Supramolecular Allosteric Signal-amplification Sensing Based on Flexible Polymers
| Project/Area Number |
16H06041
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Polymer chemistry
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| Research Institution | Tokyo Institute of Technology (2017-2018)
Osaka University (2016) |
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Principal Investigator |
Fukuhara Gaku 東京工業大学, 理学院, 准教授 (30505996)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2017: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2016: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | アロステリズム / 化学センサー / カードラン / ポリチオフェン / 静水圧 / 光学センシング / 超分子化学 / 分析化学 / 超分子分析化学 / 糖センシング / センサー / 高分子化学 |
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| Outline of Final Research Achievements |
The present studies obtained provided with new concepts for "Supramolecular Allosteric Signal-amplification Sensing" proposed by us. A new series of reporter-modified curdlans showed very high cooperativity and positive homotropic allosterism with high limit of detection. All of the results thus obtained can be expanded to other oligosaccharides and analytes that are difficult to sense in biomolecular media.
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| Academic Significance and Societal Importance of the Research Achievements |
本成果である光学出力をアロステリズムによって増幅し様々な分光分析手法(紫外可視近赤外、蛍光、円二色性)によって読み取るSASSは、幅広い検体を高感度かつ選択的にセンシングできる手法であり、大きなフロンティアとなった。つまり、本コンセプトに基づく医学系の新たな診断計測技術の構築とともにそれら材料の機能を能動的に制御できるため、関連科学からフォトニクスに至る多方面に大きく貢献できると考えられる。従って、今回見出したSASSがセンサー科学を飛躍的に発展させた新機構であることは疑いなく、この発想を利用してこれまでの計測科学・イメージング技術を向上させ得る手段となった。
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Report
(4 results)
Research Products
(69 results)
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[Journal Article] Supramolecular Photochirogenesis Driven by Higher-Order Complexation: Enantiodifferentiating Photocyclodimerization of 2-Anthracenecarboxylate to Slipped Cyclodimers via a 2:2 Complex with β-Cyclodextrin2018
Author(s)
Wei, X.#; Wu, W.#; Matsushita, R.#; Yan, Z.#; Zhou, D.; Chruma, J. J.; Nishijima, M.; Fukuhara, G.; Mori, T.; Inoue, Y.*; Yang, C.* (# Equal contributions)
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Journal Title
J. Am. Chem. Soc.
Volume: 140
Issue: 11
Pages: 3959-3974
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Inherently Chiral Azonia[6]helicene-Modified beta-Cyclodextrin: Synthesis, Characterization, and Chirality Sensing of Underivatized Amino Acids in Water2016
Author(s)
Huang, Q.; Jiang, L.; Liang, W.; Gui, J.; Xu, D.; Wu, W.; Nakai, Y.; Nishijima, M.; Fukuhara, G.; Mori, T.; Inoue, Y.*; Yang, C.*
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Journal Title
J. Org. Chem.
Volume: 81
Issue: 8
Pages: 3430-3434
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Electrostatically Promoted Dynamic Hybridization of Glucans with Cationic Polythiophene2016
Author(s)
Fukuhara, G.; Imai, M.; Fuentealba, D.; Ishida, Y.; Kurohara, H.; Yang, C.; Mori, T.; Uyama, H.; Bohne, C.; Inoue, Y.
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Journal Title
Org. Biomol. Chem.
Volume: 14
Issue: 41
Pages: 9741-9750
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Supramolecular Photochirogenesis with a Higher-Order Complex: Highly Accelerated Exclusively Head-to-Head Photocyclodimerization of 2-Anthracenecarboxylic Acid via 2:2 Complexation with Prolinol2016
Author(s)
Kawanami, Y.; Katsumata, S.-y.; Nishijima, M.; Fukuhara, G.; Asano, K.; Suzuki, T.; Yang, C.; Nakamura, A.; Mori, T.; Inoue, Y.
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Journal Title
J. Am. Chem. Soc.
Volume: 138
Issue: 37
Pages: 12187-12201
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Dynamic Hybridization of Glucans with Cationic Polythiophene to Chiral Hetero-Triplex and -Duplexes2016
Author(s)
Gaku Fukuhara, Mami Imai, Denis Fuentealba, Yuki Ishida, Hiroki Kurohara, Cheng Yang, Tadashi Mori, Hiroshi Uyama, Cornelia Bohne, Yoshihisa Inoue
Organizer
Chirality 2016
Place of Presentation
Heidelberg, Germany
Year and Date
2016-07-24
Related Report
Int'l Joint Research
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[Presentation] Bio-Supramolecular Hetero-Triplex and Hetero-Duplex Architectures: Dynamic Hybridization of Glucans with Cationic Polythiophene2016
Author(s)
Gaku Fukuhara, Mami Imai, Denis Fuentealba, Yuki Ishida, Hiroki Kurohara, Cheng Yang, Tadashi Mori, Hiroshi Uyama, Cornelia Bohne, Yoshihisa Inoue
Organizer
11th ISMSC-2016
Place of Presentation
The K-Hotel, Seoul, Korea
Year and Date
2016-07-10
Related Report
Int'l Joint Research
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