Achievements |
We developed various catalytic systems which effectively promote cross-coupling reaction of alkyl halides with alkyl Grignard reagents to construct saturated hydrocarbon frameworks. As a functionalization of 1,3-butadiene, we developed internal carbon selective alkylation reaction by copper catalyst with alkyl fluorides. When Ni was used instead of Cu, dimerization and double functionalization by carbon nucleophiles and carbon electrophiles proceeded to give mulit component coupling products.
In these catalytic reactions, anionic transition metal complexes arising from transition metal complex with organometallic reagents were found to be the catalytic active species.
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