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development of innovative brain function activation method using hybrid materials based on interfacial control

Research Project

Project/Area Number 16H06047
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Organic and hybrid materials
Research InstitutionOsaka University

Principal Investigator

Osakada Yasuko  大阪大学, 産業科学研究所, 准教授 (00579245)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywordsナノ材料 / 光操作 / 電子移動反応 / 光化学 / 機能材料 / 生体膜 / 光機能性界面 / 細胞機能 / 活性化 / 光熱効果反応 / ハイブリッド材料 / 界面 / 膜電位 / 神経 / 光活性化 / 電子移動 / 光熱反応 / 光機能性分子
Outline of Final Research Achievements

This research "development of innovative brain function activation method using hybrid materials based on interfacial control" is to constract a nano-level photofunctional interface on the electronic and thermal energy states of the cellular membrane. We aimed to develop nanomaterials that control the photofucntion using light. A: Porphyrin nanosheet, and B:perylene molecules for membrane potential photoconversion were synthesized successfully. In fact that, we succeeded in synthesizing the porphyrin nanoscheet in the A project. It should be noted that unexpectedly thin two-dimensional porphyrin nanosheets with a thickness of several nanometers were synthesized, and used as sentiziters in photocatalytic reaction. In B project; we reported we have achieved photoinduced electron transfer reaction and its membrane potential conversion in the synthesized small molecule at the cellular level.

Academic Significance and Societal Importance of the Research Achievements

Aでは、これまでにCOFsを剥離することでは合成が達成できなかった1 nmの薄さを有する二次元高分子の新たな合成方法を示し、さらにその剥離したポルフィリン二次元ディスクの近赤外光照射による水素発生反応の光触媒の高機能化を示した。このような薄層二次元ポリマーの合成例とその光触媒機能の向上に関する研究例はなく、今後の生体機能操作への利用が期待される。Bでは、イミド類での光誘起電子移動反応は多く報告されているが、従来全く試みられていないイミド分子での光誘起分子間電子移動反応の細胞利用を示した。

Report

(4 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (19 results)

All 2020 2019 2017 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (11 results) Remarks (2 results)

  • [Int'l Joint Research] Department of Biochemistry/School of Molecular and Cellular Biology/UIUC(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Synthesis of porphyrin nanodisks from COFs through mechanical stirring and their photocatalytic activity2020

    • Author(s)
      Li Xinxi、Goto Tomoyo、Nomura Kota、Zhu Mingshan、Sekino Tohru、Osakada Yasuko
    • Journal Title

      Applied Surface Science

      Volume: 513 Pages: 145720-145720

    • DOI

      10.1016/j.apsusc.2020.145720

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hard X-ray excited optical luminescence from protein-directed Au?20 clusters2020

    • Author(s)
      Liu Zuoyue、Jung Kyung Oh、Takahata Ryo、Sakamoto Masanori、Teranishi Toshiharu、Fujitsuka Mamoru、Pratx Guillem、Osakada Yasuko
    • Journal Title

      RSC Advances

      Volume: 10 Issue: 23 Pages: 13824-13829

    • DOI

      10.1039/d0ra01935f

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synthesis and photocatalytic activity of ultrathin two-dimensional porphyrin nanodisks via covalent organic framework exfoliation2019

    • Author(s)
      Fan Zeyu、Nomura Kota、Zhu Mingshan、Li Xinxi、Xue Jiawei、Majima Tetsuro、Osakada Yasuko
    • Journal Title

      Communications Chemistry

      Volume: 2 Issue: 1

    • DOI

      10.1038/s42004-019-0158-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Live Cell Imaging Using Photoswitchable Diarylethene-Doped Fluorescent Polymer Dots2017

    • Author(s)
      Osakada Yasuko、Fukaminato Tuyoshi、Ichinose Yuma、Fujitsuka Mamoru、Harada Yoshie、Majima Tetsuro
    • Journal Title

      Chemistry - An Asian Journal

      Volume: 12 Issue: 20 Pages: 2660-2665

    • DOI

      10.1002/asia.201701038

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single-particle tracking reveals a dynamic role of actin filaments in assisting long-range axonal transport in neurons.2017

    • Author(s)
      Osakada Y, Zhang K.
    • Journal Title

      Bull. Chem. Soc. Jpn.

      Volume: 90 Issue: 6 Pages: 714-719

    • DOI

      10.1246/bcsj.20170090

    • NAID

      130006770652

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Development of photo-functional nanomaterials with new properties and their application to bioscience2020

    • Author(s)
      Yasuko Osakada
    • Organizer
      日本化学会第100回春年会2020
    • Related Report
      2018 Annual Research Report
  • [Presentation] Synthesis of 2D polymer using common solvent from porphyrin comprised covalent organic frameworks by mechanical stirring2020

    • Author(s)
      LI, Xinxi; OSAKADA, Yasuko
    • Organizer
      日本化学会第100回春年会2020
    • Related Report
      2018 Annual Research Report
  • [Presentation] Synthesis and application of photo-luminescent polymer dots doped with iridium complex2020

    • Author(s)
      LIU, Zuoyue; OSAKADA, Yasuko
    • Organizer
      日本化学会第100回春年会2020
    • Related Report
      2018 Annual Research Report
  • [Presentation] 共有結合性有機骨格構造の剥離による超薄型二次元ポルフィリンナノディスクの合成と光触媒活性2019

    • Author(s)
      FAN ZEYU・小阪田泰子
    • Organizer
      第9回CSJ化学フェスタ2019
    • Related Report
      2018 Annual Research Report
  • [Presentation] Exfoliation of Two-Dimensional Nanosheets from Porphyrin Containing Covalent Organic Frameworks Using Common Solvents2019

    • Author(s)
      Li Xinxi・小阪田泰子
    • Organizer
      第9回CSJ化学フェスタ2019
    • Related Report
      2018 Annual Research Report
  • [Presentation] 共有結合性有機骨格構造剥離による薄層二次元ポルフィリンナノディスクの合成と光触媒活性2019

    • Author(s)
      小阪田 泰子
    • Organizer
      第68回高分子討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Photoluminescence and X-ray imaging of protein-directed gold clusters2019

    • Author(s)
      Zuoyue Liu,Yasuko Osakada
    • Organizer
      放射線化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Synthesis and photocatalytic activity of ultrathin two-dimensional porphyrin nanodisks via covalent organic framework exfoliation2019

    • Author(s)
      FAN, Zeyu、OSAKADA, Yasuko
    • Organizer
      光化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Facile synthesis of thin layered porphyrin comprising covalent organic nanosheets using common solvents and evaluation of their photocatalytic activity2019

    • Author(s)
      LI,Xinxi・OSAKADA, Yasuko
    • Organizer
      光化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Synthesis and photoluminescence of gold nanoclusters directed by various proteins2019

    • Author(s)
      LIU, Zuoyue・OSAKADA, Yasuko
    • Organizer
      光化学討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Radiation and photochemistry based bioscience2019

    • Author(s)
      Yasuko Osakada
    • Organizer
      2019 The 4th Osaka Univ. KAERI Joint Workshop on Radiation Research
    • Related Report
      2018 Annual Research Report
  • [Remarks]

    • URL

      http://yasuko-osakada.strikingly.com/

    • Related Report
      2017 Annual Research Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/mec/osakada%20research.html

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2022-05-23  

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